Effects of Blood Gas Perturbations

NCT07701603 | Not Yet Recruiting

• 1 other identifier: REMEX-WP3
• Study Type: interventional
• Target: 16
• Locations: 0 countries
• Sites: N/A

Brief Summary

In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Diaphragm contractility

  Diaphragm contractility measured before/during/following the gas exposures and the volitional respiratory muscle exercises using transdiaphragmatic and mouth pressure responses.

  Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec

Other Outcomes (1)

• Quadriceps contractility

  Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec.

Study Arms (1)

Gas perturbations

EXPERIMENTAL

Each participant will be tested on 4 different days, on each day with a different inspiratory gas mixture applied for 2h.

Other: Gas perturbation

Interventions

Gas perturbation OTHER

Participants will be breathing a gas mixture of either room air, or hypoxia, or hypercapnia, or a combination of both during 2h. This is followed by an all-out breathing exercise test against a small resistance, while still being in the respective gas condition.

Gas perturbations

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy
• non.smoking
• normal lung function
• BMI: 18.5-29.9 kg/m2
• willing to adhere to study rules

You may not qualify if:

• Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
• Intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep
• Any metal or electronics inside of the body
• Presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators
• History of seizures or epilepsy
• Tattoos on the stimulation sites
• Previous enrolment in this study
• For women: Pregnancy, breastfeeding, or intention to become pregnant during the study

Sponsors & Collaborators

• Swiss Federal Institute of Technology: lead

Study Officials

• Spengler M. Christina, Prof.

  Exercise Physiology Lab, Department of Health Sciences and Technology

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Christina M. Spengler, Prof.

CONTACT

+41 44 632 5007; christina.spengler@hest.ethz.ch

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 8, 2026
• First Posted: July 14, 2026
• Study Start: August 31, 2026
• Primary Completion (Estimated): December 31, 2029
• Study Completion (Estimated): December 31, 2029
• Last Updated: July 14, 2026

Record last verified: 2026-07