Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
MARITIME-HF
A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Maridebart Cafraglutide on Mortality and Morbidity in Participants Living With Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity (MARITIME-HF)
1 other identifier
interventional
5,056
32 countries
574
Brief Summary
This trial will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascular (CV) deaths and improvement in HF symptoms in participants with HF with preserved ejection fraction (HFpEF) and HF with mildly reduced ejection fraction (HFmrEF) who are obese. This is a phase 3, global, multicenter, 2-part trial with a double-blind period and an open-label extension (OLE). The trial is event-driven, and Part 1 will conclude when approximately 850 primary endpoint events have occurred.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Jun 2025
Longer than P75 for phase_3
574 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 16, 2025
CompletedFirst Posted
Study publicly available on registry
June 25, 2025
CompletedStudy Start
First participant enrolled
June 25, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
September 29, 2030
April 16, 2026
April 1, 2026
3 years
June 16, 2025
April 15, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Time to First Occurrence of a Composite Endpoint Consisting of: CV Death or HF Events
Heart Failure events include: hospitalization for HF or urgent HF visits.
Up to approximately 35 months
Secondary Outcomes (32)
Change From Baseline in Kansas City Cardiomyopathy Questionnaire (KCCQ) Clinical Summary Score (CSS) for Participants with Baseline KCCQ-CSS Score ≤ 80
Baseline and Week 48
Change from Baseline in the KCCQ Total Symptom Score (TSS) for Participants with Baseline KCCQ-CSS Score ≤ 80
Baseline and Week 48
Total Number of HF Events Including First and Recurrent HF Events
Up to approximately 35 months
Time to First Occurrence of a Composite Endpoint Consisting of: Myocardial Infarction (MI), Ischemic Stroke, CV Death (Major Adverse Cardiac Events [MACE]), or HF Events
Up to approximately 35 months
Time to First Event of a Composite Nephropathy Endpoint
Up to approximately 35 months
- +27 more secondary outcomes
Study Arms (2)
Maridebart Cafraglutide
EXPERIMENTALParticipants will receive maridebart cafraglutide subcutaneously (SC)
Placebo
PLACEBO COMPARATORParticipants will receive placebo SC
Interventions
Maridebart cafraglutide will be administered SC.
Eligibility Criteria
You may qualify if:
- Age ≥ 18 years at the time of informed consent.
- BMI ≥ 30.0 kg/m\^2 at the time of randomization.
- HF diagnosed for at least 30 days with New York Heart Association (NYHA) Class II-IV at the time of informed consent.
- Managed with HF standard of care therapies.
- Left ventricular ejection fraction (LVEF) of \> 40% within 12 months from the beginning of screening.
- Elevated NT-proBNP.
- Participants must have at least one of the following:
- Structural heart disease within 12 months prior to screening OR
- Documented hospitalization with a primary diagnosis of decompensated HF which required IV loop diuretic treatment \> 30 days and \< 12 months prior to randomization OR
- Evidence of elevated filling pressures within 12 months before randomization.
You may not qualify if:
- History of any of the following within 60 days prior to or during screening: Type I (spontaneous) MI, valvular replacement or repair, coronary revascularization, coronary artery bypass graft surgery or other major cardiovascular surgery, stroke.
- HF due to: hypertrophic cardiomyopathy, infiltrative cardiomyopathy, active myocarditis, constrictive pericarditis, cardiac tamponade, arrhythmogenic right ventricular or left ventricular cardiomyopathy/dysplasia, uncorrected primary valvular heart disease, clinically significant congenital heart disease.
- Any lifetime history of LVEF ≤ 40%.
- Hospitalized with acute decompensated HF at the time of or during the screening period.
- Type 1 diabetes mellitus, or any type of diabetes with the exception of T2DM or history of gestational diabetes.
- For participants with a prior diagnosis of T2DM (including those diagnosed during screening):
- HbA1c \> 10.0% (86 mmol/mol) at screening
- Uncontrolled diabetes requiring immediate therapy
- History of diabetic ketoacidosis or hyperosmolar state/coma within 12 months before randomization
- One or more episodes of severe hypoglycemia within 6 months before randomization and/or history of hypoglycemia unawareness
- History or presence of either proliferative diabetic retinopathy, or diabetic maculopathy, or severe non-proliferative diabetic retinopathy; or currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema.
- SBP ≥ 180 mmHg during the screening period, or on three or more blood pressure-lowering drugs with a SBP \> 160 mmHg during the screening period.
- History of chronic pancreatitis or acute pancreatitis in the 180 days before screening or during the screening period.
- Any personal lifetime history of, or family history(first-degree relative\[s\]) of medullary thyroid carcinoma or MEN-2.
- eGFR \< 20 mL/min/1.73 m\^2 (CKD-EPI creatinine (Cr)-cystatin C equation) or receiving dialysis at screening.
- +8 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Amgenlead
Study Sites (590)
University of Alabama at Birmingham
Birmingham, Alabama, 35205, United States
SEC Clinical Research
Dothan, Alabama, 36305, United States
Eastern Shore Research Institute
Fairhope, Alabama, 36532, United States
Heart Center Research LLC
Huntsville, Alabama, 35801-4317, United States
HonorHealth
Phoenix, Arizona, 85006, United States
Medical Advancement Centers of Arizona
Phoenix, Arizona, 85044, United States
Pima Heart and Vascular Clinical Research
Tucson, Arizona, 85704, United States
Yuma Clinical Trials
Yuma, Arizona, 85365, United States
Arkansas Cardiology
Little Rock, Arkansas, 72205, United States
National Heart Institute
