NCT07472517

Brief Summary

This study is open to adults with advanced small cell lung cancer (SCLC). The purpose of this study is to find out if a study medicine called obrixtamig plus standard treatment (atezolizumab, carboplatin, and etoposide) improves survival when compared to standard treatment alone. Obrixtamig is an antibody-like molecule that may help the immune system fight cancer. Another purpose of the study is to test a medical device being developed to measure levels of the tumour marker DLL3. Participants are put into 2 groups randomly, which means by chance. One group receives obrixtamig and standard treatment. The other group receives standard treatment without obrixtamig. All treatments are given as infusions into a vein. Participants are in the study for up to 3 years. During this time, they visit the study site regularly. Participants in the group receiving obrixtamig stay overnight at the study site following the first 2 obrixtamig treatments. At the visits, doctors check the size of the tumour(s). The results are compared between the 2 groups to see whether the treatment works. The doctors also regularly check participants' health and take note of any unwanted effects.

Trial Health

88
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
670

participants targeted

Target at P75+ for phase_3

Timeline
38mo left

Started Apr 2026

Typical duration for phase_3

Geographic Reach
40 countries

216 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress5%
Apr 2026Jul 2029

First Submitted

Initial submission to the registry

March 4, 2026

Completed
12 days until next milestone

First Posted

Study publicly available on registry

March 16, 2026

Completed
28 days until next milestone

Study Start

First participant enrolled

April 13, 2026

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 9, 2028

Expected
11 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 30, 2029

Last Updated

June 9, 2026

Status Verified

June 1, 2026

Enrollment Period

2.4 years

First QC Date

March 4, 2026

Last Update Submit

June 8, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Overall survival (OS)

    OS, defined as the time from randomisation until death from any cause

    Up to 36 months

Secondary Outcomes (10)

  • Progression free survival (PFS)

    Up to 36 months

  • Change From Baseline in Selected Disease Symptoms Included in the European Organization for Research and Treatment of Lung Cancer Quality of Life Questionnaire (EORTC-QLQ-LC13)

    At baseline and up to 1 year

  • Overall response (OR)

    Up to 36 months

  • Occurrence of treatment-emergent Cytokine Release Syndrome (CRS) during the on-treatment period

    Up to 36 months

  • Occurrence of treatment-emergent Immune effector cell-associated neurotoxicity syndrome (ICANS) during the on-treatment period

    Up to 36 months

  • +5 more secondary outcomes

Study Arms (2)

obrixtamig + atezolizumab, carboplatin, and etoposide treatment arm

EXPERIMENTAL
Drug: obrixtamigDrug: atezolizumabDrug: carboplatinDrug: etoposide

atezolizumab, carboplatin, and etoposide control arm

EXPERIMENTAL
Drug: atezolizumabDrug: carboplatinDrug: etoposide

Interventions

obrixtamig

obrixtamig + atezolizumab, carboplatin, and etoposide treatment arm

atezolizumab

atezolizumab, carboplatin, and etoposide control armobrixtamig + atezolizumab, carboplatin, and etoposide treatment arm

carboplatin

atezolizumab, carboplatin, and etoposide control armobrixtamig + atezolizumab, carboplatin, and etoposide treatment arm

etoposide

atezolizumab, carboplatin, and etoposide control armobrixtamig + atezolizumab, carboplatin, and etoposide treatment arm

