NCT01351415

Brief Summary

This open-label, randomized, multicenter study will evaluate the efficacy and safety of bevacizumab (Avastin) in combination with standard of care (SOC) treatment in participants with advanced non-squamous NSCLC. Participants will be enrolled at documentation of progression of disease (PD) after 4-6 cycles of first-line treatment with bevacizumab plus a platinum doublet-containing therapy and a minimum of two cycles of bevacizumab maintenance treatment prior to PD. Participants will be randomly assigned to one of two treatment arms to receive either bevacizumab plus SOC treatment or SOC treatment alone.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
485

participants targeted

Target at P50-P75 for phase_3

Timeline
Completed

Started Jun 2011

Longer than P75 for phase_3

Geographic Reach
18 countries

179 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 9, 2011

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 10, 2011

Completed
2 months until next milestone

Study Start

First participant enrolled

June 25, 2011

Completed
5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 25, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 25, 2016

Completed
1.2 years until next milestone

Results Posted

Study results publicly available

September 18, 2017

Completed
Last Updated

September 18, 2017

Status Verified

August 1, 2017

Enrollment Period

5 years

First QC Date

May 9, 2011

Results QC Date

June 20, 2017

Last Update Submit

August 17, 2017

Conditions

Outcome Measures

Primary Outcomes (1)

  • Overall Survival (OS)

    Overall survival (OS) was defined as the time from the date of randomization at first progression of disease to the date of death, regardless of the cause of death.

    Up to data cut-off date 24 June 2016 (approximately 5 years)

Secondary Outcomes (7)

  • Progression-free Survival (PFS) According to Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1)

    Up to data cut-off date 24 June 2016 (approximately 5 years)

  • Percentage of Participants With Objective Response According to RECIST v1.1

    Up to data cut-off date 24 June 2016 (approximately 5 years)

  • Percentage of Participants With Disease Control According to RECIST v1.1

    Up to data cut-off date 24 June 2016 (approximately 5 years)

  • Duration of Response (DoR) According to RECIST v1.1

    Up to data cut-off date 24 June 2016 (approximately 5 years)

  • Percentage of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs)

    Up to data cut-off date 24 June 2016 (approximately 5 years)

  • +2 more secondary outcomes

Study Arms (2)

Bevacizumab + Standard of Care

EXPERIMENTAL

Participants will receive bevacizumab on Day 1 of every 21-days cycle along with standard of care (Erlotinib or Docetaxel or Pemetrexed) as second line treatment, until the occurrence of an unacceptable toxicity or withdrawal of consent (whichever occurs first).

Drug: BevacizumabDrug: DocetaxelDrug: ErlotinibDrug: Pemetrexed

Standard of Care

ACTIVE COMPARATOR

Participants will receive investigator's choice of standard of care (Erlotinib or Docetaxel or Pemetrexed) according to local practice until the occurrence of an unacceptable toxicity or withdrawal of consent (whichever occurs first).

Drug: DocetaxelDrug: ErlotinibDrug: Pemetrexed

Interventions

Participants will receive bevacizumab 7.5 or 15 milligrams per kilogram (mg/kg) intravenously.

Also known as: Avastin
Bevacizumab + Standard of Care

Docetaxel 60 or 75 milligram per meter square (mg/m\^2) on Day 1 every 21 days.

Bevacizumab + Standard of CareStandard of Care

Erlotinib 150 mg daily taken on an empty stomach at least one hour before or two hours after the ingestion of food.

Bevacizumab + Standard of CareStandard of Care

Pemetrexed 500 mg/m\^2 IV over 10 minutes on Day 1 every 21 days.

Bevacizumab + Standard of CareStandard of Care

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Histologically or cytologically confirmed non-squamous NSCLC
  • Documented progression of disease (locally recurrent or metastatic) per investigator assessment following first-line treatment with 4-6 cycles of Bevacizumab plus a platinum doublet-containing chemotherapy regimen and a minimum of 2 cycles of Bevacizumab (monotherapy) maintenance treatment prior to first progression of disease
  • No treatment interruption of Bevacizumab treatment greater than 2 consecutive cycles (42 days) between the start of first-line treatment to start of Cycle 1 of second line treatment
  • Randomization within 4 weeks of progression of disease
  • At least one unidimensionally measurable lesion meeting RECIST v1.1 criteria
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-2
  • Participants with adequate hematological, liver, and renal function
  • Female participants must not be pregnant or breast-feeding. Female participants of childbearing potential and fertile male participants must agree to use a highly effective contraceptive during the trial and for a period of at least 6 months following the last administration of trial drug(s)

