NCT06858839

Brief Summary

The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
3,853

participants targeted

Target at P75+ for phase_3 obesity

Timeline
12mo left

Started Mar 2025

Geographic Reach
17 countries

243 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress55%
Mar 2025Apr 2027

First Submitted

Initial submission to the registry

February 28, 2025

Completed
5 days until next milestone

First Posted

Study publicly available on registry

March 5, 2025

Completed
7 days until next milestone

Study Start

First participant enrolled

March 12, 2025

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 21, 2027

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 16, 2027

Last Updated

October 20, 2025

Status Verified

October 1, 2025

Enrollment Period

1.9 years

First QC Date

February 28, 2025

Last Update Submit

October 15, 2025

Conditions

Keywords

OverweightBMIBody weightMaridebart cafraglutideChronic weight managementMariTide

Outcome Measures

Primary Outcomes (1)

  • Percent Change From Baseline in Body Weight at Week 72

    Baseline and Week 72

Secondary Outcomes (20)

  • Change From Baseline in Waist Circumference at Week 72

    Baseline and Week 72

  • Participant achieving ≥ 5% reduction in body weight from baseline at week 72

    Week 72

  • Participant achieving ≥ 10% reduction in body weight from baseline at week 72

    Week 72

  • Participant achieving ≥ 15% reduction in body weight from baseline at week 72

    Week 72

  • Participant achieving ≥ 20% reduction in body weight from baseline at week 72

    Week 72

  • +15 more secondary outcomes

Study Arms (4)

Maridebart Cafraglutide High Dose

EXPERIMENTAL

Participants will receive maridebart cafraglutide high dose subcutaneously (SC) for 72 weeks.

Drug: Maridebart Cafraglutide

Maridebart Cafraglutide Medium Dose

EXPERIMENTAL

Participants will receive maridebart cafraglutide medium dose SC for 72 weeks.

Drug: Maridebart Cafraglutide

Maridebart Cafraglutide Low Dose

EXPERIMENTAL

Participants will receive maridebart cafraglutide low dose SC for 72 weeks.

Drug: Maridebart Cafraglutide

Placebo

PLACEBO COMPARATOR

Participants will receive placebo SC for 72 weeks.

Drug: Placebo

Interventions

Maridebart cafraglutide will be administered SC.

Also known as: AMG 133, MariTide
Maridebart Cafraglutide High DoseMaridebart Cafraglutide Low DoseMaridebart Cafraglutide Medium Dose

Placebo will be administered SC.

Placebo

Eligibility Criteria

Age18 Years - 99 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age ≥ 18 years.
  • Body mass index ≥ 30 kg/m2 or ≥27 kg/m² to \< 30 kg/m2 with at least 1 of the following weight-related comorbidities: hypertension, dyslipidemia, history of obstructive sleep apnea, history of cardiovascular disease, history of metabolic dysfunction-associated steatotic liver disease (MASLD) or Metabolic Dysfunction-Associated Steatohepatitis (MASH).
  • History of at least 1 self-reported unsuccessful attempt at weight loss by diet and exercise.

You may not qualify if:

  • Type 1 or Typ2 diabetes mellitus.
  • Obesity induced by other endocrinologic disorders.
  • Self-reported change in body weight \> 5 kg within 90 days before screening.
  • Family (first-degree relative\[s\]) or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2.
  • History of chronic pancreatitis or history of acute pancreatitis within 180 days before screening.
  • History of unstable major depressive disorder (MDD) or other severe psychiatric disorder within 2 years before screening.
  • Lifetime history of suicide attempt.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (243)