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients with histologically confirmed Extensive-stage Small Cell Lung Cancer (ES-SCLC)
  • Patients without any previous systematic anti-cancer treatment for ES-SCLC. Patients who received previous systematic anti-cancer treatment during limited stage are eligible if the treatment has been completed more than 6 months before the diagnosis of ES-SCLC.
  • Adequate archival formalin-fixed paraffin-embedded (FFPE) tumour tissue, as specified in the Laboratory Manual, must be available for central laboratory analysis of Delta-like ligand 3 (DLL3) expression status and other biomarkers. The central laboratory investigational VENTANA DLL3 (SP347) RxDx test result must be available prior to randomisation.
  • Patients with asymptomatic brain metastasis are eligible if they meet one of the following criteria:
  • Treatment for brain metastases (e.g. whole brain radiation therapy, stereotactic radiotherapy, or radiosurgery) completed at least 14 days prior to randomisation and neurologically stable without the use of glucocorticoids or therapeutic anti-convulsant for at least 7 days prior to randomisation
  • Untreated brain metastases that do not require treatment and are neurologically stable without the use of glucocorticoids or therapeutic anti-convulsant for at least 28 days prior to randomisation
  • Eastern Cooperative Oncology Group (ECOG) score of 0 or 1
  • Eligible for continuing carboplatin + etoposide + atezolizumab regimen as first-line Standard of care (SoC) treatment within 28 days after the start of the initial cycle of standard therapy

You may not qualify if:

  • Presence of leptomeningeal disease and/or carcinomatous meningitis
  • Previous treatment targeting DLL3 (e.g. T cell engagers (TcEs), cell therapies, antibody-drug conjugates, or radiopharmaceuticals)
  • Radiotherapy of any anatomical sites within 14 days prior to randomisation
  • Persistent toxicity from previous treatments that has not resolved to ≤ Common Terminology Criteria for Adverse Events (CTCAE) Grade 1 (except for alopecia, asthenia/fatigue, amenorrhea/menstrual disorders, CTCAE Grade 2 peripheral neuropathy, and CTCAE Grade 2 endocrinopathies controlled by replacement therapy, and toxicities, which are considered irreversible but stable for at least 4 weeks prior to randomisation, per investigator judgment)
  • Patient with active autoimmune disease or a documented history of autoimmune disease that requires systemic treatment (e.g. glucocorticoids or immunosuppressive drugs). Patients with vitiligo, resolved childhood asthma/atopy, alopecia, or any chronic skin condition that does not require systemic therapy, patients with autoimmune-related hypothyroidism on a stable dose of thyroid replacement hormone and/or controlled Type 1 diabetes mellitus on a stable insulin regimen may be included if in the opinion of the investigator it is appropriate and safe to do so.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (236)

Infirmary Cancer Care

Mobile, Alabama, 36607, United States

NOT YET RECRUITING

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States

NOT YET RECRUITING

Bioresearch Partner - Hialeah Hospital

Hialeah, Florida, 33013, United States

NOT YET RECRUITING

Emory University

Atlanta, Georgia, 30322, United States

NOT YET RECRUITING

Norton Cancer Institute, Downtown

Louisville, Kentucky, 40202, United States

NOT YET RECRUITING

Epic Medical Research - Monroe

Monroe, Louisiana, 71201, United States

NOT YET RECRUITING

Epic Medical Research - Shreveport

Shreveport, Louisiana, 71105, United States

NOT YET RECRUITING

University of Maryland School of Medicine

Baltimore, Maryland, 21201, United States

NOT YET RECRUITING

Veterans Affairs Ann Arbor Healthcare System

Ann Arbor, Michigan, 48105, United States

NOT YET RECRUITING

HCA MidAmerica Division, Inc.

Kansas City, Missouri, 64132, United States

NOT YET RECRUITING

University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

NOT YET RECRUITING

AHN Cancer Institute - Allegheny General

Pittsburgh, Pennsylvania, 15212, United States

NOT YET RECRUITING

Baptist Cancer Center - Memphis

Memphis, Tennessee, 38120, United States

NOT YET RECRUITING

University of Wisconsin

Madison, Wisconsin, 53792, United States

NOT YET RECRUITING

Hospital Britanico de Buenos Aires

CABA, 1280AEB, Argentina

NOT YET RECRUITING

Clinica Adventista Belgrano

CABA, 1430, Argentina

NOT YET RECRUITING

Clinica Privada Independencia

Munro, B1605, Argentina

NOT YET RECRUITING

Sanatorio Allende S.A.

Nueva Córdoba, X5000JHQ, Argentina

NOT YET RECRUITING

Sanatorio Parque S.A.

