S0016 Combination Chemotherapy With Monoclonal Antibody Therapy in Newly Diagnosed Non-Hodgkin's Lymphoma
A Phase III Trial of CHOP Plus Rituximab vs CHOP Plus Iodine-131-Labeled Monoclonal Anti-B1 Antibody (Tositumomab) for Treatment of Newly Diagnosed Follicular Non-Hodgkin's Lymphomas
4 other identifiers
interventional
571
1 country
259
Brief Summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies can locate tumor cells and either kill them or deliver radioactive tumor-killing substances to them without harming normal cells. It is not yet known which monoclonal antibody plus combination chemotherapy regimen is more effective in treating non-Hodgkin's lymphoma. PURPOSE: This randomized phase III trial is comparing 2 different monoclonal antibodies given together with combination chemotherapy to see how well they work in treating patients with newly-diagnosed non-Hodgkin's lymphoma.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 lymphoma
Started Mar 2001
Longer than P75 for phase_3 lymphoma
259 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 6, 2000
CompletedStudy Start
First participant enrolled
March 1, 2001
CompletedFirst Posted
Study publicly available on registry
January 27, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2011
CompletedResults Posted
Study results publicly available
February 26, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2025
CompletedMarch 16, 2026
February 1, 2026
10.5 years
December 6, 2000
November 2, 2012
February 24, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Progression-free Survival at 2 Years
Measured from time of registration to date of of first observation of progression/relapse, or death due to any cause, or last contact date
0-2 years
Progression-free Survival at 5 Years
Measured from time of registration to date of of first observation of progression/relapse, or death due to any cause, or last contact date
0-5 years
Overall Survival at 2 Years
Measured from date of registration to date of death due to any cause
0-2 years
Overall Survival at 5 Years
Measured from date of registration to date of death due to any cause
0-5 years
Secondary Outcomes (2)
Objective Response (Confirmed and Unconfirmed Complete and Partial Responses)
Assessed 200 days and 365 days after initiation of therapy and then every 6 months until death
Number of Patients With Grade 3 Through Grade 5 Adverse Events That Are Related to Study Drug
Patients were assessed for adverse events at end of cycle 1-6 of CHOP or R-CHOP, the end of cycle 1-6 of CHOP and once 2 weeks after the completion of I-131 treatment. For either arm, once 3 months after removal from protocol treatment
Study Arms (3)
Arm I (CHOP only)
ACTIVE COMPARATORPatients receive cyclophosphamide IV over 15 minutes, doxorubicin IV over 5-20 minutes, and vincristine IV over 5-15 minutes on day 1\. Patients also receive oral prednisone daily on days 1-5. Treatment continues every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. (Arm I closed to accrual as of 12/15/02)
Arm II (CHOP + rituximab)
EXPERIMENTALPatients receive cyclophosphamide IV over 15 minutes, doxorubicin IV over 5-20 minutes, and vincristine IV over 5-15 minutes on days 8, 29, 50, 71, 92, and 113. Patients also receive oral prednisone daily on days 8-12, 29-33, 50-54, 71-75, and 113-117 and rituximab IV over 4-6 hours on days 1, 6, 48, 90, 134, and 141.
Arm III (CHOP + tositumomab)
EXPERIMENTALPatients receive chemotherapy as in arm I and tositumomab (monoclonal antibody anti-B1) IV over 1 hour followed by iodine I 131 tositumomab IV over 20 minutes on days 134 and 141.
