Comparative Effects of Aerobic Exercises, Resistance Training and Combined Training on Heart Failure Patients

NCT04937231 | Completed DMC

• 1 other identifier: REC/00880 Mahnoor Shabbir
• Study Type: interventional
• Target: 92
• Locations: 1 country
• Sites: 1

Brief Summary

To compare the effectiveness of aerobic training and resistance training and combined training on heart failure patients.

Conditions

Heart Failure

Keywords

Aerobic Exercises; Resistance Training; Combined Training

Outcome Measures

Primary Outcomes (5)

• Hospital Anxiety and Depression Scale

  Hospital Anxiety and Depression Scale (HADS) is a 14-item scale with seven items each for anxiety and depression subscales. Scoring for each item ranges from zero to three. A subscale score \>8 denotes anxiety or depression. Changes from the Baseline will be measured.

  4th week

• Minnesota living with heart failure questionnaire

  Minnesota living with heart failure questionnaire (MLHFQ) is a self-administered, 21-item disease-specific instrument for patients with heart failure. MLHFQ is an instrument which has been widely used to assess quality of life among heart failure patients. Each item is scored in a 6-point Likert Scale (0 to 5), thus the total score could range from 0 to 105, with higher scores indicating more significant impairment in health-related quality of life. The MLHFQ has two domains; physical domain (eight items, score range from 0 to 40) and emotional domain (five items, score range from 0 to 25). Changes from the Baseline will be measured

  4th week

• 6 Min walk test (Distance in meters)

  Changes from the baseline, 6 Min Walk Distance (6 MWD) was used to measure Functional capacity. It is a sub maximal exercise test which can aid in assessing functional capacity of patients with cardiopulmonary diseases, in this test we find out the maximum distance in meters which an individual covers in 6 min without any support.

  4th Week

• Peak VO2 with formula

  A generalized equation can be used to determined Peak rate of oxygen consumption (peak VO2). The generalized equation can be used to accurately estimate mean peak VO2 from mean 6 MWD, among groups of patients with diverse diseases without the need for cardiopulmonary exercise testing. The equation is: Mean peak VO2(ml/kg/mins) = 4.948 + 0.023\*Mean 6 MWD (meter) Changes From the Baseline will be measured.

  4th Week

• Heart Rate/Pulse Rate

  Changes from baseline, Pulse rate was measured per minute through pulse oximeter. Crossly it was measure by Chest belt (Polar Heart Rate monitors). Changes from the Baseline will be measure.

  4th Week

Study Arms (3)

Aerobic exercises

EXPERIMENTAL

Treadmill and Cycle ergometer

Other: Aerobic exercises

Resistance exercises

EXPERIMENTAL

unilateral leg press, Bilateral leg press, unilateral arm curls

Other: Resistance exercises

Combined training

EXPERIMENTAL

Treadmill and Cycle ergometer along with resistive Training

Other: Combined training

Interventions

Aerobic exercises OTHER

For Week 1 and 2 : Treadmill 3-5days/weeks Intensity: 50-70 vo2 peak Or HRR 60-80% Duration of 10-20 minutes For Week 3 and 4; Cycle ergometer 3-5days/weeks Intensity: 50-70 vo2 peak Or HRR 60-80% Duration of 30-40 minutes

Aerobic exercises

Resistance exercises OTHER

For Week 1 and 2; 2 x 10 rep (unilateral leg press) 4x 12 reps (Bilateral leg press 1 x 8 rep ( unilateral arm curls For Week 3 and 4; 1 x 10 reps Shoulder press 1 x15 rep Bilateral knee extension 1 x 10 reps Bilateral arm curls

Resistance exercises

Combined training OTHER

For Week 1 and 2; Aerobic exercise on Treadmill along with dumbbell to perform upper limb exercises (biceps curls, side curls extensions, upright row, back fly) and used Thera band to perform lower limb exercises for 10-20 minutes For Week 3 and 4; Aerobic exercise on Treadmill along with dumbbell and Thera band to perform upper limb and lower limb exercises for 30-40 minutes

Combined training

Eligibility Criteria

• Age: 35 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Heart failure patients with ejection fraction greater than 35%

You may not qualify if:

• Patients with unstable angina
• Patients who had severe pain in the lower limbs
• Patients with Blood pressure greater than 190/120mmHg were excluded
• Patients who had positive contraindication for cardiac rehabilitation were not admitted in this study

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Rawalpindi Institute of Cardiology

Rawalpindi, Punjab Province, 44000, Pakistan

Location

MeSH Terms

Conditions

Heart Failure

Interventions

Exercise

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Muhammad Iqbal Tariq, MSCPPT

  Riphah International University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 15, 2021
• First Posted: June 23, 2021
• Study Start: October 15, 2020
• Primary Completion: September 30, 2021
• Study Completion: September 30, 2021
• Last Updated: October 20, 2021

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)