Effect of Aerobic Training Versus Resistance Training on Plasma Homocystiene in Diabetic Patients

NCT05845190 | Unknown

• 1 other identifier: P.T.REC/012/003654
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this \[clinical trial\] is to \[ compare \] in \[ diabetic male patients \]. The main question to answer is : Will be any difference between aerobic exercises and resistance exercises in improving levels of homocysteine, cholesterol and insulin in diabetic patients? Participants will take their medications and group of them do aerobic exercises and another group do resistance training

Conditions

Diabete Type 2

Outcome Measures

Primary Outcomes (1)

• homocystiene

  Homocysteine was measured with an enzyme linked immunosorbent (ELISA) method. The upper limit of normal is 15 μmol/l

  12 weeks of training

Secondary Outcomes (2)

• insulin

  12 weeks of training

• cholestrol

  12 weeks of trianing

Study Arms (2)

aerobic exercises group (group A )

EXPERIMENTAL

20 male patients with diabetes mellites Attended the program of walking on treadmill for 12 weeks according to the following parameters. Exercise prescription: Intensity: started by 60-75% of target heart rate according to each patient response. Duration: Each session consisted of five minutes warming up firstly then 25-30 minutes time of session ended by five minutes cool down exercises Frequency: Three times / week (day after day) for 12 weeks

Other: aerobic exercises

resistance exercises group (group B)

EXPERIMENTAL

20 male patients with diabetes mellites will participate in resistance training exercises 30-45 mins. The subject will warm up and cool down for at least five to seven minutes each, (before and after exercise) with initial load of 60% of 1 repetition maximum. This program consists of 3 sets of 8 to 12 repetitions, then increasing load when subject was able to complete 12 repetitions. A rest period of 1.5 min was established between each set. Mode: 4 upper body exercises (bench press, seated row, shoulder press, and pull down), 3 leg exercises (leg press, extension, and flexion), abdominal crunches and back extensions. with the individualized workloads at 60% of 1RM. Duration: 30 min-45 min (total session). Frequency: Three times / week (day after day). Intensity: increased load was established when subject was able to complete 12 repetitions.

Other: resistance exercises

Interventions

aerobic exercises OTHER

aerobic exercises in form of walking on treadmill

Also known as: group A

aerobic exercises group (group A )

resistance exercises OTHER

60% of One-repetition maximum 3 sets ( 8 to 12 ) repetitions

Also known as: group B

resistance exercises group (group B)

Eligibility Criteria

• Age: 40 Years - 55 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Their ages will range from 40 -55 years 2- Their body mass indexes will range between (25 to 35 Kg / m²). 3-All patients are diagnosed with type 2 diabetes mellites.
• Diagnostic criteria for type 2 diabetes were: 1) a fasting plasma glucose concentration of 7.0 mmol·L-1 or higher or 2) a plasma glucose concentration of 11.1 mmol·L-1 or higher two hours after an oral glucose challenge. (Punthakee et al.,2018).
• All subjects took oral hypoglycemic drugs but none of them were being treated with insulin when enrolled.
• All patients are medically and psychologically stable

You may not qualify if:

• Patients with uncontrolled blood glucose level
• Patients with unstable cardiovascular conditions (those with a known history of uncontrolled hypertension, ischemic attacks, stroke, congestive heart failure, currently on anticoagulation therapy) were excluded from this study.
• Patients with severe pulmonary disease (with restrictive lung disease or with obstructive lung disease).
• Patients with musculoskeletal disorders (Diagnosed with severe osteoporosis or severe osteoarthritis).
• Patients with BMI \> 35 will be excluded from the study.

Sponsors & Collaborators

• Egyptian Chinese University: lead

Study Sites (1)

Egyptian Chineese University

Cairo, Gesr Elsuez, Egypt

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Interventions

Exercise

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• hanan hassan

  Egyptian Chinese University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer

Model Details: simple randomization using a randomization table created by a computer software program

Study Record Dates

• First Submitted: April 26, 2023
• First Posted: May 6, 2023
• Study Start: April 4, 2022
• Primary Completion: May 15, 2023
• Study Completion: May 15, 2023
• Last Updated: May 6, 2023

Record last verified: 2023-04

Data Sharing

• IPD Sharing: Will share
• Time Frame: immediately following publication , no end data
• Access Criteria: anyone who whishes to access the data, for any purpose

Locations

EG (1)