Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

NCT07100080 | Recruiting Phase 2 DMC FDA Drug

• 4 other identifiers: CA244-0010EU CTRWHOCA2440010
• Study Type: interventional
• Target: 596
• Locations: 25 countries
• Sites: 186

Brief Summary

A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy

Conditions

Non-Small Cell Lung Cancer

Keywords

Epidermal Growth Factor Receptor; Tyrosine Kinase Inhibitors; Osimertinib; Standard of Care; Lung Neoplasms; Antineoplastic Agents; Izalontamab brengitecan; Iza-bren; BL-B01D1; Carboplatin; Cisplatin; Pemetrexed

Outcome Measures

Primary Outcomes (2)

• Recommended Phase 3 Dose (RP3D) of BMS-986507

  Phase 2

  Approximately 3 months after the first dose

• Progression-Free Survival (PFS) Assessed by Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) per blinded independent central review (BICR)

  Phase 3

  Up to 3 years

Secondary Outcomes (8)

• Objective Response (OR) Assessed by RECIST v1.1 per BICR

  Up to 3 years

• PFS Assessed by RECIST v1.1 per BICR

  Up to 3 years

• Overall Survival (OS)

  Up to 5 years

• PFS Assessed by RECIST v1.1 per investigator assessment

  Up to 3 years

• OR Assessed by RECIST v1.1 per BICR

  Up to 3 years

Study Arms (5)

Arm A

EXPERIMENTAL

Drug: Iza-bren

Arm B

EXPERIMENTAL

Drug: Iza-bren

Arm C

ACTIVE COMPARATOR

Drug: Carboplatin; Drug: Cisplatin; Drug: Pemetrexed

Arm D

EXPERIMENTAL

Drug: Iza-bren

Arm E

ACTIVE COMPARATOR

Drug: Carboplatin; Drug: Cisplatin; Drug: Pemetrexed

Interventions

Cisplatin DRUG

Specified dose on specified days

Arm C; Arm E

Pemetrexed DRUG

Specified dose on specified days

Arm C; Arm E

Iza-bren DRUG

Specified dose on specified days

Also known as: BMS-986507, BL-B01D1, Izalontamab brengitecan

Arm A; Arm B; Arm D

Carboplatin DRUG

Specified dose on specified days

Arm C; Arm E

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Non-squamous NSCLC, not amenable to treatment in curative intent.
• Documented evidence of EGFR mutation (exon 19 deletion, L858R mutation).
• Progressive disease on a 3rd-generation (such as osimertinib, furmonertinib, lazertinib,...) EGFR-TKI-based mono- or combination therapy regimen as the most recent line of therapy in an adjuvant, locally advanced, or metastatic treatment setting.
• Eligible to receive a platinum-based doublet chemotherapy regimen (either cisplatin or carboplatin in combination with pemetrexed).

You may not qualify if:

• Inadequate organ function and/or bone marrow reserve.
• Leptomeningeal metastases or spinal cord compression.
• Poorly controlled systemic medical conditions.

Sponsors & Collaborators

• Bristol-Myers Squibb: lead

Study Sites (186)

