NCT07351253

Brief Summary

this aim of this study is to compare the analgesic effect of Erector spinae plane (ESP) block and lateral transversus abdominis plan (TAP) block in patients undergoing open appendectomy.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
68

participants targeted

Target at P50-P75 for not_applicable

Timeline
0mo left

Started Jan 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress86%
Jan 2026May 2026

First Submitted

Initial submission to the registry

January 10, 2026

Completed
10 days until next milestone

First Posted

Study publicly available on registry

January 20, 2026

Completed
5 days until next milestone

Study Start

First participant enrolled

January 25, 2026

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2026

Last Updated

March 17, 2026

Status Verified

January 1, 2026

Enrollment Period

3 months

First QC Date

January 10, 2026

Last Update Submit

March 15, 2026

Conditions

AppendicectomyPostoperative AnalgesiaRegional Anaesthesia

Outcome Measures

Primary Outcomes (1)

  • Total morphine consumption

    mg

    from extubation until 24 hours postoperative

Secondary Outcomes (2)

  • numeric rating scale

    AT 0.5, 2, 6, 12, and 24 hours postoperative.

  • quality of recovery

    24 hours after suregry

Study Arms (2)

ESP group

ACTIVE COMPARATOR
Other: Erector Spinae Plane Block

TAP group

ACTIVE COMPARATOR
Other: Transversus abdominis plane (TAP) block

Interventions

Erector Spinae Plane BlockOTHER

Patients will receive the ESP block at the level of the 10th thoracic (T10) transverse process using a linear 6-13 MHz ultrasound transducer. A 20 mL of 0.25% bupivacaine will be injected below the muscle

ESP group
Transversus abdominis plane (TAP) blockOTHER

Patient will received TAP block using the lateral approach while in supine position. A 20 mL of 0.25% bupivacaine will be injected after negative aspiration.

TAP group

Eligibility Criteria

Age21 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • adult patients, undergoing open appendectomy.

You may not qualify if:

  • American society of anesthesiologist-physical status \>III,
  • allergy to any of the study drugs,
  • coagulopathy
  • local infection,
  • history of chronic pain or regular opioid use;
  • inability to comprehend the Numeric Rating Scale (NRS),
  • pregnant or lactating women.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cairo University

Cairo, Cairo Governorate, Egypt

RECRUITING

MeSH Terms

Interventions

Dental Occlusion

Intervention Hierarchy (Ancestors)

DentistryDental Physiological PhenomenaDigestive System and Oral Physiological Phenomena

Central Study Contacts

Maha Mostafa, MD

CONTACT

+201000365115maha.mostafa@cu.edu.eg

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

January 10, 2026

First Posted

January 20, 2026

Study Start

January 25, 2026

Primary Completion (Estimated)

May 1, 2026

Study Completion (Estimated)

May 1, 2026

Last Updated

March 17, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

data regarding this research will be available upon reasonable request from the PI

Locations

EG(1)