Transversus Abdominis Plane Block Versus External Oblique Intercostal Plane Block for Postoperative Analgesia in Pediatrics Undergoing Open Nephrectomy

NCT06452225 | Completed

• 1 other identifier: 36264PR641/4/24
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to compare the ultrasound guided TAP Block and EOIP block for postoperative analgesia in pediatrics undergoing open nephrectomy.

Conditions

Transversus Abdominis Plane Block; External Oblique Intercostal Plane Block; Postoperative Analgesia; Pediatrics; Open Nephrectomy

Outcome Measures

Primary Outcomes (1)

• Time to the 1st rescue analgesia

  A standardized analgesic regimen will be prescribed in the post-operative period. All patients will receive paracetamol 15 mg /kg/8 hrs as routine analgesia. Rescue analgesia of morphine will be given as 0.05 mg/kg if face, legs, activity, and cry consolability scale (FLACC) ≥ 4 and the maximum allowed dose is 0.1mg/kg every 4 hours. FLACC will be assessed at 0, 2, 4, 8, 12 and 24h postoperatively. it will be measured from the end of surgery to first dose of morphine administrated.

  24 hours postoperatively

Secondary Outcomes (4)

• Intraoperative fentanyl consumption

  Intraoperatively

• Total morphine consumption

  24 hours postoperatively

• Degree of pain

  24 hours postoperatively

• Mean arterial pressure

  Every 15 minutes till the end of surgery

Other Outcomes (1)

• Heart rate

  Every 15 minutes till the end of surgery

Study Arms (2)

External Oblique Intercostal Plane Block

EXPERIMENTAL

Patients will receive external oblique intercostal plane block.

Other: External Oblique Intercostal Plane Block

Transversus Abdominis Plane Block

EXPERIMENTAL

Patients will receive ultrasound guided transversus abdominis plane block.

Other: Transversus Abdominis Plane Block

Interventions

External Oblique Intercostal Plane Block OTHER

Patients will receive external oblique intercostal plane block.

External Oblique Intercostal Plane Block

Transversus Abdominis Plane Block OTHER

Patients will receive ultrasound guided transversus abdominis plane block.

Transversus Abdominis Plane Block

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Age ≤ 18 years.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I-III.
• Scheduled for open nephrectomy.

You may not qualify if:

• Abnormal blood coagulation.
• Scar, infection, and tumor of puncture site.
• History or family history of high malignant fever.
• Severe cardiovascular problems.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: May 30, 2024
• First Posted: June 11, 2024
• Study Start: June 12, 2024
• Primary Completion: October 20, 2025
• Study Completion: October 20, 2025
• Last Updated: November 25, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year
• Access Criteria: The data will be available upon a reasonable request from the corresponding author

Locations

EG (1)