Local Institution - 0279

Irvine, California, 92612, United States

NOT YET RECRUITING

Local Institution - 0154

Orange, California, 92868, United States

NOT YET RECRUITING

Shaw Cancer Center

Edwards, Colorado, 81632, United States

RECRUITING

Local Institution - 0085

Gainesville, Florida, 32610, United States

WITHDRAWN

Local Institution - 0142

Pembroke Pines, Florida, 33028, United States

NOT YET RECRUITING

Piedmont Healthcare

Atlanta, Georgia, 30318, United States

RECRUITING

John B Amos Cancer Center

Columbus, Georgia, 31904, United States

RECRUITING

Local Institution - 0153

Chicago, Illinois, 60612, United States

NOT YET RECRUITING

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States

RECRUITING

Washington University School of Medicine

St Louis, Missouri, 63108, United States

RECRUITING

Renown Regional Medical Center

Reno, Nevada, 89502, United States

RECRUITING

Perlmutter Cancer Center at NYU Langone Hospital - Long Island

Mineola, New York, 11501, United States

RECRUITING

NYU Langone Health

New York, New York, 10016, United States

RECRUITING

Local Institution - 0158

New York, New York, 10065, United States

NOT YET RECRUITING

Rochester General Hospital Infectious Disease

Rochester, New York, 14621, United States

RECRUITING

University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States

RECRUITING

Local Institution - 0284

Columbus, Ohio, 43210, United States

NOT YET RECRUITING

Providence Cancer Institute Franz Clinic

Portland, Oregon, 97213, United States

RECRUITING

Providence St. Vincent Medical Center

Portland, Oregon, 97225, United States

RECRUITING

Local Institution - 0171

Portland, Oregon, 97239, United States

NOT YET RECRUITING

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

RECRUITING

Local Institution - 0088

Pittsburgh, Pennsylvania, 15212, United States

NOT YET RECRUITING

Local Institution - 0268

Chattanooga, Tennessee, 37404, United States

WITHDRAWN

Tennessee Oncology

Nashville, Tennessee, 37203, United States

RECRUITING

Local Institution - 0025

Houston, Texas, 77030, United States

NOT YET RECRUITING

Local Institution - 0173

San Antonio, Texas, 78229, United States

NOT YET RECRUITING

University of Virginia Health System

Charlottesville, Virginia, 22908, United States

RECRUITING

Virginia Commonwealth University (Vcu)

