PCO2 Gab Marker of Tissue Adequacy of Cardiac Output in Shock State
PCO2 Gab as a Marker of Tissue Adequacy of Cardiac Output in Sever Shock State, Compared to Other Tissue Perfusion Indicators.
1 other identifier
observational
137
0 countries
N/A
Brief Summary
- 1.To assess validity of of central and pulmonary veno - arterial CO2 gradient to predict fluid responsiveness and to guide fluid management and determine the cut off point to continue or stop resuscitation.
- 2.comparison between PCO2 gab and left ventricular outflow tract velocity time integral to determine whether to continue or stop resuscitation and whether PCO2 gab is a surrogate of cardiac output or not.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2023
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 24, 2022
CompletedStudy Start
First participant enrolled
January 1, 2023
CompletedFirst Posted
Study publicly available on registry
January 11, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
January 30, 2024
CompletedJanuary 11, 2023
December 1, 2022
1 year
December 24, 2022
December 24, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Improvement of heamodynamic state, need of fluid resuscitation and inotropes.
Assessing need of fluid resuscitation and need of inotropes to continue resuscitation to maintain stable heamodynamic status.
January 2023 to January 2024
Secondary Outcomes (1)
Duration of hospital stay, time to control various clinical and laboratory abnormalities (BP, PP, RR, lactate, renal chemistry) and development of complications as; pulmonary edema and use of mechanical ventilation.
January 2023 to January 2024
Eligibility Criteria
All critical ill-patients of all age groups, who presented shocked, with good echocardiographic window, with CVC insertion.
You may qualify if:
- all critical ill-patients with acute physiological assessment and chronic health evaluation II score (APACHE II score)≥25 with central line insertion, in the critical care uint of internal medicine department of Assuit university hospital in the period between January 2023 to January 2024.
You may not qualify if:
- Pateints with poor echocardiographic window.
- Pateints with APACHE II score \< 25.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Gavelli F, Teboul JL, Monnet X. How can CO2-derived indices guide resuscitation in critically ill patients? J Thorac Dis. 2019 Jul;11(Suppl 11):S1528-S1537. doi: 10.21037/jtd.2019.07.10.
PMID: 31388457BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Khaled Ali
Assiut University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MMAELGHANY
Study Record Dates
First Submitted
December 24, 2022
First Posted
January 11, 2023
Study Start
January 1, 2023
Primary Completion
January 1, 2024
Study Completion
January 30, 2024
Last Updated
January 11, 2023
Record last verified: 2022-12