NCT07378813

Brief Summary

This study will compare the effects of high-load resistance training to low-load resistance training, on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
13mo left

Started Jan 2026

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress20%
Jan 2026May 2027

First Submitted

Initial submission to the registry

January 22, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

January 30, 2026

Completed
Same day until next milestone

Study Start

First participant enrolled

January 30, 2026

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 30, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 30, 2027

Last Updated

February 2, 2026

Status Verified

January 1, 2026

Enrollment Period

1.3 years

First QC Date

January 22, 2026

Last Update Submit

January 30, 2026

Conditions

Activity, Motor

Outcome Measures

Primary Outcomes (2)

  • Change in neuromuscular performance as measured by 1-repetition maximum (1RM)

    Maximal load that can be lifted in one repetition (1RM) will be assessed in both leg press and chest press exercises. The loads on the testing equipment will be increased across 5 to 7 testing repetitions. The persons 1RM will be the highest load the person can move through the range of motion of the exercise. There are no minimum or maximum scores for this test. The higher the 1RM the stronger the person is. The unit of measurement is kilograms.

    [Time Frame: Baseline, 12 weeks]

  • Change in neuromuscular performance as measured by Power Production

    This test measures the power a person can produce at maximal speed using loads of 20%, 40%, 60%, 80%, and 90% of 1RM for the chest press and leg press. Power shows how fast a person can do work. Unit of measure is Watts.

    Baseline, 12 weeks

Secondary Outcomes (4)

  • Change in the Speed of the Ten-Meter Walk Test.

    Baseline, 12 weeks

  • Change in Time for the Five Times Sit-to-Stand Test.

    Baseline, 12 weeks

  • Change in the time required to complete the timed Up-and-Go Test.

    Baseline, 12 weeks

  • Change in Distance of the Seated Medicine Ball Throw.

    Baseline, 12 weeks

Study Arms (2)

Low-Load Resistance Training

ACTIVE COMPARATOR

Participants will receive low-load resistance training, twice per week for at least 24 sessions for up to 12 weeks.

Behavioral: Low-Load Resistance Training

High-Load Resistance Training

ACTIVE COMPARATOR

Participants will receive high-load resistance training, twice per week for at least 24 sessions for up to 12 weeks.

Behavioral: High-Load Resistance Training

Interventions

High-Load Resistance TrainingBEHAVIORAL

Participants will receive a total of twenty-four 45-minutes in-person training sessions, twice per week using four sets of eight repetitions per set. During training participants will be allowed 2-minute rests between sets. Exercises will include four upper-body exercises and two lower-body exercises.

High-Load Resistance Training
Low-Load Resistance TrainingBEHAVIORAL

Participants will receive a total of twenty-four 45-minutes in-person training sessions, twice per week using three sets of eight repetitions per set. During training participants will be allowed 2-minute rests between sets. Exercises will include four upper-body exercises and two lower-body exercises.

Low-Load Resistance Training

Eligibility Criteria

Age50 Years - 85 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Parkinson's Disease Hoehn \& Yahr Stages 1-3
  • Able to walk 50m unassisted
  • Able to understand and communicate in English
  • A Montreal Cognitive Assessment (MoCA) score above 18

You may not qualify if:

  • Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
  • Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
  • Unresolved injury or surgery to the upper or lower limbs that prevents weight training.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Laboratory of Neruomuscular Research and Active Aging

Coral Gables, Florida, 33147, United States

RECRUITING

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

  • Joseph F. Signorile, PhD

    University of Miami

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Ethan J Elway, MS

CONTACT

3052844173exe453@miami.edu

Joseph F. Signorile, PhD

CONTACT

3052843105jsignorile@miami.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

January 22, 2026

First Posted

January 30, 2026

Study Start

January 30, 2026

Primary Completion (Estimated)

May 30, 2027

Study Completion (Estimated)

May 30, 2027

Last Updated

February 2, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

Locations

US(1)