Rosario, S2000DSV, Argentina

NOT YET RECRUITING

Prince of Wales Hospital-Randwick-66496

Randwick, New South Wales, 2031, Australia

NOT YET RECRUITING

Ballarat Regional Integrated Cancer Centre

Ballarat, Victoria, 3350, Australia

NOT YET RECRUITING

Cancer Research South Australia

Adelaide, Australia

NOT YET RECRUITING

Hospital Elisabethinen Linz

Linz, 4020, Austria

NOT YET RECRUITING

Johannes Kepler University Linz

Linz, 4020, Austria

NOT YET RECRUITING

Standort Penzing der Klinik Ottakring

Vienna, 1160, Austria

NOT YET RECRUITING

Edegem - UNIV UZ Antwerpen

Edegem, 2650, Belgium

NOT YET RECRUITING

Universitair Ziekenhuis Brussel

Jette, 1090, Belgium

NOT YET RECRUITING

UZ Leuven

Leuven, 3000, Belgium

NOT YET RECRUITING

Hospital de Amor

Barretos, 14784-400, Brazil

NOT YET RECRUITING

Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa Sociedade Simples

Porto Alegre, 90110-270, Brazil

NOT YET RECRUITING

Irmandade da Santa Casa de Misericórdia de Porto Alegre

Porto Alegre - RS, CEP 90020-090, Brazil

NOT YET RECRUITING

Fundação Faculdade Regional de Medicina de São José do Rio Preto

São José do Rio Preto, 15090-000, Brazil

NOT YET RECRUITING

Multiprofile Hospital For Active Treatment-Uni Hospital Ltd.

Panagyurishte, 4500, Bulgaria

NOT YET RECRUITING

MHAT Heart and brain

Pleven, 5800, Bulgaria

NOT YET RECRUITING

Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD

Sofia, 1407, Bulgaria

NOT YET RECRUITING

Sault Area Hospital

Sault Ste. Marie, Ontario, P6B 0A8, Canada

NOT YET RECRUITING

Icegclinic

La Florida, 8240000, Chile

NOT YET RECRUITING

Clinica Santa Maria

Providencia, Chile

NOT YET RECRUITING

Instituto Oncológico FALP

Providencia, Chile

NOT YET RECRUITING

Bradford Hill- Centro de Investigación Clínica

Recoleta, 8420383, Chile

NOT YET RECRUITING

Clínica Alemana de Santiago S.A.