Beverly Hills, California, 90211, United States
National Institute of Clinical Research
Huntington Beach, California, 92648, United States
310 Clinical Research
Inglewood, California, 90301, United States
Radin Cardiovascular Medical Group
Newport Beach, California, 92663, United States
Valley Clinical Trials
Northridge, California, 91325, United States
University of California Irvine
Orange, California, 92868, United States
Empire Clinical Research
Pomona, California, 91767, United States
San Diego Cardiac Center
San Diego, California, 92123, United States
NorthBay Clinical Research LLC
Santa Rosa, California, 95405, United States
Manshadi Heart Institute
Stockton, California, 95204, United States
Cardiology Associates of Fairfield County PC
Stamford, Connecticut, 06905, United States
Orlando Heart and Vascular Institute
Altamonte Springs, Florida, 32714, United States
Excel Medical Clinical Trials
Boca Raton, Florida, 33434, United States
Cardiovascular and Vein Center of Florida
Bradenton, Florida, 34209, United States
Millennium Medical Research
Coral Gables, Florida, 33134, United States
Elite Cardiac Research Center LLC
Hialeah, Florida, 33013, United States
Encore Medical Research LLC
Hollywood, Florida, 33024, United States
Nature Coast Clinical Research
Inverness, Florida, 34452, United States
East Coast Institute for Research
Jacksonville, Florida, 32216, United States
First Coast Cardiovascular Institute PA
Jacksonville, Florida, 32216, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
Clearwater Cardiovascular Consultants
Largo, Florida, 33777, United States
Ocala Cardiovascular Research
Ocala, Florida, 34471, United States
Orlando Health Heart Institute
Orlando, Florida, 32806, United States
Ormond Beach Clinical Research
Ormond Beach, Florida, 32174, United States
Broward Research Center
Pembroke Pines, Florida, 33024, United States
Ascension Sacred Heart
Pensacola, Florida, 32504, United States
Cardiovascular Center of Sarasota
Sarasota, Florida, 34239, United States
Cardiology Partners Clinical Research Institute
Wellington, Florida, 33449, United States
Guardian Research Organization LLC
Winter Park, Florida, 32792, United States
Privia Medical Group Georgia LLC
Peachtree City, Georgia, 30269, United States
High Desert Heart and Vascular
Meridian, Idaho, 83642, United States
Chicago Medical Research LLC
Hazel Crest, Illinois, 60429, United States
Midwest Cardiovascular Research And Education Foundation
Elkhart, Indiana, 46514, United States
Ascension Medical Group
Indianapolis, Indiana, 46260, United States
Cardiovascular Research of Northwest Indiana LLC
Munster, Indiana, 46321, United States
Reid Physician Associates
Richmond, Indiana, 47374, United States
Johnson County Clintrials
Lenexa, Kansas, 66219, United States
Kansas Nephrology Research Institute LLC
Wichita, Kansas, 67214, United States
The Research Group of Lexington LLC
Lexington, Kentucky, 40503, United States
Our Lady of the Lake Medical Center
Baton Rouge, Louisiana, 70808, United States
Louisiana Heart Center - Hammond
Covington, Louisiana, 70433, United States
Heart Clinic of Hammond
Hammond, Louisiana, 70403, United States
Northshore Heart and Vascular LLC
Mandeville, Louisiana, 70448, United States
Johns Hopkins University
Baltimore, Maryland, 21287, United States
Metropolitan Cardiovascular Consultants LLC
Beltsville, Maryland, 20705, United States
Flourish Bowie
Bowie, Maryland, 20715, United States
Healthy Heart Cardiology
Grand Rapids, Michigan, 49546, United States
Advanced Cardiology Associates
Rochester Hills, Michigan, 48307, United States
Fairview Health Services M Health Fairview St Johns Hospital
Maplewood, Minnesota, 55109, United States
University of Minnesota
Minneapolis, Minnesota, 55455, United States
Saint Luke's Hospital of Kansas City
Kansas City, Missouri, 64111, United States
Kalispell Regional Medical Center
Kalispell, Montana, 59901, United States
Bryan Heart
Lincoln, Nebraska, 68506, United States
Methodist Physicians Clinic Heart Consultants
Omaha, Nebraska, 68114, United States
Advanced Heart Care LLC
Bridgewater, New Jersey, 08807, United States
Virtua Health Incorporated
Marlton, New Jersey, 08053, United States
Saint Michaels Medical Center
Newark, New Jersey, 07102, United States
CardioMetabolic Collaborative Clinic
Somerset, New Jersey, 08873, United States
Capital Cardiology Associates
Albany, New York, 12211, United States
Icahn School of Medicine at Mount Sinai
New York, New York, 10019, United States
Hudson Valley Cardiovascular Practice PC
Poughkeepsie, New York, 12601, United States
Richmond University Medical Center
Staten Island, New York, 10310, United States
Duke University Health System
Durham, North Carolina, 27719, United States
Accellacare of Wilmington
Wilmington, North Carolina, 28401, United States
South Oklahoma Heart Research
Oklahoma City, Oklahoma, 73135, United States
Abington Medical Specialists
Horsham, Pennsylvania, 19044, United States
Monument Health Clinical Research
Rapid City, South Dakota, 57701, United States
Apex Research Foundation, LLC
Jackson, Tennessee, 38301, United States
The Jackson Clinic PA
Jackson, Tennessee, 38305, United States
Parkway Cardiology Associates
Oak Ridge, Tennessee, 37830, United States
Cardiovascular Research of Knoxville North Knoxville Medical Center
Powell, Tennessee, 37849, United States
Tennessee Center for Clinical Trials
Tullahoma, Tennessee, 37388, United States
PharmaTex Research, LLC
Amarillo, Texas, 79106, United States
Javara Research
Conroe, Texas, 77384, United States
Dallas Heart and Vascular Consultants
Duncanville, Texas, 75137, United States
David Turbay, MD
El Paso, Texas, 79905, United States
East Texas Cardiology PA
Houston, Texas, 77002, United States
Biopharma Informatic
Houston, Texas, 77025, United States
Biopharma Informatic, LLC
Houston, Texas, 77043, United States
Biopharma Informatic
Houston, Texas, 77084, United States
