Acute High Intensity Interval Training and Blood Flow Restriction

NCT05835544 | Completed

• 1 other identifier: IRB-2022-135
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims to look at the blood flow restriction (BFR) + high intensity interval training (HIIT) variables to induce an optimal acute training stimulus (i.e., acute responses in main outcome measures of muscular activation, muscular deoxygenation, and secondary outcome measures of heart rate (HR), blood lactate (bLa), subjective ratings of perceived exertion and discomfort) The hypotheses for this study are: (i) BFR increases muscular deoxygenation, muscular activation when HIIT exercise is of the same intensity, (ii) however, comparing between a lower BFR + HIIT exercise intensity (e.g. 80% V̇O2max) and higher HIIT exercise intensity (e.g. 100% V̇O2max), muscular deoxygenation and activation will be similar but HR will be lower in the BFR + HIIT condition.

Conditions

Activity, Motor

Outcome Measures

Primary Outcomes (4)

• Heart rate

  Heart rate using short-range telemetry

  Measured and compared between each acute arm (condition)

• Blood lactate concentration

  Fingertip capillary measure

  Measured and compared between each acute arm (condition)

• Muscle activation

  Surface electromyography of the vastus lateralis and biceps femoris muscles to determine electrical activity of the motor units (physiological parameter)

  Measured and compared between each acute arm (condition)

• Muscle oxygenation

  Near infra-red spectroscopy to examine regional tissue (the vastus lateralis muscle) oxygenation i.e, the percentage of haemoglobin and deoxyhaemoglobin (physiological parameter)

  Measured and compared between each acute arm (condition)

Secondary Outcomes (2)

• Rating of perceived exertion

  Measured and compared between each acute arm (condition)

• Exertion and Pain scale

  Measured and compared between each acute arm (condition)

Study Arms (4)

HIIT Control

ACTIVE COMPARATOR

High intensity interval cycling

Other: Active Comparator: HIIT Control

HIIT + BFR between cycling sets

EXPERIMENTAL

High intensity interval cycling with blood flow restriction applied between sets of cycling

Other: Experimental: HIIT + BFR between cycling sets

HIIT + BFR moderate occlusion during cycling

EXPERIMENTAL

High intensity interval cycling with moderate blood flow restriction applied during cycling

Other: Experimental: HIIT + BFR moderate occlusion during cycling

HIIT + BFR high occlusion during cycling

EXPERIMENTAL

High intensity interval cycling with high blood flow restriction applied during cycling

Other: Experimental: HIIT + BFR high occlusion during cycling

Interventions

Active Comparator: HIIT Control OTHER

Complete 3 sets of five repetitions of 30 seconds cycling at 100% of maximal aerobic power with 30 seconds of active unloaded recovery between repetitions; 3 minutes of passive rest between sets.

HIIT Control

Experimental: HIIT + BFR between cycling sets OTHER

Complete 3 sets of five repetitions of 30 seconds cycling at 100% of maximal aerobic power with 30 seconds of active unloaded recovery between repetitions; 3 minutes of passive rest between sets. Blood flow restriction is applied for 2 minutes during the passive rest at 80% of limb occlusion pressure.

HIIT + BFR between cycling sets

Experimental: HIIT + BFR moderate occlusion during cycling OTHER

Complete 3 sets of five repetitions of 30 seconds cycling at 70% of maximal aerobic power with 30 seconds of active unloaded recovery between repetitions; 3 minutes of passive rest between sets. Blood flow restriction is applied during and between exercise repetitions at 50% of limb occlusion pressure and deflated during passive rest periods.

HIIT + BFR moderate occlusion during cycling

Experimental: HIIT + BFR high occlusion during cycling OTHER

Complete 3 sets of five repetitions of 30 seconds cycling at 70% of maximal aerobic power with 30 seconds of active unloaded recovery between repetitions; 3 minutes of passive rest between sets. Blood flow restriction is applied during and between exercise repetitions at 80% of limb occlusion pressure and deflated during passive rest periods.

HIIT + BFR high occlusion during cycling

Eligibility Criteria

• Age: 18 Years - 40 Years
• Gender Eligibility Details: Male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male
• Age: 18-40 years
• Competed in competitive varsity sports (endurance, tennis, badminton, squash, football, basketball, etc.) at the varsity/club level
• Actively training for at least 2 sessions (1 - 1.5h) per week
• Healthy (free from illnesses) and no musculoskeletal injuries for the past 6 months
• No history of cardiometabolic, vascular diseases or similar conditions (high blood pressure, peripheral vascular diseases, heart diseases, metabolic syndrome, diabetes, stroke, etc.).
• Pass pre-participation health screening tests - Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) and Australian Institute of Sport (AIS) Blood Flow Restriction (BFR) pre-screening questionnaire (no history of any risk factors).
• Maximal oxygen uptake (VO2max) of ≥40mmol/min/kg during a maximal aerobic cycling test.
• Non-smoker
• Drink alcohol less than 3 times each week and less than 3 drinks each time

You may not qualify if:

• Any diagnosed form of cardiometabolic disease (CVD, diabetes, metabolic syndrome, hypertension)
• Any symptoms contraindication of exercise testing (eg chest pains)
• Any balance or dizziness problems
• Any chronic medical conditions (whether medicated or not)
• Any bone joint problems
• Any Physician diagnosed contraindications to exercise

Sponsors & Collaborators

• Nanyang Technological University: lead

Study Sites (1)

Human Bioenergetics Laboratory, National Institute of Education, Nanyang Technological University

Singapore, 637616, Singapore

Location

Related Publications (1)

• Chua M, Sim A, Burns SF. Acute physiological and perceptual responses to three blood flow restricted interval exercise protocols: a randomised controlled trial. Appl Physiol Nutr Metab. 2025 Jan 1;50:1-13. doi: 10.1139/apnm-2024-0423.

  PMID: 39919270 DERIVED

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Stephen Burns, PhD

  Nanyang Technological University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 5, 2023
• First Posted: April 28, 2023
• Study Start: August 1, 2022
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: April 3, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: ANALYTIC CODE
• Time Frame: Upon publication - permanent repository
• Access Criteria: Public repository - exact web address available upon publication.

Locations

SG (1)