External Oblique Intercostal Plane Block Versus Transversus Abdominis Plane Block for Postoperative Analgesia in Adult Patients Undergoing Open Nephrectomy

NCT06452238 | Completed

• 1 other identifier: 36264PR639/4/24
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to compare external oblique intercostal plane (EOIP) block and ultrasound guided transversus abdominis plane (TAP) Block for postoperative analgesia in adult patients undergoing open nephrectomy.

Conditions

External Oblique Intercostal Plane Block; Transversus Abdominis Plane Block; Postoperative Analgesia; Nephrectomy

Outcome Measures

Primary Outcomes (1)

• Total pethidine consumption in the 1st 24hr

  A standardized analgesic regimen will be prescribed in the postoperative period. All patients will receive paracetamol 1 gm every 6 h as routine analgesia. Rescue analgesia of pethidine will be given as 2 mg bolus if the Numerical Rating Scale (NRS) \> 3 to be repeated after 30 min if pain persists until the Numerical Rating Scale (NRS) \< 4. NRS will be assessed at 0, 4, 8, 12, 18 and 24h postoperatively.

  24 hours postoperatively

Secondary Outcomes (5)

• Intraoperative fentanyl consumption

  Intraoperatively

• Time to the 1st rescue analgesia.

  24 hours postoperatively

• Degree of pain

  24 hours postoperatively

• Mean arterial pressure

  Every 15 minutes till the end of surgery

• Heart rate

  Every 15 minutes till the end of surgery

Study Arms (2)

External Oblique Intercostal Plane Block

EXPERIMENTAL

Patients will receive external oblique intercostal plane block .

Other: External Oblique Intercostal Plane Block

Transversus Abdominis Plane Block

EXPERIMENTAL

Patients will receive ultrasound guided transversus abdominis plane block.

Other: Transversus Abdominis Plane Block

Interventions

External Oblique Intercostal Plane Block OTHER

Patients will receive external oblique intercostal plane block .

External Oblique Intercostal Plane Block

Transversus Abdominis Plane Block OTHER

Patients will receive ultrasound-guided transversus abdominis plane block.

Transversus Abdominis Plane Block

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 years.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I-II.
• Scheduled for open nephrectomy.

You may not qualify if:

• Bleeding disorders.
• Skin lesions or infection at the site of proposed needle insertion.
• Allergy to local anesthetics.
• Neurological disorders.
• Drug abuse.
• BMI \> 30 kg/m2.
• Pregnancy.
• Diabetic neuropathy.
• Severe cardiovascular problems.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: May 30, 2024
• First Posted: June 11, 2024
• Study Start: June 12, 2024
• Primary Completion: October 22, 2025
• Study Completion: October 22, 2025
• Last Updated: November 25, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author

Locations

EG (1)