Vital Heart and Vein
Humble, Texas, 77338, United States
North Dallas Research Associates
McKinney, Texas, 75069, United States
Texas Institute of Cardiology
McKinney, Texas, 75071, United States
Sherman Clinical Research
Sherman, Texas, 75092, United States
Northwest Houston Clinical Research PLLC
Tomball, Texas, 77375, United States
Virginia Heart
Falls Church, Virginia, 22042, United States
Carient Heart and Vascular
Manassas, Virginia, 20109, United States
Roanoke Heart Institute PLC
Roanoke, Virginia, 24014, United States
Salem VA Medical Center
Salem, Virginia, 24153, United States
Pulse Heart Institute
Puyallup, Washington, 98372, United States
Advocate Aurora Saint Lukes Medical Center
Milwaukee, Wisconsin, 53215, United States
Imoba Investigaciones medicas
CABA, Buenos Aires, 1178, Argentina
Centro de Investigaciones Metabolicas Cinme
CABA, Buenos Aires, C1056ABI, Argentina
Cemedic Centro de Especialidades Medicas
CABA, Buenos Aires, C1407GTN, Argentina
Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada
CABA, Buenos Aires, C1425AGC, Argentina
Fundacion Respirar - Consultorios Medicos Dr Doreski
CABA, Buenos Aires, C1426ABP, Argentina
Cemic - Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno
CABA, Buenos Aires, C1431FWO, Argentina
Cardiología Palermo
Ciudad Autonoma de Buenos Aires, Buenos Aires, 1425, Argentina
Ciprec Centro de Investigacion y Prevencion Cardiovascular
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1061AAT, Argentina
Mautalen Salud e Investigacion Expertia SA-Osteo
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1128AAF, Argentina
Ciad - Consultorio Integral de Atencion al Diabetico
Morón, Buenos Aires, B1708EPE, Argentina
Dim Clinica Privada
Ramos Meija, Buenos Aires, B1704ETD, Argentina
Go Centro Medico San Nicolas
San Nicolás de los Arroyos, Buenos Aires, 2900, Argentina
Instituto de Investigaciones Clinicas de San Nicolas
San Nicolás de los Arroyos, Buenos Aires, B2900DMH, Argentina
Clinica Fusavim Privada SRL
Villa María, Córdoba Province, 5900, Argentina
Instituto de Investigaciones Clínicas Rosario-Sanatorio Delta
Rosario, Santa Fe Province, S2000CVD, Argentina
Instituto CAICI - Centro de Asistencia e Investigacion Clinica Integral
Rosario, Santa Fe Province, S2000PBJ, Argentina
Centro Modelo de Cardiologia
San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Investigaciones Clinicas Tucuman
San Miguel de Tucumán, Tucumán Province, T4000ICL, Argentina
Instituto Medico Damic
Córdoba, X5003DCE, Argentina
INECO Neurociencias Oronio
Rosario, S2000DSR, Argentina
Hospital Dr Jose Maria Cullen
Santa Fe, S3000EOZ, Argentina
Centro de Investigaciones Clinicas del Litoral
Santa Fe, S3000FWO, Argentina
Instituto de Investigaciones Clinicas Zarate
Zárate, 2800, Argentina
Canberra Hospital
Garran, Australian Capital Territory, 2605, Australia
Sydney Cardiometabolic Centre
Liverpool, New South Wales, 2170, Australia
Royal North Shore Hospital
St Leonards, New South Wales, 2065, Australia
Advara HeartCare Wesley
Auchenflower, Queensland, 4066, Australia
Sunshine Coast University Hospital
Birtinya, Queensland, 4575, Australia
Royal Brisbane and Womens Hospital
Herston, Queensland, 4029, Australia
Core Research Group Pty Ltd
Milton, Queensland, 4064, Australia
Gold Coast Hospital and Health Service
Southport, Queensland, 4215, Australia
Dr Heart Pty Ltd
Woolloongabba, Queensland, 4102, Australia
Flinders Medical Centre
Bedford Park, South Australia, 5042, Australia
Advara HeartCare Leabrook
Leabrook, South Australia, 5068, Australia
Victorian Heart Hospital
Clayton, Victoria, 3168, Australia
The Alfred Hospital
Melbourne, Victoria, 3004, Australia
Advara HeartCare Mulgrave
Mulgrave, Victoria, 3170, Australia
Advara HeartCare Joondalup
Joondalup, Western Australia, 6027, Australia
Fiona Stanley Hospital
Murdoch, Western Australia, 6150, Australia
Krankenhaus Sankt Josef Braunau
Braunau am Inn, 5280, Austria
Medizinische Universitaet Graz
Graz, 8036, Austria
Klinikum Klagenfurt am Woerthersee
Klagenfurt, 9020, Austria
Ordensklinikum Linz Elisabethinen
Linz, 4020, Austria
Landeskrankenhaus Salzburg
Salzburg, 5020, Austria
Universitaetsklinikum Sankt Poelten
Sankt Pölten, 3100, Austria
Universitaetsklinikum Allgemeines Krankenhaus Wien
Vienna, 1090, Austria
Ordinationszentrum imedneunzehn privat
Vienna, 1190, Austria
Krankenhaus Nord - Klinik Floridsdorf
Vienna, 1210, Austria
Azorg Campus Aalst - Moorselbaan
Aalst, 9300, Belgium
Universitair Ziekenhuis Brussel
Brussels, 1090, Belgium
Algemeen Ziekenhuis Sint Blasius
Dendermonde, 9200, Belgium
Ziekenhuis Oost-Limburg - Campus Sint-Jan
Genk, 3600, Belgium
Algemeen Ziekenhuis Maria Middelares
Ghent, 9000, Belgium
Universitair Ziekenhuis Gent
Ghent, 9000, Belgium
Jessa Ziekenhuis - Campus Virga Jesse
Hasselt, 3500, Belgium
AZ Herentals
Herentals, 2200, Belgium
Algemeen Ziekenhuis Groeninge - Campus Kennedylaan
Kortrijk, 8500, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
Leuven, 3000, Belgium
Centre Hospitalier Regional de la Citadelle
Liège, 4000, Belgium
Clinique Centre Hospitalier Chrétien MontLégia
Liège, 4000, Belgium
AZ Delta Campus Rumbeke
Roeselare, 8800, Belgium
Algemeen Ziekenhuis Turnhout
Turnhout, 2300, Belgium
Universite Catholique de Louvain Cliniques Universitaires de Mont-Godinne
Yvoir, 5530, Belgium
Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo
Vitória, Espírito Santo, 29055-450, Brazil
Hospital das Clinicas da Universidade Federal de Goias
Goiânia, Goiás, 74605-020, Brazil
Ccih - Consultoria em Controle de Infecção Hospitalar
Belo Horizonte, Minas Gerais, 30150-320, Brazil
Cardresearch Cardiologia Assistencial de Pesquisa
Belo Horizonte, Minas Gerais, 31110-580, Brazil
Nucleo de Pesquisa Clinica
Curitiba, Paraná, 80730-150, Brazil
Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90410-000, Brazil
Fz Pesquisa e Servicos em Cardiologia Clinica Ltda
Porto Alegre, Rio Grande do Sul, 91350-280, Brazil
jmf Clinica do Coracao ltda
