Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
MARITIME-CV
A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
1 other identifier
interventional
12,800
34 countries
741
Brief Summary
The primary objective of this trial is to demonstrate that maridebart cafraglutide is superior to placebo when given as an adjunct to standard of care with respect to reducing cardiovascular (CV) morbidity and mortality.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Jul 2025
Longer than P75 for phase_3
741 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 16, 2025
CompletedFirst Posted
Study publicly available on registry
June 25, 2025
CompletedStudy Start
First participant enrolled
July 25, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
September 29, 2030
April 24, 2026
April 1, 2026
2.9 years
June 16, 2025
April 22, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Time to First Occurrence of a Composite Endpoint Consisting of: CV Death, Myocardial Infarction (MI), or Ischemic Stroke (3-point Major Adverse Cardiac Events [3-P MACE])
Up to approximately 35 months
Time to First Occurrence of a Composite Endpoint Consisting of: All-cause Death, MI, Ischemic Stroke, Coronary Revascularization, or Heart Failure (HF) Event (5-point MACE)
Up to approximately 35 months
Secondary Outcomes (48)
Time to First Occurrence of a Composite Endpoint Consisting of: CV Death, MI, Ischemic Stroke, or HF Event
Up to approximately 35 months
Time to First Occurrence of a Composite Endpoint Consisting of: CV Death, MI, Ischemic Stroke or Coronary Revascularization
Up to approximately 35 months
Time to First MI
Up to approximately 35 months
Time to First Ischemic Stroke
Up to approximately 35 months
Time to CV Death
Up to approximately 35 months
- +43 more secondary outcomes
Study Arms (2)
Maridebart Cafraglutide
EXPERIMENTALParticipants will receive maridebart cafraglutide subcutaneously (SC).
Placebo
PLACEBO COMPARATORParticipants will receive placebo SC.
Interventions
Maridebart cafraglutide will be administered SC.
Eligibility Criteria
You may qualify if:
- Age ≥ 45 years at screening.
- BMI of ≥ 27.0 kg/m\^2 at screening.
- History of Atherosclerotic Cardiovascular Disease (ASCVD) with a documented history of at least one of the following:
- Prior MI (presumed atherothrombotic event due to plaque rupture/erosion).
- Prior ischemic stroke (presumed due to atherosclerosis; may include ischemic stroke with hemorrhagic transformation).
- Symptomatic peripheral arterial disease (PAD), as evidenced by intermittent claudication with ankle-brachial index (ABI) \< 0.9 (at rest), or peripheral arterial revascularization procedure, or amputation due to atherosclerotic disease.
You may not qualify if:
- History of any of the following within 60 days before screening or between screening and randomization: MI, hospitalization for unstable angina, arterial revascularization (eg, coronary, cerebrovascular or peripheral) major cardiovascular surgery, stroke, or transient ischemic attack (TIA).
- New York Heart Association (NYHA) class IV HF during screening or hospitalization for HF within 60 days before screening or between screening and randomization.
- Type 1 DM, or any other type of diabetes with the exception of T2DM or prior gestational diabetes. Participants with a history of gestational diabetes should be stratified according to their current diabetes classification.
- For participants with T2DM (including those without a prior history of T2DM but with a HbA1c ≥ 6.5% during screening):
- HbA1c \> 10.0% (86 mmol/mol) at screening.
- History of diabetic ketoacidosis or hyperosmolar state/coma within 12 months before randomization.
- One or more episodes of severe hypoglycemia within 6 months before randomization and/or history of hypoglycemia unawareness.
- History of proliferative diabetic retinopathy, diabetic maculopathy, severe non-proliferative diabetic retinopathy, or currently receiving or planning to receive treatment for diabetic retinopathy and/or diabetic macular edema.
- Use of any glucagon-like peptide-1 receptor agonist (GLP-1 RA), glucose-dependent insulinotropic polypeptide (GIP) agonists or antagonists, or amylin analogs within 90 days before randomization or planned use during the conduct of the trial.
- History of chronic pancreatitis or history of acute pancreatitis in the 180 days before screening or between screening and randomization.
- Family (first-degree relative\[s\]), or personal history of medullary thyroid carcinoma (MTC), or multiple endocrine neoplasia syndrome type 2 (MEN-2).
- Calcitonin ≥ 50 ng/L (pg/mL) at screening.
- Acute or chronic hepatitis; signs and symptoms of any liver disease other than metabolic dysfunction-associated steatotic liver disease, or alanine aminotransferase (ALT) \> 3.0 x the upper limit of normal (ULN) during screening, or total bilirubin (TBL) \> 1.8 x ULN during screening (for participants with a known diagnosis of Gilbert syndrome, direct bilirubin should be used instead of TBL).
- History of malignancy within the last 5 years before screening or between screening and randomization (except for the following treated with curative intent: non-melanoma skin cancer, breast ductal carcinoma in situ, cervical carcinoma in situ, or prostate cancer in situ).
- Participants of childbearing potential planning to become pregnant while on study or unwilling to use protocol-specified methods of contraception during treatment.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Amgenlead
Study Sites (759)
Alliance For Multispecialty Research - Daphne
Daphne, Alabama, 36526, United States
Eastern Shore Research Institute
Fairhope, Alabama, 36532, United States
Heart Center Research LLC
Huntsville, Alabama, 35801, United States
Mobile Heart Specialists PC
Mobile, Alabama, 36608, United States
Syed Research Consultants LLC
Sheffield, Alabama, 35660, United States
Synexus Clinical Research US, Inc.
Phoenix, Arizona, 85020, United States
Medical Advancement Centers of Arizona
Phoenix, Arizona, 85044, United States
Valley Clinical Trials, LLC dba Flourish Research
Covina, California, 91723, United States
Velocity Clinical Research- Huntington Park
Huntington Park, California, 90255, United States
Velocity Clinical Research- Los Angeles
La Mesa, California, 91942, United States
Orange County Research Center
Lake Forest, California, 92630, United States
Biopharma Informatic - The Cardiovascular Center
Redding, California, 96001, United States
Acclaim Clinical Research
San Diego, California, 92120, United States
Encompass Clinical Research
Spring Valley, California, 91978, United States
Diablo Clinical Research
Walnut Creek, California, 94598, United States
Focus Clinical Research
West Hills, California, 91307, United States
Family Practice Associates
Wilmington, Delaware, 19805, United States
Excel Medical Clinical Trials
Boca Raton, Florida, 33434, United States
Velocity Clinical Research - New Smyrna Beach
Edgewater, Florida, 32132, United States
Alliance for Multispecialty Research - Fort Myers
Fort Myers, Florida, 33912, United States
Indago Research and Health Center
Hialeah, Florida, 33012, United States
Elite Cardiac Research Center LLC
Hialeah, Florida, 33013, United States
Elite Clinical Research
Hialeah, Florida, 33018, United States
Zenith Clinical Research
Hollywood, Florida, 33021, United States
Encore Medical Research LLC
