Effects of Interrupting Prolonged Sitting With Different Standing Intervals on Vascular Health in Women

NCT07802574 | Recruiting

• 1 other identifier: E-25-10479
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to examine the effects of interrupting prolonged sitting with different standing intervals on vascular health in healthy women aged 18-45 years. The main questions it aims to answer are: Does interrupting prolonged sitting with short standing intervals (10 minutes every hour) improve blood pressure and pulse wave velocity more than prolonged continuous standing intervals (30 minutes every hour)? Does interrupting prolonged sitting with prolonged intermittent standing intervals (30 minutes every hour divided into three 10-minute standing bouts) improve blood pressure and pulse wave velocity more than prolonged continuous standing intervals (30 minutes every hour)? The researcher will compare three different sitting interruption conditions to evaluate their effects on vascular health outcomes: Standing for 10 minutes every hour. Continuous standing for 30 minutes every hour. Intermittent standing for 30 minutes every hour divided into three 10-minute standing bouts. Participants will: Attend three experimental sessions in random order separated by at least 7 days. Complete 3 hours of sitting with different standing interruption protocols. Undergo measurements of blood pressure, pulse wave velocity, and heart rate before sitting and after each hour of the experiment. Undergo height, weight, and body mass index measurements.

Conditions

Prolonged Sitting; Vascular Health; Sedentary Behavior

Outcome Measures

Primary Outcomes (3)

• Blood Pressure

  Systolic and diastolic blood pressure will be measured before sitting and after each hour during the experimental sessions.

  Baseline, 1 hour, 2 hours, and 3 hours

• Pulse Wave Velocity

  Baseline, 1 hour, 2 hours, and 3 hours

• Heart Rate

  Baseline, 1 hour, 2 hours, and 3 hours

Study Arms (3)

Short Standing Interval

EXPERIMENTAL

Participants will complete 3 hours of sitting interrupted with 10 minutes of standing every hour.

Behavioral: Short Standing Interval

Continuous Standing Interval

EXPERIMENTAL

Participants will complete 3 hours of sitting interrupted with 30 continuous minutes of standing every hour.

Behavioral: Continuous Standing Interval

Intermittent Standing Interval

EXPERIMENTAL

Participants will complete 3 hours of sitting interrupted with 30 minutes of standing every hour divided into three 10-minute standing bouts.

Behavioral: Intermittent Standing Interval

Interventions

Continuous Standing Interval BEHAVIORAL

Participants will interrupt prolonged sitting with 30 continuous minutes of standing every hour during 3 hours of sitting.

Continuous Standing Interval

Intermittent Standing Interval BEHAVIORAL

Participants will interrupt prolonged sitting with 30 minutes of standing every hour divided into three 10-minute standing bouts during 3 hours of sitting.

Intermittent Standing Interval

Short Standing Interval BEHAVIORAL

Participants will interrupt prolonged sitting with 10 minutes of standing every hour during 3 hours of sitting.

Short Standing Interval

Eligibility Criteria

• Age: 18 Years - 45 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Female participants aged 18-45 years. Healthy individuals with normal blood pressure levels (systolic blood pressure \<130 mmHg and diastolic blood pressure \<80 mmHg).
• Body mass index (BMI) less than 30 kg/m². Ability to stand without support. No history of cardiovascular disease or chronic diseases that may affect study outcomes.

You may not qualify if:

• Pregnancy or breastfeeding. Back injuries preventing prolonged sitting. Use of medications that may affect cardiovascular responses, including antihypertensive, antidiabetic, antidepressant, or hormonal medications.
• Presence of chronic diseases or cardiovascular conditions affecting vascular health.

Sponsors & Collaborators

• King Saud University: lead

Study Sites (1)

King Saud University

Riyadh, Saudi Arabia

RECRUITING

MeSH Terms

Conditions

Sedentary Behavior

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Abdullah B Alansare, PhD

  King Saud University

  STUDY CHAIR

Central Study Contacts

Bushra k Alharbi

CONTACT

+966556913301; bu1.kh2@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Physical Education Teacher and Master's Student

Model Details: Participants will complete three experimental conditions in random order using a randomized crossover design. Each participant will undergo all three sitting interruption protocols with at least 7 days between sessions.

Study Record Dates

• First Submitted: August 31, 2026
• First Posted: September 3, 2026
• Study Start: April 2, 2026
• Primary Completion: September 20, 2026
• Study Completion (Estimated): October 10, 2026
• Last Updated: September 3, 2026

Record last verified: 2026-05

Locations

SA (1)