Top Set and Parkinson's Disease

NCT06801704 | Completed

• 1 other identifier: 20241248
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This project will focus on improving power in adults with Parkinson's disease, since power is related to performance of daily activities and memory and decision making. The study will compare traditional power training, where the participant does all exercises as fast as possible to top set resistance training, where the participant does power training, but it is preceded by warm-up sets that progress in weight until the participant reaches 90% of the person's maximum strength. If the top set method is better than traditional power training, it could be more beneficial than existing methods in improving independence in adults with Parkinson's disease.

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (2)

• Change in neuromuscular performance as measured by power production.

  This test measures the power a person can produce at maximal speed using a load of 50% of 1RM for the chest press and leg press. There are no minimum or maximum scores. The higher score indicates higher power. Power shows how fast a person can do work. The test typically takes about five minutes. Unit of measure is Watts.

  Baseline, 12 weeks

• Change in neuromuscular performance as measured by 1-repetition maximum (1RM

  Maximal load that can be lifted in one repetition (1RM) will be assessed for in both leg press and chest press exercises. The loads on the testing equipment will be increased over 5 to 7 testing sets. The persons 1RM will be the highest load the person can move through the range of motion of the exercise. There are no minimum or maximum scores for this test. The test typically takes 5 to 10 minutes. The higher the 1RM the stronger the person is.

  Baseline, 12 weeks

Secondary Outcomes (17)

• Change in the Speed of the Ten-Meter Walk Test.

  Baseline, 12 weeks

• Changes in Swing time of Gait.

  Baseline, 12 weeks

• Changes in Stance Time of Gait.

  Baseline, 12 weeks

• Changes in Double Support Time of Gait.

  Baseline, 12 weeks

• Changes in Step Time of Gait.

  Baseline, 12 weeks

Study Arms (2)

Top Set Resistance Training

OTHER

Participants will be in this group receiving the top set resistance training for up to 12 weeks.

Behavioral: Top Set Resistance Training

Power Resistance Training

OTHER

Participants will be in this group receiving the power resistance training for up to 12 weeks.

Behavioral: Power Resistance Training

Interventions

Top Set Resistance Training BEHAVIORAL

Participants will receive four warm-up sets at increasingly higher resistance, followed by three sets of eight repetitions per set on six resistance-training exercises. During training participants will be allowed 1-minute rests between sets. Participants will come in person for up to 12 weeks, twice per week, for approximately 45 minutes per day.

Top Set Resistance Training

Power Resistance Training BEHAVIORAL

Participants will receive a total of 24 in-person training sessions using three sets of eight repetitions per set on six power resistance-training exercises. During training participants will be allowed 1-minute rests between sets. Participants will come in person for up to 12 weeks, twice per week, for approximately 45 minutes per day.

Power Resistance Training

Eligibility Criteria

• Age: 30 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Confirmed diagnosis of Parkinson's disease
• Between the ages of 30-90 years of age
• A Hoehn and Yahr score of ≤3, which will be provided by the participant's medical provider within 1 year of the study's inception.

You may not qualify if:

• Uncontrolled cardiovascular disease that prevents participation in a training program
• Documented HIV infection or another immunodeficiency syndrome
• Other neuromuscular diseases besides Parkinson's disease
• Current musculoskeletal injury that prevents exercise.
• Having a pacemaker
• Pregnancy
• Incarcerated individuals
• Montreal Cognitive Assessment Score below 18

Sponsors & Collaborators

• University of Miami: lead

Study Sites (1)

Laboratory of Neruomuscular Research and Active Aging

Coral Gables, Florida, 33147, United States

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Joseph F. Signorile, PhD

  University of Miami

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 24, 2025
• First Posted: January 30, 2025
• Study Start: January 28, 2025
• Primary Completion: June 30, 2025
• Study Completion: June 30, 2025
• Last Updated: August 15, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)