Richmond, Virginia, 23219, United States

RECRUITING

Local Institution - 0008

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

NOT YET RECRUITING

Local Institution - 0004

ABB, Buenos Aires F.D., C1199ABB, Argentina

NOT YET RECRUITING

Local Institution - 0094

Córdoba, Córdoba Province, 5016, Argentina

NOT YET RECRUITING

Local Institution - 0280

Wilrijk, Antwerpen, 2610, Belgium

NOT YET RECRUITING

Local Institution - 0161

Auderghem, Bruxelles-Capitale, Région de, 1160, Belgium

NOT YET RECRUITING

Local Institution - 0022

Yvoir, Namur, 5530, Belgium

NOT YET RECRUITING

Local Institution - 0023

Ghent, Oost-Vlaanderen, 9000, Belgium

NOT YET RECRUITING

Local Institution - 0024

Sint-Niklaas, Oost-Vlaanderen, B-9100, Belgium

NOT YET RECRUITING

Local Institution - 0190

Calgary, Alberta, T2N 5G2, Canada

NOT YET RECRUITING

Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada

RECRUITING

Local Institution - 0184

Chicoutimi, Quebec, G7H 5H6, Canada

NOT YET RECRUITING

Local Institution - 0185

Montreal, Quebec, H4J 1C5, Canada

NOT YET RECRUITING

Local Institution - 0006

Santiago, Santiago Metropolitan, 0, Chile

NOT YET RECRUITING

Local Institution - 0005

Santiago, Santiago Metropolitan, 7500921, Chile

NOT YET RECRUITING

Local Institution - 0007

Santiago, Santiago Metropolitan, 8420383, Chile

NOT YET RECRUITING

Local Institution - 0244

Beijing, Beijing Municipality, 100142, China

NOT YET RECRUITING

Local Institution - 0259

Chongqing, Chongqing Municipality, 400030, China

NOT YET RECRUITING

Fujian Cancer Hospital

Fuzhou, Fujian, 350014, China

RECRUITING

Jiangmen Center Hospital

Jiangmen, Guangdong, 0, China

RECRUITING

Local Institution - 0271

Anyang, Henan, 455000, China

NOT YET RECRUITING

Local Institution - 0261

Luoyang, Henan, 471003, China

NOT YET RECRUITING

Local Institution - 0267

Jingzhou, Hubei, 0, China

NOT YET RECRUITING

Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology

Wuhan, Hubei, 430030, China

RECRUITING

Local Institution - 0255

Changsha, Hunan, 410013, China

NOT YET RECRUITING

Local Institution - 0256

Xuzhou, Jiangsu, 221009, China

NOT YET RECRUITING

Local Institution - 0247

Nanchang, Jiangxi, 330209, China

NOT YET RECRUITING

Local Institution - 0246

Changchun, Jilin, 130000, China

NOT YET RECRUITING

Local Institution - 0257

Shenyang, Liaoning, 110001, China

NOT YET RECRUITING

Local Institution - 0248

Jinan, Shandong, 250117, China

NOT YET RECRUITING

Local Institution - 0250

Shanghai, Shanghai Municipality, 200030, China

NOT YET RECRUITING

Shanxi Cancer Hospital

Taiyuan, Shanxi, 030000, China

RECRUITING

Local Institution - 0252

Hangzhou, Zhejiang, 310022, China

NOT YET RECRUITING

Local Institution - 0251

Linhai, Zhejiang, 317000, China

NOT YET RECRUITING

Local Institution - 0260

Nanning, 530021, China

NOT YET RECRUITING

Local Institution - 0249

Shanghai, 200032, China

NOT YET RECRUITING

Local Institution - 0229

Valledupar, Cesar Department, 200001, Colombia

NOT YET RECRUITING

Local Institution - 0228

Bogotá, Cundinamarca, 111511, Colombia

NOT YET RECRUITING

Local Institution - 0227

Montería, Departamento de Córdoba, 230002, Colombia

NOT YET RECRUITING

Local Institution - 0226

Cali, Valle del Cauca Department, 760032, Colombia

NOT YET RECRUITING

Local Institution - 0014

Strasbourg, Alsace, 67091, France

NOT YET RECRUITING

Local Institution - 0017

Toulouse, Haute-Garonne, 31059, France

NOT YET RECRUITING

Local Institution - 0010

Lille, Hauts-de-France, 59037, France

NOT YET RECRUITING

Local Institution - 0018

La Tronche, Isère, 38700, France

