BICEPS-PT
Initial Adaptations in the Biceps Brachii Muscles to Different Modalities of Resistance Training: A Randomized Top-down Proteomic Pilot Study
Sponsor study identifier
interventional
10
0 countries
N/A
Study Start
September 1, 2004
Actual (reported)Primary Completion
January 23, 2014
Actual (reported)Study Completion
June 29, 2026
Actual (reported)This study examined how two types of resistance training affect the biceps muscle over six weeks in healthy young men. Participants performed either low-repetition, heavy-load training designed to improve maximal strength or high-repetition training designed to improve muscular endurance. Training was supervised and performed twice weekly. Researchers measured arm strength and muscular endurance before and after training. They also collected small samples of biceps muscle tissue to examine muscle-fibre characteristics and changes in muscle proteins. These protein measurements were intended to identify early changes in muscle that may occur before visible changes in muscle size or measurable improvements in performance. The study found no clear differences between the two training approaches in strength, endurance, muscle-fibre size, or muscle-fibre type after six weeks. However, the two programs were associated with different patterns of change in muscle proteins. These findings may help researchers understand the early biological processes through which different types of resistance exercise affect skeletal muscle. This was a small exploratory study, so the results may not apply to other populations or longer training programs.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 29, 2026
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 1, 2004
Actual (reported)January 23, 2014
Actual (reported)June 29, 2026
Actual (reported)October 23, 2026
Actual (reported)October 29, 2026
Actual (reported)Change in biceps brachii muscle protein profile
Muscle-protein abundance was assessed in biceps brachii biopsy samples collected before and after the training intervention. Intact proteins were separated and quantified using two-dimensional difference gel electrophoresis (2D-DIGE). Protein spots with changed abundance were selected for identification by mass spectrometry. The outcome was the within-group change in abundance of individual protein spots from baseline to after training, compared between the maximal-strength and endurance-oriented strength-training groups.
Baseline and immediately after the 6-week resistance-training intervention (approximately Day 45).
A supervised, isolated biceps-brachii resistance-training intervention delivered twice weekly for six weeks. Participants performed bilateral preacher curls (Scott curls) with free weights on an EZ bar, using a standardized range of motion from full elbow extension to 135 degrees of elbow flexion. Each session comprised five sets of three-repetition maximum (3RM) with four minutes of rest between sets. The concentric phase was performed at maximal intended speed, while the eccentric phase was controlled over approximately three seconds. The load was individually progressed as the participant's 3RM improved. This intervention differs from the endurance-oriented arm primarily in its low-repetition, high-load prescription
A supervised, isolated biceps-brachii resistance-training intervention delivered twice weekly for six weeks. Participants performed bilateral preacher curls (Scott curls) with free weights on an EZ bar, using the same standardized range of motion from full elbow extension to 135 degrees of elbow flexion. Each session comprised three sets of 30-repetition maximum (30RM) with four minutes of rest between sets. The concentric phase was performed at maximal intended speed, while the eccentric phase was controlled over approximately three seconds. The load was individually progressed as the participant's 30RM improved. This intervention differs from the maximal-strength arm primarily in its high-repetition, lower-load prescription.
A supervised, isolated biceps-brachii resistance-training intervention delivered twice weekly for six weeks. Participants performed bilateral preacher curls (Scott curls) with free weights on an EZ bar, using a standardized range of motion from full elbow extension to 135 degrees of elbow flexion.
Hammert WB, Yamada Y, Kataoka R, Song JS, Spitz RW, Wong V, Seffrin A, Loenneke JP. Changes in Absolute and Relative Muscular Endurance After Resistance Training: A Review of the Literature With Considerations for Future Research. J Strength Cond Res. 2025 Apr 1;39(4):474-491. doi: 10.1519/JSC.0000000000005084.
10 participants (actual enrollment reported by the registry).
First Submitted
October 23, 2026
First Posted
October 29, 2026
Study Start
September 1, 2004
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
January 23, 2014
Actual (reported)Study Completion
June 29, 2026
Actual (reported)Last Updated
October 29, 2026
Record last verified: 2026-10
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Source: ClinicalTrials.gov.
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