NCT07017075

Brief Summary

Use Transesophageal ultrasound in OHCA patients to identify the proper compression location

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for not_applicable

Timeline
8mo left

Started Feb 2025

Typical duration for not_applicable

Geographic Reach
1 country

2 active sites

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress63%
Feb 2025Jan 2027

Study Start

First participant enrolled

February 21, 2025

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

May 6, 2025

Completed
1 month until next milestone

First Posted

Study publicly available on registry

June 12, 2025

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 21, 2026

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

January 21, 2027

Expected
Last Updated

November 19, 2025

Status Verified

January 1, 2025

Enrollment Period

11 months

First QC Date

May 6, 2025

Last Update Submit

November 16, 2025

Conditions

Cardiac Arrest (CA)

Keywords

OHCATEE

Outcome Measures

Primary Outcomes (1)

  • stroke volume, ejection fraction, end-diastolic volume, and end-systolic volume

    built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography)

    2 mins

Study Arms (2)

CPR location without adjustment

OTHER

If the AMC was located at the LV identified by TEE, the CPR compression site was not altered.

Behavioral: adjustment of CPR location

CPR location with adjustment

OTHER

If the AMC was not located at the LV, the CPR compression site was altered.

Behavioral: adjustment of CPR location

Interventions

adjustment of CPR locationBEHAVIORAL

Transesophageal ultrasound with built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography) to evaluate stroke volume and cardiac output in traditional CPR location and the better position

CPR location with adjustmentCPR location without adjustment

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Out-of-hospital cardiac arrest patients

You may not qualify if:

  • DNR was signed
  • Age under 18
  • Trauma patients
  • Patients hard to establish an advanced airway
  • Inavailability of ultrasound machine or operators

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Chang Bing Show Chawan Memorial Hospital

Changhua, Taiwan

Location

National Taiwan University Hospital

Taipei, Taiwan

Location

Related Publications (4)

  • Chen CC, Huang CS, Yen HT, Lien WC. A visualization of ejection fraction change after adjusting the area of maximal compression. Resuscitation. 2024 Jan;194:110097. doi: 10.1016/j.resuscitation.2023.110097. Epub 2023 Dec 20. No abstract available.

    PMID: 38128870RESULT

  • Teran F, Owyang CG, Martin-Flores M, Lao D, King A, Palasz J, Araos JD. Hemodynamic impact of chest compression location during cardiopulmonary resuscitation guided by transesophageal echocardiography. Crit Care. 2023 Aug 19;27(1):319. doi: 10.1186/s13054-023-04575-7. No abstract available.

    PMID: 37598201RESULT

  • Hwang SO, Zhao PG, Choi HJ, Park KH, Cha KC, Park SM, Kim SC, Kim H, Lee KH. Compression of the left ventricular outflow tract during cardiopulmonary resuscitation. Acad Emerg Med. 2009 Oct;16(10):928-33. doi: 10.1111/j.1553-2712.2009.00497.x. Epub 2009 Sep 3.

    PMID: 19732038RESULT

  • Olasveengen TM, Semeraro F, Ristagno G, Castren M, Handley A, Kuzovlev A, Monsieurs KG, Raffay V, Smyth M, Soar J, Svavarsdottir H, Perkins GD. European Resuscitation Council Guidelines 2021: Basic Life Support. Resuscitation. 2021 Apr;161:98-114. doi: 10.1016/j.resuscitation.2021.02.009. Epub 2021 Mar 24.

    PMID: 33773835RESULT

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Study Officials

  • WANCHING LIEN

    National Taiwan University Hospital

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 6, 2025

First Posted

June 12, 2025

Study Start

February 21, 2025

Primary Completion

January 21, 2026

Study Completion (Estimated)

January 21, 2027

Last Updated

November 19, 2025

Record last verified: 2025-01

Data Sharing

IPD Sharing
Will share

all collected IPD

Shared Documents
STUDY PROTOCOL
Time Frame
starting 6 months after publication

Locations

TW(2)