Interventions
Given IV
Given IV
Given orally
Given IV
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
- SWOG Cancer Research Networklead
- National Cancer Institute (NCI)collaborator
- Cancer and Leukemia Group Bcollaborator
- Eastern Cooperative Oncology Groupcollaborator
Study Sites (259)
Alaska Regional Hospital Cancer Center
Anchorage, Alaska, 99508, United States
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
Fairbanks, Alaska, 99701, United States
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Fort Smith, Arkansas, 72903, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
Alta Bates Summit Comprehensive Cancer Center
Berkeley, California, 94704, United States
Peninsula Medical Center
Burlingame, California, 94010, United States
Marin Cancer Institute at Marin General Hospital
Greenbrae, California, 94904, United States
Sutter Health - Western Division Cancer Research Group
Greenbrae, California, 94904, United States
Desert Regional Medical Center Comprehensive Cancer Center
Palm Springs, California, 92262, United States
University of California Davis Cancer Center
Sacramento, California, 95817, United States
California Pacific Medical Center - California Campus
San Francisco, California, 94118, United States
Stanford Cancer Center
Stanford, California, 94305-5824, United States
Sutter Solano Medical Center
Vallejo, California, 94589, United States
Helen and Harry Gray Cancer Center at Hartford Hospital
Hartford, Connecticut, 06102-5037, United States
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
Washington D.C., District of Columbia, 20007, United States
Center for Cancer Care and Research at Watson Clinic, LLP
Lakeland, Florida, 33805, United States
Sacred Heart Cancer Center at Sacred Heart Hospital
Pensacola, Florida, 32504, United States
West Florida Cancer Institute at West Florida Hospital - Pensacola
Pensacola, Florida, 32514, United States
Piedmont Hospital
Atlanta, Georgia, 30309, United States
Northside Hospital Cancer Center
Atlanta, Georgia, 30342-1611, United States
Saint Joseph's Hospital of Atlanta
Atlanta, Georgia, 30342-1701, United States
CCOP - Atlanta Regional
Atlanta, Georgia, 30342, United States
WellStar Cobb Hospital
Austell, Georgia, 30106, United States
Charles B. Eberhart Cancer Center at DeKalb Medical Center
Decatur, Georgia, 30033, United States
Dwight David Eisenhower Army Medical Center
Fort Gordon, Georgia, 30905-5650, United States
Northeast Georgia Medical Center
Gainesville, Georgia, 30501, United States
Gwinnett Medical Center
Lawrenceville, Georgia, 30045, United States
Kennestone Cancer Center at Wellstar Kennestone Hospital
Marietta, Georgia, 30060, United States
Southern Regional Medical Center
Riverdale, Georgia, 30274-2600, United States
Pearlman Comprehensive Cancer Center at South Georgia Medical Center
Valdosta, Georgia, 31603, United States
Tripler Army Medical Center
Honolulu, Hawaii, 96859, United States
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
Boise, Idaho, 83706, United States
Mountain States Tumor Institute at St. Luke's Regional Medical Center
Boise, Idaho, 83712, United States
Saint Anthony's Hospital at Saint Anthony's Health Center
Alton, Illinois, 62002, United States
Rush-Copley Cancer Care Center
Aurora, Illinois, 60504, United States
St. Joseph Medical Center
Bloomington, Illinois, 61701, United States
Graham Hospital
Canton, Illinois, 61520, United States
Memorial Hospital
Carthage, Illinois, 62321, United States
University of Illinois Cancer Center
Chicago, Illinois, 60612-7243, United States
University of Chicago Cancer Research Center
Chicago, Illinois, 60637-1470, United States
Decatur Memorial Hospital Cancer Care Institute
Decatur, Illinois, 62526, United States
Eureka Community Hospital
Eureka, Illinois, 61530, United States
Galesburg Clinic, PC
Galesburg, Illinois, 61401, United States
Galesburg Cottage Hospital
Galesburg, Illinois, 61401, United States
Mason District Hospital
Havana, Illinois, 62644, United States
Veterans Affairs Medical Center - Hines
Hines, Illinois, 60141, United States
Hopedale Medical Complex
Hopedale, Illinois, 61747, United States
Joliet Oncology-Hematology Associates, Limited - West
Joliet, Illinois, 60435, United States