NOT YET RECRUITING

Local Institution - 0170

Saint-Herblain, Loire-Atlantique, 44805, France

NOT YET RECRUITING

Local Institution - 0162

Bron, Rhône, 69677, France

NOT YET RECRUITING

Local Institution - 0019

Villejuif, Val-de-Marne, 94800, France

NOT YET RECRUITING

Local Institution - 0012

Marseille, 13915, France

NOT YET RECRUITING

Local Institution - 0278

Nantes, 44200, France

NOT YET RECRUITING

Local Institution - 0011

Paris, 75248, France

NOT YET RECRUITING

Local Institution - 0015

Paris, 75970, France

NOT YET RECRUITING

Local Institution - 0207

Esslingen am Neckar, Baden-Wurttemberg, 73730, Germany

NOT YET RECRUITING

Local Institution - 0238

Esslingen am Neckar, Baden-Wurttemberg, 73730, Germany

NOT YET RECRUITING

Local Institution - 0212

Stuttgart, Baden-Wurttemberg, 70376, Germany

NOT YET RECRUITING

Local Institution - 0236

Donauwörth, Bavaria, 86609, Germany

NOT YET RECRUITING

Local Institution - 0209

Oldenburg, Lower Saxony, 26121, Germany

NOT YET RECRUITING

Local Institution - 0213

Cologne, North Rhine-Westphalia, 51109, Germany

NOT YET RECRUITING

Local Institution - 0208

Chemnitz, Saxony, 09116, Germany

NOT YET RECRUITING

Local Institution - 0274

Kiel, Schleswig-Holstein, 24105, Germany

NOT YET RECRUITING

Local Institution - 0211

Berlin, 13125, Germany

NOT YET RECRUITING

Local Institution - 0215

Gauting, 82131, Germany

NOT YET RECRUITING

Local Institution - 0242

Hamburg, 22307, Germany

NOT YET RECRUITING

Local Institution - 0210

Heidelberg, 69126, Germany

NOT YET RECRUITING

Local Institution - 0239

Kassel, 34125, Germany

NOT YET RECRUITING

Local Institution - 0241

Ulm, 89081, Germany

NOT YET RECRUITING

Local Institution - 0054

Athens, Attikí, 115 27, Greece

NOT YET RECRUITING

Local Institution - 0060

Chaïdári, Attikí, 124 62, Greece

NOT YET RECRUITING

Local Institution - 0056

Thessaloniki, Kentrikí Makedonía, 540 07, Greece

NOT YET RECRUITING

Local Institution - 0062

Thessaloniki, Thessaloníki, 570 10, Greece

NOT YET RECRUITING

Local Institution - 0083

Ahmedabad, Gujarat, 380016, India

WITHDRAWN

Local Institution - 0073

Ahmedabad, Gujarat, 380054, India

NOT YET RECRUITING

Local Institution - 0072

Gurugram, Haryana, 122001, India

WITHDRAWN

Local Institution - 0069

Bengaluru, Karnataka, 560017, India

NOT YET RECRUITING

Local Institution - 0077

Mumbai, Maharashtra, 400 057, India

NOT YET RECRUITING

Local Institution - 0071

Mumbai, Maharashtra, 400012, India

NOT YET RECRUITING

Local Institution - 0097

Nagpur, Maharashtra, 440001, India

NOT YET RECRUITING

Local Institution - 0070

New Delhi, National Capital Territory of Delhi, 110029, India

NOT YET RECRUITING

Local Institution - 0078

Howrah, West Bengal, 711103, India

WITHDRAWN

Local Institution - 0028

Ravenna, Emilia-Romagna, 48121, Italy

NOT YET RECRUITING

Local Institution - 0036

Aviano, Friuli Venezia Giulia, 33081, Italy

NOT YET RECRUITING

Local Institution - 0031

Orbassano, Piedmont, 10043, Italy

NOT YET RECRUITING

Local Institution - 0277

Candiolo, Torino, 10060, Italy

NOT YET RECRUITING

Local Institution - 0137

Avellino, 83100, Italy

NOT YET RECRUITING

Local Institution - 0032

Milan, 20141, Italy

NOT YET RECRUITING

Local Institution - 0034

Naples, 80131, Italy

NOT YET RECRUITING

Local Institution - 0029

Parma, 43126, Italy

NOT YET RECRUITING

Local Institution - 0196

Nagoya, Aichi-ken, 464-8681, Japan

NOT YET RECRUITING

Local Institution - 0191

Kashiwa, Chiba, 277-8577, Japan

NOT YET RECRUITING

Local Institution - 0203

Tōon, Ehime, 791-0295, Japan

NOT YET RECRUITING

Local Institution - 0201

