NCT06821321

Brief Summary

This study will compare the effects of high-speed power resistance training or plyometric jump training on muscle stiffness, jump performance and measures of daily activity in older adults living independently in the community.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
48

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Aug 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 6, 2025

Completed
5 days until next milestone

First Posted

Study publicly available on registry

February 11, 2025

Completed
6 months until next milestone

Study Start

First participant enrolled

August 13, 2025

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2025

Completed
Last Updated

April 22, 2026

Status Verified

April 1, 2026

Enrollment Period

5 months

First QC Date

February 6, 2025

Last Update Submit

April 17, 2026

Conditions

Outcome Measures

Primary Outcomes (7)

  • Change in Quadriceps Muscle Stiffness measured by Kilopascals

    For muscle stiffness, three images will be taken in the longitudinal view in shear wave mode to assess stiffness of the vastus lateralis, vastus medialis and rectus femoris muscles. Color-coded images with a scale from blue (soft) to red (hard) will then be generated depending on muscle stiffness. Imaging software will then convert the wave speed data into a stiffness measures called kilopascals.

    Baseline, 10 weeks

  • Change in Triceps Surae Muscle Stiffness measured by Kilopascals

    For muscle stiffness, three images will be taken in the longitudinal view in shear wave mode to assess stiffness of the gastrocnemius lateralis, gastrocnemius medialis and soleus muscles. Color-coded images with a scale from blue (soft) to red (hard) will then be generated depending on muscle stiffness. Imaging software will then convert the wave speed data into a stiffness measures called kilopascals.

    Baseline, 10 weeks

  • Change in Quadriceps Tendon Stiffness measured by Kilopascals

    For tendon stiffness, three images will be taken in the longitudinal view in shear wave mode to assess stiffness of the quadriceps tendon. Color-coded images with a scale from blue (soft) to red (hard) will then be generated depending on tendon stiffness. Imaging software will then convert the wave speed data into a stiffness measures called kilopascals.

    Baseline, 12 weeks

  • Change in Patellar Tendon Stiffness measured by Kilopascals

    For tendon stiffness, three images will be taken in the longitudinal view in shear wave mode to assess stiffness of the patellar tendon. Color-coded images with a scale from blue (soft) to red (hard) will then be generated depending on tendon stiffness. Imaging software will then convert the wave speed data into a stiffness measures called kilopascals.

    Baseline, 12 weeks

  • Change in Achilles Tendon Stiffness measured by Kilopascals

    For tendon stiffness, three images will be taken in the longitudinal view in shear wave mode to assess stiffness of the Achilles tendon. Color-coded images with a scale from blue (soft) to red (hard) will then be generated depending on tendon stiffness. Imaging software will then convert the wave speed data into a stiffness measures called kilopascals.

    Baseline, 12 weeks

  • Changes in Stored Elastic Energy measured by joules

    For assessment of stored elastic energy, subjects will perform a Squat Jump and a Countermovement Jump on the force platform. The Squat Jump will be performed with the subject starting in a squatted position at the knee angle of approximately 90 degrees. The subject will hold that position for 1-2 s, and then jump into the air with maximal effort. For the Countermovement Jump, the subject will start in an upright position, rapidly squat down and then jump into the air with maximal effort. For both jumps, subject's hand will be held at the waist to eliminate the effect resulting from arm swing during jump performance. For each jump, three trials will be conducted with 1 min rests between trials. For safety, an experienced assistant will stand alongside each subject while performing the test to prevent injury. Energy will be measured in Joules.

    Baseline, 12 weeks

  • Change in Gait Economy

    Gait Economy will be measured using oxygen consumption on a treadmill at each subject's usual walking speed, one-half of the maximal walking speed, and 75% of the maximal walking speed. Each bout will last 5 minutes, with a 3-minute standing rest between bouts. Oxygen consumptions for the last 2 minutes of each bout will be used to compute energy cost and determine gait economy. Gait economy will be assessed as the oxygen used at each of the three walking speeds measured in milliliters of oxygen per kilogram of body weight per minute.

    Baseline, 12 weeks

Secondary Outcomes (9)

  • Change in Muscle Thickness measured in centimeters

    Baseline, 12 weeks

  • Change in Muscle Quality measured using grayscale

    Baseline, 12 weeks

  • Change in neuromuscular performance as measured by 1-repetition maximum (1RM).

    Baseline, 12 weeks

  • Change in the Speed of the Ten-Meter Walk Test.

    Baseline, 12 weeks

  • Change in Time for the Five Times Sit-to-Stand Test.

    Baseline, 12 weeks

  • +4 more secondary outcomes

Study Arms (2)

Plyometric Training

OTHER

Participants in this group will receive plyometric training for up to 12 weeks.

Behavioral: Plyometric Training

Power Resistance Training

OTHER

Participants in this group will receive power resistance training for up to 12 weeks.

Behavioral: Power Training

Interventions

Participants will receive a total of twenty-four 45-minutes in-person resistance-training sessions, twice per week, using three sets of eight repetitions per set on five upper body exercises. During resistance-training participants will be allowed 1-minute rests between sets. Participants will also perform two jump training exercises on a horizontal Pilates reformer, the leg plyometric and ankle plantar plyometric jumps.

Plyometric Training
Power TrainingBEHAVIORAL

Participants will receive a total of twenty-four 45-minutes in-person training sessions, twice per week using three sets of eight repetitions per set. During training participants will be allowed 1-minute rests between sets. Exercises will include five upper-body exercises and two lower-body exercises.

Power Resistance Training

Eligibility Criteria

Age55 Years - 90 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Independently living
  • Between 55-90 years of age

You may not qualify if:

  • Uncontrolled cardiovascular disease that prevents participation in a training program.
  • Documented HIV infection or another immunodeficiency syndrome.
  • Current neuromuscular diseases that prevent exercise.
  • Current musculoskeletal injury that prevents exercise.
  • Incarcerated individuals
  • Montreal Cognitive Assessment (MoCA) Score below 18

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Laboratory of Neruomuscular Research and Active Aging

Coral Gables, Florida, 33147, United States

Location

MeSH Terms

Conditions

Motor Activity

Interventions

Plyometric Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Joseph F. Signorile, PhD

    University of Miami

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

February 6, 2025

First Posted

February 11, 2025

Study Start

August 13, 2025

Primary Completion

December 30, 2025

Study Completion

December 30, 2025

Last Updated

April 22, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Locations