Success Metrics

Clinical Success Rate
76.1%

Based on 217 completed trials

Completion Rate
76%(217/285)
Active Trials
14(4%)
Results Posted
82%(178 trials)
Terminated
68(19%)

Phase Distribution

Ph phase_2
185
52%
Ph phase_3
39
11%
Ph phase_4
7
2%
Ph not_applicable
6
2%
Ph early_phase_1
2
1%
Ph phase_1
107
30%

Phase Distribution

109

Early Stage

185

Mid Stage

46

Late Stage

Phase Distribution346 total trials
Early Phase 1First-in-human
2(0.6%)
Phase 1Safety & dosage
107(30.9%)
Phase 2Efficacy & side effects
185(53.5%)
Phase 3Large-scale testing
39(11.3%)
Phase 4Post-market surveillance
7(2.0%)
N/ANon-phased studies
6(1.7%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

73.3%

217 of 296 finished

Non-Completion Rate

26.7%

79 ended early

Currently Active

14

trials recruiting

Total Trials

356

all time

Status Distribution
Active(15)
Completed(217)
Terminated(79)
Other(45)

Detailed Status

Completed217
Terminated68
unknown44
Withdrawn11
Active, not recruiting8
Recruiting6

Development Timeline

Analytics

Development Status

Total Trials
356
Active
14
Success Rate
76.1%
Most Advanced
Phase 4

Trials by Phase

Early Phase 12 (0.6%)
Phase 1107 (30.9%)
Phase 2185 (53.5%)
Phase 339 (11.3%)
Phase 47 (2.0%)
N/A6 (1.7%)

Trials by Status

unknown4412%
active_not_recruiting82%
completed21761%
terminated6819%
withdrawn113%
recruiting62%
not_yet_recruiting10%
suspended10%

Recent Activity

Clinical Trials (356)

Showing 20 of 356 trialsScroll for more
NCT02194738Not Applicable

Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

Active Not Recruiting
NCT00883480Not Applicable

Individualized Treatment Based on Epidermal Growth Factor Receptor Mutations and Level of BRCA1 Expression in Advanced Adenocarcinoma

Completed
NCT06483555Phase 1

Basal-like PDAC Treated With Gemcitabine, Erlotinib, and Nab-paclitaxel

Recruiting
NCT04981509Phase 2

Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer

Recruiting
NCT03297606Phase 2

Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)

Recruiting
NCT02759614Phase 3

Compare Bevacizumab in Combination With Erlotinib Versus Erlotinib Alone in NSCLC Patients Activating EGFR Mutations

Completed
NCT04449874Phase 1

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

Active Not Recruiting
NCT02152631Phase 3

A Study of Abemaciclib (LY2835219) in Participants With Previously Treated KRAS Mutated Lung Cancer

Active Not Recruiting
NCT06545695Phase 1

Epidermal Growth Factor Receptor Inhibition for Keratinopathies

Not Yet Recruiting
NCT01897480Phase 2

A Study of LY2875358 in Participants With Non-Small Cell Lung Cancer With Activating Epidermal Growth Factor Receptor Mutations

Completed
NCT05827614Phase 1

Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications

Active Not Recruiting
NCT02411448Phase 3

A Study of Ramucirumab (LY3009806) in Combination With Erlotinib in Previously Untreated Participants With EGFR Mutation-Positive Metastatic NSCLC (RELAY)

Active Not Recruiting
NCT00596648Phase 1

A Study of XL184 (Cabozantinib) With or Without Erlotinib in Subjects With Non-Small Cell Lung Cancer (NSCLC)

Completed
NCT01927744Phase 2

Study of Chemotherapy With Cisplatin/Carboplatin, and Docetaxel With or Without Erlotinib in Patients With Head and Neck Squamous Cell Carcinomas Amenable for Surgical Resection

Completed
NCT03498521Phase 2

A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site

Completed
NCT01186861Phase 2

Phase 2 Study of Maintenance OSI-906 Plus Erlotinib (Tarceva®), or Placebo Plus Erlotinib in Patients With Nonprogression Following 4 Cycles of Platinum-based Chemotherapy

Completed
NCT01221077Phase 2

Study of Erlotinib (Tarceva®) in Combination With OSI-906 in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) With Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene

Completed
NCT00600496Phase 1

A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)

Active Not Recruiting
NCT00977470Phase 2

Erlotinib With or Without Hydroxychloroquine in Chemo-Naive Advanced NSCLC and (EGFR) Mutations

Active Not Recruiting
NCT03653546Phase 2

First Line Treatment in EGFR Mutation Positive Advanced NSCLC Patients With Central Nervous System (CNS) Metastases

Completed

Drug Details

Intervention Type
DRUG
Total Trials
356