Consistency of Fluid Tolerance Evaluation Methods and Their Correlation With Clinical Outcomes in Patients With Shock

NCT07373717 | Enrolling By Invitation

• 1 other identifier: 20251107 fluid management
• Study Type: observational
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to explore the feasibility and scientific validity of carotid-jugular Doppler in evaluating volume tolerance in shock patients (with the VExUS score as an important reference standard), and to conduct an in-depth analysis of the correlation between its monitoring indicators and patient prognosis.The primary endpoint is comparison of the agreement between hands-free carotid-jugular Doppler and the VExUS score in evaluating volume tolerance.The secondary endpoint is correlation between volume tolerance assessed by hands-free carotid-jugular Doppler and the clinical outcomes of shock patients.

Conditions

Shock

Keywords

VExUS; Fluid Resuscitation; Fluid Responsiveness; Fluid Overload; Shock

Outcome Measures

Primary Outcomes (1)

• Hands-free Carotid Artery and Vein Doppler Parameters

  Elevate the patient's upper body to 45°, keep the legs flat, place the long axis of the probe perpendicular to the carotid vessels (with the probe height not exceeding the upper edge of the thyroid cartilage), locate the optimal signals of the common carotid artery and internal jugular vein waveforms, and then fix the probe.

  Time of shock in ICU within 3 days

Secondary Outcomes (11)

• PiCCO

  Time of shock in ICU within 3 days

• Venous Excess Ultrasound Score

  Time of shock in ICU within 3 days

• Bioelectrical Impedance Analysis

  Time of shock in ICU within 3 days

• Duration of shock

  Time of shock in ICU within 28 days

• Duration of Mechanical Ventilation

  up to 24 weeks

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to the ICU

You may qualify if:

• Shock patients admitted to the ICU are defined as those with persistent hypotension (systolic blood pressure \< 90 mmHg or a decrease of ≥ 40 mmHg from the baseline blood pressure) accompanied by signs of tissue hypoperfusion.
• Age ≥ 18 years old.
• The patient or their legal representatives signed the informed consent form.

You may not qualify if:

• Patients with severe pulmonary circulatory disorders such as severe pulmonary hypertension and acute pulmonary embolism.
• Patients with right ventricular myocardial infarction or severe tricuspid regurgitation.
• Patients with severe neck trauma or deformity that affects Doppler examination of cervical arteries and veins, or those with anatomical contraindications preventing evaluation of at least one cervical artery or vein.
• Pregnant or lactating women.
• Patients with diseases that may interfere with abdominal ultrasound examination.

Sponsors & Collaborators

• Southeast University, China: lead

Study Sites (1)

Zhongda Hospital Affiliated to Southeast University

Nanjing, Jiangsu, 210000, China

Location

MeSH Terms

Conditions

Shock; Edema

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 29, 2025
• First Posted: January 28, 2026
• Study Start: November 2, 2025
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): March 1, 2027
• Last Updated: January 28, 2026

Record last verified: 2026-01

Locations

CN (1)