McDonough District Hospital
Macomb, Illinois, 61455, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood, Illinois, 60153, United States
Good Samaritan Regional Health Center
Mount Vernon, Illinois, 62864, United States
Edward Hospital Cancer Center
Naperville, Illinois, 60540, United States
BroMenn Regional Medical Center
Normal, Illinois, 61761, United States
Community Cancer Center
Normal, Illinois, 61761, United States
Community Hospital of Ottawa
Ottawa, Illinois, 61350, United States
Oncology Hematology Associates of Central Illinois, PC - Ottawa
Ottawa, Illinois, 61350, United States
Cancer Treatment Center at Pekin Hospital
Pekin, Illinois, 61554, United States
Proctor Hospital
Peoria, Illinois, 61614, United States
CCOP - Illinois Oncology Research Association
Peoria, Illinois, 61615, United States
Oncology Hematology Associates of Central Illinois, PC - Peoria
Peoria, Illinois, 61615, United States
Methodist Medical Center of Illinois
Peoria, Illinois, 61636, United States
OSF St. Francis Medical Center
Peoria, Illinois, 61637, United States
Illinois Valley Community Hospital
Peru, Illinois, 61354, United States
Perry Memorial Hospital
Princeton, Illinois, 61356, United States
St. Margaret's Hospital
Spring Valley, Illinois, 61362, United States
Regional Cancer Center at Memorial Medical Center
Springfield, Illinois, 62781-0001, United States
Carle Cancer Center at Carle Foundation Hospital
Urbana, Illinois, 61801, United States
CCOP - Carle Cancer Center
Urbana, Illinois, 61801, United States
St. Francis Hospital and Health Centers - Beech Grove Campus
Beech Grove, Indiana, 46107, United States
Elkhart General Hospital
Elkhart, Indiana, 46515, United States
Howard Community Hospital
Kokomo, Indiana, 46904, United States
Center for Cancer Therapy at LaPorte Hospital and Health Services
La Porte, Indiana, 46350, United States
Saint Anthony Memorial Health Centers
Michigan City, Indiana, 46360, United States
Reid Hospital & Health Care Services
Richmond, Indiana, 47374, United States
CCOP - Northern Indiana CR Consortium
South Bend, Indiana, 46601, United States
Memorial Hospital of South Bend
South Bend, Indiana, 46601, United States
Saint Joseph Regional Medical Center
South Bend, Indiana, 46617, United States
Siouxland Hematology-Oncology Associates, LLP
Sioux City, Iowa, 51101, United States
Mercy Medical Center - Sioux City
Sioux City, Iowa, 51104, United States
St. Luke's Regional Medical Center
Sioux City, Iowa, 51104, United States
Cancer Center of Kansas, PA - Chanute
Chanute, Kansas, 66720, United States
Cancer Center of Kansas, PA - Dodge City
Dodge City, Kansas, 67801, United States
Cancer Center of Kansas, PA - El Dorado
El Dorado, Kansas, 67042, United States
Cancer Center of Kansas-Independence
Independence, Kansas, 67301, United States
Providence Medical Center
Kansas City, Kansas, 66112, United States
Cancer Center of Kansas, PA - Kingman
Kingman, Kansas, 67068, United States
Lawrence Memorial Hospital
Lawrence, Kansas, 66044, United States
Southwest Medical Center
Liberal, Kansas, 67901, United States
Cancer Center of Kansas, PA - Newton
Newton, Kansas, 67114, United States
Menorah Medical Center
Overland Park, Kansas, 66209, United States
Johnson County Radiation Therapy
Overland Park, Kansas, 66210, United States
Cancer Center of Kansas, PA - Parsons
Parsons, Kansas, 67357, United States
Cancer Center of Kansas, PA - Pratt
Pratt, Kansas, 67124, United States
Cancer Center of Kansas, PA - Salina
Salina, Kansas, 67042, United States
Tammy Walker Cancer Center at Salina Regional Health Center
Salina, Kansas, 67401, United States
Shawnee Mission Medical Center
Shawnee Mission, Kansas, 66204, United States
Cotton-O'Neil Cancer Center
Topeka, Kansas, 66606, United States
Cancer Center of Kansas, PA - Wellington
Wellington, Kansas, 67152, United States
Associates in Womens Health, PA - North Review
Wichita, Kansas, 67208, United States
Cancer Center of Kansas, PA - Medical Arts Tower
Wichita, Kansas, 67208, United States
Cancer Center of Kansas, PA - Wichita
Wichita, Kansas, 67214, United States
CCOP - Wichita
Wichita, Kansas, 67214, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, 67214, United States
