Effects of Different Exercise Types on Irisin, Leptin, and Ghrelin Levels in Sedentary Women

NCT07805772 | Not Yet Recruiting

• 1 other identifier: IRISIN-LEPTIN-2026-248
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This interventional study aims to investigate the acute effects of three different exercise modalities-aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)-on irisin, leptin, and ghrelin levels in sedentary women. A total of 20 sedentary women will participate in the study. Hormonal responses will be evaluated in relation to the exercise sessions to determine exercise-induced changes in irisin, leptin, and ghrelin and to compare the responses associated with the three exercise modalities.

Conditions

Exercise Physiology; Metabolic Hormones

Keywords

Irisin; Leptin; Ghrelin; Sedentary Women

Outcome Measures

Primary Outcomes (3)

• Change in Irisin Level

  Irisin levels will be assessed in relation to each exercise condition to determine the change in circulating irisin levels associated with aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)

  Pre-exercise and immediately post-exercise during each exercise session

• Change in Leptin Level

  Leptin levels will be assessed in relation to each exercise condition to determine the change in circulating leptin levels associated with aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT).

  Pre-exercise and immediately post-exercise during each exercise session

• Change in Ghrelin Level

  Ghrelin levels will be assessed in relation to each exercise condition to determine the change in circulating ghrelin levels associated with aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT).

  Pre-exercise and immediately post-exercise during each exercise session

Study Arms (1)

Multiple Exercise Modalities

EXPERIMENTAL

Participants in this arm will complete three different exercise conditions in separate sessions: aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT). Irisin, leptin, and ghrelin levels will be assessed in relation to each exercise condition to evaluate and compare acute hormonal responses across the three exercise modalities.

Behavioral: Aerobic Exercise; Behavioral: Anaerobic Exercise; Behavioral: High-Intensity Interval Training (HIIT)

Interventions

Aerobic Exercise BEHAVIORAL

Participants will complete an aerobic exercise session as one of the three exercise conditions. Irisin, leptin, and ghrelin levels will be assessed in relation to the exercise session to determine the acute hormonal response to aerobic exercise.

Multiple Exercise Modalities

Anaerobic Exercise BEHAVIORAL

Participants will complete an anaerobic exercise session as one of the three exercise conditions. Irisin, leptin, and ghrelin levels will be assessed in relation to the exercise session to determine the acute hormonal response to anaerobic exercise.

Multiple Exercise Modalities

High-Intensity Interval Training (HIIT) BEHAVIORAL

Participants will complete a high-intensity interval training (HIIT) session as one of the three exercise conditions. Irisin, leptin, and ghrelin levels will be assessed in relation to the exercise session to determine the acute hormonal response to HIIT.

Multiple Exercise Modalities

Eligibility Criteria

• Age: 18 Years - 24 Years
• Gender Eligibility Details: Only sedentary women are eligible to participate in this study, in accordance with the predefined study population.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

Sponsors & Collaborators

• Inonu University: lead

Study Sites (1)

Exercise Physiology Laboratory, Faculty of Sport Sciences, Karabuk University

Karabük, Karabük Province, Turkey (Türkiye)

Location

MeSH Terms

Interventions

Exercise; High-Intensity Interval Training

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Physical Conditioning, Human

Central Study Contacts

Özgür EKEN, PhD

CONTACT

+905532132795; ozgur.eken@inonu.edu.tr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: No masking was applied because participants and investigators were aware of the exercise condition performed during each session.
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof.Dr.

Model Details: All participants will complete three exercise conditions-aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)-in separate sessions. Each participant will therefore serve as her own control, allowing within-participant comparisons of irisin, leptin, and ghrelin responses across the three exercise modalities.

Study Record Dates

• First Submitted: September 1, 2026
• First Posted: September 4, 2026
• Study Start: September 5, 2026
• Primary Completion: September 25, 2026
• Study Completion: September 30, 2026
• Last Updated: September 4, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)