You may not qualify if:

  • Mixed, non-small cell and small cell tumors or mixed adenosquamous carcinomas with a predominant squamous component
  • Epidermal growth factor receptor (EGFR)-mutation-positive disease according to local laboratory testing
  • History of hemoptysis greater than or equal to (\>/=) grade 2 within 3 months of randomization
  • History or evidence of inherited bleeding diathesis or coagulopathy with a risk of bleeding and active gastrointestinal bleeding
  • Major cardiac disease
  • Treatment with any other investigational agent within 28 days prior to randomization
  • Known hypersensitivity to bevacizumab or any of its excipients, or any SOC drugs foreseen
  • Malignancy other than NSCLC within 5 years prior to randomization and evidence of any other disease that contraindicates the use of an investigational or SOC drug

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (179)

USA Mitchell Cancer Institute

Mobile, Alabama, 36688, United States

Location

Palo Verde Hema/Onc

Glendale, Arizona, 85304, United States

Location

Arizona Center for Cancer Care

Glendale, Arizona, 85306, United States

Location

Clopton Clinic

Jonesboro, Arkansas, 72401, United States

Location

East Valley Hematology ; Oncology Medical Group

Burbank, California, 91505, United States

Location

California Cancer Associates for Research & Excellence, Inc.

Encinitas, California, 92008, United States

Location

Scripps Clinic; Hematology & Oncology

La Jolla, California, 92037-1027, United States

Location

Sutter Cancer Center

Sacramento, California, 95816, United States

Location

Coastal Integrative Cancer Care

San Luis Obispo, California, 93401, United States

Location

Innovative Clinical Research Institute

Whittier, California, 90603, United States

Location

The Hospital of Central CT

New Britain, Connecticut, 06050, United States

Location

Eastern Ct Hema/Onco Assoc; Dept of Oncology

Norwich, Connecticut, 06360, United States

Location

Lynn Cancer Institute - West

Boca Raton, Florida, 33428, United States

Location

Baptist - MD Anderson Cancer Center

Jacksonville, Florida, 32207, United States

Location

Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy)

Jacksonville, Florida, 32256, United States

Location

Mount Sinai Medical Center

Miami Beach, Florida, 33140, United States

Location

Cancer Care Centers of Brevard

Rockledge, Florida, 32955, United States

Location

Emory Univ Winship Cancer Inst

Atlanta, Georgia, 30322, United States

Location

Summit Cancer Care PC

Savannah, Georgia, 31405, United States

Location

Kootenai Cancer Center

Post Falls, Idaho, 83854, United States

Location

Alexian Brothers Neurosci Inst

Elk Grove Village, Illinois, 60007, United States

Location

Oncology-Evanston Nthwest Healthcare Kellogg Cancer Care Ctr

Evanston, Illinois, 60201, United States

Location

Joliet Oncology Hematology Associates, Ltd.

