NCT06098794

Brief Summary

This was a randomized, double-blind, placebo controlled, crossover trial. The study aimed to assess the effect of sodium bicarbonate on the ability to perform a repeated sprint task by female football players. The researches hypothesis was that sodium bicarbonate increases the ability to remove lactic acid from muscle cells reducing its intracellular accumulation and increasing energetic efficiency resulting in the increase of peak power output, mean power output, or total work or in the decrease of the sprint decrement in each set of the repeated sprints task.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Oct 2021

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 15, 2021

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 27, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 27, 2022

Completed
1.4 years until next milestone

First Submitted

Initial submission to the registry

October 6, 2023

Completed
19 days until next milestone

First Posted

Study publicly available on registry

October 25, 2023

Completed
Last Updated

October 25, 2023

Status Verified

October 1, 2023

Enrollment Period

6 months

First QC Date

October 6, 2023

Last Update Submit

October 23, 2023

Conditions

Keywords

Ergogenic Dietary SupplementRepeated Sprints PerformanceMuscle OxygenationOxygen Consumption

Outcome Measures

Primary Outcomes (4)

  • Peak power output

    Watt

    3 minutes through each set of the repeated sprints tasks

  • Mean power output

    Watt

    3 minutes through each set of the repeated sprints tasks

  • Total Work

    Joule

    3 minutes through each set of the repeated sprints tasks

  • Sprint Decrement

    percentage of power decrease

    3 minutes through each set of the repeated sprints tasks

Secondary Outcomes (8)

  • Countermovement jump height

    Before and after each repeated sprints tasks

  • Lactate accumulation

    Before the repeated sprints tasks, between sets of the repeated sprints tasks, immediatly after the repeated sprints tasks, 2 minutes after the repeated sprints tasks

  • Oxygen uptake

    3 minutes through each set of the repeated sprints tasks

  • carbon dioxide production

    3 minutes through each set of the repeated sprints tasks

  • Ventilation

    3 minutes through each set of the repeated sprints tasks

  • +3 more secondary outcomes

Study Arms (2)

Sodium Bicarbonate - Placebo

EXPERIMENTAL

First exercise performance assessment after ingesting sodium bicarbonate. Second exercise performance assessment after ingesting placebo

Dietary Supplement: Sodium BicarbonateDietary Supplement: Placebo

Placebo - Sodium Bicarbonate

EXPERIMENTAL

First exercise performance assessment after ingesting placebo. Second exercise performance assessment after ingesting sodium bicarbonate

Dietary Supplement: Sodium BicarbonateDietary Supplement: Placebo

Interventions

Sodium BicarbonateDIETARY_SUPPLEMENT

Capsules containing 0.3 g/kg of body weight of sodium bicarbonate were ingested in two doses. The first intake (0.2 g/kg) was performed together with a carbohydrate-enriched meal 2 h before a repeated sprint exercise protocol, and the second (0.1 g/kg) occurred 1 h later.

Placebo - Sodium BicarbonateSodium Bicarbonate - Placebo
PlaceboDIETARY_SUPPLEMENT

Capsules containing 0.3 g/kg of body weight of celulose were ingested in two doses. The first intake (0.2 g/kg) was performed together with a carbohydrate-enriched meal 2 h before a repeated sprint exercise protocol, and the second (0.1 g/kg) occurred 1 h later.

Placebo - Sodium BicarbonateSodium Bicarbonate - Placebo

Eligibility Criteria

Age18 Years - 30 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Football players
  • Regularly training with a weekly microcycle consisting of 3 to 5 training sessions and 1 game at the weekend
  • Able to provide informed consent

You may not qualify if:

  • Injury occurrence in the month previous to data collection
  • Ergogenic supplements consumption in the month previous to data collection
  • Having known intolerance to sodium bicarbonate

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Human Kinetics

Lisbon, 1495-002 Cruz-Quebrada, Portugal

Location

MeSH Terms

Interventions

Sodium Bicarbonate

Intervention Hierarchy (Ancestors)

BicarbonatesCarbonatesCarbonic AcidCarbon Compounds, InorganicInorganic ChemicalsSodium Compounds

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

October 6, 2023

First Posted

October 25, 2023

Study Start

October 15, 2021

Primary Completion

April 27, 2022

Study Completion

April 27, 2022

Last Updated

October 25, 2023

Record last verified: 2023-10

Data Sharing

IPD Sharing
Will not share

Locations