Aracaju, Sergipe, 49055-530, Brazil
Instituto de Pesquisa Clinica de Campinas - Ipecc
Campinas, São Paulo, 13060-080, Brazil
Loema Instituto de Pesquisa Clinica e Consultores Ltda - Clinica Loema
Campinas, São Paulo, 13092-133, Brazil
Instituto do Coracao de Marilia
Marília, São Paulo, 17515-000, Brazil
Clinicor Clinica Cardiologica
Ribeirão Preto, São Paulo, 14026-900, Brazil
Pesquisare Saude Ltda
Santo André, São Paulo, 09080-110, Brazil
Praxis Pesquisa Medica
Santo André, São Paulo, 09090-790, Brazil
Hospital de Base de Sao Jose do Rio Preto
São José do Rio Preto, São Paulo, 15090-000, Brazil
Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
São Paulo, São Paulo, 05403-900, Brazil
Instituto de Molestias Cardiovasculares de Tatui
Tatuí, São Paulo, 18270-170, Brazil
IBPClin Instituto Brasil de Pesquisa Clinica
Rio de Janeiro, 20241-180, Brazil
Ambulatory for special outpatient medical aid in Cardiology-Private Practice Dr Elena Dotcheva EOOD
Burgas, 8000, Bulgaria
Multiprofile Hospital for Active Treatment - Haskovo AD
Haskovo, 6300, Bulgaria
University Multiprofile Hospital for Active Treatment Sveti Georgi EAD
Plovdiv, 4001, Bulgaria
Medical Center Futuremeds EOOD
Plovdiv, 4002, Bulgaria
Multiprofile Hospital for Active Treatment Knyaginya Klementina - Sofia EAD
Sofia, 1233, Bulgaria
National Multiprofile Transport Hospital Tzar Boris III
Sofia, 1233, Bulgaria
Multiprofile Hospital for Active Treatment National Hospital of Cardiology EAD
Sofia, 1309, Bulgaria
Diagnostic-Consultative Center Alexandrovska EOOD
Sofia, 1431, Bulgaria
Medical Center Hera EOOD
Sofia, 1510, Bulgaria
Diagnostic-Consultative Center XX-Sofia EOOD
Sofia, 1618, Bulgaria
Diagnostic-Consultative Center Convex OOD
Sofia, 1680, Bulgaria
Multiprofile Regional Hospital for Active Treatment Dr Stefan Cherkezov AD
Veliko Tarnovo, 5000, Bulgaria
Specialised Hospital for Active Cardiology Treatment EAD
Yambol, 8600, Bulgaria
St Boniface Hospital
Winnipeg, Manitoba, R2H 2A6, Canada
Cardio 1
Winnipeg, Manitoba, R3L 1Z5, Canada
Brampton Clinical Trials
Brampton, Ontario, L6Z 4N5, Canada
Cambridge Cardiac Care Centre
Cambridge, Ontario, N1R 6V6, Canada
Saul Vizel Professional Medicine Corporation - Vizel Cardiac Research
Cambridge, Ontario, N1R 7R1, Canada
Partners in Advanced Cardiac Evaluation
Newmarket, Ontario, L3Y 2P6, Canada
North York Diagnostic and Cardiac Centre
North York, Ontario, M6B 3H7, Canada
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2, Canada
CardioQuest Research Centre
Sarnia, Ontario, N7T 4P5, Canada
Heart Health Institute Research Incorporated
Scarborough Village, Ontario, M1B 4Z8, Canada
KMH Cardiology Centres Incorporated Hamilton
Stoney Creek, Ontario, L8J 3W2, Canada
Curans Heart Center
Thunder Bay, Ontario, P7B 5N3, Canada
Womens College Hospital
Toronto, Ontario, M5S 1B2, Canada
Diabetes Heart Research Centre
Toronto, Ontario, M6G 1M2, Canada
Winchester District Memorial Hospital
Winchester, Ontario, K0C 2K0, Canada
Ecogene-21
Chicoutimi, Quebec, G7H 7K9, Canada
Montreal Heart Institute
Montreal, Quebec, H1T 1C8, Canada
Diex Recherche Sherbrooke Est
Sherbrooke, Quebec, J1E 0N8, Canada
Diex Recherche Trois Rivieres
Trois-Rivières, Quebec, G9A 4P3, Canada
Centro de Investigacion Clinica del Sur
Temuco, Cautín, 4781156, Chile
Centro de Estudios Cardiologicos y Medicina Interna CECMI
Temuco, Cautín, 4813299, Chile
Hospital Las Higueras
Talcahuano, Concepción, 4270918, Chile
Oncocentro Apys
Viña del Mar, Región de Valparaíso, 2520598, Chile
Cinvec Estudios Clinicos quinta region Limitada
Viña del Mar, Región de Valparaíso, 2520997, Chile
Fundacion Innovacion Cardiovascular Clinica Ensenada
Independencia, Santiago Metropolitan, Chile
Enroll SpA
Providencia, Santiago Metropolitan, 7500587, Chile
Biocinetic servicios medicos limitada
Santiago, 8320000, Chile
Pontificia Universidad Catolica de Chile
Santiago, 8330034, Chile
Clinical Research Chile SpA
Valdivia, 5110683, Chile
The Second Hospital of Anhui Medical University
Hefei, Anhui, 230601, China
Beijing Hospital
Beijing, Beijing Municipality, 100020, China
Fuwai Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, 100037, China
Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, 100050, China
Peking University Third Hospital
Beijing, Beijing Municipality, 100191, China
Guangdong Provincial Peoples Hospital
Guangzhou, Guangdong, 519041, China
The Affiliated Hospital of Inner Mongolia Medical University
Haikou, Hainan, 570311, China
First Hospital of Qinhuangdao
Qinhuangdao, Hebei, 066099, China
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, 050000, China
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, 150001, China
Huaihe Hospital of Henan University
Kaifeng, Henan, 475000, China
Luoyang Third Peoples Hospital
Luoyang, Henan, 471002, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052, China
The Third Peoples Hospital of Hubei Province
Wuhan, Hubei, 430033, China
The Second Xiangya Hospital of Central South University
Changsha, Hunan, 410011, China
The Third Xiangya Hospital of Central South University
Changsha, Hunan, 410013, China
The Third Hospital of Changsha
Changsha, Hunan, 410015, China
Hebei General Hospital
Hengyang, Hunan, 421001, China
First Affiliated Hospital of Baotou Hospital, Inner
Baotou, Inner Mongolia, 014010, China
Affiliated Hospital of Chifeng University
Chifeng, Inner Mongolia, 024050, China
The First Peoples Hospital of Changzhou
Changzhou, Jiangsu, 210300, China
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, 210011, China
Zhongda Hospital Southeast University
Nanjing, Jiangsu, 211000, China
Wuxi Peoples Hospital
Wuxi, Jiangsu, 214023, China
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006, China
Pingxiang Peoples Hospital
Pingxiang, Jiangxi, 337000, China
Jilin Province Peoples Hospital
Changchun, Jilin, 130021, China
The First Bethune Hospital of Jilin University
Changchun, Jilin, 130021, China