Joliet, Illinois, 60435, United States

Location

Cancer Care & Hematology; Specialists of Chicagoland

Niles, Illinois, 60714, United States

Location

W. Suburban Ctr for Cncer Care

River Forest, Illinois, 60305, United States

Location

St. Francis Medical Group

Indianapolis, Indiana, 46237, United States

Location

Oncology Hematology Associates of Southwest Indiana

Newburgh, Indiana, 47630, United States

Location

McFarland Clinic

Ames, Iowa, 50010, United States

Location

Cancer Center of Kansas

Wichita, Kansas, 67214-3728, United States

Location

University of Kentucky Medical Center

Lexington, Kentucky, 40536, United States

Location

Jewish Cancer Care

Louisville, Kentucky, 40245, United States

Location

Hematology/Oncology Clinic, LLP

Baton Rouge, Louisiana, 70809, United States

Location

Louisiana Oncology Associates

Lafayette, Louisiana, 70508, United States

Location

New England Cancer Specialists

Scarborough, Maine, 04074, United States

Location

York Hospital

York Village, Maine, 03909, United States

Location

Anne Arundel Health System Research Instit-Annapolis Oncology Ctr

Annapolis, Maryland, 21401, United States

Location

Tufts Medical Center; Neely Cancer Center

Boston, Massachusetts, 02111, United States

Location

Ann Arbor Hematology Oncology

Ann Arbor, Michigan, 48106, United States

Location

Henry Ford Hospital; Hematology Oncology

Detroit, Michigan, 48202, United States

Location

Cancer & Hematology Center of West Michigan

Grand Rapids, Michigan, 49546, United States

Location

Metro-Minnesota CCOP

Saint Louis Park, Minnesota, 55416, United States

Location

St Joseph Oncology

Saint Joseph, Missouri, 64507, United States

Location

Heartland CCOP/Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States

Location

Stony Brook Univ Cancer Ctr; Medical Oncology Clinic

Stony Brook, New York, 11794-9447, United States

Location

Carolina Oncology Specialists, PA - Hickory

Hickory, North Carolina, 28602, United States

Location

Aultman Hospital

Canton, Ohio, 44710, United States

Location

Mid Ohio Onc Hematology Inc

Columbus, Ohio, 43219, United States

Location

Dayton Clinical Oncology Prog

Dayton, Ohio, 45420, United States

Location

Signal Point Clinical; Research Center, LLC

Middletown, Ohio, 45042, United States

Location

Toledo Hospital; CCOP Toledo

Toledo, Ohio, 43617, United States

Location

Bay Area Hospital

Coos Bay, Oregon, 97420, United States

Location

St. Lukes Hospital and Health Network

Bethlehem, Pennsylvania, 18015, United States

Location

Hematology & Oncology Assoc; North Eastern Pennsylvania

Dunmore, Pennsylvania, 18512, United States

Location

St. Mary Medical Center

Langhorne, Pennsylvania, 19047, United States

Location

University of Pennsylvania; Radiation Oncology

Philadelphia, Pennsylvania, 19104, United States

Location

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States

Location

Lankenau Hospital

Wynnewood, Pennsylvania, 19096, United States

Location

Memorial Hospital of Rhode Island

Pawtucket, Rhode Island, 02860, United States

Location

West Clinic

Germantown, Tennessee, 38138, United States

Location

University of Tennessee Medical Center Cancer Institute

Knoxville, Tennessee, 37920, United States

Location

Unv of TX SW Med Cntr; Hematology/Onc

Dallas, Texas, 75390-9015, United States

Location

Delta Hematology/ Oncology Associates

Portsmouth, Virginia, 23704, United States

Location

Blue Ridge Cancer Care - Roanoke

Roanoke, Virginia, 24014, United States

Location

Medical Oncology Associates

Spokane, Washington, 99208, United States

Location

Fox Valley Hema and Onc SC

Appleton, Wisconsin, 54915, United States

Location

Gundersen Lutheran

La Crosse, Wisconsin, 54601, United States

Location

UNI OF WISCONSIN SCHOOL OF MEDICINE; GI Oncology Research Group, Paul P Carbone Cancer Center

Madison, Wisconsin, 53792, United States

Location

Inst. Alexander Fleming; Oncology Dept

Buenos Aires, C1426ANZ, Argentina

Location

Centro Oncologico Infinito; Oncologia

La Pampa, 6300, Argentina

Location

Hospital Privado de Comunidad; Oncology

Mar del Plata, 7600, Argentina

Location

Sanatorio Parque de Rosario

Rosario, S2000DSV, Argentina

Location

ISIS Clinica Especializada

Santa Fe, 03000, Argentina

Location

Clínica Viedma

Viedma, Rio Negro, 8500, Argentina

Location

LKH Hohenems; Abteilung für Pulmologie

Hohenems, 6845, Austria

Location

Tiroler Landeskrankenanstalten Ges.M.B.H.; Innere Medizin Abt. Für Hämatologie & Onkologie

Innsbruck, 6020, Austria

Location

Lkh Natters; Abt. Für Atemwegs- & Lungenkrankheiten

Natters, 6161, Austria

Location

A.Ö. LKH; Abt. für Lungenkrankheiten

Steyr, 4400, Austria

Location

Medizinische Universität Wien; Univ.Klinik für Innere Medizin I - Abt. für Onkologie

Vienna, 1090, Austria

Location

Krankenhaus Der Stadt Wien Lainz; V. Medizinische Abt.

Vienna, 1130, Austria

Location

SMZ - Baumgartner Hohe, Pavilion Leopold; 1.Interne Lungenabteilung, Onkologische Tagesklinik

Vienna, 1140, Austria

Location

Klinikum Wels-Grieskirchen; Lungenabt.