Hollywood, Florida, 33024, United States
East Coast Institute for Research, LLC
Jacksonville, Florida, 32216, United States
Clinical Research of Central Florida
Lakeland, Florida, 33805, United States
South Florida Clinical Research
Margate, Florida, 33063, United States
Finlay Medical Research
Miami, Florida, 33126, United States
Suncoast Research Group LLC
Miami, Florida, 33135, United States
New Horizon Research Center
Miami, Florida, 33165, United States
Panax Clinical Research
Miami Lakes, Florida, 33014, United States
San Marcus Research Clinic Inc
Miami Lakes, Florida, 33014, United States
West Orange Endocrinology
Ocoee, Florida, 34761, United States
Cardiology Partners Clinical Research Institute
Palm Beach Gardens, Florida, 33410, United States
Peace River Cardiovascular Center
Port Charlotte, Florida, 33952, United States
Progressive Medical Research
Port Orange, Florida, 32127, United States
Saint Johns Center for Clinical Research
Saint Augustine, Florida, 32086, United States
Intercoastal Medical Group
Sarasota, Florida, 34239, United States
Winter Haven Hospital
Winter Haven, Florida, 33881, United States
East Coast Institute for Research LLC at Canton Georgia
Canton, Georgia, 30114, United States
The Jones Center Clinical Research
Macon, Georgia, 31210, United States
Velocity Clinical Research - Savannah
Savannah, Georgia, 31419, United States
Velocity Clinical Research - Boise
Meridian, Idaho, 83642, United States
Endeavor Health-Northwest Community Healthcare
Arlington Heights, Illinois, 60005, United States
Eagle Clinical Research
Chicago, Illinois, 60621, United States
University of Chicago
Chicago, Illinois, 60637, United States
Alliance For Multispecialty Research - Oak Brook
Oak Brook, Illinois, 60523, United States
Prarie Education and Research
Springfield, Illinois, 62701, United States
Cardiovascular Research of Northwest Indiana LLC
Munster, Indiana, 46321, United States
Velocity Clinical Research - Valparaiso
Valparaiso, Indiana, 46383, United States
McFarland Clinic PC
Ames, Iowa, 50010, United States
Midwest Cardiovascular Research Foundation
Davenport, Iowa, 52801, United States
Cotton-ONeil Diabetes and Endocrinology Center
Topeka, Kansas, 66606, United States
Monroe Biomedical Research
Louisville, Kentucky, 40213, United States
Cardiovascular Associates Research, LLC
Covington, Louisiana, 70433, United States
Tandem Clinical Research - Marrero
Marrero, Louisiana, 70072, United States
Ascension Saint Agnes Heart Care
Baltimore, Maryland, 21229, United States
MD Medical Research
Oxon Hill, Maryland, 20745, United States
Velocity Clinical Research - Rockville
Rockville, Maryland, 20854, United States
Btc of New Bedford
New Bedford, Massachusetts, 02740, United States
Fairview Health Services M Health Fairview St Johns Hospital
Maplewood, Minnesota, 55109, United States
Minneapolis Heart Institute Foundation
Minneapolis, Minnesota, 55407, United States
Jackson Heart Clinic
Jackson, Mississippi, 39216, United States
Cardiology Associates of North Mississippi
Tupelo, Mississippi, 38801, United States
StudyMetrix Research
City of Saint Peters, Missouri, 63303, United States
Alliance for Multispecialty Research - Kansas City
Kansas City, Missouri, 64114, United States
Kansas City Veterans Affairs Medical Center
Kansas City, Missouri, 64128, United States
Saint Louis Heart and Vascular PC
St Louis, Missouri, 63136, United States
Bryan Heart
Lincoln, Nebraska, 68506, United States
University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States
Primary Clinical Research
Papillion, Nebraska, 68046, United States
Excel Clinical Research
Las Vegas, Nevada, 89109, United States
Vector Clinical Trials
Las Vegas, Nevada, 89128, United States
CardioMetabolic Collaborative Clinic
Somerset, New Jersey, 08873, United States
Velocity Clinical Research - Binghamton
Binghamton, New York, 13905, United States
Hudson Valley Cardiovascular Practice PC
Poughkeepsie, New York, 12601, United States
Rochester Clinical Research
Rochester, New York, 14609, United States
Saratoga Clinical Research, LLC
Saratoga Springs, New York, 12866, United States
Southgate Medical Group
West Seneca, New York, 14224, United States
Novant Health Heart and Vascular Institute
Charlotte, North Carolina, 28204, United States
Velocity Clinical Research - Durham
Durham, North Carolina, 27701, United States
Moses H Cone Memorial Hospital
Greensboro, North Carolina, 27401, United States
Monroe Biomedical Research
Monroe, North Carolina, 28112, United States
West Clinical Research
Morehead City, North Carolina, 28557, United States
Burke Primary Care Family Practice
Morganton, North Carolina, 28655, United States
Accellacare of Raleigh
Raleigh, North Carolina, 27609, United States
Accellacare of Piedmont Healthcare
Statesville, North Carolina, 28625, United States
Brookview Hills Research Associates Llc
Winston-Salem, North Carolina, 27103, United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
Velocity Clinical Research - Cleveland
Beachwood, Ohio, 44122, United States
Aultman Hospital, Cardiovascular Consultants, Inc
Canton, Ohio, 44710, United States
Velocity Clinical Research - Auburn
Cincinnati, Ohio, 45219, United States
Endocrinology Associates Inc
Columbus, Ohio, 43201, United States
Nexgen Research
Lima, Ohio, 45801, United States
Alliance for Multispecialty Research - Norman
Norman, Oklahoma, 73069, United States
Heritage Valley Multispecialty Group Inc
Beaver, Pennsylvania, 15009, United States
Capital Area Research LLC
Camp Hill, Pennsylvania, 17011, United States
Abington Medical Specialists
Horsham, Pennsylvania, 19044, United States
Velocity Clinical Research - Providence
East Greenwich, Rhode Island, 02818, United States
Accellacare Charleston
Mt. Pleasant, South Carolina, 29464, United States
Monument Health Clinical Research
Rapid City, South Dakota, 57701, United States
Stern Cardiovascular Foundation Inc
Germantown, Tennessee, 38138, United States
Accellacare of Knoxville
Knoxville, Tennessee, 37912, United States
Cardiovascular Research of Knoxville North Knoxville Medical Center
Powell, Tennessee, 37849, United States
Tennessee Center for Clinical Trials
Tullahoma, Tennessee, 37388, United States
PharmaTex Research, LLC
Amarillo, Texas, 79106, United States
Austin Heart
Austin, Texas, 78705, United States
Velocity Clinical Research - Austin
Austin, Texas, 78759, United States
Thyroid Endocrinology and Diabetes
Dallas, Texas, 75208, United States
Soltero Cardiovascular Research Center
Dallas, Texas, 75226, United States
Zenos Clinical Research
Dallas, Texas, 75230, United States
Cedar Health Research, LLC
Dallas, Texas, 75251, United States
University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
David Turbay, MD
El Paso, Texas, 79905, United States
Academy of Diabetes Thyroid and Endocrine
El Paso, Texas, 79935, United States
Biopharma Informatic, LLC
Houston, Texas, 77043, United States
Cardiovascular Specialists of Willowbrook
Houston, Texas, 77070, United States
PlanIt Research, PLLC
Houston, Texas, 77079, United States
Research Physicians Network, LLC
Houston, Texas, 77089, United States
Vital Heart and Vein
Humble, Texas, 77338, United States
Tcr Institute Llc
Kingwood, Texas, 77339, United States
Helium Research Group
Lake Jackson, Texas, 77566, United States
Epic Clinical Research
Lewisville, Texas, 75057, United States
