Eating Behavior, Nutritional Status and Appetite Hormones After Bariatric Surgery

NCT07636239 | Not Yet Recruiting

• 1 other identifier: BCKLY-YDB-2026
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate changes in eating behavior attitudes, nutritional status, and appetite-regulating hormonal parameters in individuals who have undergone Laparoscopic Sleeve Gastrectomy (LSG). The study will be conducted at Bursa Yıldırım Doruk Hospital, Department of General Surgery. A total of 40 volunteer participants who underwent LSG within the last month will be included. Participants will be assessed at baseline (shortly after surgery) and at 6-month follow-up. Assessments will include anthropometric measurements (body weight, height, waist and hip circumference, BMI, waist-to-hip ratio), 3-day dietary intake records analyzed using BeBIS 8.2 software, and the Adult Eating Behavior Scale. Biochemical parameters including fasting blood glucose, total cholesterol, triglycerides, HDL, LDL, VLDL cholesterol, and insulin will be obtained from patient files and analyzed using Advia Chemistry 2400 and Advia XPT devices. Additionally, appetite-regulating hormones (ghrelin, GLP-1, PYY) will be analyzed from residual blood samples using the ELISA method with RelAssay Diagnostics kits by Teknogen Bioengineering Laboratory. All data will be compared between baseline and 6-month follow-up to evaluate the impact of bariatric surgery on nutritional and hormonal outcomes.

Conditions

Laparoscopic Sleeve Gastrectomy; Eating Behavior; Nutritional Status; Obesity; Bariatric Surgery

Keywords

Obesity; Bariatric Surgery; Laparoscopic Sleeve Gastrectomy; Eating Behavior; Nutritional status; Ghrelin; GLP-1; Peptite YY; Appetite hormones; Body mass index; Weight loss; Dietary intake

Outcome Measures

Primary Outcomes (8)

• Change in Serum Ghrelin Concentration (pg/mL)

  Change in serum ghrelin levels between baseline and 6-month follow-up, assessed by ELISA method.

  Baseline and 6 months after surgery

• Change in Serum GLP-1 Concentration (pmol/L)

  Change in serum glucagon-like peptide-1 (GLP-1) levels between baseline and 6-month follow-up, assessed by ELISA method.

  Baseline and 6 months after surgery

• Change in Serum PYY Concentration (pg/mL)

  Change in serum peptide YY (PYY) levels between baseline and 6-month follow-up, assessed by ELISA method.

  Baseline and 6 months after surgery

• Change in Adult Eating Behavior Scale Total Score (0-100)

  Change in Adult Eating Behavior Scale total score between baseline and 6-month follow-up. Scale is scored between 0-100; higher scores indicate more positive eating behavior attitudes.

  Baseline and 6 months after surgery

• Change in Daily Energy Intake (kcal/day)

  Change in daily energy intake assessed by 3-day dietary intake records at baseline and 6-month follow-up. Food portions will be estimated using the Food and Nutrient Photo Catalog. Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022.

  Baseline and 6 months after surgery

• Change in Daily Protein Intake (g/day)

  Change in daily protein intake assessed by 3-day dietary intake records at baseline and 6-month follow-up. Food portions will be estimated using the Food and Nutrient Photo Catalog. Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022

  Baseline and 6 months after surgery

• Change in Daily Carbohydrate Intake (g/day)

  Change in daily carbohydrate intake assessed by 3-day dietary intake records at baseline and 6-month follow-up. Food portions will be estimated using the Food and Nutrient Photo Catalog. Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022.

  Baseline and 6 months after surgery

• Change in Daily Fat Intake (g/day)

  Change in daily fat intake assessed by 3-day dietary intake records at baseline and 6-month follow-up. Food portions will be estimated using the Food and Nutrient Photo Catalog. Data will be analyzed using BeBIS 8.2 software and evaluated according to Turkish Dietary Guidelines 2022.

  Baseline and 6 months after surgery

Secondary Outcomes (12)

• Change in Body Weight (kg)

  Baseline and 6 months after surgery

• Change in Body Mass Index (kg/m²)

  Baseline and 6 months after surgery

• Change in Waist Circumference (cm)

  Baseline and 6 months after surgery

• Change in Hip Circumference (cm)

  Baseline and 6 months after surgery

• Change in Waist-to-Hip Ratio

  Baseline and 6 months after surgery

Study Arms (1)

LSG Patients

Individuals who underwent Laparoscopic Sleeve Gastrectomy (LSG) within the last month at Bursa Yıldırım Doruk Hospital, General Surgery Clinic, and meet the inclusion and exclusion criteria. Participants will be assessed at baseline (shortly after surgery) and at 6-month follow-up.

Other: Anthropometric Measurements and Dietary Assessment

Interventions

Anthropometric Measurements and Dietary Assessment OTHER

Anthropometric measurements (body weight, height, waist and hip circumference, BMI, waist-to-hip ratio), 3-day dietary intake records, Adult Eating Behavior Scale, and biochemical and hormonal parameters (fasting blood glucose, lipid profile, insulin, ghrelin, GLP-1, PYY) will be assessed at baseline and at 6-month follow-up.

Also known as: Biochemical and Hormonal Parameter Analysis, Adult Eating Behavior Scale, 3-Day Dietary Intake Record

LSG Patients

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients who underwent Laparoscopic Sleeve Gastrectomy (LSG) within the last month at Bursa Yıldırım Doruk Hospital, General Surgery Clinic, under the supervision of Assoc. Prof. Dogukan Durak, and who meet the inclusion and exclusion criteria.