Wels, 4600, Austria

Location

Clin. Europe (Ste Elisabeth)

Brussels, 1180, Belgium

Location

Centro de Pesquisa Clínica- Instituto do Câncer do Ceará- ICC

Fortaleza, Ceará, 60125-120, Brazil

Location

Nucleo de Oncologia da Bahia - NOB

Salvador, Bahia, Estado de Bahia, 40170-380, Brazil

Location

Sociedade beneficente de senhoras Hospital Sirio Libanes

Brasília, Federal District, 70200-730, Brazil

Location

Centro de Estudos e Pesquisas Oncologicas - CESPO

Brasília, Federal District, 70390-150, Brazil

Location

Instituto de Câncer de Brasília

Taguatinga, Federal District, 72110-980, Brazil

Location

Clinicas Oncologicas Integradas - COI

Rio de Janeiro, Rio de Janeiro, 22793-080, Brazil

Location

Hospital de Caridade de Ijui; Oncologia

Ijuí, Rio Grande do Sul, 98700-000, Brazil

Location

Clinica de Neoplasias Litoral

Itajaí, Santa Catarina, 88301-220, Brazil

Location

Hospital A. C. Camargo; Oncologia

São Paulo, São Paulo, 01509-010, Brazil

Location

Hospital Sao Jose

São Paulo, São Paulo, CEP 01321-001, Brazil

Location

Nordsjællands Hospital, Hillerød, Onkologisk Afdeling

Hillerød, 3400, Denmark

Location

Poly Parc Rambot La Provencale; Chimiotherapie Ambulatoire

Aix-en-Provence, 13617, France

Location

Centre Francois Baclesse; Oncologie

Caen, 14076, France

Location

Centre Hospitalier Intercommunal; Service de Pneumologie

Créteil, 94010, France

Location

Hopital Nord Ouest;Unite 2c

Gleizé, 69400, France

Location

Centre Oscar Lambret

Lille, 59020, France

Location

Hopital Calmette; Pneumologie

Lille, 59037, France

Location

Hopital Louis Pradel; Cardiologie B

Lyon, 69394, France

Location

Hôpital Saint Joseph; Oncologie Medicale

Marseille, 13285, France

Location

Hopital Nord; Service d'Oncologie Multidisciplinaire et Innovation Thérapeutique

Marseille, 13915, France

Location

Centre Antoine Lacassagne

Nice, 06189, France

Location

Ch Lyon Sud; Chir Onc Gyne Sct Jules Courmont

Pierre-Bénite, 69310, France

Location

CH Rene Dubos; Oncologie

Pontoise, 95300, France

Location

Ico Rene Gauducheau; Oncologie

Saint-Herblain, 44805, France

Location

Institut de Cancérologie de Loire

Saint-Priest-en-Jarez, 42271, France

Location

Centre Paul Strauss; Oncologie Medicale

Strasbourg, 67065, France

Location

Hia Sainte Anne; Pneumologie

Toulon, 83041, France

Location

Hopital Sainte Musse; Pneumologie

Toulon, 83056, France

Location

Clinique Pasteur; Pneumologie

Toulouse, 31076, France

Location

Chi De La Haute Saone De Vesoul; Pneumologie

Vesoul, 70014, France

Location

Zentralklinik Bad Berka GmbH; Pneumologie

Bad Berka, 99437, Germany

Location

Praxis Dr. med. David Borquez

Bergisch Gladbach, 51465, Germany

Location

Klinikum Esslingen; Klinik für Kardiologie, Angiologie und Pneumologie

Esslingen am Neckar, 73730, Germany

Location

Krankenhaus Nordwest; Klinik f. Onkologie und Hämatologie

Frankfurt, 60488, Germany

Location

SRH Wald-Klinikum Gera; Klinik für Hautkrankheiten und Allergologie

Gera, 07548, Germany

Location

LungenClinic Großhansdorf

Großhansdorf, 22927, Germany

Location

Krankenhaus Martha-Maria Halle-Doelau gGmbH; Klinik fuer Innere Medizin I

Halle, 06120, Germany

Location

Universitaetsklinikum des Saarlandes; Innere Medizin V

Homburg/Saar, 66421, Germany

Location

Fachklinik für Lungenerkrankungen

Immenhausen, 34376, Germany

Location

St. Vincentius Kliniken Karlsruhe; Abteilung Hämatologie / Onkologie

Karlsruhe, 76137, Germany

Location

Robert-Koch-Klinik; Pneumologie

Leipzig, 04207, Germany

Location

Praxis Christian Geßner

Leipzig, 04357, Germany

Location

Johannes-Wesling-Klinikum Minden; Onkologische Ambulanz / Tagesklinik

Minden, 32429, Germany

Location

Ludwig-Maximilians Uni Klinik Innenstadt; Medizinische Klinik

München, 80336, Germany

Location

Pius-Hospital; Klinik fuer Haematologie und Onkologie

Oldenburg, 26121, Germany

Location

Sotiria Hospital

Athens, 11527, Greece

Location

Metropolitan Hospital; 2Nd Oncology Clinic

Piraeus, 185 47, Greece

Location

General Hospital of Thessaloniki Papanikolaou; Uni Pneumonology Dept.

