NCT02589990

Brief Summary

The study investigates the effect of maximal strength training on muscular strength and power in different age groups from 20 to 80 year old. It also relates the training adaptations to different known genes such as angiotensin I-converting enzyme (ACE) and Alpha-actinin-3 (ACTN3). Participants will complete an eight weeks, three times per week training intervention of maximal strength training with a pre-post design. In addition, blood samples will be collected for the analyses of genetic variances.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
76

participants targeted

Target at P75+ for not_applicable healthy

Timeline
Completed

Started Jan 2016

Longer than P75 for not_applicable healthy

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 24, 2015

Completed
1 month until next milestone

First Posted

Study publicly available on registry

October 28, 2015

Completed
2 months until next milestone

Study Start

First participant enrolled

January 1, 2016

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2018

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

September 3, 2018

Completed
Last Updated

September 28, 2018

Status Verified

September 1, 2018

Enrollment Period

2.6 years

First QC Date

September 24, 2015

Last Update Submit

September 27, 2018

Conditions

Healthy

Keywords

healthmuscle strengthexercise genomics

Outcome Measures

Primary Outcomes (1)

  • Maximal muscle strength measured by 1 RM leg press in leg press machine

    8 weeks

Secondary Outcomes (3)

  • Blood sample will be collected to assess gene types Alpha Actinin 3, Angiotensin Converting Enzyme, Angiotensinogen

    8 weeks

  • rate of force development in leg press measured by MuscleLab (Ergotest Tech., Langesund Norway)

    8 weeks

  • agility will be measured by counter movement jump using the MuscleLab system by Ergotest Tech. (Langesund, Norway)

    8 weeks

Study Arms (1)

Strength training

EXPERIMENTAL

Strength training, 4 rep of 4RM x 4 sets in leg press.

Behavioral: Strength training

Interventions

Strength trainingBEHAVIORAL

see arm description

Strength training

Eligibility Criteria

Age20 Years - 90 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Healthy adults 20 to 90 years old

You may not qualify if:

  • Contraindications to maximum strength training and testing

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Telemark University College

Bø, Telemark, 3800, Norway

Location

Norwegian University of Science and Technology

Trondheim, Norway

Location

Related Publications (2)

  • Storen O, Helgerud J, Stoa EM, Hoff J. Maximal strength training improves running economy in distance runners. Med Sci Sports Exerc. 2008 Jun;40(6):1087-92. doi: 10.1249/MSS.0b013e318168da2f.

    PMID: 18460997BACKGROUND

  • Sunde A, Storen O, Bjerkaas M, Larsen MH, Hoff J, Helgerud J. Maximal strength training improves cycling economy in competitive cyclists. J Strength Cond Res. 2010 Aug;24(8):2157-65. doi: 10.1519/JSC.0b013e3181aeb16a.

    PMID: 19855311BACKGROUND

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Øyvind Støren, PhD

    University of South-Eastern Norway

    STUDY CHAIR

  • Mona Sæbø, PhD

    University of South-Eastern Norway

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
SCREENING
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 24, 2015

First Posted

October 28, 2015

Study Start

January 1, 2016

Primary Completion

August 1, 2018

Study Completion

September 3, 2018

Last Updated

September 28, 2018

Record last verified: 2018-09

Data Sharing

IPD Sharing
Will not share

Locations

NO(2)