Wesley Medical Center
Wichita, Kansas, 67214, United States
Cancer Center of Kansas, PA - Winfield
Winfield, Kansas, 67156, United States
Greenebaum Cancer Center at University of Maryland Medical Center
Baltimore, Maryland, 21201, United States
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
Baltimore, Maryland, 21215, United States
Lahey Clinic Medical Center - Burlington
Burlington, Massachusetts, 01805, United States
Berkshire Hematology Oncology, PC
Pittsfield, Massachusetts, 01201, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, 48109-0942, United States
Battle Creek Health System Cancer Care Center
Battle Creek, Michigan, 49017, United States
Bay Regional Medical Center
Bay City, Michigan, 48708, United States
Mecosta County Medical Center
Big Rapids, Michigan, 49307, United States
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201-1379, United States
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit, Michigan, 48202, United States
Butterworth Hospital at Spectrum Health
Grand Rapids, Michigan, 49503, United States
CCOP - Grand Rapids
Grand Rapids, Michigan, 49503, United States
Lacks Cancer Center at Saint Mary's Health Care
Grand Rapids, Michigan, 49503, United States
Holland Community Hospital
Holland, Michigan, 49423, United States
Borgess Medical Center
Kalamazoo, Michigan, 49001, United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007-3731, United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007, United States
Hackley Hospital
Muskegon, Michigan, 49442, United States
Lakeland Regional Cancer Care Center - St. Joseph
Saint Joseph, Michigan, 49085, United States
Oncology Care Associates, PLLC
Saint Joseph, Michigan, 49085, United States
Munson Medical Center
Traverse City, Michigan, 49684, United States
Metro Health Hospital
Wyoming, Michigan, 49519, United States
University of Mississippi Cancer Clinic
Jackson, Mississippi, 39216, United States
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703, United States
Saint Luke's Hospital
Chesterfield, Missouri, 63017, United States
Veterans Affairs Medical Center - Columbia (Truman Memorial)
Columbia, Missouri, 65201, United States
Ellis Fischel Cancer Center at University of Missouri - Columbia
Columbia, Missouri, 65203, United States
Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
Gape Girardeau, Missouri, 63701, United States
Independence Regional Health Center
Independence, Missouri, 64050, United States
Freeman Cancer Institute at Freeman Health System
Joplin, Missouri, 64804, United States
St. John's Regional Medical Center
Joplin, Missouri, 64804, United States
Truman Medical Center - Hospital Hill
Kansas City, Missouri, 64108, United States
Saint Luke's Cancer Institute at Saint Luke's Hospital
Kansas City, Missouri, 64111, United States
Kansas City Cancer Center at St. Joseph's Medical Mall
Kansas City, Missouri, 64114, United States
St. Joseph Medical Center
Kansas City, Missouri, 64114, United States
North Kansas City Hospital
Kansas City, Missouri, 64116, United States
Parvin Radiation Oncology
Kansas City, Missouri, 64116, United States
CCOP - Kansas City
Kansas City, Missouri, 64131, United States
Radiation Oncology Associates of Kansas City at Northland Radiation Oncology Center
Kansas City, Missouri, 64154, United States
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506, United States
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, 65802, United States
St. John's Regional Health Center
Springfield, Missouri, 65804, United States
Hulston Cancer Center at Cox Medical Center South
Springfield, Missouri, 65807, United States
Midwest Hematology Oncology Group, Incorporated
St Louis, Missouri, 63109, United States
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
St Louis, Missouri, 63110, United States
CCOP - St. Louis-Cape Girardeau
St Louis, Missouri, 63141, United States
David C. Pratt Cancer Center at St. John's Mercy
St Louis, Missouri, 63141, United States
CCOP - Montana Cancer Consortium
Billings, Montana, 59101, United States
Hematology-Oncology Centers of the Northern Rockies - Billings
Billings, Montana, 59101, United States
Northern Rockies Radiation Oncology Center
Billings, Montana, 59101, United States