Santiago, 7650568, Chile

NOT YET RECRUITING

Beijing Cancer Hospital

Beijing, 100036, China

NOT YET RECRUITING

Beijing Chest Hospital, Capital Medical University

Beijing, 101149, China

NOT YET RECRUITING

The First Affiliated Hospital Of Bengbu Medical College

Bengbu, 233004, China

NOT YET RECRUITING

Hunan Province Tumor Hospital

Changsha, 410013, China

NOT YET RECRUITING

Sichuan Cancer Hospital

Chengdu, 610041, China

NOT YET RECRUITING

West China Hospital, Sichuan University

Chengdu, 610041, China

NOT YET RECRUITING

Fujian Cancer Hospital

Fuzhou, 350014, China

NOT YET RECRUITING

Sun Yat-Sen University Cancer Center

Guangzhou, 510060, China

NOT YET RECRUITING

The First Affiliated Hospital,Sun Yat-sen University

Guangzhou, 510080, China

NOT YET RECRUITING

The First Affiliated Hospital, Zhejiang University

Hangzhou, 310003, China

NOT YET RECRUITING

Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine

Hangzhou, 310016, China

NOT YET RECRUITING

Harbin Medical University Cancer Hospital

Harbin, 150081, China

NOT YET RECRUITING

Shandong Cancer Hospital

Jinan, 250117, China

NOT YET RECRUITING

Linyi Cancer Hospital

Linyi, 276034, China

RECRUITING

The First Affiliated Hospital of Nanchang University

Nanchang, 330000, China

NOT YET RECRUITING

The Second Affiliated Hospital to Nanchang University

Nanchang, 330006, China

NOT YET RECRUITING

Nanjing Drum Tower Hospital

Nanjing, 210008, China

NOT YET RECRUITING

The Affiliated Cancer Hospital, Guangxi Medical University

Nanning, 530021, China

NOT YET RECRUITING

The First Affiliated Hospital of Ningbo University

Ningbo, 315010, China

NOT YET RECRUITING

Shanghai Chest Hospital

Shanghai, 200030, China

RECRUITING

Shanghai Pulmonary Hospital

Shanghai, 200433, China

NOT YET RECRUITING

Shanghai Geriatric Medical Center

Shanghai, 201104, China

NOT YET RECRUITING

Shanghai General Hospital

Shanghai, 210000, China

NOT YET RECRUITING

China Shenyang Chest Hospital

Shenyang, 110000, China

NOT YET RECRUITING

Shanxi Cancer hospital

Taiyuan, 030000, China

NOT YET RECRUITING

Tianjin Cancer Hospital

Tianjin, 300060, China

NOT YET RECRUITING

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, 325000, China

NOT YET RECRUITING

Wuhan Union Hospital

Wuhan, 430048, China

NOT YET RECRUITING

Xiangyang Central Hospital

Xiangyang, 441138, China

NOT YET RECRUITING

Affiliated Hospital, Xuzhou Medical college

Xuzhou, 221006, China

NOT YET RECRUITING

Northern Jiangsu People's Hospital

Yangzhou, 225001, China

RECRUITING

Henan Cancer Hospital

Zhengzhou, 450003, China

NOT YET RECRUITING

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, 450015, China

NOT YET RECRUITING

University Hospital Olomouc

Olomouc, 77900, Czechia

NOT YET RECRUITING

University Thomayer´s Hospital

Prague, 140 59, Czechia

NOT YET RECRUITING

North Estonia Medical Centre Foundation, Tallinn

Tallinn, 13419, Estonia

NOT YET RECRUITING

Tartu University Hospital

Tartu, 50406, Estonia

NOT YET RECRUITING

KYS Sädesairaala

Kuopio, 70029, Finland

NOT YET RECRUITING

Oulun yliopistollinen keskussairaala

Oulu, 90220, Finland

NOT YET RECRUITING

Turun Yliopistollinen sairaala

Turku, 20521, Finland

NOT YET RECRUITING

INS Bergonie

Bordeaux, 33000, France

NOT YET RECRUITING

CTR François Baclesse

Caen, 14076, France

NOT YET RECRUITING

CTR Georges-François Leclerc

Dijon, 21079, France

NOT YET RECRUITING

INS Paoli-Calmettes

Marseille, 13009, France

NOT YET RECRUITING

HOP Nord Laennec

Nantes, 44093, France

NOT YET RECRUITING

INS Curie

Paris, 75005, France

NOT YET RECRUITING

Hôpital Cochin

Paris, 75014, France

NOT YET RECRUITING

HOP Villefranche-sur-Saône

Villefranche-sur-Saône, 69400, France

NOT YET RECRUITING

Institut Gustave Roussy

Villejuif, 94800, France

NOT YET RECRUITING

ARENSIA Exploratory Medicine LLC

Tbilisi, 0112, Georgia

NOT YET RECRUITING

Universitätsklinikum Aachen, AöR

Aachen, 52074, Germany

NOT YET RECRUITING

Charité - Universitätsmedizin Berlin

Berlin, 13353, Germany

NOT YET RECRUITING

Vivantes Klinikum Spandau

Berlin-Spandau, 13585, Germany

NOT YET RECRUITING

Technische Universität Dresden

Dresden, 01307, Germany

NOT YET RECRUITING

Universitätsklinikum Frankfurt

Frankfurt, 60590, Germany

NOT YET RECRUITING

Universitätsklinikum Freiburg

Freiburg im Breisgau, 79106, Germany

NOT YET RECRUITING

Asklepios Fachkliniken München-Gauting

Gauting, 82131, Germany

NOT YET RECRUITING

Universitätsmedizin Göttingen, Georg-August-Universität

Göttingen, 37075, Germany

NOT YET RECRUITING

LungenClinic Grosshansdorf GmbH

Großhansdorf, 22927, Germany

NOT YET RECRUITING

Asklepios Kliniken GmbH & Co. KGaA

Hamburg, 21075, Germany

NOT YET RECRUITING

Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg

Heidelberg, 69126, Germany

NOT YET RECRUITING

Westfälische Wilhelms-Universität Münster

Münster, 48149, Germany

NOT YET RECRUITING

Pius-Hospital, Oldenburg

Oldenburg, 26121, Germany

NOT YET RECRUITING

Universitätsklinikum Würzburg AÖR

Würzburg, 97078, Germany

NOT YET RECRUITING

Chest Hospital of Athens "Sotiria"

