Gas6 and Soluble MerTK in Periodontal Diseases

NCT07535177 | Recruiting

• 1 other identifier: BAIBU-SBF-NE-02
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to investigate gingival crevicular fluid (GCF) and serum soluble MerTK (sMerTK) and Gas6 levels in periodontal health and disease. A total of 90 individuals, 30 patients with stage III grade B periodontitis, 30 with gingivitis and 30 periodontally healthy individuals were included. Whole-mouth and site-specific clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index, plaque index were recorded. GCF and serum sMerTK and Gas6 levels were measured by enzyme-linked immunosorbent assay. Statistical analysis was performed by using non-parametric tests.

Conditions

Periodontitis

Outcome Measures

Primary Outcomes (2)

• Gas6 Levels in Gingival Crevicular Fluid

  Quantitative measurement of Gas6 levels (pg/mL) in gingival crevicular fluid samples using enzyme-linked immunosorbent assay (ELISA), and comparison of these levels among periodontally healthy, gingivitis, and periodontitis groups.

  baseline

• Soluble MerTK (sMerTK) Levels in Gingival Crevicular Fluid

  Quantitative measurement of soluble MerTK (sMerTK) levels (pg/mL) in gingival crevicular fluid samples using enzyme-linked immunosorbent assay (ELISA), and comparison of these levels among periodontally healthy, gingivitis, and periodontitis groups.

  baseline

Secondary Outcomes (4)

• Plaque Index

  baseline

• Probing Depth

  baseline

• Clinical Attachment Loss

  baseline

• Gingival Index

  baseline

Study Arms (3)

periodontally healthy (H) group

Other: gingival crevicular fluid collection

gingivitis (G) group

Other: gingival crevicular fluid collection

stage III grade B periodontitis (P) group

Other: gingival crevicular fluid collection

Interventions

gingival crevicular fluid collection OTHER

Gingival crevicular fluid collection using sterile paper strips inserted into the gingival sulcus for 30 seconds from selected periodontal sites (healthy, gingivitis, and periodontitis) for biomarker analysis (Gas6 and sMerTK).

gingivitis (G) group; periodontally healthy (H) group; stage III grade B periodontitis (P) group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This clinical study will be conducted on individuals who apply to the Department of Periodontology, Faculty of Dentistry, Abant İzzet Baysal University.

You may qualify if:

• Individuals without systemic diseases that may affect periodontal tissues (such as cardiovascular diseases, atherosclerosis, immune system disorders, rheumatoid arthritis, obesity, cancer, and diabetes)
• Individuals who have not used antibiotics within the last 3 months
• Individuals not taking any medications known to affect periodontal tissues
• Individuals without infectious diseases such as HIV, hepatitis B virus (HBV), or tuberculosis
• Individuals with at least 16 natural teeth, excluding third molars
• Individuals aged 18 years and older

You may not qualify if:

• Pregnant or lactating individuals
• Individuals who have received periodontal treatment within the last 6 months
• Current smokers

Sponsors & Collaborators

• Abant Izzet Baysal University: lead

Study Sites (1)

Bolu Abant Izzet Baysal University Faculty of Dentistry

Bolu, Bolu, 14030, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: April 2, 2026
• First Posted: April 16, 2026
• Study Start: March 25, 2026
• Primary Completion (Estimated): May 10, 2026
• Study Completion (Estimated): May 20, 2026
• Last Updated: April 16, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)