Predictive Role of the Full-mouth Plaque Score on the Outcomes of Non-surgical Periodontal Therapy.

NCT07524504 | Not Yet Recruiting

• 1 other identifier: 02042026
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Oral hygiene quality is a key determinant of outcomes in both non-surgical and surgical periodontal therapy. Previous studies have demonstrated the negative impact of site-specific plaque accumulation on periodontal parameters. However, to the best of our knowledge, no studies have specifically investigated the correlation between plaque index and the percentage reduction in periodontal pocket depth, nor its association with other periodontal clinical parameters. The aim of this study is to evaluate the relationship between plaque index and the percentage reduction in periodontal pockets, as well as its association with key periodontal parameters. Following baseline data collection, patients will undergo non-surgical periodontal therapy in accordance with current guidelines. Clinical outcomes will be reassessed at 3, 6, 9, and 12 months post-treatment.

Conditions

Periodontitis

Keywords

Periodontitis; Non-surgical periodontal therapy; Re-evaluation

Outcome Measures

Primary Outcomes (1)

• Percentage of probing pocket depth reduction

  The primary outcome is the percentage reduction in probing pocket depth (PPD) at treated sites compared to baseline. PPD will be measured using a calibrated periodontal probe at each follow-up visit (3, 6, 9, and 12 months).

  Baseline, 3, 6 9 and 12 months

Study Arms (1)

Non-Surgical Periodontal Therapy Cohort - Plaque Index Evaluation

This cohort includes patients diagnosed with periodontitis who will undergo non-surgical periodontal therapy according to current guidelines. Baseline full mouth plaque index (FMPS) and other periodontal parameters will be recorded. FMPS will be collected at each follow-up visit. Clinical outcomes, including pocket depth reduction and other periodontal measures, will be assessed at 3, 6, 9, and 12 months post-treatment to evaluate the association between oral hygiene and treatment response.

Procedure: Non-surgical periodontal therapy (NSPT)

Interventions

Non-surgical periodontal therapy (NSPT) PROCEDURE

Patients will receive non-surgical periodontal therapy, including professional supragingival (Step 1) and subgingival scaling and root planing (Step 2), according to current guidelines (Herrera et al., 2023). Oral hygiene instructions will be provided at baseline and reinforced at each follow-up visit. Clinical outcomes, including percentage of pocket depth reduction and plaque index (FMPS), will be recorded at 3, 6, 9, and 12 months post-treatment.

Non-Surgical Periodontal Therapy Cohort - Plaque Index Evaluation

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

At least 100 patients with a baseline diagnosis of periodontitis, aged between 18 and 80 years, who have never received periodontal treatment, will be included in the study. Patients will be recruited from the Unit of Periodontology and Dental Hygiene at the Dental Clinic of the Department of Innovative Technologies in Medicine and Dentistry, University of "Gabriele D'Annunzio" of Chieti. Periodontitis will be diagnosed according to the criteria of Tonetti et al., 2018, regardless of grade, stage, or extent of the disease, in cases where periodontal diagnosis and treatment are indicated. Patients must have a confirmed diagnosis of periodontitis and be within the age range of 18 to 80 years. Individuals who have previously received periodontal treatment, are currently taking antibiotics or have taken antibiotics in the past three months, are pregnant or breastfeeding, or have systemic diseases or are on medications that contraindicate periodontal treatment or could influence study outc

You may qualify if:

• Diagnosis of periodontitis according to current guidelines.
• Age between 18 and 80 years.

You may not qualify if:

• Patients who have previously received periodontal treatment.
• Patients currently on antibiotic therapy or who have taken antibiotics in the past 3 months.
• Pregnant or breastfeeding women.
• Presence of systemic diseases or use of medications in which periodontal treatment is contraindicated or could affect study outcomes (e.g., antihypertensives, antiepileptics, immunosuppressants).

Sponsors & Collaborators

• G. d'Annunzio University: lead

Study Sites (1)

Clinica Odontoiatrica

Chieti, Chieti, 66100, Italy

Location

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Matteo Serroni

  'G. D'annunzio' University of Chieti-Pescara

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Matteo Serroni, DDS

CONTACT

+393395824161; serronimatteo@gmail.com

Matteo Serroni, DDS

CONTACT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD Candidate

Study Record Dates

• First Submitted: April 2, 2026
• First Posted: April 13, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): December 15, 2027
• Study Completion (Estimated): December 15, 2027
• Last Updated: April 13, 2026

Record last verified: 2026-04

Locations

IT (1)