Athens, 115 27, Greece

NOT YET RECRUITING

Henry Dunant Hospital, Athens

Athens, 11526, Greece

NOT YET RECRUITING

General Hospital of Thessaloniki "G. Papanikolaou"

Thessaloniki, 57010, Greece

NOT YET RECRUITING

Queen Mary Hospital

Hong Kong, Hong Kong

NOT YET RECRUITING

Prince of Wales Hospital-Hong Kong-20715

Shatin, 999077, Hong Kong

NOT YET RECRUITING

Koranyi National Institute For Pulmonolgy

Budapest, 1121, Hungary

NOT YET RECRUITING

University of Debrecen Clinical Centre

Debrecen, 4032, Hungary

NOT YET RECRUITING

Bacs-Kiskun Megyei Onkormanyzat Hospital

Kecskemét, 6000, Hungary

NOT YET RECRUITING

Tolna County Balassa Janos Hospital

Szekszárd, 7100, Hungary

NOT YET RECRUITING

Reformed Pulmonology Center

Törökbálint, 2045, Hungary

NOT YET RECRUITING

Cork University Hospital

Cork, T12 DFK4, Ireland

NOT YET RECRUITING

Centro di riferimento Oncologico

Aviano (PN), 33081, Italy

NOT YET RECRUITING

Istituto Tumori Giovanni Paolo II

Bari, 70124, Italy

NOT YET RECRUITING

ASST degli Spedali Civili di Brescia

Brescia, 25123, Italy

NOT YET RECRUITING

A. O. Universitaria Careggi

Florence, 50134, Italy

NOT YET RECRUITING

Istituto Scientifico Romagnolo

Meldola (FC), 47014, Italy

NOT YET RECRUITING

AOU San Luigi Gonzaga

Orbassano (TO), 10043, Italy

NOT YET RECRUITING

Istituto Oncologico Veneto IRCCS

Padova, 35128, Italy

NOT YET RECRUITING

Azienda Ospedaliera Unversitaria di Parma

Parma, 43100, Italy

NOT YET RECRUITING

Fondazione Policlinico Universitario Campus Bio-medico

Roma, 00128, Italy

NOT YET RECRUITING

Azienda Ospedaliera Universitaria Integrata Verona

Verona, 37126, Italy

NOT YET RECRUITING

Fujita Health University Hospital

Aichi, Toyoake, 470-1192, Japan

RECRUITING

Hirosaki University Hospital

Aomori, Hirosaki, 036-8563, Japan

NOT YET RECRUITING

Kyushu University Hospital

Fukuoka, Fukuoka, 812-8582, Japan

RECRUITING

Hokkaido University Hospital

Hokkaido, Sapporo, 060-8648, Japan

NOT YET RECRUITING

Kagoshima University Hospital

Kagoshima, Kagoshima, 890-8520, Japan

NOT YET RECRUITING

Sendai Kousei Hospital

Miyagi, Sendai, 981-0914, Japan

NOT YET RECRUITING

Kindai University Hospital

Osaka, Sakai, 590-0197, Japan

NOT YET RECRUITING

Saitama Medical University International Medical Center

Saitama, Hidaka, 350-1298, Japan

RECRUITING

Hamamatsu University Hospital

Shizuoka, Hamamatsu, 431-3192, Japan

NOT YET RECRUITING

National Cancer Center Hospital

Tokyo, Chuo-ku, 104-0045, Japan

NOT YET RECRUITING

Japanese Foundation for Cancer Research

Tokyo, Koto-ku, 135-8550, Japan

RECRUITING

Wakayama Medical University Hospital

Wakayama, Wakayama, 641-8510, Japan

NOT YET RECRUITING

Pauls Stradins Clinical University Hospital

Riga, 1002, Latvia

NOT YET RECRUITING

Riga East University Hospital

Riga, 1079, Latvia

NOT YET RECRUITING