You may qualify if:

• Having undergone Laparoscopic Sleeve Gastrectomy (LSG) within the last month
• Aged between 18-50 years
• Signing the informed consent form
• Having a Body Mass Index (BMI) of 40 kg/m2 or between 35-40 kg/m2 with obesity-related comorbidities
• No diagnosis of depression
• No eating behavior disorder
• No psychiatric disorder

You may not qualify if:

• Not having undergone Laparoscopic Sleeve Gastrectomy (LSG) or not planning to undergo bariatric surgery
• Not being in the age range of 18-50 years
• Not signing the informed consent form
• Having a Body Mass Index (BMI) greater than 40 kg/m2 or less than 35 kg/m2 without obesity-related comorbidities
• Having a diagnosis of depression
• Having an eating behavior disorder
• Having a psychiatric disorder

Sponsors & Collaborators

• Özlem ÖZPAK AKKUŞ: lead

Study Sites (1)

Bursa Yıldırım Doruk Hastanesi, General Surgery Clinic

Bursa, Bursa, 16130, Turkey (Türkiye)

Location

Related Publications (14)

• Celik E, Karabulut E, Bilgic P. Bariatrik Cerrahi Hastalarinda Beslenme ve Davranis Tutumu Olcegi. Bes Diy Derg. 2017;45(2):107-15.

  BACKGROUND

• Pekcan G, Sanlier N, Bas M, Acar Tek N, Gokmen Ozel H. Turkiye Beslenme Rehberi (TUBER) 2022. Ankara: Hazar Reklamcilik; 2022.

  BACKGROUND

• Beslenme Bilgi Sistemleri Paket Programi (BeBIS 8.2). Istanbul: Software NDB; 2015.

  BACKGROUND

• Merdol TK. Toplu Beslenme Yapilan Kurumlar icin Standard Yemek Tarifleri. Hatipoglu Yayinlari; 2003.

  BACKGROUND

• Rakicioglu N, Tek NA, Ayaz A, Pekcan G. Yemek ve Besin Fotograf Katalogu Olcu ve Miktarlar. Nadir Kitap; 2012.

  BACKGROUND

• Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995;854:1-452.

  PMID: 8594834 BACKGROUND

• Pekcan G. Beslenme Durumunun Saptanmasi. Diyet El Kitabi. Ankara: Hatipoglu Yayinevi; 2013:67-142.

  BACKGROUND

• Baltaci G. Obezite ve egzersiz. Saglik Bakanligi Yayinlari, Ankara; 2008.

  BACKGROUND

• World Health Organization. Prevention and management of the global epidemic of obesity. Report of the WHO Consultation on Obesity. Geneva: WHO; 1997.

  BACKGROUND

• Rigamonti AE, Bini S, Rocco MC, Giardini V, Massimini D, Crippa MG, Saluzzi A, Casati M, Marazzi N, Perotti M, Cimino V, Grassi G, Sartorio A, Pincelli AI. Post-prandial anorexigenic gut peptide, appetite and glucometabolic responses at different eating rates in obese patients undergoing laparoscopic sleeve gastrectomy. Endocrine. 2017 Jan;55(1):113-123. doi: 10.1007/s12020-016-0933-6. Epub 2016 Mar 29.

  PMID: 27022941 BACKGROUND

• Devlin MJ, Goldfein JA, Flancbaum L, Bessler M, Eisenstadt R. Surgical management of obese patients with eating disorders: a survey of current practice. Obes Surg. 2004 Oct;14(9):1252-7. doi: 10.1381/0960892042386940.

  PMID: 15527644 BACKGROUND

• Brown W, Dixon JB, Brien PO. Management of obesity--the role of surgery. Aust Fam Physician. 2006 Aug;35(8):584-6.

  PMID: 16894430 BACKGROUND

• Katsanos CS, Madura JA 2nd, Roust LR. Essential amino acid ingestion as an efficient nutritional strategy for the preservation of muscle mass following gastric bypass surgery. Nutrition. 2016 Jan;32(1):9-13. doi: 10.1016/j.nut.2015.07.005. Epub 2015 Aug 5.

  PMID: 26456190 BACKGROUND

• Sherf Dagan S, Goldenshluger A, Globus I, Schweiger C, Kessler Y, Kowen Sandbank G, Ben-Porat T, Sinai T. Nutritional Recommendations for Adult Bariatric Surgery Patients: Clinical Practice. Adv Nutr. 2017 Mar 15;8(2):382-394. doi: 10.3945/an.116.014258. Print 2017 Mar.

  PMID: 28298280 BACKGROUND

MeSH Terms

Conditions

Obesity; Feeding Behavior; Weight Loss

Interventions

Nutrition Assessment

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior, Animal; Behavior; Body Weight Changes

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Epidemiologic Measurements; Public Health; Environment and Public Health

Study Officials

• Özlem ÖZPAK AKKUŞ, Assoc. Prof.

  Toros University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Özlem ÖZPAK AKKUŞ, Assoc. Prof.

CONTACT

+903246253300; dytozlemozpak@hotmail.com

Doğukan DURAK, Assoc. Prof.

CONTACT

+905327243733; dogukandurak404@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assoc. Prof.

Study Record Dates

• First Submitted: May 20, 2026
• First Posted: June 9, 2026
• Study Start (Estimated): July 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: June 9, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)