Velocity-Loss Training and Parkinson's Disease

NCT07840508 | Recruiting

• 1 other identifier: 20260975
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study will compare the effects of velocity-loss resistance training at 10% and 30% velocity loss thresholds on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.

Conditions

Activity, Motor

Outcome Measures

Primary Outcomes (2)

• Change in neuromuscular performance as measured by 1-repetition maximum (1RM)

  Maximal load that can be lifted in one repetition (1RM) will be assessed in both leg press and chest press exercises. The loads on the testing equipment will be increased across 5 to 7 testing repetitions. The persons 1RM will be the highest load the person can move through the range of motion of the exercise. There are no minimum or maximum scores for this test. The higher the 1RM the stronger the person is. The unit of measurement is kilograms.

  Baseline, 12 weeks

• Change in neuromuscular performance as measured by Watts

  This test measures the power a person can produce at maximal speed using loads of 20%, 40%, 60%, 80%, and 90% of 1RM for the chest press and leg press. Power shows how fast a person can do work. There are no minimum or maximum possible values. Higher values indicate better neuromuscular performance. Unit of measure is Watts.

  Baseline, 12 weeks

Secondary Outcomes (6)

• Change in the Speed of the Ten-Meter Walk Test.

  Baseline, 12 weeks

• Change in Time for the Five Times Sit-to-Stand Test.

  Baseline, 12 weeks

• Change in the time required to complete the timed Up-and-Go Test.

  Baseline, 12 weeks

• Change in Distance of the Seated Medicine Ball Throw.

  Baseline, 12 weeks

• Change in Muscle Thickness using Ultrasound.

  Baseline, 12 weeks

Study Arms (2)

10% Velocity-Loss Threshold Resistance Training

ACTIVE COMPARATOR

Participants will receive velocity-based resistance training at 10% velocity-loss threshold, twice per week for at least 24 sessions for up to 12 weeks.

Behavioral: 10% Velocity-Loss Threshold Resistance Training

30% Velocity-Loss Threshold Resistance Training

EXPERIMENTAL

Participants will receive velocity-based resistance training at 30% velocity-loss threshold, twice per week for at least 24 sessions for up to 12 weeks.

Behavioral: 30% Velocity-Loss Threshold Resistance Training

Interventions

10% Velocity-Loss Threshold Resistance Training BEHAVIORAL

Participants will receive a total of twenty-four 45-minutes in-person training sessions at 10% velocity-loss threshold, twice per week using three sets of eight repetitions per set. During training participants will be allowed 1-minute rests between sets. Exercises will include four upper-body exercises and 2 lower-body exercises.

10% Velocity-Loss Threshold Resistance Training

30% Velocity-Loss Threshold Resistance Training BEHAVIORAL

Participants will receive a total of twenty-four 45-minutes in-person training sessions at 30% velocity-loss threshold, twice per week using three sets of eight repetitions per set. During training participants will be allowed 1-minute rests between sets. Exercises will include four upper-body exercises and 2 lower-body exercises.

30% Velocity-Loss Threshold Resistance Training

Eligibility Criteria

• Age: 50 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Parkinson's Disease Hoehn \& Yahr Stages 1-3
• Able to walk 50 meters unassisted
• Able to understand and communicate in English

You may not qualify if:

• Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
• Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
• Unresolved injury or surgery to the upper or lower limbs that prevents weight training.

Sponsors & Collaborators

• University of Miami: lead

Study Sites (1)

Laboratory of Neruomuscular Research and Active Aging

Coral Gables, Florida, 33147, United States

RECRUITING

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Joseph F. Signorile, PhD

  University of Miami - Coral Gables Campus

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ethan A Elkins, MS

CONTACT

3052844173; exe453@miami.edu

Joseph F. Signorile, PhD

CONTACT

3052843105; jsignorile@miami.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 18, 2026
• First Posted: September 25, 2026
• Study Start: September 25, 2026
• Primary Completion (Estimated): December 30, 2026
• Study Completion (Estimated): December 30, 2026
• Last Updated: September 28, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)