Biopharma Informatic-McAllen
McAllen, Texas, 78503, United States
Southern Endocrinology Associates PA
Mesquite, Texas, 75149, United States
North Hills Medical Research
North Richland Hills, Texas, 76180, United States
Bandera Family Health Care
San Antonio, Texas, 78249, United States
Consano Clinical Research - Shavano Park
Shavano Park, Texas, 78231, United States
Sugar Lakes Family Practice
Sugar Land, Texas, 77479, United States
Wichita Falls Heart Clinic
Wichita Falls, Texas, 76301, United States
Boeson Research
Provo, Utah, 84604, United States
Velocity Clinical Research - Salt Lake City
West Jordan, Utah, 84088, United States
Inova Cardiology - Fairfax
Fairfax, Virginia, 22031, United States
Virginia Heart
Falls Church, Virginia, 22042, United States
VA Puget Sound Healthcare System
Seattle, Washington, 98108, United States
Velocity Clinical Research - Spokane
Spokane, Washington, 99218, United States
Vaught Neurological Services
Crab Orchard, West Virginia, 25827, United States
Aspirus Cardiovascular Associates
Wausau, Wisconsin, 54401, United States
Centro Medico Viamonte
CABA, Buenos Aires, 1120, Argentina
Imoba Investigaciones medicas
CABA, Buenos Aires, 1178, Argentina
Conexa Investigacion Clinica SA
CABA, Buenos Aires, C1012AAY, Argentina
Stat Research
CABA, Buenos Aires, C1023AAB, Argentina
Cedic - Centro de Investigacion Clinica
CABA, Buenos Aires, C1060ABN, Argentina
Cemedic Centro de Especialidades Medicas
CABA, Buenos Aires, C1407GTN, Argentina
Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada
CABA, Buenos Aires, C1425AGC, Argentina
Consultorios Medicos Dr Besada
CABA, Buenos Aires, C1426ABP, Argentina
Fundacion Respirar - Consultorios Medicos Dr Doreski
CABA, Buenos Aires, C1426ABP, Argentina
Glenny Corp SA
CABA, Buenos Aires, C1430CKE, Argentina
Cinme - Centro de Investigaciones Metabolicas
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1056ABI, Argentina
Ciprec - Centro de Investigacion y Prevencion Cardiovascular
Ciudad Autonoma de Buenos Aires, Buenos Aires, C1061AAT, Argentina
Hospital Italiano de La Plata
La Plata, Buenos Aires, B1900AUR, Argentina
Centro de Investigaciones Medicas Mar del Plata
Mar del Plata, Buenos Aires, B7600DHK, Argentina
Instituto de Investigaciones clinicas de Mar del Plata
Mar del Plata, Buenos Aires, B7600FZN, Argentina
Dim Clinica Privada
Ramos Meija, Buenos Aires, B1704ETD, Argentina
Instituto de Investigaciones Clinicas de San Nicolas
San Nicolás de los Arroyos, Buenos Aires, 2900, Argentina
Go Centro Medico San Nicolas
Zárate, Buenos Aires, B2800DGH, Argentina
Instituto de Investigaciones Clinicas Zarate
Zárate, Buenos Aires, B2800DGH, Argentina
Centro Diabetologico Dr Waitman
Córdoba, Córdoba Province, 5000, Argentina
Clinica Privada del Prado
Córdoba, Córdoba Province, 5000, Argentina
Instituto Medico Rio Cuarto SA
Río Cuarto, Córdoba Province, X5800AEV, Argentina
Clinica Fusavim Privada SRL
Villa María, Córdoba Province, 5900, Argentina
mit - Medicina Investigacion y Tratamiento
Santa Rosa, La Pampa Province, L6304BWE, Argentina
CIPADi
Godoy Cruz, Mendoza Province, M5501ARP, Argentina
Instituto Medico Catamarca Imec
Rosario, Santa Fe Province, S2000AJU, Argentina
Centro Medico de Nutricion y Diabetes
CABA, C1440AAD, Argentina
Instituto Medico Damic
Córdoba, X5003DCE, Argentina
INECO Neurociencias Oronio
Rosario, S2000DSR, Argentina
Centro de Investigaciones Clinicas del Litoral
Santa Fe, S3000FWO, Argentina
Novatrials
Charlestown, New South Wales, 2290, Australia
Royal North Shore Hospital
St Leonards, New South Wales, 2065, Australia
Momentum Clinical Research - Darlinghurst
Sydney, New South Wales, 2010, Australia
Advara HeartCare Wesley
Auchenflower, Queensland, 4066, Australia
Royal Brisbane and Womens Hospital
Herston, Queensland, 4029, Australia
Core Research Group Pty Ltd
Milton, Queensland, 4064, Australia
Dr Heart Pty Ltd
Woolloongabba, Queensland, 4102, Australia
Flinders Medical Centre
Bedford Park, South Australia, 5042, Australia
Advara HeartCare Leabrook
Leabrook, South Australia, 5068, Australia
The Queen Elizabeth Hospital
Woodville South, South Australia, 5011, Australia
Victorian Heart Hospital
Clayton, Victoria, 3168, Australia
Barwon Health Geelong Hospital
Geelong, Victoria, 3220, Australia
Austin Health, Heidelberg Repatriation Hospital
Heidelberg West, Victoria, 3081, Australia
The Alfred Hospital
Melbourne, Victoria, 3004, Australia
Advara HeartCare Mulgrave
Mulgrave, Victoria, 3170, Australia
Advara HeartCare Joondalup
Joondalup, Western Australia, 6027, Australia
Fiona Stanley Hospital
Murdoch, Western Australia, 6150, Australia
Linear Clinical Research Limited
Nedlands, Western Australia, 6009, Australia
Landeskrankenhaus Feldkirch
Feldkirch, 6800, Austria
Medizinische Universitaet Graz
Graz, 8036, Austria
Klinikum Klagenfurt am Woerthersee
Klagenfurt, 9020, Austria
Krankenhaus der Barmherzigen Brueder Linz
Linz, 4021, Austria
Klinik Landstrasse
Vienna, 1030, Austria
Zentrum fuer klinische Studien - Dr Hanusch GmbH
Vienna, 1060, Austria
Universitaetsklinikum Allgemeines Krankenhaus Wien
Vienna, 1090, Austria
Klinik Hietzing
Vienna, 1130, Austria
Azorg Campus Aalst - Moorselbaan
Aalst, 9300, Belgium
Imelda Ziekenhuis vzw
Bonheiden, 2820, Belgium
Algemeen Ziekenhuis Sint-Jan Brugge
Bruges, 8000, Belgium
Cliniques universitaires de Bruxelles Hopital Erasme
Brussels, 1070, Belgium
Universitair Ziekenhuis Antwerpen
Edegem, 2650, Belgium
Ziekenhuis Oost-Limburg - Campus Sint-Jan
Genk, 3600, Belgium
Algemeen Ziekenhuis Sint Lucas
Ghent, 9000, Belgium
Centres Hospitaliers Universitaires - Helora - Hopital de La Louviere - Site Jolimont
La Louvière, 7100, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
Leuven, 3000, Belgium
Centre Hospitalier Universitaire de Liege - Sart Tilman
Liège, 4000, Belgium
AZ Oostende - Damiaan
Ostend, 8400, Belgium
Universite Catholique de Louvain Cliniques Universitaires de Mont-Godinne
Yvoir, 5530, Belgium
Centro de Pesquisas em Diabetes e Doencas Endocrino Metabolicas
Fortaleza, Ceará, 60430-350, Brazil
Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo
Vitória, Espírito Santo, 29055-450, Brazil
Hospital Ana Nery
Salvador, Estado de Bahia, 40301-155, Brazil
Inovace Pesquisa Clinica
Salvador, Estado de Bahia, 40301-155, Brazil
Instituto de Ensino e Pesquisa do Hospital do Coracao do Brasil
Brasília, Federal District, 70390-700, Brazil
Assoc Amparo Saude Ensin e Pesquisa
Brasília, Federal District, 71625-175, Brazil
NS Clinica De Endocrinologia E Diabetes - Cendi
Goiânia, Goiás, 74230-035, Brazil
Hospital das Clinicas da Universidade Federal de Goias
Goiânia, Goiás, 74605-020, Brazil
Hospital Universitario Maria Aparecida Pedrossian
Campo Grande, Mato Grosso do Sul, 79080-190, Brazil
Santa Casa de Misericordia de Belo Horizonte
Belo Horizonte, Minas Gerais, 30150-221, Brazil
Ccih - Consultoria em Controle de Infecção Hospitalar
Belo Horizonte, Minas Gerais, 30150-320, Brazil
Cardresearch Cardiologia Assistencial de Pesquisa
Belo Horizonte, Minas Gerais, 31110-580, Brazil
Eurolatino Pesquisas Medicas
Uberlândia, Minas Gerais, 38400-500, Brazil
Quanta Diagnostico por Imagem
Curitiba, Paraná, 80045-170, Brazil
Hospital Universitário João de Barros Barreto
Belém, Pará, 66073-005, Brazil
Hospital Agamenon Magalhaes
Recife, Pernambuco, 52051-380, Brazil
Instituto Atena de Pesquisa Clínica
Natal, Rio Grande do Norte, 59020-500, Brazil
Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90410-000, Brazil
Nucleo de Pesquisa do Rio Grande do Sul
Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
jmf Clinica do Coracao ltda
Aracaju, Sergipe, 49055-530, Brazil
Loema Instituto de Pesquisa Clinica e Consultores Ltda - Clinica Loema
Campinas, São Paulo, 13010-001, Brazil
Instituto de Pesquisa Clinica de Campinas - Ipecc
Campinas, São Paulo, 13060-080, Brazil
Instituto do Coracao de Marilia
Marília, São Paulo, 17515-000, Brazil
Praxis Pesquisa Medica
Santo André, São Paulo, 09090-790, Brazil
Cemec Centro Multidisciplinar Estudos Clinicos
São Bernardo do Campo, São Paulo, 09715-090, Brazil
Hospital de Base de Sao Jose do Rio Preto
São José do Rio Preto, São Paulo, 15090-000, Brazil
Ispem - Instituto Sao Jose dos Campos em Pesquisas Medicas
São José dos Campos, São Paulo, 12243-280, Brazil
Centro de Pesquisas Clinicas Cpclin
São Paulo, São Paulo, 01228-200, Brazil
Instituto de Molestias Cardiovasculares de Tatui
Tatuí, São Paulo, 18270-170, Brazil
Integral Pesquisa e Ensino
Votuporanga, São Paulo, 15501-405, Brazil
IBPClin Instituto Brasil de Pesquisa Clinica
Rio de Janeiro, 20241-180, Brazil
Ruschel Medicina e Pesquisa Clinica
Rio de Janeiro, 22270-060, Brazil
Br Trials - Ensaios Clínicos e Consultoria
São Paulo, 01236-030, Brazil
CPQuali Pesquisa Clinica Ltda
São Paulo, 01240-020, Brazil
Centro Paulista de Investigacao Clinica Cepic
São Paulo, 04266-010, Brazil
Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
São Paulo, 05403-000, Brazil
Multiprofile Hospital for Active Treatment Puls AD
Blagoevgrad, 2700, Bulgaria
Medical Center Doctor Staikov EOOD
Burgas, 8008, Bulgaria
Medical Center Medconsult Pleven OOD
Pleven, 5800, Bulgaria
Multiprofile Hospital for Active Treatment Heart and Brain EAD
Pleven, 5804, Bulgaria
Multiprofile Hospital for Active Treatment Sveta Karidad EAD
Plovdiv, 4004, Bulgaria
National Multiprofile Transport Hospital Tzar Boris III
Sofia, 1233, Bulgaria
University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
Sofia, 1527, Bulgaria
Military Medical Academy - Multiprofile Hospital for Active Treatment Sofia
Sofia, 1606, Bulgaria
University Multiprofile Hospital for Active Treatment and Emergency Medicine N I Pirogov EAD
Sofia, 1606, Bulgaria
Medical Center Dr Kalchev OOD
Sofia, 1700, Bulgaria
Janek Senaratne Professional Medical Corporation
Edmonton, Alberta, T6K 4C1, Canada
Vancouver General Hospital, Gordon and Leslie Diamond Health Care Centre
Vancouver, British Columbia, V5Z 1M9, Canada
Discovery Clinical Services Ltd
Victoria, British Columbia, V8T 5G4, Canada
G A Research Associates Limited
Moncton, New Brunswick, E1G 1A7, Canada
Centricity Research Brampton
Brampton, Ontario, L6S 0C6, Canada
Aggarwal and Associates Ltd
Brampton, Ontario, L6T 0G1, Canada
North York Diagnostic and Cardiac Centre
North York, Ontario, M6B 3H7, Canada
Heart Health Institute Research Incorporated
Scarborough Village, Ontario, M1B 4Z8, Canada
KMH Cardiology Centres Incorporated Hamilton
Stoney Creek, Ontario, L8J 3W2, Canada
Diabetes Heart Research Centre
Toronto, Ontario, M6G 1M2, Canada
Ecogene-21
Chicoutimi, Quebec, G7H 7K9, Canada
Montreal Heart Institute
Montreal, Quebec, H1T 1C8, Canada
Centre de Recherche du Centre Hospitalier de l Universite de Montreal
Montreal, Quebec, H2X 0C1, Canada
Research Institute of McGill University Health Center - Glen Site
Montreal, Quebec, H4A 3J1, Canada
Institut Universitaire de cardiologie et de pneumologie de Quebec
Québec, Quebec, G1V 4G5, Canada
Centre intégré de santé et service sociaux de Lanaudière
Saint-Charles-Borromée, Quebec, J6E 6J2, Canada
Hospital Las Higueras
Talcahuano, Biobio, 4260000, Chile
Centro de Investigacion Clinica del Sur
Temuco, Cautín, 4781156, Chile
Fundacion Innovacion Cardiovascular Clinica Ensenada
Independencia, Santiago Metropolitan, Chile
Enroll SpA
Providencia, Santiago Metropolitan, 7500587, Chile
Cinvec Estudios Clinicos quinta region Limitada
Viña del Mar, Valparaiso, 2520997, Chile
Biocinetic servicios medicos limitada
Santiago, 8320000, Chile
Clinical Research Chile SpA
Valdivia, 5110683, Chile
The First Affiliated Hospital of Bengbu Medical University
Bengbu, Anhui, 233300, China
Beijing Hospital
Beijing, Beijing Municipality, 100020, China
Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, 100050, China
Peking University Third Hospital
Beijing, Beijing Municipality, 100191, China
Beijing Tsinghua Changgung Hospital
Beijing, Beijing Municipality, 102218, China
Guangdong Provincial Peoples Hospital
Guangzhou, Guangdong, 510080, China
Sun Yat-sen Memorial Hospital Sun Yat-sen University
Guangzhou, Guangdong, 510120, China
Huizhou Central Peoples Hospital
Huizhou, Guangdong, 516001, China
The First Peoples Hospital of Yulin
Yulin, Guangxi, 537006, China
First Hospital of Qinhuangdao
Qinhuangdao, Hebei, 066099, China
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, 050000, China
The Fourth Hospital of Harbin Medical University
Harbin, Heilongjiang, 150001, China
The First Affiliated Hospital of Henan University of Science And Technology
Luoyang, Henan, 471000, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, 430022, China
The Second Xiangya Hospital of Central South University
Changsha, Hunan, 410011, China
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, 210011, China
Nanjing First Hospital
Nanjing, Jiangsu, 210012, China
Zhongda Hospital Southeast University
Nanjing, Jiangsu, 211000, China
Wuxi Peoples Hospital
Wuxi, Jiangsu, 214023, China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, 221006, China
Affiliated Hospital of Jiangsu University
Zhenjiang, Jiangsu, 212001, China
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006, China
The First Bethune Hospital of Jilin University
Changchun, Jilin, 130021, China
China Japan Union Hospital of Jilin University
Changchun, Jilin, 130033, China
The Peoples Hospital of Liaoning Province
Shenyang, Liaoning, 110016, China
Shaanxi Provincial Peoples Hospital
Xi'an, Shaanxi, 710068, China
Xi'an Daxing Hospital
Xi'an, Shaanxi, 710082, China
Jinan Central Hospital
Jinan, Shandong, 250013, China
Shanghai Ninth Peoples Hospital Affiliated Shanghai JiaoTong University School of Medicine
Shanghai, Shanghai Municipality, 200011, China
Zhongshan Hospital Fudan University
Shanghai, Shanghai Municipality, 200032, China
Shanghai Tenth Peoples Hospital
Shanghai, Shanghai Municipality, 200072, China
The Fifth Peoples Hospital of Shanghai, Fudan University
Shanghai, Shanghai Municipality, 200240, China
The First Affiliated Hospital of Xi An Jiao Tong University
Xi’an, Shanxi, 710061, China
West China Hospital Sichuan University
Chengdu, Sichuan, 610041, China
Chengdu Fifth Peoples Hospital
Chengdu, Sichuan, 611130, China
The Second Affiliated Hospital of Chongqing Medical University
Chongqing, Sichuan, 400010, China
Tianjin Peoples Hospital
Tianjin, Tianjin Municipality, 300121, China
Teda International Cardiovascular Hospital
Tianjin, Tianjin Municipality, 300457, China
The First Affiliated Hospital of Ningbo University
Ningbo, Zhejiang, 315010, China
Innera sro
Benešov, 256 01, Czechia
Medicentrum Beroun as
Beroun, 266 01, Czechia
MUDr Libor Nechvatal sro
Brno, 602 00, Czechia
Centrum pro zdravi sro
Brno, 603 00, Czechia
MUDr Karel Kamenik sro
Brno, 603 00, Czechia
Kardiologicka ambulance Brno sro
Brno, 612 00, Czechia
Fakultni nemocnice Brno
