Integrated Near-Infrared Spectroscopy and Hemodynamic Monitoring for Cerebral Autoregulation in Post-Cardiac Arrest Care Neuroprognostication

NCT07875348 | Not Yet Recruiting

• 1 other identifier: 202606297RINA
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Neurological outcome is the primary outcome for post-cardiac arrest patients. Hypoxic-ischemic brain injury is a key element in post-cardiac arrest syndrome, and remains the leading cause of mortality and morbidity in post-cardiac arrest patients. In patients with hypoxic-ischemic brain injury, impaired cerebral autoregulation makes cerebral blood flow highly vulnerable to blood pressure fluctuations, which might trigger secondary brain injuries. Although the pressure reactivity index (PRx) calculated via invasive intracranial pressure (ICP) monitoring is considered the gold standard for assessing cerebral autoregulation, its clinical application in post-cardiac arrest patients is limited due to invasive risks. Alternatively, cerebral near-infrared spectroscopy (NIRS) combined with hemodynamic monitoring offers a non-invasive approach to measure the cerebral oxygenation index (COx). However, its consistency with invasive methods and its accuracy in post-cardiac arrest care warrant further validation. The aim of this study is to assess cerebral autoregulation via COx calculated with NIRS and hemodynamic parameters in post-cardiac arrest patients, and to analyze the impact of this index on neurological outcomes. The further goal is to estimate optimal mean arterial pressure (MAPopt) and subsequently establish personalized post-resuscitation blood pressure targets.

Conditions

Cardiac Arrest (CA)

Outcome Measures

Primary Outcomes (1)

• Neurological Outcome

  Cerebral Performance Category Scale (1-5), higher scores mean a worse outcome

  up to 1 year

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

post-cardiac arrest patients admitted to ICU

You may qualify if:

• non-traumatic cardiac arrest
• admitted to ICU
• unable to follow verbal instructions (GCS: motor \<=5)

You may not qualify if:

• traumatic cardiac arrest
• pregnancy
• cognitive impairment before cardiac arrest (CPC scale \>=3)
• severe peripheral artery diseases
• Raynaud's syndrome

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan

Location

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Dean-An Ling

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Dean-An Ling, MD

CONTACT

+886-02-23123456; speckle0714@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 5, 2026
• First Posted: October 15, 2026
• Study Start (Estimated): January 1, 2027
• Primary Completion (Estimated): July 31, 2029
• Study Completion (Estimated): December 31, 2029
• Last Updated: October 15, 2026

Record last verified: 2026-10

Locations

TW (1)