Chronic Grape Extract in Crosstraining Athletes: A Randomized Crossover Trial

NCT07106281 | Not Yet Recruiting

• 1 other identifier: CROSSUVA
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the effect of cronic GSE intake in crosstraining may have a favorable impact on biochemical markers, recovery, and performance.

Conditions

Performance

Keywords

grape seed extract; muscle damage; concurrent exercise; nutrition; recovery

Outcome Measures

Primary Outcomes (2)

• Performance

  Performance measured through the countermovement jump

  48 hours

• Performance

  Deep squat test at 70% of repetition maximum

  60 minutes

Secondary Outcomes (11)

• Attention

  60 minutes

• Performance: Weight used in the crosstraining session

  60 minutes

• Performance: Time performed in the crosstraining session

  60 minutes

• Subjective fatigue throug the the RPE scale

  60 minutes

• Gastrointestinal distress

  60 minutes

Study Arms (2)

Grape seed extract

EXPERIMENTAL

600 mg of Grape seed extract

Dietary Supplement: Grape Seed Extract

Placebo

PLACEBO COMPARATOR

Preparation of colorants, sweeteners, aromas, and acidulants

Dietary Supplement: Placebo

Interventions

Grape Seed Extract DIETARY_SUPPLEMENT

600mg of Grape Seed Extract

Grape seed extract

Placebo DIETARY_SUPPLEMENT

Placebo

Placebo

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age: 18-35 years.
• Body mass index: 18.5-30 kg/m2.
• Ability to understand the instructions, objectives, and study protocol.
• Minimum of 3 years of experience in crosstraining, with at least 6 hours of weekly training over the past 3 months.
• Resident on the island of Tenerife.

You may not qualify if:

• History of a significant adverse cardiovascular event, renal insufficiency, cirrhosis, eating disorder, weight control surgical intervention, or type 2 diabetes mellitus.
• Any chronic pathology in which the intake of nutritional supplements, especially use of antioxidant supplements during the 4 weeks prior to the start of the study.
• Any condition that, in the investigator's judgment, would impair the ability to participate in the study or represent a personal risk to the participant.
• Use of medications that may affect the study results.
• Unstable body weight for 3 months prior to the start of the study (\> 4 kg loss or gain in weight).
• Active tobacco abuse or illicit drug use, or history of treatment for alcohol abuse.
• On a special diet or prescribed for other reasons (e.g., celiac disease).

Sponsors & Collaborators

• Universidad de Granada: lead
• Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.: collaborator

Study Sites (1)

Universidad de la Laguna

Santa Cruz de Tenerife, Spain

Location

MeSH Terms

Interventions

Grape Seed Extract

Intervention Hierarchy (Ancestors)

Plant Extracts; Plant Preparations; Biological Products; Complex Mixtures; Pharmaceutical Preparations

Central Study Contacts

Lucas Jurado-Fasoli, PhD

CONTACT

618375662; juradofasoli@ugr.es

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: July 21, 2025
• First Posted: August 6, 2025
• Study Start: September 1, 2025
• Primary Completion: December 20, 2025
• Study Completion: January 31, 2026
• Last Updated: August 6, 2025

Record last verified: 2025-07

Locations

ES (1)