Brno, 625 00, Czechia
Vojenska nemocnice Brno
Brno, 636 00, Czechia
Amkardia sro
Brno, 639 00, Czechia
CorMedico sro
Bruntál, 792 01, Czechia
Kardio Chlumec sro
Chlumec nad Cidlinou, 503 51, Czechia
Ordinace pro choroby srdce sro
Chomutov, 430 02, Czechia
Dika centrum sro
Havirov - Mesto, 736 01, Czechia
Edumed sro
Hradec Králové, 500 02, Czechia
Nemocnice Jihlava po
Jihlava, 586 33, Czechia
Interna a diabetologie MUDr Vodickova sro
Liberec, 460 01, Czechia
Kardiologie - Liberec sro
Liberec, 460 01, Czechia
Edumed sro
Náchod, 547 01, Czechia
Interni a diabetologicka ordinace sro
Náchod, 547 01, Czechia
PreventaMed sro
Olomouc, 779 00, Czechia
Ostin sro
Ostrava, 700 30, Czechia
CCR Ostrava sro
Ostrava, 702 00, Czechia
MUDr Miroslav Koliba sro
Ostrava, 702 00, Czechia
Diahelp sro
Pardubice, 530 02, Czechia
Pratia Pardubice as
Pardubice, 530 02, Czechia
Kardiologie a Angiologie Praha sro - Komplexni Centrum Vyzkumu, Prevence a Lecby Kardiov Nemoci
Prague, 101 00, Czechia
Kardiologie a angiologie sro
Prague, 101 00, Czechia
Avicena - kardiologie, interna sro
Prague, 110 00, Czechia
Kardiologie Vinohrady sro
Prague, 110 00, Czechia
Kardiologie Vinohrady sro
Prague, 120 00, Czechia
Institut klinicke a experimentalni mediciny
Prague, 140 21, Czechia
Milan Kvapil sro
Prague, 149 00, Czechia
Restrial sro
Prague, 181 00, Czechia
Endokrinologie Cerny Most sro
Prague, 198 00, Czechia
Kardiologie Cor sro
Praha 10 - Zabehlice, 106 00, Czechia
MUDr Jarmila Otrubova
Prostějov, 796 01, Czechia
Kardio Vaclavik sro
Přerov, 750 02, Czechia
Nemocnice Slany
Slaný, 274 01, Czechia
MUDrych sro
Svitavy, 568 02, Czechia
Clinical Trials Service sro
Uherské Hradiště, 686 01, Czechia
Kardiologie - Usti nad Labem sro
Ústí nad Labem, 400 01, Czechia
Aalborg Universitetshospital
Aalborg, 9000, Denmark
Aarhus Universitetshospital
Aarhus N, 8200, Denmark
Esbjerg sygehus Syddansk universitetshospital
Esbjerg, 6700, Denmark
Sanos Gandrup
Gandrup, DK-9362, Denmark
Steno Diabetes Center Copenhagen
Herlev, 2730, Denmark
Regionshospitalet Gødstrup
Herning, 7400, Denmark
Holbaek Sygehus
Holbæk, 4300, Denmark
Hvidovre Hospital
Hvidovre, 2650, Denmark
Frederiksberg Hospital
København NV, 2400, Denmark
Amager Hospital
København S, 2300, Denmark
Sjaellands Universitetshospital, Roskilde
Roskilde, 4000, Denmark
Svendborg Sygehus
Svendborg, 5700, Denmark
Sanos Vejle
Vejle, 7100, Denmark
Helsinki University Hospital
Helsinki, 000290, Finland
Helsinki University Hospital
Helsinki, 00029, Finland
Studycor Oy
Jyväskylä, 40620, Finland
Health Step Finland
Kuopio, 70600, Finland
Oulu University Hospital
OYS, 90029, Finland
Tays sydankeskus oy
Tampere, 33520, Finland
Centre Hospitalier Regional Universitaire de Besancon - Hopital Jean Minjoz
Besançon, 25030, France
Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand
Dijon, 21079, France
Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon
Grenoble, 38700, France
Centre Hospitalier Louis Pasteur
Le Coudray, 28630, France
Hopital le Creusot
Le Creusot, 71200, France
Centre Hospitalier Saint Joseph Saint Luc
Lyon, 69007, France
Hopital de la Conception
Marseille, 13005, France
Centre Hospitalier Universitaire de Nice - Hopital Pasteur
Nice, 06000, France
Hopital Europeen Georges Pompidou
Paris, 75015, France
Hopital Bichat Claude Bernard
Paris, 75018, France
Centre Hospitalier Universitaire de Bordeaux - Hopital Haut Leveque
Pessac, 33604, France
Hospices Civils de Lyon - Centre Hospitalier Lyon Sud
Pierre-Bénite, 69495, France
Centre Hospitalier Regional Universitaire de Strasbourg - Hopital de Hautepierre
Strasbourg, 67000, France
Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil
Toulouse, 31059, France
Polyclinique Vauban
Valenciennes, 59300, France
Centre Hospitalier Universitaire de Nancy - Hopital de Brabois
Vandœuvre-lès-Nancy, 54511, France
Zentrum fuer klinische Studien Bad Homburg
Bad Homburg, 61348, Germany
Universitaets-Herzzentrum Freiburg - Bad Krozingen
Bad Krozingen, 79189, Germany
Universitaetsklinikum der Ruhr-Universitaet Bochum
Bad Oeynhausen, 32545, Germany
Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin
Berlin, 12203, Germany
Diabetespraxis Dr. Hermann Braun
Berlin, 13187, Germany
Charite - Universitaetsmedizin Berlin, Campus Virchow
Berlin, 13353, Germany
Berufsgenossenschaftliches Universitaetsklinikum Bergmannsheil gGmbH
Bochum, 44789, Germany
Universitaetsklinikum Bonn
Bonn, 53127, Germany
Klinikum Lippe
Detmold, 32756, Germany
Diabeteszentrum Dortmund
Dortmund, 44137, Germany
Sankt-Johannes-Hospital
Dortmund, 44137, Germany
Cardiologicum Dresden und Pirna Facharztpraxis für Kardiologie und Angiologie
Dresden, 01277, Germany
Universitaetsklinikum Dresden
Dresden, 01307, Germany
Zentrum fuer Klinische Studien Suedbrandenburg GmbH
Elsterwerda, 04910, Germany
Praxis am Markt Dr. Bernd Becker
Essen, 45355, Germany
Unterfrintroper Hausarztzentrum
Essen, 45359, Germany
Universitaetsklinikum Frankfurt
Frankfurt am Main, 60590, Germany
ClinPhenomics CVC GmbH
Frankfurt am Main, 60596, Germany
Universitaetsklinikum Hamburg-Eppendorf
Hamburg, 20251, Germany
Cardiologicum Hamburg GbR
Hamburg, 22041, Germany
Diabeteszentrum Hamburg West
Hamburg, 22607, Germany
Braun Ambulantes Herzzentrum Kassel
Kassel, 34121, Germany
Universitaetsklinikum Leipzig
Leipzig, 04103, Germany
AmBeNet GmbH
Leipzig, 04107, Germany
Universitaetsklinikum Schleswig-Holstein - Luebeck
Lübeck, 23538, Germany
Kardiologische Praxis Doktor Jens Taggeselle
Markkleeberg, 04416, Germany
Klinikum rechts der Isar der TUM
München, 80636, Germany
Centrum für Diagnostik und Gesundheit
München, 80809, Germany
Institut für Diabetesforschung Münster GmbH
Münster, 48145, Germany
Universitaetsklinikum Muenster
Münster, 48149, Germany
Praxis Segner - Dr. Braun - Kirsch
Oberwürzbach, 66386, Germany
Red-Institut GmbH
Oldenburg, 23758, Germany
Kardiologische Gemeinschaftspraxis Papenburg
Papenburg, 26871, Germany
Praxis Reinfeld Mitte Dr Joachim Weimer und Dr Katharina Pfeiffer
Reinfeld (Holstein), 23858, Germany
Praxis Dr med Ayham Al-Zoebi Facharzt fuer Innere Medizin und Kardiologie
Wermsdorf, 04779, Germany
University Hospital of Alexandroupolis
Alexandroupoli, 68100, Greece
Athens Naval Hospital
Athens, 11521, Greece
General Hospital for Thoracic Diseases of Athens "Sotiria"
Athens, 11527, Greece
General Hospital for Thoracic Diseases of Athens "Sotiria
Athens, 11527, Greece
General Hospital of Athens Ippokrateio
Athens, 11527, Greece
General Hospital of Athens Laiko
Athens, 11527, Greece
Alexandra Hospital
Athens, 11528, Greece
University General Hospital Attikon General Hospital Of West Attica H Agia Varvara
Athens, 12462, Greece
Hygeia Hospital
Athens, 15123, Greece
General Hospital Asklipieio Voulas
Athens, 16673, Greece
University Hospital of Ioannina
Ioannina, 45500, Greece
Ahepa University Hospital
Thessaloniki, 54636, Greece
University General Hospital of Thessaloniki Ahepa
Thessaloniki, 54636, Greece
Papageorgiou General Hospital of Thessaloniki
Thessaloniki, 56403, Greece
Queen Mary Hospital, The University of Hong Kong
Hong Kong, Hong Kong
Prince of Wales Hospital, Chinese University of Hong Kong
Shatin, New Territories, Hong Kong
Lausmed Kft
Baja, 6500, Hungary
DRC Gyogyszervizsgalo Kozpont Kft
Balatonfüred, 8230, Hungary
Tagore Medical Center
Balatonfüred, 8230, Hungary
Dr Lakatos Ferenc Private Cardiology Practice
Békéscsaba, 5600, Hungary