Hospital Pulau Pinang-Georgetown, Pulau Pinang-40766

George Town, 10450, Malaysia

NOT YET RECRUITING

Hospital Wanita Dan Kanak-Kanak Sabah

Kota Kinabalu, 88996, Malaysia

NOT YET RECRUITING

Sarawak General Hospital

Kuching, 93586, Malaysia

NOT YET RECRUITING

National Cancer Institute (IKN)

Putrajaya, 62250, Malaysia

NOT YET RECRUITING

Sunway Medical Centre

Selangor Darul Ehsan, 47500, Malaysia

NOT YET RECRUITING

Health Pharma Professional Research S.A. de C.V.

Mexico City, 03100, Mexico

NOT YET RECRUITING

Centro Oncologico Personalizado

México, 06760, Mexico

NOT YET RECRUITING

Instituto Nacional de Cancerologia

México, 14080, Mexico

NOT YET RECRUITING

Centro Medico Zambrano Hellion

Monterrey, 66278, Mexico

NOT YET RECRUITING

Hospital Universitario Dr Jose Eleuterio Gonzalez

Nuevo León, 64460, Mexico

NOT YET RECRUITING

Centro Oncologico Estatal ISSEMyM "Dr. Jose Luis Barrera Franco"

Toluca, 50180, Mexico

NOT YET RECRUITING

ARENSIA Exploratory Medicine

Chisinau, MD-2025, Moldova

NOT YET RECRUITING

Nederlands Kanker Instituut - Antoni van Leeuwenhoek Amsterdam (METC AVL)

Amsterdam, 1066CX, Netherlands

NOT YET RECRUITING

Maastricht University Medisch Centrum

Maastricht, 6229 HX, Netherlands

NOT YET RECRUITING

Erasmus Medisch Centrum

Rotterdam, 3015 GD, Netherlands

NOT YET RECRUITING

Auckland City Hospital

Auckland, 1023, New Zealand

NOT YET RECRUITING

Waikato Hospital

Hamilton, 3204, New Zealand

NOT YET RECRUITING

Haukeland Universitetssykehus

Bergen, 5021, Norway

NOT YET RECRUITING

Oslo Universitetssykehus HF, Radiumhospitalet

Oslo, N-0379, Norway

NOT YET RECRUITING

St. Olavs Hospital, Universitetssykehuset i Trondheim

Trondheim, 7030, Norway

NOT YET RECRUITING

UCK Clinical Research Support Center

Gdansk, 80-214, Poland

NOT YET RECRUITING

Polish Mother's Memorial Hospital - Research Institute

Lodz, 93338, Poland

NOT YET RECRUITING

University Clinical Hospital No. 4 in Lublin

Lublin, 20090, Poland

NOT YET RECRUITING

Warmia and Mazury Center for Lung Diseases in Olsztyn

Olsztyn, 10-357, Poland

NOT YET RECRUITING

4. Military Clinical Hospital with Polyclinic SP ZOZ

Wroclaw, 50-981, Poland

NOT YET RECRUITING

ULS Braga

Braga, 4710-243, Portugal

NOT YET RECRUITING

CHUC - Centro Hospitalar e Universitário de Coimbra, EPE

Coimbra, 3004-561, Portugal

NOT YET RECRUITING

Hospital da Luz

Lisbon, 1500-650, Portugal

NOT YET RECRUITING

Hospital CUF Porto

Porto, 4100-180, Portugal

NOT YET RECRUITING

IPO Porto Francisco Gentil, EPE

Porto, 4200-072, Portugal

NOT YET RECRUITING

Institutul Oncologic Prof. Dr. Alexandru Trestioreanu Bucuresti

Bucharest, 022328, Romania

NOT YET RECRUITING

Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca

Cluj-Napoca, 400015, Romania

NOT YET RECRUITING

Centrul De Oncologie SF Nectarie S.R.L.

