Tissue Perfusion Pressure for Predicting Fluid Responsiveness in Patients With Shock

NCT07670390 | Not Yet Recruiting

• 1 other identifier: 2025ZDSYLL481-P01
• Study Type: observational
• Target: 34
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective observational study aims to evaluate the ability of tissue perfusion pressure (TPP) to predict fluid responsiveness in critically ill patients with shock and tissue hypoperfusion. Eligible patients requiring fluid resuscitation will undergo a standardized fluid challenge test. Hemodynamic parameters, including cardiac output and TPP, will be recorded before and after fluid administration. Fluid responsiveness will be defined according to the change in cardiac output following fluid loading. The study will assess the correlation between changes in TPP and cardiac output and evaluate the diagnostic performance of TPP for predicting fluid responsiveness. The results may support the use of TPP as a practical and physiologically relevant parameter for individualized fluid management in patients with shock.

Conditions

Shock

Keywords

shock; tissue perfusion pressure

Outcome Measures

Primary Outcomes (2)

• Δ Cardiac output

  Periprocedural

• Δ Tissue perfusion pressure

  Periprocedural

Study Arms (1)

all

Behavioral: When the attending physician determines that fluid resuscitation is clinically indicated: Patients will remain in the supine position. Crystalloid solution will be administered intravenously via centr

Interventions

When the attending physician determines that fluid resuscitation is clinically indicated: Patients will remain in the supine position. Crystalloid solution will be administered intravenously via centr BEHAVIORAL

all

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study population will consist of critically ill adult patients with shock and tissue hypoperfusion admitted to the Intensive Care Unit of Zhongda Hospital, Southeast University. Patients requiring fluid resuscitation and invasive hemodynamic monitoring as part of routine clinical care will be screened for eligibility and consecutively enrolled in this prospective observational study.

You may qualify if:

• Age ≥18 years
• Admitted to the Intensive Care Unit (ICU)
• Diagnosed with shock and evidence of tissue hypoperfusion
• Judged by the treating physician to require fluid resuscitation
• Receiving invasive hemodynamic monitoring
• Written informed consent obtained from the patient or legally authorized representative

You may not qualify if:

• Pregnancy
• Immediate requirement for extracorporeal life support, including: VV-ECMO, VA-ECMO, Ventricular assist devices
• Expected survival less than 72 hours
• Absence of invasive arterial pressure monitoring or arterial waveform availability \<25%
• Any condition deemed unsuitable for study participation by the investigator.

Sponsors & Collaborators

• Jingyuan,Xu: lead

Related Links

• Related Info

MeSH Terms

Conditions

Shock

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Jingyuan Xu

CONTACT

8602583262550; xujingyuanmail@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Zhongda Hospital

Study Record Dates

• First Submitted: June 4, 2026
• First Posted: June 26, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): April 1, 2028
• Study Completion (Estimated): June 1, 2028
• Last Updated: June 26, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share