Trial Pharma Kft
Budapest, 1023, Hungary
Clinexpert Kft
Budapest, 1033, Hungary
Obudai Egeszsegugyi Centrum Kft
Budapest, 1036, Hungary
PVN Kutato Kft
Budapest, 1102, Hungary
Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika
Budapest, 1122, Hungary
Eszak-Pesti Centrum Korhaz - Honvedkorhaz
Budapest, 1134, Hungary
Budapesti Uzsoki Utcai Korhaz
Budapest, 1145, Hungary
Zugloi Egeszsegugyi Szolgalat
Budapest, 1148, Hungary
Strazsahegy Medicina Bt
Budapest, 1171, Hungary
Borvo Clinic Kft
Debrecen, 4025, Hungary
Debreceni Egyetem Klinikai Kozpont
Debrecen, 4032, Hungary
Obudai Egeszsegugyi Centrum Kft
Dunaújváros, 2400, Hungary
Gyongyosi Bugat Pal Korhaz
Gyöngyös, 3200, Hungary
BKS Research Kft
Hatvan, 3000, Hungary
Obudai Egeszsegugyi Centrum Kft
Kaposvár, 7400, Hungary
Trial Pharma Kft
Kecskemét, 6000, Hungary
Komaromi Selye Janos Korhaz
Komárom, 2921, Hungary
Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatokorhaz
Miskolc, 3526, Hungary
IPR Hungary Kft
Miskolc, 3530, Hungary
Borbanya Praxis Egeszsegugyi Kft
Nyíregyháza, 4405, Hungary
Dr Nagy Laszlo Kardiologiai maganrendeles es SMO
Orosháza, 5900, Hungary
COROMED-SMO Kft
Pécs, 7623, Hungary
DaVinci Maganklinika
Pécs, 7635, Hungary
KomplexLabor Diagnosztika Kft
Szeged, 6724, Hungary
Complex Rendelo Med Zrt
Székesfehérvár, 8000, Hungary
Obudai Egeszsegugyi Centrum Kft
Zalaegerszeg, 8900, Hungary
Azienda Unita Locale Socio Sanitaria Berica 8 Ospedale Cazzavillan
Arzignano, 36071, Italy
Azienda Ospedaliera Sant Anna e San Sebastiano
Caserta, 81100, Italy
Casa della salute Ceccano Ospedale
Ceccano, 03023, Italy
Ospedale Santissima Annunziata
Chieti, 66100, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia
Foggia, 71122, Italy
Azienda Sanitaria Locale Abruzzo 1 Avezzano, Sulmona e L'Aquila - Ospedale regionale San Salvatore
L’Aquila, 67100, Italy
IRCCS Ospedale San Raffaele
Milan, 20132, Italy
IRCCS Centro Cardiologico Monzino
Milan, 20138, Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milan, 20162, Italy
Azienda Unita Sanitaria Locale Romagna
Rimini, 47923, Italy
Policlinico Universitario Campus Biomedico
Roma, 00128, Italy
Azienda Ospedaliera Ordine Mauriziano di Torino
Torino, 10128, Italy
Chubu Rosai Hospital
Nagoya, Aichi-ken, 455-8530, Japan
Fujita Health University Hospital
Toyoake-shi, Aichi-ken, 470-1192, Japan
Miyanosawa Clinic of Internal Medicine and Cardiology
Sapporo, Hokkaido, 063-0826, Japan
Nakakinen Clinic
Naka, Ibaraki, 311-0113, Japan
JA Toride Medical Center
Toride-shi, Ibaraki, 302-0022, Japan
Tsuchiura Kyodo General Hospital
Tsuchiura-shi, Ibaraki, 300-0028, Japan
Ishikawa Prefectural Central Hospital
Kanazawa, Ishikawa-ken, 920-8530, Japan
National Hospital Organization Kanazawa Medical Center
Kanazawa, Ishikawa-ken, 920-8650, Japan
Takamatsu Red Cross Hospital
Takamatsu, Kagawa-ken, 760-0017, Japan
Kagawa Prefectural Central Hospital
Takamatsu, Kagawa-ken, 760-8557, Japan
Tenyoukai Central Clinic
Kagoshima, Kagoshima-ken, 892-0822, Japan
Saiseikai Yokohamashi Tobu Hospital
Yokohama, Kanagawa, 230-8765, Japan
Yokohama Minami Kyousai Hospital
Yokohama, Kanagawa, 236-0037, Japan
Kumamoto University Hospital
Kumamoto, Kumamoto, 860-8556, Japan
Rakuwakai Otowa Hospital
Kyoto, Kyoto, 607-8062, Japan
KKR Tohoku Kosai Hospital
Sendai, Miyagi, 980-0803, Japan
Miyazaki Medical Association Hospital
Miyazaki, Miyazaki, 880-2102, Japan
Oita Red Cross Hospital
Ōita, Oita Prefecture, 870-0033, Japan
Okayama Rosai Hospital
Okayama, Okayama-ken, 702-8055, Japan
Urasoe General Hospital
Urasoe-shi, Okinawa, 901-2102, Japan
Saiseikai Senri Hospital
Suita-shi, Osaka, 565-0862, Japan
Medical corporation Sekishin-kai Saitama Sekishinkai Hospital
Sayama-shi, Saitama, 350-1305, Japan
Sayama Renal Clinic
Sayama-shi, Saitama, 350-1305, Japan
Japanese Red Cross Hamamatsu Hospital
Hamamatsu, Shizuoka, 434-8533, Japan
Medical Corporation Kenshinkai Minamino Cardiovascular Hospital
Hachioji-shi, Tokyo, 192-0918, Japan
Affiliated Central Clinic of Higashiyamato Hospital
Higashiyamato-shi, Tokyo, 207-0014, Japan
Teikyo University Hospital
Itabashi-ku, Tokyo, 173-8606, Japan
Tokyo Saiseikai Central Hospital
Minato-ku, Tokyo, 108-0073, Japan
NewHeart Watanabe Institute
Suginami-ku, Tokyo, 168-0065, Japan
Sanin Rosai Hospital
Yonago-shi, Tottori, 683-8605, Japan
Tokuyama Central Hospital
Shunan-shi, Yamaguchi, 745-8522, Japan
Private Practice Dr. Francisco Padilla Padilla
Guadalajara, Jalisco, 44670, Mexico
Soluciones Terapeuticas Medico Quirurgicas
Mexico City, Mexico City, 03650, Mexico
Instituto de Diabetes Obesidad y Nutricion
Cuernavaca, Morelos, 62250, Mexico
Cardiolink Clin Trials
Monterrey, Nuevo León, 64060, Mexico
Unidad Biomedica Avanzada Monterrey
Monterrey, Nuevo León, 64460, Mexico
Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC
Culiacán, Sinaloa, 80230, Mexico
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares SC
Tampico, Tamaulipas, 89000, Mexico
Medical Care and Research Sociedad Anonima
Mérida, Yucatán, 97070, Mexico
Centro de Estudios Clinicos de Queretaro
Querétaro, 76000, Mexico
Sociedad de Metabolismo y Corazon
Veracruz, 91855, Mexico
Noordwest Ziekenhuisgroep
Alkmaar, 1815 JD, Netherlands
Ziekenhuisgroep Twente
Almelo, 7609 PP, Netherlands
EB Medical Research
Almere Stad, 1311 RL, Netherlands
Meander Medisch Centrum
Amersfoort, 3813 TZ, Netherlands
Ziekenhuis Amstelland
Amstelveen, 1186 AM, Netherlands
Onze Lieve Vrouwe Gasthuis
Amsterdam, 1091 AC, Netherlands
Amsterdam Universitair Medisch Centrum
Amsterdam, 1105 AZ, Netherlands
Gelre Ziekenhuizen
Apeldoorn, 7334 DZ, Netherlands
Rijnstate Ziekenhuis
Arnhem, 6815 AD, Netherlands
Amphia ziekenhuis
Breda, 4818 CK, Netherlands
Reinier de Graaf Gasthuis
Delft, 2625 AD, Netherlands
Deventer Ziekenhuis
Deventer, 7416 SE, Netherlands
Slingeland Ziekenhuis
Doetinchem, 7009 BL, Netherlands
Albert Schweitzer Ziekenhuis location Dordwijk
Dordrecht, 3318 AT, Netherlands
Albert Schweitzer Ziekenhuis, Locatie Dordwijk
Dordrecht, 3318 AT, Netherlands
Catharina Ziekenhuis
Eindhoven, 5623 EJ, Netherlands
Spaarne Gasthuis, locatie Haarlem Zuid
Haarlem, 2035 RC, Netherlands
Sint Jansdal Ziekenhuis
Harderwijk, 3844 DG, Netherlands
Elkerliek Ziekenhuis
Helmond, 5707 HA, Netherlands
Tergooiziekenhuizen, locatie Hilversum
Hilversum, 1213 XZ, Netherlands
Bethesda Diabetes Research Center
Hoogeveen, 7909 AA, Netherlands
Frisius Medisch Centrum, locatie Leeuwarden
Leeuwarden, 8934 AD, Netherlands
Leids Universitair Medisch Centrum
Leiden, 2333 ZA, Netherlands
Radboud Universitair Medisch Centrum
Nijmegen, 6525 GA, Netherlands
Erasmus Medisch Centrum
Rotterdam, 3015 GD, Netherlands
Ikazia Ziekenhuis
Rotterdam, 3083 AN, Netherlands
D and A Research and Genetics
Sneek, 8601 ZR, Netherlands
Haga Ziekenhuis
The Hague, 2545 AA, Netherlands
Ziekenhuis Rivierenland
Tiel, 4002 WP, Netherlands
Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX, Netherlands
VieCuri Medisch Centrum
Venlo, 5912 BL, Netherlands
Niepubliczny Zaklad Opieki Zdrowotnej Vita Diabetica Malgorzata Buraczyk
Bialystok, 15-879, Poland
American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
Bielsko-Biala, 43-316, Poland
Centrum Medyczne Kermed - Renata Bijata-Bronisz i Ewa Kowalinska Spolka Jawna
Bydgoszcz, 85-231, Poland
Centrum Medyczne Lukamed Spzoo
Chojnice, 89-600, Poland
American Heart of Poland Spolka Akcyjna
Chrzanów, 32-500, Poland
Etg Lublin Spzoo
