Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy

NCT07287540 | Recruiting

• 1 other identifier: Recep TayyipErdoğan University
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to determine the effect of anti-inflammatory nutrition on non-surgical periodontal treatment in individuals with periodontitis by evaluating gingival crevicular fluid (GCF) and serum biomarkers and clinical periodontal parameters. A total of 100 volunteers identified as having a pro-inflammatory diet (Q3 and Q4) will be included in the study. Individuals will be assigned to two groups. These groups will then be further divided into two groups based on whether or not they will receive anti-inflammatory nutrition education. Group Q3-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q3-2 (n=25) will receive only non-surgical periodontal treatment. Group Q4-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q4-2 (n=25) will receive only non-surgical periodontal treatment. After the periodontal index measurements are completed, the patients will receive non-surgical periodontal treatment. GCF and serum samples, periodontal clinical parameters and Dietary Inflammatory Index will be collected 3 times: at baseline, 1.5 and 3 months after non-surgical periodontal treatment. Levels of interleukin (IL)-1β, IL-10, tumor necrosis factor (TNF)-α, total oxidant status (TOS), total antioxidant status (TAS), and C-reactive protein (CRP) will be assessed from these samples. This will investigate the role of anti-inflammatory nutrition in reducing periodontal inflammation and increasing treatment success.

Conditions

Periodontitis

Keywords

periodontitis; diet inflammatory index; anti-inflammatory nutrition

Outcome Measures

Primary Outcomes (2)

• periodontal pocket depth

  It will be calculated by measuring the distance between the gingival margin and the pocket base. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.

  baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.

• Clinical attachment loss

  It will be calculated by measuring the distance between the cementoenemal border and the pocket base. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.

  baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.

Secondary Outcomes (6)

• interleukin (IL)-1β level

  baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.

• interleukin (IL)-10 level

  baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.

• tumor necrosis factor (TNF)-α level

  baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.

• serum total oxidant status (TOS) level

  baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.

• serum total antioxidant status (TAS) level

  baseline, after nonsurgical periodontal treatment at 1.5 months, after nonsurgical periodontal treatment at 3 months.

Study Arms (4)

Q3-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education

Other: non surgical periodontal trearment; Other: anti-inflammatory nutrition education

Q3-2: Only nonsurgical periodontal treatment

Other: non surgical periodontal trearment

Q4-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education

Other: non surgical periodontal trearment; Other: anti-inflammatory nutrition education

Q4-2: Only nonsurgical periodontal treatment

Other: non surgical periodontal trearment

Interventions

anti-inflammatory nutrition education OTHER

Participants in Groups Q3-1 and Q4-1 will receive anti-inflammatory nutrition education

Q3-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education; Q4-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education

non surgical periodontal trearment OTHER

All participants will receive nonsurgical periodontal treatment

Q3-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education; Q3-2: Only nonsurgical periodontal treatment; Q4-1: Nonsurgical periodontal treatment and anti-inflammatory nutrition education; Q4-2: Only nonsurgical periodontal treatment

Eligibility Criteria

• Age: 20 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study included individuals who applied to Recep Tayyip Erdogan University, Faculty of Dentistry, Department of Periodontology for treatment

You may qualify if:

• Being systemically healthy
• Not smoking
• Not using anti-inflammatory drugs in the last 3 months, antibiotics, or systemic corticosteroids in the last 6 months
• Not being pregnant or lactating
• Not having received periodontal treatment in the last 6 months
• Having at least 20 teeth in the mouth
• Being diagnosed with periodontitis by the investigator
• Having a dietary inflammatory index \>0

You may not qualify if:

• Having a systemic disease
• Smoking
• Using anti-inflammatory drugs within the last 3 months, antibiotics within the last 6 months, or systemic corticosteroids
• Being pregnant or lactating
• Having received periodontal treatment within the last 6 months
• Having fewer than 20 teeth in the mouth
• No periodontitis

Sponsors & Collaborators

• Recep Tayyip Erdogan University: collaborator
• Recep Tayyip Erdogan University Training and Research Hospital: lead

Study Sites (1)

Recep Tayyip Erdoğan University

Rize, 53020, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Central Study Contacts

Hatice Yemenoglu

CONTACT

+905052977517; htcymnglu@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: December 17, 2025
• Study Start: November 22, 2025
• Primary Completion: February 21, 2026
• Study Completion: April 1, 2026
• Last Updated: December 17, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)