China Japan Union Hospital of Jilin University
Changchun, Jilin, 130033, China
The Second Hospital of Jilin University
Changchun, Jilin, 130041, China
Siping City Center Peoples Hospital
Siping, Jilin, 136000, China
Zhongshan Hospital Affiliated to Dalian University
Shenyang, Liaoning, 110002, China
The Peoples Hospital of Liaoning Province
Shenyang, Liaoning, 110016, China
Shaanxi Provincial Peoples Hospital
Xi'an, Shaanxi, 710068, China
The First Affiliated Hospital of Xi An Medical University
Xi'an, Shaanxi, 710077, China
Qilu Hospital of Shandong University
Jinan, Shandong, 250012, China
Jinan Central Hospital
Jinan, Shandong, 250013, China
Shanghai General Hospital
Shanghai, Shanghai Municipality, 200080, China
First Hospital of Shanxi Medical University
Taiyuan, Shanxi, 030001, China
Shanxi Cardiovascular Hospital
Taiyuan, Shanxi, 030024, China
The First Affiliated Hospital of Xi An Jiao Tong University
Xi’an, Shanxi, 710061, China
Yuncheng Central hospital
Yuncheng, Shanxi, 044000, China
Chengdu Fifth Peoples Hospital
Chengdu, Sichuan, 611130, China
The Second Affiliated Hospital of Chongqing Medical University
Chongqing, Sichuan, 400010, China
Tianjin Peoples Hospital
Tianjin, Tianjin Municipality, 300121, China
The First Affiliated Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310003, China
Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310016, China
Lishui Central Hospital
Lishui, Zhejiang, 323000, China
Shanghai East Hospital
Shanghai, 200120, China
Medicus Services sro
Brandýs nad Labem, 250 01, Czechia
MUDr Libor Nechvatal sro
Brno, 602 00, Czechia
MUDr Karel Kamenik sro
Brno, 603 00, Czechia
Fakultni nemocnice Brno
Brno, 625 00, Czechia
Vojenska nemocnice Brno
Brno, 636 00, Czechia
Edumed sro
Broumov, 550 01, Czechia
CorMedico sro
Bruntál, 792 01, Czechia
Dika centrum sro
Havirov - Mesto, 736 01, Czechia
Kardio Holesov sro
Holešov, 769 01, Czechia
Edumed sro
Hradec Králové, 500 02, Czechia
Edumed sro
Jaroměř, 551 01, Czechia
Kardiologie - Liberec sro
Liberec, 460 01, Czechia
Cevni ambulance Melnik
Mělník, 276 01, Czechia
Edumed sro
Náchod, 547 01, Czechia
PreventaMed sro
Olomouc, 779 00, Czechia
CCR Ostrava sro
Ostrava, 702 00, Czechia
MUDr Miroslav Koliba sro
Ostrava, 702 00, Czechia
Pratia Pardubice as
Pardubice, 530 02, Czechia
Nemocnice Pardubickeho kraje as
Pardubice, 532 03, Czechia
Kardiologie a Angiologie Praha sro - Komplexni Centrum Vyzkumu, Prevence a Lecby Kardiov Nemoci
Prague, 101 00, Czechia
Avicena - kardiologie, interna sro
Prague, 110 00, Czechia
Kardiologie Vinohrady sro
Prague, 110 00, Czechia
Kardiologie Vinohrady sro
Prague, 120 00, Czechia
Institut klinicke a experimentalni mediciny
Prague, 140 21, Czechia
Kardiologicke centrum MUDr Janky Skrobakove sro
Praha 5 - Smichov, 150 00, Czechia
MUDr Jarmila Otrubova
Prostějov, 796 01, Czechia
Kardio Vaclavik sro
Přerov, 750 02, Czechia
Nemocnice Slany
Slaný, 274 01, Czechia
Kardiologicka ambulance MUDr Ferkl, sro
Trutnov, 541 01, Czechia
Ansaldo sro
Uherské Hradiště, 686 01, Czechia
Clinical Trials Service sro
Uherské Hradiště, 686 01, Czechia
Kardiologicka Ambulance MUDr Michaela Cervinkova, sro
Ústí nad Labem, 400 01, Czechia
Kardiologie - Usti nad Labem sro
Ústí nad Labem, 400 01, Czechia
Aarhus Universitetshospital
Aarhus N, 8200, Denmark
Esbjerg sygehus Syddansk universitetshospital
Esbjerg, 6700, Denmark
Frederiksberg/Bispebjerg Hospitaler
Frederiksberg, 2000, Denmark
Herlev and Gentofte Hospital
Herlev, 2730, Denmark
Regionshospitalet Gødstrup
Herning, 7400, Denmark
Hvidovre Hospital
Hvidovre, 2650, Denmark
Sjaellands Universitetshospital, Roskilde
Roskilde, 4000, Denmark
Helsinki University Hospital
Helsinki, 000290, Finland
Terveystalo Ruoholahti
Helsinki, 00180, Finland
Terveystalo Jyvaskyla
Jyväskylä, 40100, Finland
Turku University Hospital Tyks
Turku, 20520, Finland
Centre Hospitalier Universitaire Amiens Picardie - Site Sud
Amiens, 80054, France
Centre Hospitalier de Beziers
Béziers, 34525, France
Hospices Civils de Lyon Groupement Hospitalier Est - Hopital Louis Pradel
Bron, 69677, France
Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand
Dijon, 21000, France
Hopital prive Le Bois
Lille, 59000, France
Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon
Lille, 59037, France
Centre Hospitalier Universitaire de Montpellier - Hopital Arnaud de Villeneuve
Montpellier, 34090, France
Hopital prive du Confluent
Nantes, 44277, France
Centre Hospitalier Universitaire de Nice - Hopital Pasteur
Nice, 06000, France
Hopital Saint Antoine
Paris, 75012, France
Hopital Pitie-Salpetriere
Paris, 75013, France
Hopital Bichat Claude Bernard
Paris, 75877, France
Centre Hospitalier Intercommunal Toulon-La Seyne-sur-Mer - Hopital Sainte Musse
Toulon, 83056, France
Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil
Toulouse, 31059, France
Centre Hospitalier de Tourcoing - Hopital Guy Chatiliez
Tourcoing, 59208, France
Centre Hospitalier Regional Universitaire de Tours - Hopital Trousseau
Tours, 37044, France
Zentralklinik Bad Berka GmbH
Bad Berka, 99437, Germany
Rhoehn Klinik Campus Bad Neustadt
Bad Neustadt an der Saale, 97616, Germany
Segeberger Kliniken GmbH
Bad Segeberg, 23795, Germany
policum Berlin Friedenau
Berlin, 12157, Germany
Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin
Berlin, 12203, Germany
Charite - Universitaetsmedizin Berlin, Campus Virchow
Berlin, 13353, Germany
Universitaetsklinikum Bonn
Bonn, 53127, Germany
Klinikum Lippe
Detmold, 32756, Germany
Zentrum fuer klinische Pruefungen in der Facharztzentrum Dresden-Neustadt Betriebsgesellschaft
Dresden, 01099, Germany
Universitaetsklinikum Dresden
Dresden, 01307, Germany
Universitaetsklinikum Duesseldorf
Düsseldorf, 40225, Germany
ClinPhenomics CVC GmbH
Frankfurt am Main, 60596, Germany
Universitaetsklinikum Frankfurt
Frankfurt am Main, 60596, Germany
Medizinisches Versorgungszentrum im Altstadt-Carree Fulda
Fulda, 36037, Germany
Universitaetsklinikum Hamburg Eppendorf
Hamburg, 20251, Germany