Dębica, 39-200, Poland
Futuremeds Spolka z ograniczona odpowiedzialnoscia
Gdynia, 81-384, Poland
Emc Silesia Spolka z ograniczona odpowiedzialnoscia
Katowice, 40-353, Poland
Salvia-Lekston i Madej Spolka Jawna
Katowice, 40-772, Poland
American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
Kędzierzyn-Koźle, 47-200, Poland
Medyczne Centrum Diabetologiczno-Endokrynologiczno-Metaboliczne Diab-Endo-Met Sp zoo
Krakow, 31-261, Poland
Unicardia And Unimedica And Uniestetica
Krakow, 31-271, Poland
Futuremeds spolka z ograniczona odpowiedzialnoscia
Krakow, 31-501, Poland
Beata Miklaszewicz i Dariusz Dabrowski Cardiamed Spolka Jawna
Legnica, 59-220, Poland
Futuremeds spolka z ograniczona odpowiedzialnoscia
Lodz, 91-363, Poland
Clinical Best Solutions Sp zoo Spolka Komandytowa Gabinet Lekarski
Lublin, 20-011, Poland
Ekamed Spolka z Ograniczona Odpowiedzialnoscia
Lublin, 20-718, Poland
Futuremeds spolka z ograniczona odpowiedzialnoscia
Olsztyn, 10-165, Poland
Uniwersytecki Szpital Kliniczny w Opolu
Opole, 45-401, Poland
G and G Medvision Spolka z ograniczona odpowiedzialnoscia
Oświęcim, 32-600, Poland
Centrum Zdrowia Metabolicznego Pawel Bogdanski
Poznan, 60-589, Poland
Praktyka Lekarska Ewa Krzyzagorska
Poznan, 61-655, Poland
Centrum Medyczne Medyk Spolka z Ograniczona Odpowiedzialnoscia Spolka Komandytowa
Rzeszów, 35-055, Poland
Nowe Zdrowie-Ck Kieltucki i Wspolnicy Spolka Jawna
Staszów, 28-200, Poland
Osrodek Badan Klinicznych Labmed Sp zoo
Szczecin, 71-526, Poland
Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M Zabowka E Zabowka Spolka cywilna
Tarnów, 33-100, Poland
Metabolica Spolka z Ograniczona Odpowiedzialnoscia
Tarnów, 33-100, Poland
Praktyka Lekarska Lidia Pawlowicz
Torun, 87-100, Poland
Wojewodzki Szpital Zespolony im L Rydygiera w Toruniu
Torun, 87-100, Poland
American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca
Tychy, 43-100, Poland
Futuremeds Spolka z ograniczona odpowiedzialnoscia
Warsaw, 00-215, Poland
Clinical Best Solutions Sp zoo Spolka komandytowa
Warsaw, 00-710, Poland
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji
Warsaw, 02-507, Poland
Szpital Grochowski imienia Doktora medycyny Rafala Masztaka Spzoo
Warsaw, 04-073, Poland
Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy
Warsaw, 04-635, Poland
4 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ we Wroclawiu
Wroclaw, 50-981, Poland
Futuremeds spolka z ograniczona odpowiedzialnoscia
Wroclaw, 53-673, Poland
Velocity Nova Sp zoo Velocity Zamosc
Zamość, 22-400, Poland
Halina Serafin NZOZ Centrum Medyczne "Serafin-Med"
Żarów, 58-130, Poland
Unidade Local de Saude de Braga, EPE
Braga, 4710-243, Portugal
Unidade Local de Saude de Lisboa Ocidental, EPE - Hospital de Santa Cruz
Carnaxide, 2790-134, Portugal
Unidade Local de Saude de Coimbra, EPE
Coimbra, 3000-075, Portugal
Unidade Local de Saude do Alto Ave, EPE
Guimarães, 4835-044, Portugal
Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria
Lisbon, 1649-035, Portugal
Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano
Matosinhos Municipality, 4464-513, Portugal
Ucardio - Centro Clinico Cardiovascular
Riachos, Torres Novas, 2350-325, Portugal
Unidade Local de Saude de Entre Douro e Vouga, EPE - Hospital de Sao Sebastiao
Santa Maria da Feira, 4520-211, Portugal
Unidade Local de Saude de Gaia-Espinho, EPE
Vila Nova de Gaia, 4430-502, Portugal
Research and Cardiovascular
Ponce, 00717, Puerto Rico
Cardioplus Center SRL
Baia Mare, 430124, Romania
cmi Pop Lavinia
Baia Mare, 430222, Romania
Mariodiab Clinic SRL
Brasov, 500101, Romania
Thera Card SRL
Brasov, 500102, Romania
Centrul Medical de Diagnostic si Tratament Ambulator Neomed
Brasov, 500283, Romania
Geea Medical Easy Diet
Bucharest, 010627, Romania
Centrul pentru Studiul Metabolismului - Hightech Medical Services SRL
Bucharest, 011053, Romania
Institutul National de Diabet si Nutritie si Boli Metabolice N C Paulescu
Bucharest, 030167, Romania
Spitalul Universitar de Urgenta Bucuresti
Bucharest, 050098, Romania
Milena Sante
Galati, 800001, Romania
Consultmed SRL
Iași, 700544, Romania
Diabdana SRL
Oradea, 410147, Romania
Clinica Korall
Satu Mare, 440055, Romania
Mediab SRL
Târgu Mureş, 540142, Romania
Cabinet Medical Individual Dr Podoleanu Cristian
Târgu Mureş, 540143, Romania
Sengkang General Hospital
Singapore, Sengkang, 544886, Singapore
National University Hospital
Singapore, 119074, Singapore
National Heart Centre Singapore
Singapore, 169609, Singapore
Tan Tock Seng Hospital
Singapore, 308433, Singapore
Changi General Hospital
Singapore, 529889, Singapore
Ng Teng Fong General Hospital
Singapore, 690606, Singapore
Alian, sro
Bardejov, 085 01, Slovakia
MediTask, sro
Bratislava, 831 03, Slovakia
Novate sro
Bratislava, 841 04, Slovakia
Medispektrum sro
Bratislava, 851 01, Slovakia
Medical group Kosice sro
Košice, 040 01, Slovakia
Cardio D and R, sro Kosice
Košice, 040 22, Slovakia
Kardio 1 sro
Lučenec, 984 01, Slovakia
MediVet, sro
Malacky, 901 01, Slovakia
Nemocnicna as
Malacky, 901 22, Slovakia
Nemocnica s poliklinikou Stefana Kukuru Michalovce, as
Michalovce, 071 01, Slovakia
Oralek, sro
Námestovo, 029 01, Slovakia
InterStom, sro
Nitra, 949 11, Slovakia
Intermedis sro
Prešov, 080 01, Slovakia
Medispol, sro
Prešov, 080 01, Slovakia
Tatratrial sro
Rožňava, 048 01, Slovakia
Medi-Dia sro
Sabinov, 083 01, Slovakia
Interna SK, sro
Svidník, 089 01, Slovakia
Pentes, sro
Žilina, 010 01, Slovakia
Daegu Catholic University Medical Center
Daegu, 42472, South Korea
Keimyung University Dongsan Medical Center
Daegu, 42601, South Korea
Myongji Hospital
Goyang-si, Gyeonggi-do, 10475, South Korea
Gachon University Gil Medical Center
Incheon, 21565, South Korea
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620, South Korea
Kyung Hee University Hospital
Seoul, 02447, South Korea
Korea University Anam Hospital
Seoul, 02841, South Korea
Seoul National University Hospital
Seoul, 03080, South Korea
Kangbuk Samsung Hospital
Seoul, 03181, South Korea
Severance Hospital Yonsei University Health System
Seoul, 03722, South Korea
Kyung Hee University Hospital at Gangdong
Seoul, 05278, South Korea
The Catholic University of Korea Seoul St Marys Hospital
Seoul, 06591, South Korea
Ulsan University Hospital
Ulsan, 44033, South Korea
Yonsei University Wonju Severance Christian Hospital
Wonju-si, Gangwon-do, 26426, South Korea
Hospital Vithas Sevilla
Castilleja de la Cuesta, Andalusia, 41950, Spain
Hospital Universitario Reina Sofia
Córdoba, Andalusia, 14004, Spain
Complejo Hospitalario de Jaen
Jaén, Andalusia, 23007, Spain
Hospital QuironSalud Malaga
Málaga, Andalusia, 29004, Spain
Hospital Clinico Universitario Virgen de la Victoria
Málaga, Andalusia, 29010, Spain
Hospital Regional Universitario de Malaga
Málaga, Andalusia, 29010, Spain
Nuevas Tecnologias en Diabetes y Endocrinologia
Seville, Andalusia, 41003, Spain
Hospital Universitario Virgen del Rocio
Seville, Andalusia, 41013, Spain
Hospital Universitario de Canarias
San Cristóbal de La Laguna, Canary Islands, 38320, Spain
Hospital Universitario Marques de Valdecilla
Santander, Cantabria, 39008, Spain
Hospital Universitari Germans Trias i Pujol
Badalona, Catalonia, 08916, Spain
Hospital Universitari Vall d Hebron
Barcelona, Catalonia, 08035, Spain
Hospital Clinic i Provincial de Barcelona
Barcelona, Catalonia, 08036, Spain
Hospital Universitari Sant Joan de Reus
Reus, Catalonia, 43204, Spain
Hospital Universitario de Badajoz
