NCT00380757

Brief Summary

STUDY OBJECTIVES The overall goal of this study is to compare bystander fatigue and CPR quality after 5 minutes of the new 30:2 versus the old 15:2 chest compression to ventilation International Resuscitation Guidelines, in a population aged 55 or greater. More specifically, we will compare each CPR ratio with regard to:

  1. 1.The achieved frequency and depth of chest compressions,
  2. 2.Participant rating of their perceived level of exertion, and
  3. 3.Resulting serum lactate levels in a subset of the participants.
  4. 4.less frequent and shallower chest compressions over the 5-minute study period;
  5. 5.higher rating of perceived level of exertion; and
  6. 6.higher serum lactate levels in a subset of participants when compared to the old 15:2 CPR ratio.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
42

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jun 2006

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2006

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2006

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

September 23, 2006

Completed
3 days until next milestone

First Posted

Study publicly available on registry

September 26, 2006

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2006

Completed
18.5 years until next milestone

Results Posted

Study results publicly available

April 15, 2025

Completed
Last Updated

April 15, 2025

Status Verified

April 1, 2025

Enrollment Period

1 month

First QC Date

September 23, 2006

Results QC Date

October 30, 2024

Last Update Submit

April 11, 2025

Conditions

Cardiac Arrest

Keywords

cardiac arrestCPRresuscitationfatiguequality

Outcome Measures

Primary Outcomes (1)

  • CPR Quality

    Number of adequate chest compressions per minute

    over a 5 minute period

Secondary Outcomes (1)

  • Borg Rating of Perceived Exertion Blood Pressure Borg Rating of Perceived Exertion Scale

    After 5 minutes of 15:2 CPR or 30:2 CPR

Study Arms (2)

CPR 30:2

ACTIVE COMPARATOR

30 chest compressions to 2 ventilations

Procedure: bystander CPR using 30:2 ratio vs 15:2 ratio

CPR 15:2

ACTIVE COMPARATOR

15 chest compressions to 2 ventilations

Procedure: bystander CPR using 30:2 ratio vs 15:2 ratio

Interventions

bystander CPR using 30:2 ratio vs 15:2 ratioPROCEDURE

Participants will use 2 CPR techniques with different chest compression to ventilation ratios

CPR 15:2CPR 30:2

Eligibility Criteria

Age55 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Male or female aged 55 or older
  • Must score 3 or less on the validated Clinical Frailty Scale 11
  • Able to follow instructions in English or French
  • Able to understand and give informed consent

You may not qualify if:

  • Musculoskeletal condition precluding the ability to kneel down and perform CPR (e.g. severe arthritis, cast, wrist sprain, recent joint surgery)
  • Cardiovascular condition precluding the ability to perform a moderate effort e.g. myocardial infarction or cardiovascular procedure in the last 3 months, recurrent angina, chest pain under investigation)
  • Pulmonary condition precluding the ability to perform a moderate effort (e.g. emphysema, severe asthma, pneumonia)
  • Active communicable disease e.g. tuberculosis, meningitis, gastro enteritis, hepatitis A or B, herpes simplex)
  • Inability to perform chest compressions at appropriate rate and depth despite positive feedback during one to two-minute practice session

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The Ottawa Hospital, Civic Campus

Ottawa, Ontario, K1Y 4E9, Canada

Location

Related Publications (1)

  • Vaillancourt C, Midzic I, Taljaard M, Chisamore B. Performer fatigue and CPR quality comparing 30:2 to 15:2 compression to ventilation ratios in older bystanders: A randomized crossover trial. Resuscitation. 2011 Jan;82(1):51-6. doi: 10.1016/j.resuscitation.2010.09.003. Epub 2010 Oct 14.

    PMID: 20947241RESULT

MeSH Terms

Conditions

Heart ArrestFatigue

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Results Point of Contact

Title
Manya Charette
Organization
Ottawa Hospital Research Institute
mancharette@ohri.ca
613-798-5555

Study Officials

  • Christian Vaillancourt, MD, Msc,

    Ottawa Hospital Research Institute

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 23, 2006

First Posted

September 26, 2006

Study Start

June 1, 2006

Primary Completion

July 1, 2006

Study Completion

November 1, 2006

Last Updated

April 15, 2025

Results First Posted

April 15, 2025

Record last verified: 2025-04

Locations

CA(1)