St. Vincent Healthcare Cancer Care Services
Billings, Montana, 59101, United States
Billings Clinic - Downtown
Billings, Montana, 59107-7000, United States
Bozeman Deaconess Cancer Center
Bozeman, Montana, 59715, United States
St. James Healthcare Cancer Care
Butte, Montana, 59701, United States
Big Sky Oncology
Great Falls, Montana, 59405-5309, United States
Great Falls Clinic - Main Facility
Great Falls, Montana, 59405, United States
Sletten Cancer Institute at Benefis Healthcare
Great Falls, Montana, 59405, United States
Unknown Facility
Great Falls, Montana, 59405, United States
St. Peter's Hospital
Helena, Montana, 59601, United States
Glacier Oncology, PLLC
Kalispell, Montana, 59901, United States
Kalispell Medical Oncology at KRMC
Kalispell, Montana, 59901, United States
Kalispell Regional Medical Center
Kalispell, Montana, 59901, United States
Community Medical Center
Missoula, Montana, 59801, United States
Guardian Oncology and Center for Wellness
Missoula, Montana, 59804, United States
Montana Cancer Specialists at Montana Cancer Center
Missoula, Montana, 59807-7877, United States
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Missoula, Montana, 59807, United States
Good Samaritan Cancer Center at Good Samaritan Hospital
Kearney, Nebraska, 68848-1990, United States
UNMC Eppley Cancer Center at the University of Nebraska Medical Center
Omaha, Nebraska, 68198-6805, United States
Roswell Park Cancer Institute
Buffalo, New York, 14263-0001, United States
Tucker Center for Cancer Care at Orange Regional Medical Center
Middletown, New York, 10940-4199, United States
New York Weill Cornell Cancer Center at Cornell University
New York, New York, 10021, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, 14642, United States
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, 27599-7295, United States
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710, United States
Wayne Memorial Hospital, Incorporated
Goldsboro, North Carolina, 27534, United States
McDowell Cancer Center at Akron General Medical Center
Akron, Ohio, 44307, United States
Mary Rutan Hospital
Bellefontaine, Ohio, 43311, United States
Adena Regional Medical Center
Chillicothe, Ohio, 45601, United States
Good Samaritan Hospital Cancer Treatment Center
Cincinnati, Ohio, 45220, United States
Charles M. Barrett Cancer Center at University Hospital
Cincinnati, Ohio, 45267, United States
Cleveland Clinic Cancer Center at Fairview Hospital
Cleveland, Ohio, 44111, United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195, United States
Riverside Methodist Hospital Cancer Care
Columbus, Ohio, 43214-3998, United States
CCOP - Columbus
Columbus, Ohio, 43215, United States
Grant Medical Center Cancer Care
Columbus, Ohio, 43215, United States
Mount Carmel Health - West Hospital
Columbus, Ohio, 43222, United States
Doctors Hospital at Ohio Health
Columbus, Ohio, 43228, United States
Grandview Hospital
Dayton, Ohio, 45405, United States
Good Samaritan Hospital
Dayton, Ohio, 45406, United States
David L. Rike Cancer Center at Miami Valley Hospital
Dayton, Ohio, 45409, United States
Samaritan North Cancer Care Center
Dayton, Ohio, 45415, United States
Veterans Affairs Medical Center - Dayton
Dayton, Ohio, 45428, United States
CCOP - Dayton
Dayton, Ohio, 45429, United States
Grady Memorial Hospital
Delaware, Ohio, 43015, United States
Blanchard Valley Medical Associates
Findlay, Ohio, 45840, United States
Middletown Regional Hospital
Franklin, Ohio, 45005-1066, United States
Community Oncology Group at Cleveland Clinic Cancer Center
Independence, Ohio, 44131, United States
Charles F. Kettering Memorial Hospital
Kettering, Ohio, 45429, United States
Fairfield Medical Center
Lancaster, Ohio, 43130, United States
St. Rita's Medical Center
Lima, Ohio, 45801, United States
Strecker Cancer Center at Marietta Memorial Hospital
Marietta, Ohio, 45750, United States
Licking Memorial Cancer Care Program at Licking Memorial Hospital
Newark, Ohio, 43055, United States
Mercy Medical Center
Springfield, Ohio, 45504, United States
Community Hospital of Springfield and Clark County
Springfield, Ohio, 45505, United States
UVMC Cancer Care Center at Upper Valley Medical Center
Troy, Ohio, 45373-1300, United States
