Effects of Intermittent Running on Metabolic Health

NCT06962605 | Recruiting

• 1 other identifier: 202502HM010
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the suitability of intermittent exercise of long and short intervals at lower intensities than HIIE on energy expenditure during and post-exercise compared to MICE, as well as determine whether similar or greater effects can be achieved for glycemic control in recreationally active adults.

Conditions

Metabolic Regulation; Energy Expenditure

Keywords

Intermittent running; Energy expenditure

Outcome Measures

Primary Outcomes (2)

• Total energy expenditure

  Changes in total energy expenditure during 40-minutes running and 30 minutes of EPOC

  70 minutes

• Substrate utilisation

  Changes in substrate utilisation during 40-minutes running and 30 minutes of EPOC

  70 minutes

Secondary Outcomes (2)

• Muscle oxygen saturation

  70 minutes

• Subjective appetite sensation

  70 minutes

Study Arms (3)

Moderate-intensity continuous running (MICE: 60% V̇O2max)

EXPERIMENTAL

Exercise

Behavioral: Moderate-intensity continuous running (MICE: 60% V̇O2max)

5-minute interval running (5MIN)

EXPERIMENTAL

Exercise

Behavioral: 5-minute interval running (5MIN)

2-minute interval running (2MIN)

EXPERIMENTAL

Exercise

Behavioral: 2-minute interval running (2MIN)

Interventions

5-minute interval running (5MIN) BEHAVIORAL

Participants run for 40 minutes at average moderate intensity with 5-minutes slow and fast cycles where speed is increased and decreased by 20%.

5-minute interval running (5MIN)

2-minute interval running (2MIN) BEHAVIORAL

Participants run for 40 minutes at average moderate intensity with 2-minutes slow and fast cycles where speed is increased and decreased by 20%.

2-minute interval running (2MIN)

Moderate-intensity continuous running (MICE: 60% V̇O2max) BEHAVIORAL

Participants run continuously for 40 minutes at moderate intensity (60-65% V̇O2max)

Moderate-intensity continuous running (MICE: 60% V̇O2max)

Eligibility Criteria

• Age: 20 Years - 45 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy recreationally active men
• BMI between 18.5-27 kg/m2
• Aged between 20 to 45 years
• Regular exercise (3 times per week and longer than 3 months) with cardio exercise longer than 30 minutes at least once a week
• Weight stable for more than 3 months (no change in weight +/- 3%)
• Non-shift workers and sleep at least 6.5-9 hours for the past 3 months
• Non-smoker

You may not qualify if:

• having any cardiovascular, metabolic or pulmonary disease (angina pectoris or uncontrolled arrhythmias)
• suffering from infectious contagious diseases,
• using medications that could affect metabolic responses (including anti-inflammatory medications)
• smoking
• heavy alcohol intake (more than 4 drinks on any day or more than 14 drinks a week).
• undergoing special diets (e.g., intermittent fasting and/or ketogenic diets)

Sponsors & Collaborators

• National Taiwan Normal University: lead

Study Sites (1)

National Taiwan Normal University

Taipei, Taiwan

RECRUITING

Central Study Contacts

Yung-Chih Chen, PhD

CONTACT

+886277496979; yc.chen@ntnu.edu.tw

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Participants will be asked to perform 4 trials in a randomized-crossover design (1) moderate-intensity continuous running (MICE: 60% V̇O2max), (2) 5-minute interval running (5MIN; 50% and 70% V̇O2max), (3) 2-minute interval running (2MIN; 50% and 70% V̇O2max).

Study Record Dates

• First Submitted: April 22, 2025
• First Posted: May 8, 2025
• Study Start: June 21, 2025
• Primary Completion: April 30, 2026
• Study Completion: April 30, 2026
• Last Updated: January 26, 2026

Record last verified: 2026-01

Locations

TW (1)