Effect of Resistance Exercises and Relaxation Therapy on Physical Function and Quality Of Life in Patients With Chronic Kidney Disease

NCT07370662 | Completed DMC

• 1 other identifier: IRB/2024/159
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The significance of this study to compare the effect of resistance exercises and relaxation therapy to find out which technique is more effective for improving physical function and quality of life in chronic kidney disease patient. The study was aimed to determine the effect of resistance exercises and relaxation therapy on physical function and quality of life in patients with chronic kidney disease. We hypothesized if there was significant effect of resistance exercises and relaxation therapy on physical function and quality of life in patients with chronic kidney disease. Group A: Relaxation therapy and Resistance exercises. Group B: Resistance exercises.

Conditions

Chronic Kidney Disease (Mild to Moderate)

Keywords

Chronic Kidney Disease; Physical Function; Quality of Life; Resistance Exercises.; Relaxation Therapy

Outcome Measures

Primary Outcomes (1)

• SF 36 (Quality of Life)

  To assess patients Quality of life SF-36 was used. It provides information on 8 scales, scoring from0(worst health) to100(best health), and on the physical component scale (PCS) and the mental component scale (MCS), normalized scores representing overall physical and mental functioning

  Pre-test (Baseline) and Post-test (08 Weeks)

Secondary Outcomes (2)

• Sit-to-Stand test

  Pre-test (Baseline) and Post-test (08 Weeks)

• 6-minute walk test

  Pre-test (Baseline) and Post-test (08 Weeks)

Study Arms (2)

Resistance exercises

ACTIVE COMPARATOR

Resistance exercise (knee and hip flexion and extension ,and elbow extension)

Other: Resistance exercises:

Relaxation exercise

EXPERIMENTAL

Diaphragmatic Breathing + Pursed Lip Breathing

Other: Resistance exercises:; Other: Relaxation exercise

Interventions

Resistance exercises: OTHER

The researcher taught patients this exercise and encouraged them to do it daily each once about 20 to 30 minutes. The exercise started with moderate intensity of no more than 10 minutes then time of practice increased gradually to 30 minutes. Resistance exercise included the following: Knee and hip flexion and extension, elbow extension. The repetition was be 15-20 times

Relaxation exercise; Resistance exercises

Relaxation exercise OTHER

Relaxation exercise (diaphragmatic breathing, pursed lip breathing) Diaphragmatic breathing is intended to help patient use the diaphragm correctly while breathing to strengthen the diaphragm and decrease the work of breathing. Patient was instructed to sit comfortably with the knees bent and the shoulders, head and neck relaxed. Breathe in slowly through the nose so that the stomach moves out against the hand. Then exhaled through pursed lib technique so that stomach moves in again. Patients was instructed to place one hand on the upper chest and the other just below the rib cage. This was allowing patient to feel the diaphragm move as he or she breathe. Patients was instructed to practice this exercise 5-10 minutes about 3-4 times per day.

Relaxation exercise

Eligibility Criteria

• Age: 30 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age (30-65years).
• Both Male and female.
• Patient able to stand and walk independently.
• Patient with mild to moderate stage of chronic kidney disease.

You may not qualify if:

• Physical disability.
• Acute Myocardial infarction.
• Kidney transplant.
• Pregnant women.

Sponsors & Collaborators

• Rashid Latif Medical College: lead

Study Sites (1)

Arif memorial teaching hospital

Lahore, Punjab Province, 54000, Pakistan

Location

Related Publications (3)

• Segura-Ortí E, Kouidi E, Lisón J. Effect of resistance exercise during hemodialysis on physical function and quality of life: randomized controlled trial. Clinical nephrology. 2009;71(5):527.

  BACKGROUND

• Barcellos FC, Santos IS, Mielke GI, Del Vecchio FB, Hallal PC. Effects of exercise on kidney function among non-diabetic patients with hypertension and renal disease: randomized controlled trial. BMC nephrology. 2012;13:1-7.

  BACKGROUND

• Abd Elbaky M, Zaki S, Amin N, Ali R. Impact of Intradialytic Rehabilitation Program on General Health of Chronic Kidney Disease Patients. American Journal of Nursing. 2018;6(5):263-72

  BACKGROUND

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The outcome assessor was kept blind. The individuals measuring or evaluating a study's results, assessor was not aware of treatment group (intervention) a participant belongs to, preventing their expectations or biases from influencing the outcome measurement and ensuring more objective results.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Group A: Resistance exercises and relaxation therapy Group B: Resistance exercises, where Resistance exercise (knee and hip flexion and extension, and elbow extension)

Study Record Dates

• First Submitted: January 19, 2026
• First Posted: January 27, 2026
• Study Start: August 12, 2024
• Primary Completion: March 15, 2025
• Study Completion: March 15, 2025
• Last Updated: January 27, 2026

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)