Thessaloniki, 570 10, Greece

Location

Diavalkaniko Hospital

Thessaloniki, 57001, Greece

Location

Citta Ospedaliera; Divisione Oncologia Medica

Avellino, Campania, 83100, Italy

Location

IRCCS Istituto Nazionale Tumori Fondazione Pascale; Oncologia Medica A

Napoli, Campania, 80131, Italy

Location

Policlinico Universitario Campus Biomedico; Uoc Oncologia Medica

Rome, Lazio, 00128, Italy

Location

Azienda Ospedaliera San Camillo Forlanini; U.O.C. Pneumologia Ad Indirizzo Oncologico 1

Rome, Lazio, 00152, Italy

Location

IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A

Genoa, Liguria, 16132, Italy

Location

Az. Osp. Di Busto P.O. Di Saronno; U.O. Di Oncologia Medica

Saronno, Lombardy, 21047, Italy

Location

A.O. Universitaria Pisana-Ospedale Cisanello; Dipartimento Cardio Toracico-Pneumologia Ii

Pisa, Tuscany, 56124, Italy

Location

Aichi Cancer Center Hospital; Respiratory Medicine

Aichi, 464-8681, Japan

Location

National Cancer Center Hospital East; Thoracic Oncology

Chiba, 277-8577, Japan

Location

National Hospital Organization Shikoku Cancer Center; Thoracic Oncology

Ehime, 791-0280, Japan

Location

National Hospital Organization Kyushu Cancer Center, Thoracic Oncology

Fukuoka, 811-1395, Japan

Location

Hyogo Cancer Center; Thoracic Oncology

Hyōgo, 673-8553, Japan

Location

Kanagawa Cardiovascular and Respiratory Center; Respiratory Medicine

Kanagawa, 236-0051, Japan

Location

Yokohama Municipal Citizen'S Hospital; Respiratory

Kanagawa, 240-8555, Japan

Location

Miyagi Cancer Center; Respiratory Medicine

Miyagi, 981-1293, Japan

Location

Okayama University Hospital; Respiratory and Allergy Medicine

Okayama, 700-8558, Japan

Location

OSAKA CITY GENERAL HOSPITAL;Medical Oncology

Osaka, 534-0021, Japan

Location

Osaka International Cancer Institute; Thoracic Oncology

Osaka, 541-8567, Japan

Location

Shizuoka Cancer Center; Thoracic Oncology

Shizuoka, 411-8777, Japan

Location

National Cancer Center Hospital; Thoracic Medical Oncology

Tokyo, 104-0045, Japan

Location

The Cancer Institute Hospital of JFCR, Respiratory Medicine

Tokyo, 135-8550, Japan

Location

American University of Beirut - Medical Center

Beirut, 11-236, Lebanon

Location

Hotel Dieu de France; Oncology

Beirut, 16830, Lebanon

Location

Middle East Inst. of Health; Oncology

Beirut, Lebanon

Location

Centenario Hospital Miguel Hidalgo

Aguascalientes, 20230, Mexico

Location

Hospital Central Sur de Alta Especialidad Petróleos Mexicanos

Mexico City, 14140, Mexico

Location

Centro Médico Abc the American British Cowdray Medical Center, I.A.P. - Centro de Cáncer

