Influence of Sodium Bicarbonate on Time-to-exhaustion at Critical Power in Endurance Athletes

NCT01621074 | Completed

• 1 other identifier: nbc
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

During endurance exercise in the heavy and severe intensity domains, the rate at which metabolites that have been associated with the fatigue process (e.g. Pi, ADP, H, and extracellular K) accumulate increases. possibly leading to exercise cessation. Sodium bicarbonate, as a nutritional supplement, has gained attention over the past decades, because it might delay of offset fatigue. To date, there is a controversial discussion about which delivery mode (amount and frequency) might be best in optimizing endurance performance. Since the high ion load consequent to multiple ingestions might increase plasma volume, and consequently decrease bicarbonate concentrations, single acute ingestion could be more beneficial. However, in multi-day competitions or tournaments it might be necessary to use the supplement on a daily basis. Here, the investigators aim at investigating the effects of single dose or multiple dose (on five consecutive days) administration of bicarbonate vs. placebo increases endurance performance and acid-base homeostasis in trained male endurance athletes.

Conditions

Performance

Outcome Measures

Primary Outcomes (1)

• Time-to-exhaustion

  5 weeks

Study Arms (2)

Sodium bicarbonate

ACTIVE COMPARATOR

Dietary Supplement: Sodium bicarbonate

Placebo

PLACEBO COMPARATOR

Dietary Supplement: Placebo

Interventions

Sodium bicarbonate DIETARY_SUPPLEMENT

Ergogenic effect

Sodium bicarbonate

Placebo DIETARY_SUPPLEMENT

Placebo effect

Placebo

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• no cold or temperature at beginning or during the study
• between 18 and 45 years of age
• active in endurance sports (3 to 5 times per week a moderate to hart training)
• non-smoker
• no known cardiovascular or orthopedic problems
• no known limitations of kidney function
• no bearer of a cardiac pacemaker
• no medications with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.
• requirements of the health questionnaire fulfilled

You may not qualify if:

• male and age under 18 or over 45 years
• cold or temperature at the beginning or during the study
• untrained (less than 3 moderate trainings per week)
• smoker
• cardiovascular or orthopedic problems
• limitations of the kidney function
• bearer of a cardiac pacemaker
• medication with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.
• requirements of the health questionnaire not fulfilled

Sponsors & Collaborators

• University of Zurich: lead
• Swiss Federal Institute of Technology: collaborator

Study Sites (1)

University Hospital Zurich, Division of Neurology

Zurich, Canton of Zurich, 8091, Switzerland

Location

Related Publications (1)

• Mueller SM, Gehrig SM, Frese S, Wagner CA, Boutellier U, Toigo M. Multiday acute sodium bicarbonate intake improves endurance capacity and reduces acidosis in men. J Int Soc Sports Nutr. 2013 Mar 26;10(1):16. doi: 10.1186/1550-2783-10-16.

  PMID: 23531361 DERIVED

MeSH Terms

Interventions

Sodium Bicarbonate

Intervention Hierarchy (Ancestors)

Bicarbonates; Carbonates; Carbonic Acid; Carbon Compounds, Inorganic; Inorganic Chemicals; Sodium Compounds

Study Officials

• Neurologie: Neurologische Forschung

  University Hospital Zurich, Division of Neurology

  STUDY DIRECTOR

• Marco Toigo, PhD

  Swiss Federal Institute of Technology Zurich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 12, 2012
• First Posted: June 15, 2012
• Study Start: October 1, 2011
• Primary Completion: August 1, 2012
• Study Completion: January 1, 2013
• Last Updated: April 12, 2013

Record last verified: 2013-04

Locations

CH (1)