Mount Carmel St. Ann's Cancer Center
Westerville, Ohio, 43081, United States
Clinton Memorial Hospital
Wilmington, Ohio, 45177, United States
Cleveland Clinic - Wooster
Wooster, Ohio, 44691, United States
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
Xenia, Ohio, 45385, United States
Genesis - Good Samaritan Hospital
Zanesville, Ohio, 43701, United States
Legacy Mount Hood Medical Center
Gresham, Oregon, 97030, United States
Providence Milwaukie Hospital
Milwaukie, Oregon, 97222, United States
Legacy Good Samaritan Hospital & Comprehensive Cancer Center
Portland, Oregon, 97210, United States
Providence Cancer Center at Providence Portland Medical Center
Portland, Oregon, 97213-2967, United States
Adventist Medical Center
Portland, Oregon, 97216, United States
CCOP - Columbia River Oncology Program
Portland, Oregon, 97225, United States
Providence St. Vincent Medical Center
Portland, Oregon, 97225, United States
Legacy Emanuel Hospital and Health Center and Children's Hospital
Portland, Oregon, 97227, United States
Legacy Meridian Park Hospital
Tualatin, Oregon, 97062, United States
Roper St. Francis Cancer Center at Roper Hospital
Charleston, South Carolina, 29401, United States
Hollings Cancer Center at Medical University of South Carolina
Charleston, South Carolina, 29425, United States
Palmetto Health South Carolina Cancer Center
Columbia, South Carolina, 29203, United States
CCOP - Greenville
Greenville, South Carolina, 29615, United States
Joe Arrington Cancer Research and Treatment Center
Lubbock, Texas, 79410-1894, United States
UMC Southwest Cancer and Research Center
Lubbock, Texas, 79415-3364, United States
Huntsman Cancer Institute at University of Utah
Salt Lake City, Utah, 84112, United States
Lynchburg Hematology-Oncology Clinic
Lynchburg, Virginia, 24501, United States
St. Joseph Cancer Center
Bellingham, Washington, 98225, United States
Olympic Hematology and Oncology
Bremerton, Washington, 98310, United States
St. Francis Hospital
Federal Way, Washington, 98003, United States
Columbia Basin Hematology
Kennewick, Washington, 99336, United States
Cascade Cancer Center at Evergreen Hospital Medical Center
Kirkland, Washington, 98033, United States
Olympic Medical Center
Port Angeles, Washington, 98362, United States
Good Samaritan Cancer Center
Puyallup, Washington, 98372, United States
Valley Medical Center
Renton, Washington, 98055, United States
CCOP - Virginia Mason Research Center
Seattle, Washington, 98101, United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98104, United States
Harborview Medical Center
Seattle, Washington, 98104, United States
Minor and James Medical, PLLC
Seattle, Washington, 98104, United States
Group Health Central Hospital
Seattle, Washington, 98112, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Seattle, Washington, 98122-4307, United States
Polyclinic First Hill
Seattle, Washington, 98122, United States
University Cancer Center at University of Washington Medical Center
Seattle, Washington, 98195-6043, United States
Cancer Care Northwest - Spokane South
Spokane, Washington, 99202, United States
Franciscan Cancer Center at St. Joseph Medical Center
Tacoma, Washington, 98405-3004, United States
Allenmore Hospital
Tacoma, Washington, 98405, United States
CCOP - Northwest
Tacoma, Washington, 98405, United States
MultiCare Regional Cancer Center at Tacoma General Hospital
Tacoma, Washington, 98405, United States
St. Clare Hospital
Tacoma, Washington, 98499, United States
Southwest Washington Medical Center Cancer Center
Vancouver, Washington, 98668, United States
Wenatchee Valley Medical Center
Wenatchee, Washington, 98801-2028, United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, 98902, United States
Schiffler Cancer Center at Wheeling Hospital
Wheeling, West Virginia, 26003, United States
Welch Cancer Center at Sheridan Memorial Hospital
Sheridan, Wyoming, 82801, United States
Related Publications (5)
Shadman M, LeBlanc M, Rimsza L, Leonard JP, Smith SM, Li H, Friedberg JW. Treatment of Follicular Lymphoma With CHOP and Anti-CD20 Therapy: 15-Year Follow-Up of the SWOG S0016 Trial. JAMA Oncol. 2026 Feb 26:e260042. doi: 10.1001/jamaoncol.2026.0042. Online ahead of print.
