Investigating ELSI Issues That May Facilitate or Impede Clinical Translation of Epigenetic Research. Phase 3b Survey
2 other identifiers
interventional
1,000
0 countries
N/A
Brief Summary
Few people realize that environmental pollution and some behaviors like physical activity and tobacco smoking can affect their health by "turning on" or "turning off" certain genes through a process called "epigenetic modification." This study will develop and test strategies for communicating about epigenetics that are understandable and that do not increase ethical, legal or social issues (ELSI).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable healthy
Started Aug 2026
Shorter than P25 for not_applicable healthy
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 8, 2026
CompletedFirst Posted
Study publicly available on registry
July 20, 2026
CompletedStudy Start
First participant enrolled
August 1, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
October 1, 2026
July 20, 2026
July 1, 2026
2 months
July 8, 2026
July 14, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Knowledge & understanding of epigenetics Information
Sum score of correct answers for 11 individual items. Scale ranges from 0 points to 11 points with higher scores indicating higher epigenetics knowledge.
Baseline survey, after intervention video
Acceptability of epigenetics information
Three constructs including perceived benefits of epigenetic research (7 items, ranging from 1 to 5 with higher scores indicating higher perceived benefits), perceived drawbacks of epigenetic research (3 items, ranging from 1 to 5 with higher scores indicating higher perceived drawbacks), and acceptance of using epigenetic research in medical support (3 items, ranging from 1 to 5 with higher scores indicating higher acceptance of using epigenetic research in medical support).
Baseline survey, after intervention video
Secondary Outcomes (1)
Perceptions of epigenetic information
Baseline survey, after intervention video
Study Arms (3)
Epigenetics Video
ACTIVE COMPARATORParticipants will watch a brief (\<5 minute) video about the concept of Epigenetics
Individual Responsibility Video
EXPERIMENTALParticipants will watch a brief (\<5 minute) video about the concept of Epigenetics as well as a brief (\<1 minute) video discussing epigenetics and health with a focus on individual behavioral factors affecting epigenetics.
External Responsibility Video
EXPERIMENTALParticipants will watch a brief (\<5 minute) video about the concept of Epigenetics as well as a brief (\<1 minute) video discussing epigenetics and health with a focus on external factors affecting epigenetics.
Interventions
Video about the concept of epigenetics
Video discussing epigenetics and health with a focus on individual behavioral factors affecting epigenetics.
Video discussing epigenetics and health with a focus on external factors affecting epigenetics.
Eligibility Criteria
You may qualify if:
- English language speaker,
- Identify as one of five racial/ethnic groups:
- Non-Hispanic White
- Non-Hispanic Black,
- Non-Hispanic Asian
- Non-Hispanic Indigenous (i.e., Alaska Native/Native Hawaiians/American Indian/Other Pacific Islander)
- Hispanic (all races)
You may not qualify if:
- Self-identify as a genetics expert
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 8, 2026
First Posted
July 20, 2026
Study Start
August 1, 2026
Primary Completion (Estimated)
October 1, 2026
Study Completion (Estimated)
October 1, 2026
Last Updated
July 20, 2026
Record last verified: 2026-07
Data Sharing
- IPD Sharing
- Will share