Combined Subcostal and Lateral Transversus Abdominis Plane Block for Postoperative Analgesia Versus Thoracic Epidural Analgesia in Patients Undergoing Major Abdominal Cancer Surgery

NCT07273136 | Recruiting

• 1 other identifier: 620
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the safety and efficacy of combined subcostal and lateral transversus abdominis plane (TAP) for postoperative analgesia versus thoracic epidural anesthesia (TEA) in patients undergoing major abdominal cancer surgery.

Conditions

Lateral; Postoperative Analgesia; Thoracic Epidural Analgesia; Subcostal; Transversus Abdominis Plane Block; Major Abdominal Cancer Surgery

Outcome Measures

Primary Outcomes (1)

• Total morphine consumption

  Rescue analgesia of morphine will be given as 3 mg bolus if the Visual Analogue Scale (VAS) \> 3 to be repeated after 30 min if pain persists until the VAS \< 4.

  24 hours postoperatively

Secondary Outcomes (5)

• Time to the 1st rescue analgesia

  24 hours postoperatively

• Mean arterial pressure

  Till the end of surgery (Up to 2 hours)

• Heart rate

  Till the end of surgery (Up to 2 hours)

• Degree of pain

  24 hours postoperatively

• Incidence of adverse events

  24 hours postoperatively

Study Arms (2)

Subcostal and lateral transversus abdominis plane block group

EXPERIMENTAL

Patients will receive an ultrasound-guided combined subcostal and lateral transversus abdominis plane block.

Other: Subcostal and lateral transversus abdominis plane block

Thoracic epidural anesthesia group

ACTIVE COMPARATOR

Patients will receive an ultrasound-guided thoracic epidural anesthesia.

Other: Thoracic epidural anesthesia

Interventions

Thoracic epidural anesthesia OTHER

Patients will receive an ultrasound-guided thoracic epidural anesthesia.

Thoracic epidural anesthesia group

Subcostal and lateral transversus abdominis plane block OTHER

Patients will receive an ultrasound-guided combined subcostal and lateral transversus abdominis plane block.

Subcostal and lateral transversus abdominis plane block group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 years.
• Both sexes.
• American Society of Anesthesiologists (ASA) physical status I-III.
• Scheduled for major abdominal surgeries including: (e.g., gastrectomy, colectomy, hepatectomy, cystectomy, total abdominal hysterectomy, Nephrectomy, pancreatectomy).

You may not qualify if:

• Intraoperative hemodynamic instability.
• History or evidence of coagulopathy.
• Infection or abdominal wall masses at injection site.
• Morbid obesity.
• Other Medical conditions including mental illness or substance abuse.
• Known allergy to local anesthetics.
• Chronic opioid use or chronic pain conditions.
• Pregnancy.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University

Asyut, 71515, Egypt

RECRUITING

Central Study Contacts

Bahaa G Saad, MD

CONTACT

00201555590977; bahaagamal@aun.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesia and Intensive Care, Faculty of Medicine, Assiut University, Assiut, Egypt.

Study Record Dates

• First Submitted: November 27, 2025
• First Posted: December 9, 2025
• Study Start: December 10, 2025
• Primary Completion: April 1, 2026
• Study Completion: April 1, 2026
• Last Updated: December 11, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)