Craiova, 200542, Romania

NOT YET RECRUITING

National Cancer Centre Singapore

Singapore, 168583, Singapore

NOT YET RECRUITING

Tan Tock Seng Hospital

Singapore, 308433, Singapore

NOT YET RECRUITING

Pusan National University Hospital

Busan, 49241, South Korea

RECRUITING

Chungnam National University Hospital

Daejoen, 35015, South Korea

NOT YET RECRUITING

National Cancer Center

Goyang, 10408, South Korea

NOT YET RECRUITING

Chonnam National University Hwasun Hospital

Hwasun, 58128, South Korea

RECRUITING

Seoul National University Bundang Hospital

Seongnam, 13620, South Korea

RECRUITING

Seoul National University Hospital

Seoul, 03080, South Korea

NOT YET RECRUITING

Severance Hospital

Seoul, 03722, South Korea

NOT YET RECRUITING

Asan Medical Center

Seoul, 05505, South Korea

RECRUITING

Samsung Medical Center

Seoul, 06351, South Korea

RECRUITING

Korea University Guro Hospital

Seoul, 08308, South Korea

RECRUITING

Complejo Hospitalario Universitario A Coruña

A Coruña, 15006, Spain

NOT YET RECRUITING

Hospital del Mar

Barcelona, 08003, Spain

NOT YET RECRUITING

Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain

NOT YET RECRUITING

Institut Català d'Oncologia de Girona.

