Success Metrics

Clinical Success Rate
77.6%

Based on 805 completed trials

Completion Rate
78%(805/1037)
Active Trials
342(21%)
Results Posted
73%(585 trials)
Terminated
232(14%)

Phase Distribution

Ph phase_4
49
3%
Ph phase_1
406
25%
Ph early_phase_1
15
1%
Ph not_applicable
41
3%
Ph phase_2
796
49%
Ph phase_3
289
18%

Phase Distribution

421

Early Stage

796

Mid Stage

338

Late Stage

Phase Distribution1596 total trials
Early Phase 1First-in-human
15(0.9%)
Phase 1Safety & dosage
406(25.4%)
Phase 2Efficacy & side effects
796(49.9%)
Phase 3Large-scale testing
289(18.1%)
Phase 4Post-market surveillance
49(3.1%)
N/ANon-phased studies
41(2.6%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

72.2%

805 of 1115 finished

Non-Completion Rate

27.8%

310 ended early

Currently Active

342

trials recruiting

Total Trials

1,638

all time

Status Distribution
Active(384)
Completed(805)
Terminated(310)
Other(139)

Detailed Status

Completed805
Terminated232
Recruiting189
Active, not recruiting153
unknown136
Withdrawn78

Development Timeline

Analytics

Development Status

Total Trials
1638
Active
342
Success Rate
77.6%
Most Advanced
Phase 4

Trials by Phase

Early Phase 115 (0.9%)
Phase 1406 (25.4%)
Phase 2796 (49.9%)
Phase 3289 (18.1%)
Phase 449 (3.1%)
N/A41 (2.6%)

Trials by Status

active_not_recruiting1539%
suspended30%
unknown1368%
enrolling_by_invitation30%
not_yet_recruiting392%
withdrawn785%
completed80549%
terminated23214%
recruiting18912%

Recent Activity

Clinical Trials (1,638)

Showing 20 of 1,638 trialsScroll for more
NCT04224493Phase 3

A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.

Active Not Recruiting
NCT06091254Phase 3

A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma

Recruiting
NCT03274375Phase 2

Immunoadsorption Therapy in Managing NMDAR Antibodies Encephalitis

Completed
NCT06337318Phase 3

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Recruiting
NCT06943872Phase 3

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

Recruiting
NCT04609046Phase 1

Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma

Recruiting
NCT03136146Phase 2

Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Burkitt Lymphoma/Leukemia, or Double-Hit Lymphoma/Leukemia

Recruiting
NCT06970743Phase 3

A Study of BGB-16673 Compared to Investigator's Choice in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Covalent Bruton Tyrosine Kinase (BTK) Inhibitors

Active Not Recruiting
NCT03147612Phase 2

Low-Intensity Chemotherapy, Ponatinib and Blinatumomab in Treating Patients With Philadelphia Chromosome-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia

Active Not Recruiting
NCT05947851Phase 3

A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).

Recruiting
NCT05139017Phase 2

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

Recruiting
NCT04002947Phase 2

Acalabrutinib With DA-EPOCH-R or R-CHOP for People With Untreated Diffuse Large B-cell Lymphoma

Recruiting
NCT01842386Phase 1

Rituximab for Anti-cytokine Autoantibody-Associated Diseases

Completed
NCT03899337Phase 2

A Trial of CHOP-R Therapy, With or Without Acalabrutinib, in Patients With Newly Diagnosed Richter's Syndrome

Active Not Recruiting
NCT07634471Phase 2

A Clinical Trial of MK-1045 and Rituximab in People With Follicular Lymphoma (MK-1045-007)

Recruiting
NCT02203526Phase 1

Phase 1 Study of Ibrutinib and Immuno-Chemotherapy Using Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib,Rituximab (TEDDI-R) in Primary CNS Lymphoma

Active Not Recruiting
NCT04765111Phase 2

Acalabrutinib and Rituximab for the Treatment of Previously Untreated Mantle Cell Lymphoma

Active Not Recruiting
NCT06846671Phase 3

A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

Recruiting
NCT06890884Phase 2

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Recruiting
NCT06091865Phase 3

A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma

Recruiting

Drug Details

Intervention Type
BIOLOGICAL
Total Trials
1,638