Predicting Periodontal Treatment Success Using Machine Learning in Periodontitis Patients

NCT07485946 | Completed

• 2 other identifiers: TBAEK-608TDH-2025-6983
• Study Type: observational
• Target: 86
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to develop a clinical decision-support model capable of predicting the optimal periodontal treatment option at the individual patient level by utilizing a multidimensional dataset composed of clinical periodontal parameters, radiographic findings, implemented treatment modalities, and demographic characteristics. In this context, the study seeks to strengthen personalized treatment planning by identifying the most effective therapeutic approach for individuals presenting for periodontal care.

Conditions

Periodontitis

Keywords

periodontitis; machine learning; clinical decision support system

Outcome Measures

Primary Outcomes (1)

• Clinical Success of Periodontal Treatment

  Binary classification (Success/Failure) of treatment outcomes based on clinical parameters. Success is defined as a reduction of at least 2mm in probing pocket depth (PPD) and a gain in clinical attachment level (CAL) at the 6-month follow-up compared to baseline.

  Baseline and 6 months post-treatment.

Study Arms (3)

Phase-1 Periodontal Therapy

Patients who received non-surgical periodontal treatment consisting of oral hygiene instructions, scaling, and root planing (SRP).

Procedure: Phase-1 Periodontal Therapy

Conventional Flap Surgery

Patients who underwent traditional periodontal flap surgery (access flap) following unsuccessful non-surgical therapy to reduce pocket depth.

Procedure: Conventional Flap Surgery

Regenerative Flap Surgery

Patients who underwent periodontal surgery involving regenerative materials (bone grafts, membranes, or enamel matrix derivatives) for the treatment of intrabony defects.

Procedure: Regenerative Flap Surgery

Interventions

Conventional Flap Surgery PROCEDURE

Periodontal access flap surgery performed for subgingival debridement and pocket depth reduction in cases unresponsive to Phase-1 therapy.

Conventional Flap Surgery

Regenerative Flap Surgery PROCEDURE

Surgical intervention utilizing regenerative materials such as bone grafts or barrier membranes for the treatment of periodontal intrabony defects.

Regenerative Flap Surgery

Phase-1 Periodontal Therapy PROCEDURE

Non-surgical periodontal treatment consisting of scaling and root planing (SRP) under local anesthesia, along with oral hygiene instructions

Phase-1 Periodontal Therapy

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of patients diagnosed with periodontitis who applied to the Akdeniz University Faculty of Dentistry, Department of Periodontology clinic between 2021 and 2025. Participants were selected from patients who underwent Phase-1 periodontal therapy or surgical periodontal procedures (conventional or regenerative flap surgery) and had complete clinical and radiographic records in the Hospital Information Management System database.

You may qualify if:

• A confirmed diagnosis of periodontitis supported by complete clinical and radiographic records.
• Completion of both first and second stage periodontal therapy, including oral hygiene instruction and scaling root planning (SRP).
• Attendance at a minimum of one follow-up visit after completion of initial and secondary periodontal treatment.
• Persistence of bleeding on probing (BoP), probing pocket depth (PPD) ≥5 mm, or worsening periodontal parameters despite adequate oral hygiene, resulting in an indication for periodontal surgery.
• Availability of detailed documentation for each tooth, including the type of active treatment performed and corresponding post treatment records.
• Patients with a previous history of cancer were eligible provided that chemotherapy or radiotherapy had been completed and medical clearance for periodontal treatment had been obtained

You may not qualify if:

• Demographic, clinical, or radiographic data were incomplete.
• Systemic conditions contraindicating periodontal treatment were present.
• Pregnancy or breastfeeding at the time of periodontal treatment.
• Ongoing chemotherapy or radiotherapy.
• Current use of bisphosphonate therapy.
• Presence of an immunocompromised condition.
• Acute systemic illness or active infection at the time of evaluation.

Sponsors & Collaborators

• Akdeniz University: lead

Study Sites (1)

Akdeniz University

Antalya, konyaaltı, 07070, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 17, 2026
• First Posted: March 20, 2026
• Study Start: August 2, 2025
• Primary Completion: January 31, 2026
• Study Completion: January 31, 2026
• Last Updated: March 25, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)