Kurume, Fukuoka, 830-0011, Japan

NOT YET RECRUITING

Local Institution - 0217

Sapporo, Hokkaido, 003-0804, Japan

NOT YET RECRUITING

Local Institution - 0199

Nishinomiya, Hyōgo, 663-8501, Japan

NOT YET RECRUITING

Local Institution - 0193

Yokohama, Kanagawa, 2418515, Japan

NOT YET RECRUITING

Local Institution - 0192

Sendai, Miyagi, 9810914, Japan

NOT YET RECRUITING

Local Institution - 0200

Kurashiki, Okayama-ken, 710-8602, Japan

NOT YET RECRUITING

Local Institution - 0198

Hirakata, Osaka, 573-1191, Japan

NOT YET RECRUITING

Local Institution - 0204

Ōsaka-sayama, Osaka, 589-8511, Japan

NOT YET RECRUITING

Local Institution - 0194

Ina-machi, Saitama, 362-0806, Japan

WITHDRAWN

Local Institution - 0197

Hamamatsu, Shizuoka, 431-3192, Japan

NOT YET RECRUITING

Local Institution - 0195

Nagaizumi-cho,Sunto-gun, Shizuoka, 411-8777, Japan

NOT YET RECRUITING

Local Institution - 0202

Koto-ku, Tokyo, 135-8550, Japan

NOT YET RECRUITING

Local Institution - 0225

Mexico City, Mexico City, 03100, Mexico

NOT YET RECRUITING

Local Institution - 0224

Oaxaca City, Oaxaca, 68020, Mexico

NOT YET RECRUITING

Local Institution - 0222

Chihuahua City, 31203, Mexico

NOT YET RECRUITING

Local Institution - 0223

Mexico City, 14210, Mexico

NOT YET RECRUITING

Local Institution - 0163

Harderwijk, Gelderland, 3844 DG, Netherlands

NOT YET RECRUITING

Local Institution - 0216

Amsterdam, North Holland, 1066 CX, Netherlands

NOT YET RECRUITING

Local Institution - 0164

Amsterdam, North Holland, 1081 HV, Netherlands

NOT YET RECRUITING

Local Institution - 0103

Drammen, Buskerud, 3004, Norway

NOT YET RECRUITING

Local Institution - 0106

Bergen, Hordaland, 5021, Norway

NOT YET RECRUITING

Local Institution - 0105

Oslo, 0450, Norway

NOT YET RECRUITING

Local Institution - 0220

Lublin, Lublin Voivodeship, 20-954, Poland

NOT YET RECRUITING

Local Institution - 0231

Gdynia, Pomeranian Voivodeship, 81-519, Poland

NOT YET RECRUITING

Local Institution - 0219

Bydgoszcz, 85796, Poland

NOT YET RECRUITING

Local Institution - 0120

Bucharest, Bucharest, 013812, Romania

NOT YET RECRUITING

Local Institution - 0123

Bucharest, Bucharest, 022328, Romania

NOT YET RECRUITING

Local Institution - 0132

Florești, Cluj, 407280, Romania

NOT YET RECRUITING

Local Institution - 0130

Craiova, Dolj, 200746, Romania

NOT YET RECRUITING

Local Institution - 0115

Bucharest, 020335, Romania

NOT YET RECRUITING

Local Institution - 0133

Cluj-Napoca, 400015, Romania

NOT YET RECRUITING

Local Institution - 0124

Iași, 700106, Romania

NOT YET RECRUITING

Local Institution - 0119

Iași, 700483, Romania

NOT YET RECRUITING

Local Institution - 0263

Singapore, 169610, Singapore

NOT YET RECRUITING

Local Institution - 0262

Singapore, 308442, Singapore

NOT YET RECRUITING

Local Institution - 0089

Cheongju-si, Chungcheongbuk-do [Chungbuk], 28644, South Korea

NOT YET RECRUITING

Local Institution - 0043

Goyang-si, Kyǒnggi-do, 10408, South Korea

NOT YET RECRUITING

Local Institution - 0044

Seongnam, Kyǒnggi-do, 13620, South Korea

NOT YET RECRUITING

Local Institution - 0046

Suwon, Kyǒnggi-do, 16247, South Korea

NOT YET RECRUITING

Local Institution - 0095

Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea

NOT YET RECRUITING

Local Institution - 0045

Seoul, Seoul-teukbyeolsi [Seoul], 03722, South Korea

NOT YET RECRUITING

Local Institution - 0092

Seoul, Seoul-teukbyeolsi [Seoul], 05505, South Korea

NOT YET RECRUITING

Local Institution - 0042

Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea

NOT YET RECRUITING

Local Institution - 0218

Barcelona, Barcelona [Barcelona], 08035, Spain