Cardiologicum Hamburg GbR
Hamburg, 22041, Germany
Kardiologische Praxis
Haßloch, 67454, Germany
Universitaetsklinikum Heidelberg
Heidelberg, 69120, Germany
Universitaetsklinikum des Saarlandes
Homburg, 66421, Germany
Universitaetsklinikum Jena
Jena, 07747, Germany
Kardiopraxis Schirmer
Kaiserslautern, 67655, Germany
Universitaetsklinikum Leipzig
Leipzig, 04103, Germany
zero Praxen GbR
Mannheim, 68165, Germany
Johannes Wesling Klinikum Minden
Minden, 32429, Germany
Klinikum rechts der Isar der TUM
München, 80809, Germany
FutureMeds Offenbach
Offenbach, 63065, Germany
Kardiologische Gemeinschaftspraxis Papenburg
Papenburg, 26871, Germany
Universitaetsklinikum Regensburg
Regensburg, 93053, Germany
Herz- und Gefaesszentrum Praxis Dr Overhoff Dr Kraemer
Siegen, 57072, Germany
Cardiologicum Herzklinik Ulm
Ulm, 89077, Germany
Praxis Dr med Ayham Al-Zoebi Facharzt fuer Innere Medizin und Kardiologie
Wermsdorf, 04779, Germany
University Hospital of Alexandroupolis
Alexandroupoli, 68100, Greece
Athens Naval Hospital
Athens, 11521, Greece
General Hospital for Thoracic Diseases of Athens "Sotiria
Athens, 11527, Greece
General Hospital of Athens Georgios Gennimatas
Athens, 11527, Greece
General Hospital of Athens Ippokrateio
Athens, 11527, Greece
Alexandra Hospital
Athens, 11528, Greece
University General Hospital Attikon General Hospital Of West Attica H Agia Varvara
Athens, 12462, Greece
General Hospital Asklipieio Voulas
Athens, 16673, Greece
General Hospital of Chios "Skilitsion"
Chios, 82131, Greece
University Hospital of Larissa
Larissa, 41110, Greece
Hygeia Hospital
Marousi, 15123, Greece
General Hospital Of Nea Ionia Konstantopouleio Patision
Nea Ionia, 14233, Greece
Tzaneio General Hospital
Piraeus, 18536, Greece
Ahepa University Hospital
Thessaloniki, 54636, Greece
Queen Mary Hospital, The University of Hong Kong
Hong Kong, Hong Kong
Prince of Wales Hospital, Chinese University of Hong Kong
Shatin, New Territories, Hong Kong
Budapesti Szent Ferenc Korhaz
Budapest, 1021, Hungary
Bajcsy-Zsilinszky Korhaz es Rendelointezet
Budapest, 1106, Hungary
Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika
Budapest, 1122, Hungary
Eszak-Pesti Centrum Korhaz - Honvedkorhaz
Budapest, 1134, Hungary
Budapesti Uzsoki Utcai Korhaz
Budapest, 1145, Hungary
Zugloi Egeszsegugyi Szolgalat
Budapest, 1148, Hungary
Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032, Hungary
Gyongyosi Bugat Pal Korhaz
Gyöngyös, 3200, Hungary
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktatokorhaz
Győr, 9024, Hungary
Bacs-Kiskun Varmegyei Oktatokorhaz
Kecskemét, 6000, Hungary
Keszthelyi Korhaz
Keszthely, 8360, Hungary
Kistarcsai Flor Ferenc Korhaz
Kistarcsa, 2143, Hungary
Komaromi Selye Janos Korhaz
Komárom, 2921, Hungary
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz
Nyíregyháza, 4400, Hungary
Oroshazi Dr Laszlo Elek Korhaz es Rendelointezet
Orosháza, 5900, Hungary
COROMED-SMO Kft
Pécs, 7623, Hungary
DaVinci Maganklinika
Pécs, 7635, Hungary
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
Szeged, 6725, Hungary
Tolna Varmegyei Balassa Janos Korhaz
Szekszárd, 7100, Hungary
Szegedi Tudomanyegyetem SZGYA Klinikai Kozpont Dr Bugyi Istvan Szentesi Multidiszciplinaris Centrum
Szentes, 6600, Hungary
Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz
Székesfehérvár, 8000, Hungary
Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointezet
Szolnok, 5000, Hungary
Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz
Szombathely, 9700, Hungary
Azienda Ospedaliero Universitaria Consorziale Policlinico
Bari, 70124, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni xxiii
Bergamo, 24127, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Brescia, 25123, Italy
Azienda Unita Sanitaria Locale Toscana sud est Ospedale S. Margherita
Cortona AR, 52044, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia
Foggia, 71122, Italy
Azienda Unita Sanitaria Locale Romagna
Forlì, 47121, Italy
IRCCS Ospedale San Raffaele
Milan, 20132, Italy
IRCCS Centro Cardiologico Monzino
Milan, 20138, Italy
Azienda Ospedaliera di Rilievo Nazionale Specialistica dei Colli Monaldi
Naples, 80131, Italy
Azienda Ospedaliera Universitaria Federico II
Naples, 80131, Italy
Fondazione IRCCS Policlinico San Matteo
Pavia, 27100, Italy
Azienda Unita Sanitaria Locale Romagna
Rimini, 47923, Italy
ASL TO3 Ospedale di Rivoli
Rivoli, 10098, Italy
Fondazione Policlinico Universitario Campus Bio-Medico
Roma, 00128, Italy
Azienda Ospedaliero Universitaria di Sassari
Sassari, 07100, Italy
Fujita Health University Hospital
Toyoake-shi, Aichi-ken, 470-1192, Japan
Fukuoka University Hospital
Fukuoka, Fukuoka, 814-0180, Japan
Miyanosawa Clinic of Internal Medicine and Cardiology
Sapporo, Hokkaido, 063-0826, Japan
Higashi Takarazuka Satoh Hospital
Takarazuka-shi, Hyōgo, 665-0873, Japan
Ishikawa Prefectural Central Hospital
Kanazawa, Ishikawa-ken, 920-8530, Japan
Takamatsu Red Cross Hospital
Takamatsu, Kagawa-ken, 760-0017, Japan
Tenyoukai Central Clinic
Kagoshima, Kagoshima-ken, 892-0822, Japan
Sagamihara Kyodo Hospital
Sagamihara-shi, Kanagawa, 252-5188, Japan
Kumamoto Kinoh Hospital
Kumamoto, Kumamoto, 860-8518, Japan
Rakuwakai Otowa Hospital
Kyoto, Kyoto, 607-8062, Japan
North Alps Medical Center Azumi Hospital
Kitaazumi-gun, Nagano, 399-8695, Japan
Niigata University Medical and Dental Hospital
Niigata, Niigata, 951-8520, Japan
Oita Red Cross Hospital
Ōita, Oita Prefecture, 870-0033, Japan
Fujinomiya City General Hospital
Fujinomiya-shi, Shizuoka, 418-0076, Japan
Japanese Red Cross Hamamatsu Hospital
Hamamatsu, Shizuoka, 434-8533, Japan
Medical Corporation Kenshinkai Minamino Cardiovascular Hospital
Hachioji-shi, Tokyo, 192-0918, Japan
Affiliated Central Clinic of Higashiyamato Hospital
Higashiyamato-shi, Tokyo, 207-0014, Japan
Tokyo Shinagawa Hospital Social Medical Corporation Association Tokyokyojuno-kai
Shinagawa-ku, Tokyo, 140-8522, Japan
NewHeart Watanabe Institute
Suginami-ku, Tokyo, 168-0065, Japan
