Key Insights

Highlights

Success Rate

74% trial completion

Published Results

423 trials with published results (21%)

Research Maturity

736 completed trials (36% of total)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 49/100

Termination Rate

12.4%

252 terminated out of 2036 trials

Success Rate

74.5%

-12.0% vs benchmark

Late-Stage Pipeline

14%

278 trials in Phase 3/4

Results Transparency

57%

423 of 736 completed with results

Key Signals

423 with results74% success252 terminated

Data Visualizations

Phase Distribution

1,719Total
Not Applicable (167)
Early P 1 (12)
P 1 (557)
P 2 (705)
P 3 (252)
P 4 (26)

Trial Status

Completed736
Unknown354
Recruiting347
Terminated252
Active Not Recruiting181
Not Yet Recruiting87

Trial Success Rate

74.5%

Benchmark: 86.5%

Based on 736 completed trials

Clinical Trials (2036)

Showing 20 of 20 trials
NCT07133425Phase 2RecruitingPrimary

A Phase 2 Platform Study of Immunomodulatory Compounds in ICI-refractory Non-small Cell Lung Cancer

NCT06049212Phase 1Active Not RecruitingPrimary

Sacituzumab Tirumotecan (MK-2870) as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors (MK-2870-008)

NCT02468024Phase 3RecruitingPrimary

JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer

NCT05925530Phase 2Active Not RecruitingPrimary

Study to Assess Neoadjuvant Durvalumab (D) and Platinum-Based Chemotherapy (CT), Followed by Either Surgery and Adjuvant D or CRT and Consolidation D, in Resectable or Borderline Resectable Stage IIB-IIIB NSCLC (MDT-BRIDGE)

NCT03157128Phase 1Active Not RecruitingPrimary

A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)

NCT07100080Phase 2RecruitingPrimary

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

NCT05642195Phase 1SuspendedPrimary

Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer

NCT05616624Phase 1Active Not Recruiting

ADI-PEG 20 in Combination With Gemcitabine and Docetaxel After Progression on Frontline Therapy in Non-small Cell and Small Cell Lung Cancers

NCT06343402Phase 1RecruitingPrimary

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

NCT05635708Phase 2Active Not RecruitingPrimary

A Study of Tislelizumab in Combination With Investigational Agents in Participants With Non-Small Cell Lung Cancer

NCT07532447CompletedPrimary

Metabolomic Characteristics of Patients With Non-small Cell Lung Cancer in Plasma, Tissue and Exhaled Breath Condensate: A Case-control Study

NCT06712316Phase 2RecruitingPrimary

Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

NCT06933329Phase 2Active Not RecruitingPrimary

Zelenectide Pevedotin in NECTIN4 Amplified Advanced or Metastatic Non-small Cell Lung Cancer

NCT06685718Phase 1Active Not RecruitingPrimary

A Study Investigating BG-60366 in Adults With Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer

NCT05877599Phase 1RecruitingPrimary

A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

NCT06120283Phase 1Recruiting

BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

NCT06946797Phase 2RecruitingPrimary

A Study to Evaluate Two Dosing Regimens of Subcutaneous Nivolumab in Combination With Intravenous Ipilimumab and Chemotherapy in Participants With Previously Untreated Metastatic or Recurrent Non-Small Cell Lung Cancer (NSCLC)

NCT05397093Phase 1Terminated

ITIL-306 in Advanced Solid Tumors

NCT01630733Phase 3CompletedPrimary

A Multinational, Randomized, Open-Label Study of Custirsen In Patients With Advanced or Metastatic (Stage IV) Non-Small Cell Lung Cancer

NCT06686771Phase 3RecruitingPrimary

Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer

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