Effect of 7 Days of Grape Seed Extract Supplementation on Cold Pressor Test and Muscle Metaboreflex in Individuals With Elevated and Stage 1 Hypertension
1 other identifier
interventional
12
1 country
1
Brief Summary
This study aimed to assess the effect of the supplementation with grape seed extract (GSE) on blood pressure during static handgrip exercise and muscle metaboreflex in individuals with elevated and state 1 hypertension.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2022
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2024
CompletedFirst Submitted
Initial submission to the registry
May 15, 2024
CompletedFirst Posted
Study publicly available on registry
May 24, 2024
CompletedMay 24, 2024
May 1, 2024
2.1 years
May 15, 2024
May 20, 2024
Conditions
Outcome Measures
Primary Outcomes (6)
heart rate (bpm)
measured these variables at rest and during static handgrip exercise and muscle metaboreflex
5 minutes, 3 minutes, and 2 minutes, respectively.
stroke volume (ml)
measured these variables at rest and during static handgrip exercise and muscle metaboreflex
5 minutes, 3 minutes, and 2 minutes, respectively.
cardiac output (l/min)
measured these variables at rest and during static handgrip exercise and muscle metaboreflex
5 minutes, 3 minutes, and 2 minutes, respectively.
systolic blood pressure (mmHg)
measured these variables at rest and during static handgrip exercise and muscle metaboreflex
5 minutes, 3 minutes, and 2 minutes, respectively.
diastolic blood pressure (mmHg)
measured these variables at rest and during static handgrip exercise and muscle metaboreflex
5 minutes, 3 minutes, and 2 minutes, respectively.
total peripheral resistance (mmHg/l/min)
measured these variables at rest and during static handgrip exercise and muscle metaboreflex
5 minutes, 3 minutes, and 2 minutes, respectively.
Study Arms (2)
Dietary Supplementation with Grape Seed Extract
EXPERIMENTALParticipants received the supplement (600 mg, capsules) via cross-over design for 7 days
Placebo
PLACEBO COMPARATORParticipants received the placebo (600 mg, capsules) via cross-over design for 7 days
Interventions
dietary supplements that rich in polyphenolic compounds
Eligibility Criteria
You may qualify if:
- systolic blood pressure: 120-139 mmHg and/or a diastolic blood pressure: 80-89 mmHg
You may not qualify if:
- taking medications that could affect cardiovascular function or BP
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
California Baptist University
Riverside, California, 92504, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jong-Kyung Kim, Ph.D.
California Baptist University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 15, 2024
First Posted
May 24, 2024
Study Start
March 1, 2022
Primary Completion
April 1, 2024
Study Completion
April 1, 2024
Last Updated
May 24, 2024
Record last verified: 2024-05
Data Sharing
- IPD Sharing
- Will not share
This study needs the Institutional Research Board (IRB) and participant's approvals to share the data. Without the approval, the data collected from this study will not be shared.