Girona, 17007, Spain

NOT YET RECRUITING

Hospital Duran i Reynals

L'Hospitalet de Llobregat, 08908, Spain

NOT YET RECRUITING

H. Universitario Insular de Canarias

Las Palmas de Gran Canaria, 35016, Spain

NOT YET RECRUITING

Hospital Universitario Ramon Y Cajal

Madrid, 28034, Spain

NOT YET RECRUITING

Fundación Jiménez Díaz

Madrid, 28040, Spain

NOT YET RECRUITING

Hospital Universitario 12 de Octubre

Madrid, 28041, Spain

NOT YET RECRUITING

Hospital Puerta de Hierro

Madrid, 28222, Spain

NOT YET RECRUITING

Hospital Regional Universitario de Málaga

Málaga, 29010, Spain

NOT YET RECRUITING

Hospital Son Espases

Palma de Mallorca, 07120, Spain

NOT YET RECRUITING

Clínica Universidad de Navarra

Pamplona, 31008, Spain

NOT YET RECRUITING

Hospital Universitario Virgen De La Macarena

Seville, 41009, Spain

NOT YET RECRUITING

Hospital Clinico Universitario de Valencia

Valencia, 46010, Spain

NOT YET RECRUITING

Hospital Universitari i Politècnic La Fe

Valencia, 46016, Spain

NOT YET RECRUITING

Hospital Clinico Universitario Lozano Blesa

Zaragoza, 50009, Spain

NOT YET RECRUITING

Gävle sjukhus

Gävle, 801 87, Sweden

NOT YET RECRUITING

Sahlgrenska Universitetssjukhuset, Östra

Gothenburg, 413 46, Sweden

NOT YET RECRUITING

Karolinska Universitetssjukhuset Solna

Stockholm, 171 76, Sweden

NOT YET RECRUITING

Kantonsspital Baden AG

Baden, 5404, Switzerland

NOT YET RECRUITING

Centre Hospitalier Universitaire Vaudois

Lausanne, 1011, Switzerland

NOT YET RECRUITING

Stadtspital Zürich

Zurich, 8063, Switzerland

NOT YET RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 807, Taiwan

RECRUITING

Taichung Veterans General Hospital

Taichung, 40705, Taiwan

NOT YET RECRUITING

National Cheng Kung University Hospital

Tainan, 70403, Taiwan

NOT YET RECRUITING

National Taiwan University Hospital

Taipei, 10048, Taiwan

NOT YET RECRUITING

National Taiwan University Cancer Center

Taipei, 106, Taiwan

NOT YET RECRUITING

Taipei Veterans General Hospital

Taipei, 11217, Taiwan

NOT YET RECRUITING

Chang Gung Memorial Hospital, Linkou

Taoyuan City, 333, Taiwan

NOT YET RECRUITING

Vajira Hospital

Bangkok, 10300, Thailand

NOT YET RECRUITING

Siriraj Hospital

Bangkok, 10700, Thailand

NOT YET RECRUITING

Maharaj Nakom Chiangmai Hospital

Chiang Mai, 50200, Thailand

NOT YET RECRUITING

Songklanagarind Hospital

Hat Yai, 90110, Thailand

NOT YET RECRUITING

Adana Şehir Hastanesi

Adana, Turkey (Türkiye)

NOT YET RECRUITING

Medical Park Adana Hastanesi

Adana, Turkey (Türkiye)

NOT YET RECRUITING

Sağlık Bilimleri Üniversitesi Gülhane Eğitim ve Araştırma Hastanesi

Ankara, 06018, Turkey (Türkiye)

NOT YET RECRUITING

Dr. Abdurrahman Yurtaslan Ankara Onkoloji Eğitim ve Araştırma Hastanesi

Ankara, Turkey (Türkiye)

NOT YET RECRUITING

Samsun Medical Park Hastanesi

Atakum, Turkey (Türkiye)

NOT YET RECRUITING

Medeniyet University

Istanbul, 34862, Turkey (Türkiye)

NOT YET RECRUITING

Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi

Istanbul, 34890, Turkey (Türkiye)

NOT YET RECRUITING

Ankara Bilkent Sehir Hastanesi

Türkiye, Turkey (Türkiye)

NOT YET RECRUITING

Velindre Cancer Centre

Cardiff, CF14 2TL, United Kingdom

NOT YET RECRUITING

Leicester Royal Infirmary

Leicester, LE1 5WW, United Kingdom

NOT YET RECRUITING

The Christie Hospital

Manchester, M20 4BX, United Kingdom

NOT YET RECRUITING

The Royal Marsden Hospital, Sutton

Sutton, SM2 5PT, United Kingdom

NOT YET RECRUITING

Torbay Hospital

Torquay, TQ2 7AA, United Kingdom

NOT YET RECRUITING

Hanoi Oncology Hospital

Hanoi, 100000, Vietnam

NOT YET RECRUITING

National Cancer Hospital, Hanoi

Hanoi, 100000, Vietnam

NOT YET RECRUITING

Ho Chi Minh Oncology Hospital

Ho Chi Minh City, 70000, Vietnam

NOT YET RECRUITING

University Medical Center HCMC

Ho Chi Minh City, 70000, Vietnam

NOT YET RECRUITING

Related Links

MeSH Terms

Conditions

Small Cell Lung Carcinoma

Interventions

atezolizumabCarboplatinEtoposide

Condition Hierarchy (Ancestors)

Carcinoma, BronchogenicBronchial NeoplasmsLung NeoplasmsRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Coordination ComplexesOrganic ChemicalsPodophyllotoxinTetrahydronaphthalenesNaphthalenesPolycyclic Aromatic HydrocarbonsHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbonsPolycyclic CompoundsGlucosidesGlycosidesCarbohydrates

Central Study Contacts

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Open-label
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 4, 2026

First Posted

March 16, 2026

Study Start

April 13, 2026

Primary Completion (Estimated)

September 9, 2028

Study Completion (Estimated)

July 30, 2029

Last Updated

June 9, 2026

Record last verified: 2026-06

Data Sharing

IPD Sharing
Will share

Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.clinicalstudies.boehringer-ingelheim.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement". Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.

Shared Documents
STUDY PROTOCOL, SAP, CSR
Time Frame
One year after the approval has been granted by major Regulatory Authorities and after the primary manuscript has been accepted for publication, or after termination of the development program.
Access Criteria
For study documents -upon signing of a 'Document Sharing Agreement'.For study data -1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.
More information

Locations