External Oblique and Rectus Abdominis Plane Block Versus Quadratus Lumborum Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy

NCT07082387 | Completed

• 1 other identifier: 36264PR1261/6/25
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the effects of the external oblique and rectus abdominis plane (EXORA) block and the quadratus lumborum block (QLB) on postoperative analgesia in patients undergoing laparoscopic cholecystectomy (LC).

Conditions

Quadratus Lumborum Block; Postoperative Analgesia; Laparoscopic Cholecystectomy; External Oblique and Rectus Abdominis Plane Block

Outcome Measures

Primary Outcomes (1)

• Time to the 1st rescue analgesia

  Time to the first request for the rescue analgesia (time from the end of surgery to first dose of morphine administrated).

  24 hours postoperatively

Secondary Outcomes (4)

• Total morphine consumption

  24 hours postoperatively

• Intraoperative fentanyl consumption

  Intraoperatively

• Degree of pain

  24 hours postoperatively

• Incidence of adverse events

  24 hours postoperatively

Study Arms (2)

EXORA group

EXPERIMENTAL

Patients will receive an external oblique and rectus abdominis plane (EXORA) block using 20ml of bupivacaine 0.25%.

Other: External oblique and rectus abdominis plane block

QLB group

EXPERIMENTAL

Patients will receive a quadratus lumborum block (QLB) using 20ml of bupivacaine 0.25%.

Other: Quadratus lumborum block

Interventions

External oblique and rectus abdominis plane block OTHER

Patients will receive an external oblique and rectus abdominis plane (EXORA) block using 20ml of bupivacaine 0.25%.

EXORA group

Quadratus lumborum block OTHER

Patients will receive a quadratus lumborum block (QLB) using 20ml of bupivacaine 0.25%.

QLB group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age from 18 to 65 years.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I-II.
• Undergoing laparoscopic cholecystectomy (LC) under general anesthesia.

You may not qualify if:

• History of allergies to local anesthetics.
• Opioid dependency.
• Bleeding or coagulation disorders.
• Psychiatric and neurological disorder.
• Local infection at the site of injection.
• Body mass index (BMI) \> 35.
• Hypertension.
• Uncontrolled diabetes mellitus.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: July 16, 2025
• First Posted: July 24, 2025
• Study Start: July 24, 2025
• Primary Completion: March 31, 2026
• Study Completion: March 31, 2026
• Last Updated: April 22, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)