Sanin Rosai Hospital
Yonago-shi, Tottori, 683-8605, Japan
Soluciones Terapeuticas Medico Quirurgicas
Mexico City, Mexico City, 03650, Mexico
Cardiolink Clin Trials
Monterrey, Nuevo León, 64060, Mexico
Health Pharma Queretaro Sa de Cv
Juriquilla, Querétaro, 76230, Mexico
Centro de Estudios Clinicos de Queretaro
Querétaro City, Querétaro, 76000, Mexico
Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC
Culiacán, Sinaloa, 80230, Mexico
Hospital Cardiologica Aguascalientes
Aguascalientes, 20230, Mexico
Amsterdam Universitair Medisch Centrum
Amsterdam, 1081 HV, Netherlands
Rijnstate Ziekenhuis
Arnhem, 6815 AD, Netherlands
Amphia ziekenhuis
Breda, 4818 CK, Netherlands
Reinier de Graaf Gasthuis
Delft, 2625 AD, Netherlands
Deventer Ziekenhuis
Deventer, 7416 SE, Netherlands
Albert Schweitzer Ziekenhuis, Locatie Dordwijk
Dordrecht, 3318 AT, Netherlands
Catharina Ziekenhuis
Eindhoven, 5623 EJ, Netherlands
Treant Zorggroep, locatie Scheper ziekenhuis Emmen
Emmen, 7824 AA, Netherlands
Medisch Spectrum Twente
Enschede, 7512 KZ, Netherlands
Universitair Medisch Centrum Groningen
Groningen, 9713 GZ, Netherlands
Zuyderland Medisch Centrum
Heerlen, 6419 PC, Netherlands
Frisius Medisch Centrum, locatie Leeuwarden
Leeuwarden, 8934 AD, Netherlands
Ikazia Ziekenhuis
Rotterdam, 3083 AN, Netherlands
D and A Research and Genetics
Sneek, 8601 ZR, Netherlands
Haga Ziekenhuis
The Hague, 2545 AA, Netherlands
Zaans Medisch Centrum
Zaandam, 1502 DV, Netherlands
Marek Dariusz Klimkiewicz Klimed Marek Klimkiewicz
Bialystok, 15-704, Poland
Centrum medyczne intercore sp zoo
Bydgoszcz, 85-605, Poland
American Heart of Poland Spolka Akcyjna
Chrzanów, 32-500, Poland
Centrum Badan Klinicznych Agnieszka Mital
Elblag, 82-300, Poland
Uniwersyteckie Centrum Kliniczne
Gdansk, 80-214, Poland
Pawel Miekus, NZOZ Sopockie Centrum Badan Kardiologicznych ProCordis Pawel Miekus
Gdynia, 81-423, Poland
Niepubliczny Zaklad Opieki Zdrowotnej Medica Jerzy Cygler
Giżycko, 11-500, Poland
Pro Familia Altera Sp zoo
Katowice, 40-648, Poland
Futuremeds spolka z ograniczona odpowiedzialnoscia
Krakow, 31-501, Poland
SPZOZ Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi
Lodz, 90-549, Poland
Futuremeds spolka z ograniczona odpowiedzialnoscia
Lodz, 91-363, Poland
CenterMed Spzoo Centermed Lublin
Lublin, 20-044, Poland
Szpital Swietej Anny w Miechowie
Miechów, 32-200, Poland
Futuremeds spolka z ograniczona odpowiedzialnoscia
Olsztyn, 10-165, Poland
Medicome Spolka z Ograniczona Odpowiedzialnoscia
Oświęcim, 32-600, Poland
Centrum Medyczne Medyk Spolka z Ograniczona Odpowiedzialnoscia Spolka Komandytowa
Rzeszów, 35-055, Poland
Velocity Skierniewice Spolka z Ograniczona Odpowiedzialnoscia
Skierniewice, 96-100, Poland
Praktyka Lekarska Lidia Pawlowicz
Torun, 87-100, Poland
American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
Tychy, 43-100, Poland
Oha-Med Sp zoo
Warsaw, 01-018, Poland
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji
Warsaw, 02-507, Poland
Gabinet Lekarski Maciej Karcz
Warsaw, 02-758, Poland
Uniwersytecki Szpital Kliniczny im Jana Mikulicza-Radeckiego we Wroclawiu
Wroclaw, 50-556, Poland
Futuremeds spolka z ograniczona odpowiedzialnoscia
Wroclaw, 53-673, Poland
Halina Serafin NZOZ Centrum Medyczne "Serafin-Med"
Żarów, 58-130, Poland
Unidade Local de Saude de Almada-Seixal, EPE - Hospital Garcia de Orta
Almada, 2805-267, Portugal
Unidade Local de Saude de Coimbra, EPE
Coimbra, 3000-075, Portugal
Unidade Local de Saude do Alto Ave, EPE
Guimarães, 4835-044, Portugal
Unidade Local de Saude de Lisboa Ocidental, EPE - Hospital Sao Francisco Xavier
Lisbon, 1449-005, Portugal
Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria
Lisbon, 1649-035, Portugal
Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano
Matosinhos Municipality, 4464-513, Portugal
Unidade Local de Saude de Sao Joao, EPE - Hospital de Sao Joao
Porto, 4200-319, Portugal
Cardioplus Center SRL
Baia Mare, 430124, Romania
cmi Cardiologie - Dr Pop Calin
Baia Mare, 430222, Romania
Centrul Medical de Diagnostic si Tratament Ambulator Neomed
Brasov, 500283, Romania
Spitalul Universitar de Urgenta Bucuresti
Bucharest, 050098, Romania
Matcord Biomedica Buzau
Buzău, 120133, Romania
Consultmed SRL
Iași, 700544, Romania
Sal Med SRL
Piteşti, 110438, Romania
Spitalul Clinic Judetean de Urgenta Targu Mures
Târgu Mureş, 540136, Romania
Cabinet Medical Individual Dr Podoleanu Cristian
Târgu Mureş, 540143, Romania
Spitalul Clinic Municipal de Urgenta Timisoara
Timișoara, 300079, Romania
Alian, sro
Bardejov, 085 01, Slovakia
Narodny ustav srdcovych a cievnych chorob, as
Bratislava, 833 48, Slovakia
Novate sro
Bratislava, 841 04, Slovakia
Kardiomedina sro
Dolný Kubín, 026 01, Slovakia
Nemocnica Dr Vojtecha Alexandra v Kezmarku no
Kežmarok, 060 01, Slovakia
Medical group Kosice sro
Košice, 040 01, Slovakia
Cardio D and R, sro Kosice
Košice, 040 22, Slovakia
KardioLEV sro
Levoča, 054 01, Slovakia
Kardio 1 sro
Lučenec, 984 01, Slovakia
Nemocnicna as
Malacky, 901 22, Slovakia
Oralek, sro
Námestovo, 029 01, Slovakia
Kardiomed NZ, sro
Nové Zámky, 940 01, Slovakia
KaCH, sro
Nové Zámky, 940 02, Slovakia
Nemocnica Poprad, as
Poprad, 058 45, Slovakia
Intermedis sro
Prešov, 080 01, Slovakia
Medispol, sro
Prešov, 080 01, Slovakia
Interna SK, sro
Svidník, 089 01, Slovakia
Pentes, sro
Žilina, 010 01, Slovakia
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital
Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System
Seoul, 03722, South Korea
Yonsei University Wonju Severance Christian Hospital
Wonju-si, Gangwon-do, 26426, South Korea
Hospital Universitario Reina Sofia
Córdoba, Andalusia, 14004, Spain
Hospital Clinico Universitario Virgen de la Victoria
Málaga, Andalusia, 29010, Spain
Hospital Universitario de Gran Canaria Doctor Negrin
Las Palmas de Gran Canaria, Canary Islands, 35010, Spain
Hospital Universitari Germans Trias i Pujol
Badalona, Catalonia, 08916, Spain
Hospital Universitari Vall d Hebron