NOT YET RECRUITING

Local Institution - 0177

Barcelona, Catalunya [Cataluña], 08041, Spain

NOT YET RECRUITING

Local Institution - 0175

Madrid, Madrid, Comunidad de, 28009, Spain

NOT YET RECRUITING

Local Institution - 0206

Madrid, Madrid, Comunidad de, 28041, Spain

NOT YET RECRUITING

Local Institution - 0176

Madrid, Madrid, Comunidad de, 28046, Spain

NOT YET RECRUITING

Local Institution - 0181

Majadahonda, Madrid, Comunidad de, 28222, Spain

NOT YET RECRUITING

Local Institution - 0178

Málaga, 29011, Spain

NOT YET RECRUITING

Local Institution - 0182

Seville, 41013, Spain

NOT YET RECRUITING

Local Institution - 0180

Valencia, 46026, Spain

NOT YET RECRUITING

Local Institution - 0179

Zaragoza, 50009, Spain

NOT YET RECRUITING

Kantonsspital Baden

Baden, Canton of Aargau, 5404, Switzerland

RECRUITING

Cantonal Hospital St.Gallen

Sankt Gallen, Canton of St. Gallen, 9007, Switzerland

RECRUITING

Local Institution - 0189

Bellinzona, 6500, Switzerland

NOT YET RECRUITING

E-Da hospital

Kaohsiung City, 82445, Taiwan

RECRUITING

Taichung Veterans General Hospital

Taichung, 407, Taiwan

RECRUITING

National Cheng Kung University Hospital

Tainan, 704, Taiwan

RECRUITING

National Taiwan University Hospital

Taipei, 10002, Taiwan

RECRUITING

Taipei Medical University Hospital

Taipei, 110, Taiwan

RECRUITING

Taipei Veterans General Hospital

Taipei, 11217, Taiwan

RECRUITING

Local Institution - 0265

Bangkok, Bangkok, 10700, Thailand

NOT YET RECRUITING

Local Institution - 0272

Mueng, Changwat Khon Kaen, 40002, Thailand

NOT YET RECRUITING

Local Institution - 0264

Bangkok, 10330, Thailand

NOT YET RECRUITING

Local Institution - 0266

Songkhla, 90110, Thailand

NOT YET RECRUITING

Local Institution - 0110

Glasgow, Glasgow City, G12 0YN, United Kingdom

NOT YET RECRUITING

Local Institution - 0061

London, Kensington and Chelsea, SW3 6JJ, United Kingdom

NOT YET RECRUITING

Local Institution - 0140

London, London, City of, E1 1RD, United Kingdom

NOT YET RECRUITING

Local Institution - 0281

Sulton, Surrey, SM25PT, United Kingdom

NOT YET RECRUITING

Related Links

• BMS Clinical Trial Information
• BMS Clinical Trial Patient Recruiting

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell Lung; Lung Neoplasms

Interventions

Carboplatin; Cisplatin; Pemetrexed

Condition Hierarchy (Ancestors)

Carcinoma, Bronchogenic; Bronchial Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Coordination Complexes; Organic Chemicals; Chlorine Compounds; Inorganic Chemicals; Nitrogen Compounds; Platinum Compounds; Guanine; Hypoxanthines; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Glutamates; Amino Acids, Acidic; Amino Acids; Amino Acids, Peptides, and Proteins; Amino Acids, Dicarboxylic

Study Officials

• Bristol-Myers Squibb

  Bristol-Myers Squibb

  STUDY DIRECTOR

Central Study Contacts

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

CONTACT

855-907-3286; Clinical.Trials@bms.com

First line of the email MUST contain NCT # and Site #.

CONTACT

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 31, 2025
• First Posted: August 3, 2025
• Study Start: November 5, 2025
• Primary Completion (Estimated): September 15, 2028
• Study Completion (Estimated): May 15, 2031
• Last Updated: April 16, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR
• Time Frame: See Plan Description
• Access Criteria: See Plan Description

Locations

AR (3); CN (20); JP (15); CA (4); FR (11); NL (3); SG (2); TW (6); IT (8); US (28); BE (5); ME (4); GB (4); RO (8); CH (3); NO (3); TH (4); PL (3); CO (4); KR (8); ES (10); IN (9); GR (4); DE (14); CL (3)