Mexico City, Mexico

Location

Amphia Ziekenhuis; Afdeling Longziekten

Breda, 4818 CK, Netherlands

Location

Catharina Ziekenhuis; Dept of Lung Diseases

Eindhoven, 5623 EJ, Netherlands

Location

Ziekenhuis St Jansdal; Dept of Lung Diseases

Harderwijk, 3844 DG, Netherlands

Location

Academisch Ziekenhuis Maastricht

Maastricht, 6202 AZ, Netherlands

Location

Antonius Ziekenhuis; Dept of Lung Diseases

Nieuwegein, 3435 CM, Netherlands

Location

Leyenburg Hospital; Pulmonology

The Hague, 2504 LN, Netherlands

Location

College of Medicine & Sciences, Sultan Qaboos University Hospital

Muscat, P.O Box 35, Oman

Location

Fnsp Fdr Banska Bystrica; Dep of Pneumology&Ftizeology

Banská Bystrica, 975 17, Slovakia

Location

FNsP Bratislava, Nemocnica Ruzinov

Bratislava, 826 06, Slovakia

Location

Vychodoslovensky onkologicky ustav

Košice, 04001, Slovakia

Location

Inst. of Tb & Respiratory Diseases; Dep. of Oncology

Nitra, 949 88, Slovakia

Location

Hospital de Cruces; Servicio de Oncologia

Barakaldo, Vizcaya, 48903, Spain

Location

Hospital General Univ. de Alicante; Servicio de Oncologia

Alicante, 3010, Spain

Location

Centro Oncologico MD Anderson International Espana

Madrid, 28033, Spain

Location

Hospital Universitario Clínico San Carlos; Servicio de Oncologia

Madrid, 28040, Spain

Location

Hospital Universitario La Paz; Servicio de Oncologia

Madrid, 28046, Spain

Location

Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia

Valencia, 46010, Spain

Location

Hospital Universitario Dr. Peset; Servicio de Oncologia

Valencia, 46017, Spain

Location

Hospital Universitario Miguel Servet; Servicio Oncologia

Zaragoza, 50009, Spain

Location

Tawam Hospital; Medical Oncology Department

Al Ain City, 15258, United Arab Emirates

Location

Related Publications (3)

  • Gridelli C, de Castro Carpeno J, Dingemans AC, Griesinger F, Grossi F, Langer C, Ohe Y, Syrigos K, Thatcher N, Das-Gupta A, Truman M, Donica M, Smoljanovic V, Bennouna J. Safety and Efficacy of Bevacizumab Plus Standard-of-Care Treatment Beyond Disease Progression in Patients With Advanced Non-Small Cell Lung Cancer: The AvaALL Randomized Clinical Trial. JAMA Oncol. 2018 Dec 1;4(12):e183486. doi: 10.1001/jamaoncol.2018.3486. Epub 2018 Dec 13.

  • Takeda M, Yamanaka T, Seto T, Hayashi H, Azuma K, Okada M, Sugawara S, Daga H, Hirashima T, Yonesaka K, Urata Y, Murakami H, Saito H, Kubo A, Sawa T, Miyahara E, Nogami N, Nakagawa K, Nakanishi Y, Okamoto I. Bevacizumab beyond disease progression after first-line treatment with bevacizumab plus chemotherapy in advanced nonsquamous non-small cell lung cancer (West Japan Oncology Group 5910L): An open-label, randomized, phase 2 trial. Cancer. 2016 Apr 1;122(7):1050-9. doi: 10.1002/cncr.29893. Epub 2016 Feb 1.

  • Gridelli C, Bennouna J, de Castro J, Dingemans AM, Griesinger F, Grossi F, Rossi A, Thatcher N, Wong EK, Langer C. Randomized phase IIIb trial evaluating the continuation of bevacizumab beyond disease progression in patients with advanced non-squamous non-small-cell lung cancer after first-line treatment with bevacizumab plus platinum-based chemotherapy: treatment rationale and protocol dynamics of the AvaALL (MO22097) trial. Clin Lung Cancer. 2011 Nov;12(6):407-11. doi: 10.1016/j.cllc.2011.05.002. Epub 2011 Jun 25.

MeSH Terms

Interventions

BevacizumabDocetaxelErlotinib HydrochloridePemetrexed

Intervention Hierarchy (Ancestors)

Antibodies, Monoclonal, HumanizedAntibodies, MonoclonalAntibodiesImmunoglobulinsImmunoproteinsBlood ProteinsProteinsAmino Acids, Peptides, and ProteinsSerum GlobulinsGlobulinsTaxoidsCyclodecanesCycloparaffinsHydrocarbons, AlicyclicHydrocarbons, CyclicHydrocarbonsOrganic ChemicalsDiterpenesTerpenesQuinazolinesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingHeterocyclic CompoundsGuanineHypoxanthinesPurinonesPurinesGlutamatesAmino Acids, AcidicAmino AcidsAmino Acids, Dicarboxylic

Results Point of Contact

Title
Medical Communications
Organization
Hoffmann-La Roche

Study Officials

  • Clinical Trials

    Hoffmann-La Roche

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 9, 2011

First Posted

May 10, 2011

Study Start

June 25, 2011

Primary Completion

June 25, 2016

Study Completion

June 25, 2016

Last Updated

September 18, 2017

Results First Posted

September 18, 2017

Record last verified: 2017-08

Locations