Periodization and Parkinson's Disease

NCT07141849 | Completed

• 1 other identifier: 20250800
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

This study will compare the effects of high-speed power resistance training to periodized training, which includes cycle of hypertrophy, strength and power, on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.

Conditions

Activity, Motor

Outcome Measures

Primary Outcomes (2)

• Change in neuromuscular performance as measured by 1-repetition maximum (1RM)

  Maximal load that can be lifted in one repetition (1RM) will be assessed in both leg press and chest press exercises. The loads on the testing equipment will be increased across 5 to 7 testing repetitions. The persons 1RM will be the highest load the person can move through the range of motion of the exercise. There are no minimum or maximum scores for this test. The higher the 1RM the stronger the person is. The unit of measurement is kilograms.

  Baseline, 12 weeks

• Change in neuromuscular performance as measured by Watts

  This test measures the power a person can produce at maximal speed using loads of 20%, 40%, 60%, 80%, and 90% of 1RM for the chest press and leg press. Power shows how fast a person can do work. Unit of measure is Watts.

  Baseline, 12 weeks

Secondary Outcomes (4)

• Change in the Speed of the Ten-Meter Walk Test.

  Baseline, 12 weeks

• Change in Time for the Five Times Sit-to-Stand Test.

  Baseline, 12 weeks

• Change in Distance of the Seated Medicine Ball Throw.

  Baseline, 12 weeks

• Change in the time required to complete the timed Up-and-Go Test.

  Baseline, 12 weeks

Study Arms (2)

Power Resistance Training

ACTIVE COMPARATOR

Participants will receive high-speed power resistance training, twice per week for at least 24 sessions for up to 12 weeks.

Behavioral: Power Resistance Training

Periodized Resistance Training

EXPERIMENTAL

Participants will receive periodized resistance training twice per week for at least 24 weeks.

Behavioral: Periodized Resistance Training

Interventions

Periodized Resistance Training BEHAVIORAL

Participants will receive three weeks of hypertrophy training to increase muscle size followed by six weeks of strength training, and then three weeks of power training twice per week for a total of twenty-four 45-minutes in-person training sessions. During training participants will be allowed 1-minute rests between sets. Exercises will include six upper-body exercises and five lower-body exercises.

Periodized Resistance Training

Power Resistance Training BEHAVIORAL

Participants will receive a total of twenty-four 45-minutes in-person training sessions, twice per week using three sets of eight repetitions per set. During training participants will be allowed 1-minute rests between sets. Exercises will include six upper-body exercises and five lower-body exercises.

Power Resistance Training

Eligibility Criteria

• Age: 50 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Parkinson's Disease Hoehn \& Yahr Stages 1-3
• Able to walk 50m unassisted
• Able to understand and communicate in English

You may not qualify if:

• Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
• Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
• Unresolved injury or surgery to the upper or lower limbs that prevents weight training.

Sponsors & Collaborators

• University of Miami: lead

Study Sites (1)

Laboratory of Neuromuscular Research and Active Aging

Coral Gables, Florida, 33147, United States

Location

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Joseph F. Signorile, PhD

  University of Miami

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 19, 2025
• First Posted: August 26, 2025
• Study Start: August 29, 2025
• Primary Completion: December 30, 2025
• Study Completion: December 30, 2025
• Last Updated: April 23, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)