PMID: 41746629DERIVEDFilip D, Litzmanova K, Michaelou A, Kledus F, Devan J, Boudny M, Hoferkova E, Sharma S, Seda V, Zeni PF, Borsky M, Matulova K, Kren L, Oppelt J, Blavet N, Hejret V, Urik M, Mareckova A, Rimsza LM, Kamaradova K, Belada D, Sykorova A, Mocikova H, Trneny M, Prouzova Z, Evans AG, Danilov A, Horn H, Ott G, Staber P, Mayer J, Friedberg JW, Janikova A, Mraz M. Repression of miR-29 via MYC leads to increased CD40 signaling in transformed follicular lymphoma. Leukemia. 2026 Feb 19. doi: 10.1038/s41375-026-02868-8. Online ahead of print.
PMID: 41714403DERIVEDRutherford SC, Yin J, Pederson L, Perez Burbano G, LaPlant B, Shadman M, Li H, LeBlanc ML, Kenkre VP, Hong F, Blum KA, Dockter T, Martin P, Jung SH, Grant B, Rosenbaum C, Ujjani C, Barr PM, Unger JM, Cheson BD, Bartlett NL, Kahl B, Friedberg JW, Mandrekar SJ, Leonard JP. Relevance of Bone Marrow Biopsies for Response Assessment in US National Cancer Institute National Clinical Trials Network Follicular Lymphoma Clinical Trials. J Clin Oncol. 2023 Jan 10;41(2):336-342. doi: 10.1200/JCO.21.02301. Epub 2022 Jul 5.
PMID: 35787017DERIVEDShadman M, Li H, Rimsza L, Leonard JP, Kaminski MS, Braziel RM, Spier CM, Gopal AK, Maloney DG, Cheson BD, Dakhil S, LeBlanc M, Smith SM, Fisher RI, Friedberg JW, Press OW. Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016. J Clin Oncol. 2018 Mar 1;36(7):697-703. doi: 10.1200/JCO.2017.74.5083. Epub 2018 Jan 22.
PMID: 29356608DERIVEDPress OW, Unger JM, Rimsza LM, Friedberg JW, LeBlanc M, Czuczman MS, Kaminski M, Braziel RM, Spier C, Gopal AK, Maloney DG, Cheson BD, Dakhil SR, Miller TP, Fisher RI. Phase III randomized intergroup trial of CHOP plus rituximab compared with CHOP chemotherapy plus (131)iodine-tositumomab for previously untreated follicular non-Hodgkin lymphoma: SWOG S0016. J Clin Oncol. 2013 Jan 20;31(3):314-20. doi: 10.1200/JCO.2012.42.4101. Epub 2012 Dec 10.
PMID: 23233710DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Study Statistician
- Organization
- SWOG Statistical Center
Study Officials
- STUDY CHAIR
Oliver W. Press, MD, PhD
Fred Hutchinson Cancer Center
- STUDY CHAIR
Myron S. Czuczman, MD
Roswell Park Cancer Institute
- STUDY CHAIR
Sandra J. Horning, MD
Stanford University
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 6, 2000
First Posted
January 27, 2003
Study Start
March 1, 2001
Primary Completion
September 1, 2011
Study Completion
December 1, 2025
Last Updated
March 16, 2026
Results First Posted
February 26, 2013
Record last verified: 2026-02
Data Sharing
- IPD Sharing
- Will share
https://swog.org/Visitors/Download/Policies/Policy43.pdf