Badajoz, Extremadura, 06008, Spain
Complexo Hospitalario Universitario A Coruña
A Coruña, Galicia, 15006, Spain
Complexo Hospitalario Universitario de Ferrol Hospital Universitario Arquitecto Marcide
Ferrol, Galicia, 15405, Spain
Hospital Clinico Universitario de Santiago
Santiago de Compostela, Galicia, 15706, Spain
Hospital Alvaro Cunqueiro
Vigo, Galicia, 36312, Spain
Hospital Quiron Madrid
Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario Virgen de la Arrixaca
El Palmar, Murcia, 30120, Spain
Hospital de Navarra
Pamplona, Navarre, 31008, Spain
Hospital Universitario Central de Asturias
Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario de La Ribera
Alzira, Valencia, 46600, Spain
Hospital Clinico Universitario de Valencia
Valencia, Valencia, 46010, Spain
Hospital Universitario de Leon
León, 24008, Spain
FutureMeds Madrid
Madrid, 28003, Spain
Hospital General Universitario Gregorio Marañon
Madrid, 28007, Spain
Hospital Universitario Sanitas la Zarzuela
Madrid, 28023, Spain
Hospital Universitario Ramon y Cajal
Madrid, 28034, Spain
Hospital Clinico San Carlos
Madrid, 28040, Spain
Hospital Quironsalud Infanta Luisa
Seville, 41010, Spain
Hospital Universitario Doctor Peset
Valencia, 46017, Spain
Falu Lasarett
Falun, 791 82, Sweden
Sahlgrenska Universitetssjukhus
Gothenburg, 413 45, Sweden
Helsingborgs Lasarett
Helsingborg, 251 87, Sweden
Linkopings Universitetssjukhus
Linköping, 581 85, Sweden
Clemenstorgets Hjartmottagning
Lund, 222 21, Sweden
Orebros Universitetssjukhus
Örebro, 703 62, Sweden
Karolinska Universitetssjukhuset Solna
Stockholm, 171 64, Sweden
Universitaetsspital Basel
Basel, 4031, Switzerland
Inselspital Bern
Bern, 3010, Switzerland
Hopitaux Universitaires de Geneve
Geneva, 1211, Switzerland
Istituto Cardiocentro Ticino
Lugano, 6900, Switzerland
Universitaetsspital Zuerich
Zurich, 8091, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 80756, Taiwan
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, 83301, Taiwan
Taichung Veterans General Hospital
Taichung, 40705, Taiwan
National Taiwan University Hospital
Taipei, 10002, Taiwan
Taipei Medical University Hospital
Taipei, 11031, Taiwan
Shin Kong Wu Ho-Su Memorial Hospital
Taipei, 11101, Taiwan
Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation
Taoyuan District, 33305, Taiwan
Yuregir Baskent Hastanesi
Adana, 01250, Turkey (Türkiye)
Adana Sehir Egitim ve Arastirma Hastanesi
Adana, 01370, Turkey (Türkiye)
Afyonkarahisar Saglik Bilimleri Universitesi Hastanesi
Afyonkarahisar, 03218, Turkey (Türkiye)
Ankara Bilkent Sehir Hastanesi
Ankara, 06800, Turkey (Türkiye)
Akdeniz Universitesi Tip Fakultesi
Antalya, 07058, Turkey (Türkiye)
Bursa Yuksek Ihtisas Egitim ve Arastirma Hastanesi
Bursa, 16310, Turkey (Türkiye)
Pamukkale Universitesi Tip Fakultesi Hastanesi
Denizli, 20160, Turkey (Türkiye)
Koc Universitesi Hastanesi
Istanbul, 34010, Turkey (Türkiye)
Istanbul Universitesi Cerrahpasa Tip Fakultesi
Istanbul, 34096, Turkey (Türkiye)
Bagcilar Medipol Mega Universite Hastanesi
Istanbul, 34214, Turkey (Türkiye)
Sultangazi Haseki Egitim ve Arastirma Hastanesi
Istanbul, 34265, Turkey (Türkiye)
Kanuni Sultan Suleyman Egitim ve Arastirma Hastanesi
Istanbul, 34303, Turkey (Türkiye)
Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi
Istanbul, 34722, Turkey (Türkiye)
Marmara Universitesi Tip Fakultesi Pendik Egitim ve Arastirma Hastanesi
Istanbul, 34854, Turkey (Türkiye)
Ege Universitesi Tip Fakultesi Hastanesi
Izmir, 35100, Turkey (Türkiye)
Izmir Sehir Hastanesi
Izmir, 35540, Turkey (Türkiye)
Erciyes Universitesi Tip Fakultesi Hastanesi
Kayseri, 38039, Turkey (Türkiye)
Kocaeli Universitesi Tip Fakultesi Hastanesi
Kocaeli, 41380, Turkey (Türkiye)
Inonu Universitesi Turgut Ozal Tip Merkezi
Malatya, 44280, Turkey (Türkiye)
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
Samsun, 55320, Turkey (Türkiye)
Heartlands Hospital
Birmingham, B9 5SS, United Kingdom
Waterloo Medical Centre
Blackpool, FY4 3AD, United Kingdom
Southmead Hospital
Bristol, BS10 5NB, United Kingdom
West Walk Surgery
Bristol, BS37 4AX, United Kingdom
Addenbrookes Hospital
Cambridge, CB2 0QQ, United Kingdom
Countess of Chester Hospital
Chester, CH2 1UL, United Kingdom
University Hospital Coventry
Coventry, CV2 2DX, United Kingdom
Russell Hall Hospital
Dudley, DY1 2HQ, United Kingdom
Ninewells Hospital and Medical School
Dundee, DD1 9SY, United Kingdom
Staploe Medical Centre
Ely, CB7 5JD, United Kingdom
Royal Devon and Exeter Hospital
Exeter, EX2 5DW, United Kingdom
Glasgow Royal Infirmary
Glasgow, G31 2ER, United Kingdom
Wycombe Hospital
High Wycombe, HP11 2TT, United Kingdom
Hull Royal Infirmary
Hull, HU3 2JZ, United Kingdom
Glenfield Hospital
Leicester, LE3 9QP, United Kingdom
Queen Mary University of London
London, EC1M 6BQ, United Kingdom
Chelsea and Westminster Hospital
London, SW10 9NH, United Kingdom
St Georges Hospital
London, SW17 0QT, United Kingdom
Northenden Group Practice
Manchester, M22 4DH, United Kingdom
Newcastle NIHR Commercial Research Delivery Centre
Newcastle, NE1 4LP, United Kingdom
University Hospital Llandough
Penarth, CF64 2XX, United Kingdom
Salford Royal Hospital
Salford, M5 5AP, United Kingdom
Lister Hospital
Stevenage, SG1 4AB, United Kingdom
Morriston Hospital
Swansea, SA2 8PP, United Kingdom
Musgrove Park Hospital
Taunton, TA1 5DA, United Kingdom
Torbay Hospital
Torquay, TQ2 7AA, United Kingdom
Bradford on Avon and Melksham Health Partnership
Wiltshire, BA15 1DQ, United Kingdom
Worcestershire Royal Hospital
Worcester, WR5 1DD, United Kingdom
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
MD
Amgen
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 16, 2025
First Posted
June 25, 2025
Study Start
July 25, 2025
Primary Completion (Estimated)
June 30, 2028
Study Completion (Estimated)
September 29, 2030
Last Updated
April 24, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, ICF, CSR
- Time Frame
- Data sharing requests relating to this trial will be considered beginning 18 months after the trial has ended and either 1) the product and indication (or other new use) have been granted marketing authorization in both the US and Europe, or 2) clinical development for the product and/or indication discontinues and the data will not be submitted to regulatory authorities. There is no end date for eligibility to submit a data sharing request for this trial.
- Access Criteria
- Qualified researchers may submit a request containing the research objectives, the Amgen product(s) and Amgen trial/trials in scope, endpoints/outcomes of interest, statistical analysis plan, data requirements, publication plan, and qualifications of the researcher(s). In general, Amgen does not grant external requests for individual patient data for the purpose of re-evaluating safety and efficacy issues already addressed in the product labelling. Requests are reviewed by a committee of internal advisors, and if not approved, may be further arbitrated by a Data Sharing Independent Review Panel. Upon approval, information necessary to address the research question will be provided under the terms of a data sharing agreement. This may include anonymized individual patient data and/or available supporting documents, containing fragments of analysis code where provided in analysis specifications. Further details are available at the URL below.
De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request.