Barcelona, Catalonia, 08035, Spain
Hospital Clinic i Provincial de Barcelona
Barcelona, Catalonia, 08036, Spain
Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, Catalonia, 08907, Spain
Hospital Universitario Arnau de Vilanova Lleida
Lleida, Catalonia, 25198, Spain
Complexo Hospitalario Universitario A Coruña
A Coruña, Galicia, 15006, Spain
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Madrid, 28222, Spain
Hospital Universitario Virgen de la Arrixaca
El Palmar, Murcia, 30120, Spain
Hospital Marina Salud de Denia
Denia, Valencia, 03700, Spain
Hospital Clinico Universitario de Valencia
Valencia, Valencia, 46010, Spain
Hospital Universitari i Politecnic La Fe
Valencia, Valencia, 46026, Spain
Hospital Clinico San Carlos
Madrid, 28040, Spain
Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
Hospital Universitario La Paz
Madrid, 28046, Spain
Hospital Clinico Universitario de Salamanca
Salamanca, 37007, Spain
Falu Lasarett
Falun, 791 82, Sweden
Carlanderska sjukhuset
Gothenburg, 405 45, Sweden
Helsingborgs Lasarett
Helsingborg, 251 87, Sweden
Clemenstorgets Hjartmottagning
Lund, 222 21, Sweden
Vrinnevisjukhuset i Norrkoeping
Norrköping, 601 82, Sweden
Karolinska Universitetssjukhuset Solna
Solna, 171 76, Sweden
Capio Saint Gorans Hospital
Stockholm, 112 19, Sweden
Danderyds Sjukhus
Stockholm, 182 88, Sweden
Universitaetsspital Basel
Basel, 4031, Switzerland
Inselspital Bern
Bern, 3010, Switzerland
Hopitaux Universitaires de Geneve
Geneva, 1211, Switzerland
Istituto Cardiocentro Ticino
Lugano, 6900, Switzerland
Kantonsspital Sankt Gallen
Sankt Gallen, 9007, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 80756, Taiwan
China Medical University Hospital
Taichung, 40447, Taiwan
National Cheng Kung University Hospital
Tainan, 70403, Taiwan
National Taiwan University Hospital
Taipei, 10002, Taiwan
Taipei Medical University Hospital
Taipei, 11031, Taiwan
Taipei Veterans General Hospital
Taipei, 11217, Taiwan
Afyonkarahisar Saglik Bilimleri Universitesi Hastanesi
Afyonkarahisar, 03218, Turkey (Türkiye)
Ankara Bilkent Sehir Hastanesi
Ankara, 06800, Turkey (Türkiye)
Hitit Universitesi Erol Olcok Egitim ve Arastirma Hastanesi
Çorum, 19040, Turkey (Türkiye)
Istanbul Universitesi Cerrahpasa Tip Fakultesi
Istanbul, 34096, Turkey (Türkiye)
Bagcilar Medipol Mega Universite Hastanesi
Istanbul, 34214, Turkey (Türkiye)
Mehmet Akif Ersoy Gogus Kalp ve Damar Cerrahisi Egitim ve Arastirma Hastanesi
Istanbul, 34307, Turkey (Türkiye)
Dr Siyami Ersek Gogus Kalp ve Damar Cerrahisi Egitim ve Arastirma Hastanesi
Istanbul, 34668, Turkey (Türkiye)
Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi
Istanbul, 34722, Turkey (Türkiye)
Dokuz Eylul Universitesi Tip Fakultesi Hastanesi
Izmir, 35340, Turkey (Türkiye)
Erciyes Universitesi Tip Fakultesi Hastanesi
Kayseri, 38039, Turkey (Türkiye)
Kocaeli Universitesi Tip Fakultesi Hastanesi
Kocaeli, 41380, Turkey (Türkiye)
Necmettin Erbakan Universitesi Tip Fakultesi Hastanesi
Konya, Turkey (Türkiye)
University Hospital Monklands
Airdrie, ML6 0JS, United Kingdom
North Tyneside General Hospital
Ashington, NE63 9JJ, United Kingdom
Royal Bournemouth Hospital
Bournemouth, BH7 7DW, United Kingdom
Princess of Wales Hospital
Bridgend, CF31 1RQ, United Kingdom
Southmead Hospital
Bristol, BS10 5NB, United Kingdom
St Richards Hospital
Chichester, PO19 6SE, United Kingdom
Ninewells Hospital and Medicine School
Dundee, DD1 9SY, United Kingdom
Royal Devon and Exeter Hospital
Exeter, EX2 5DW, United Kingdom
Glasgow Royal Infirmary
Glasgow, G31 2ER, United Kingdom
Wycombe Hospital
High Wycombe, HP11 2TT, United Kingdom
Highlands Clinical Research Facility, Raigmore Hospital
Inverness, IV2 3UJ, United Kingdom
University Hospital Crosshouse
Kilmarnock, KA2 0BE, United Kingdom
Glenfield Hospital
Leicester, LE3 9QP, United Kingdom
University College London Hospital
London, NW1 2BU, United Kingdom
Manchester Royal Infirmary
Manchester, M13 9WL, United Kingdom
Newcastle NIHR Commercial Research Delivery Centre
Newcastle upon Tyne, NE7 7DN, United Kingdom
Pinderfields Hospital
Wakefield, WF1 4DG, United Kingdom
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
MD
Amgen
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 16, 2025
First Posted
June 25, 2025
Study Start
June 25, 2025
Primary Completion (Estimated)
June 30, 2028
Study Completion (Estimated)
September 29, 2030
Last Updated
April 16, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, ICF, CSR
- Time Frame
- Data sharing requests relating to this trial will be considered beginning 18 months after the trial has ended and either 1) the product and indication have been granted marketing authorization in both the US and Europe or 2) clinical development for the product and/or indication discontinues and the data will not be submitted to regulatory authorities. There is no end date for eligibility to submit a data sharing request for this trial.
- Access Criteria
- Qualified researchers may submit a request containing the research objectives, the Amgen product(s) and Amgen trial/trials in scope, endpoints/outcomes of interest, statistical analysis plan, data requirements, publication plan, and qualifications of the researcher(s). In general, Amgen does not grant external requests for individual patient data for the purpose of re-evaluating safety and efficacy issues already addressed in the product labelling. Requests are reviewed by a committee of internal advisors. If not approved, a Data Sharing Independent Review Panel will arbitrate and make the final decision. Upon approval, information necessary to address the research question will be provided under the terms of a data sharing agreement. This may include anonymized individual patient data and/or available supporting documents, containing fragments of analysis code where provided in analysis specifications. Further details are available at the URL below.
De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request.