A Study of NatureU Burn on Satiety in Healthy Adults

NCT07597382 | Completed

• 2 other identifiers: NATUREU-BURN-2024-SAT2024041001
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

This single-center, single-blind, non-randomized crossover exploratory study evaluated the short-term effects of NatureU Burn on postprandial satiety in healthy adults. NatureU Burn is an oral dietary supplement containing Irvingia gabonensis seed extract and high-molecular-weight inulin. Fourteen healthy adults were enrolled, and 12 participants completed the study and were included in the effectiveness analysis. Each participant completed two test sessions separated by at least 48 hours: a reference food session with 75 g medical anhydrous glucose in 250 mL warm purified water and a test food session with one capsule of NatureU Burn plus 75 g glucose in 250 mL warm purified water. Satiety-related questionnaire scores were assessed at fasting baseline and at 30, 60, 90, 120, 180, and 240 minutes after the first bite in each session. The study assessed fullness, hunger, desire for food, and prospective food consumption, and monitored adverse reactions.

Conditions

Satiety; Food Intake; Fat Disorder; Appetite; Obesity & Overweight

Keywords

NatureU Burn; Irvingia gabonensis seed extract; high-molecular-weight inulin; satiety; prospective food consumption; dietary supplement; NatureU

Outcome Measures

Primary Outcomes (1)

• Food-Affected Fullness Score After NatureU Burn Plus Glucose Compared With Glucose Alone

  Fullness was assessed using the satiety scale. Food-affected fullness was calculated as the change from fasting baseline at each postprandial time point and compared between the NatureU Burn plus glucose test session and the glucose reference session. Fullness was assessed using the fullness item of the 100-point Satiety Rating Scale. The scale ranges from 0 to 100, with higher scores indicating greater fullness and a better satiety outcome. Food-affected fullness was calculated as the change from fasting baseline at each postprandial time point and compared between the NatureU Burn plus glucose test session and the glucose reference session. A larger positive change from baseline indicates a greater increase in fullness

  Fasting baseline before food intake and 30, 60, 90, 120, 180, and 240 minutes after the first bite in each test session.

Secondary Outcomes (3)

• Food-Affected Hunger Score After NatureU Burn Plus Glucose Compared With Glucose Alone

  Fasting baseline before food intake and 30, 60, 90, 120, 180, and 240 minutes after the first bite in each test session

• Food-Affected Desire for Food Score After NatureU Burn Plus Glucose Compared With Glucose Alone

  Fasting baseline before food intake and 30, 60, 90, 120, 180, and 240 minutes after the first bite in each test session

• Food-Affected Prospective Food Consumption Score After NatureU Burn Plus Glucose Compared With Glucose Alone

  Fasting baseline before food intake and 30, 60, 90, 120, 180, and 240 minutes after the first bite in each test session

Study Arms (2)

Reference Food Session

ACTIVE COMPARATOR

Participants consumed 75 g medical anhydrous glucose dissolved in 250 mL warm purified water during the reference food session.

Other: Glucose Reference Food

NatureU Burn Plus Glucose Session

EXPERIMENTAL

Participants consumed one capsule of NatureU Burn with 75 g medical anhydrous glucose dissolved in 250 mL warm purified water during the test food session.

Dietary Supplement: NatureU Burn Plus Glucose

Interventions

Glucose Reference Food OTHER

The reference food consisted of 75 g medical anhydrous glucose dissolved in 250 mL warm purified water.

Reference Food Session

NatureU Burn Plus Glucose DIETARY_SUPPLEMENT

The test food consisted of one capsule of NatureU Burn plus 75 g medical anhydrous glucose dissolved in 250 mL warm purified water. NatureU Burn is an oral dietary supplement containing Irvingia gabonensis seed extract and high-molecular-weight inulin.

Also known as: NatureU Burn, Irvingia gabonensis seed extract and inulin supplement

NatureU Burn Plus Glucose Session

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy adults aged 18 to 50 years.
• Male or female participants.
• Body mass index within the normal range of 18.5 to 23.9 kg/m2.
• Regular habit of eating breakfast.
• Able to fast for at least 10 hours after dinner.
• Signed informed consent before enrollment.

You may not qualify if:

• Pregnant or breastfeeding women.
• Individuals engaged in heavy physical labor or high-intensity exercise.
• Chronic sleep deprivation during the previous 3 months.
• Self-reported body weight increase or decrease of at least 4 kg during the previous 3 months.
• Current use of weight-loss medications.
• Special dietary patterns, such as low-carbohydrate diet or intermittent fasting.
• Abnormal eating attitude based on eating attitude assessment.
• Serious cardiovascular, hepatic, renal, gastrointestinal, hematologic, or neurologic dysfunction.
• History of bariatric surgery.
• Major surgery or hospitalization within the previous 3 months.
• Eating disorders, including binge eating disorder, anorexia nervosa, or bulimia nervosa.
• Abnormal glucose metabolism or lipid metabolism.
• Intolerance or allergy to the test foods.
• Excessive smoking, defined as more than 15 cigarettes per day.
• Alcohol consumption greater than 15 g alcohol per day.

Sponsors & Collaborators

• OmniSolutions Laboratory Holdings Limited: lead

Study Sites (1)

Dao County People's Hospital

Yongzhou, Hunan, 425300, China

Location

Related Publications (1)

• Luo L, Law L, Yu M, Zhang N, Yang M. Participant Experiences from Chronic Administration of Irvingia Gabonensis Seed Extract and Inulin on the Body's Satiety: An Exploratory Analysis of a Single-Blind Clinical Trial. Current Topics in Nutraceutical Research. 2025;23(1):56-63. doi:10.37290/ctnr2641-452X.22:56-63.

  RESULT

Related Links

• Published article in Current Topics in Nutraceutical Research

MeSH Terms

Conditions

Lipid Metabolism Disorders; Obesity; Overweight

Interventions

Glucose

Condition Hierarchy (Ancestors)

Metabolic Diseases; Nutritional and Metabolic Diseases; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates

Study Officials

• Luke Law, Dr

  OmniSolutions Laboratory Holdings Limited

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: The study was described as single-blind. Participants were masked. Investigator, care provider, and outcome assessor masking were not reported.
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Model Details: Each participant completed two test sessions: one reference food session with glucose alone and one test food session with NatureU Burn plus glucose. The sessions were separated by at least 48 hours. The study used a non-randomized crossover design.

Study Record Dates

• First Submitted: May 11, 2026
• First Posted: May 19, 2026
• Study Start: April 22, 2024
• Primary Completion: April 26, 2024
• Study Completion: May 5, 2024
• Last Updated: May 19, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)