Pinnacle Research Group LLC

Anniston, Alabama, 36207, United States

Location

Alliance For Multispecialty Research - Daphne

Daphne, Alabama, 36526, United States

Location

Alliance for Multispecialty Research Mobile

Mobile, Alabama, 36608, United States

Location

Avacare Foothills Research Center

Phoenix, Arizona, 85044, United States

Location

Ark Clinical Research- Tustin

Fountain Valley, California, 92708, United States

Location

Long Beach Clinical Trials Services Inc

Long Beach, California, 90806, United States

Location

Ark Clinical Research- Long Beach

Long Beach, California, 90815, United States

Location

Catalina Research Institute

Montclair, California, 91763, United States

Location

Artemis Institute for Clinical Research

Riverside, California, 92503, United States

Location

Artemis Institute for Clinical Research

San Diego, California, 92103, United States

Location

Apex Clinical Research

San Diego, California, 92120, United States

Location

Southern California Clinical Research

Santa Ana, California, 92701, United States

Location

Diablo Clinical Research

Walnut Creek, California, 94598, United States

Location

Yale School of Medicine

New Haven, Connecticut, 06520, United States

Location

Chase Medical Research LLC

Waterbury, Connecticut, 06708, United States

Location

Indago Research and Health Center

Hialeah, Florida, 33012, United States

Location

Jacksonville Center for Clinical Research

Jacksonville, Florida, 32216, United States

Location

Clinical Neuroscience Solutions - Jacksonville

Jacksonville, Florida, 32256, United States

Location

South Florida Wellness and Clinical Research Institute

Margate, Florida, 33063, United States

Location

Optimus U Corporation

Miami, Florida, 33135, United States

Location

Research Institute of South Florida

Miami, Florida, 33173, United States

Location

Renstar Medical Research

Ocala, Florida, 34470, United States

Location

Clinical Neuroscience Solutions - Orlando

Orlando, Florida, 32801, United States

Location

Combined Research Orlando Phase I IV

Orlando, Florida, 32807, United States

Location

Florida Institute for Clinical Research

Orlando, Florida, 32825, United States

Location

Encore Medical Research of Weston LLC

Weston, Florida, 33331, United States

Location

Center for Advanced Research and Education

Gainesville, Georgia, 30501, United States

Location

Rophe Adult and Pediatric Medicine/Sky Clinical Research Network Group

Union City, Georgia, 30291, United States

Location

East-West Medical Research

Honolulu, Hawaii, 96814, United States

Location

Solaris Clinical Research

Meridian, Idaho, 83646, United States

Location

Flourish Research - Great Lakes Clinical Trials

Chicago, Illinois, 60640, United States

Location

Endeavor Health Medical Group - Endocrinology and Diabetes- Skokie

Skokie, Illinois, 60077, United States

Location

Evanston Premier Healthcare Research LLC

Skokie, Illinois, 60077, United States

Location

Alliance for Multispecialty Research Newton

Newton, Kansas, 67114, United States

Location

Louisville Metabolic and Atherosclerosis Research Center

Louisville, Kentucky, 40213, United States

Location

Velocity Clinical Research - Baton Rouge

Baton Rouge, Louisiana, 70809, United States

Location

Tandem Clinical Research - Marrero

Marrero, Louisiana, 70072, United States

Location

Headlands Research - Detroit

Southfield, Michigan, 48034, United States

Location

Prime Health and Wellness Sky Clinical Research Network Group

Fayette, Mississippi, 39069, United States

Location

Alliance for Multispecialty Research - Kansas City

Kansas City, Missouri, 64114, United States

Location

Palm Research Center Inc

Las Vegas, Nevada, 89128, United States

Location

Vector Clinical Trials

Las Vegas, Nevada, 89128, United States

Location

Rochester Clinical Research

Rochester, New York, 14609, United States

Location

Velocity Clinical Research- Binghamton

Vestal, New York, 13850, United States

Location

Accellacare of Hickory

Hickory, North Carolina, 28601, United States

Location

Carolina Research Center Inc

Shelby, North Carolina, 28150, United States

Location

Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States

Location

Clinical Trial Investigator Clinical Research Center

Cincinnati, Ohio, 45212, United States

Location

Velocity Clinical Research - Cincinnati

Cincinnati, Ohio, 45219, United States

Location

Alliance for Multispecialty Research - Norman

Norman, Oklahoma, 73069, United States

Location

Capital Area Research LLC

Newport, Pennsylvania, 17074, United States

Location

Velocity Clinical Research - Providence

East Greenwich, Rhode Island, 02818, United States

Location

Tribe Clinical Research LLC Dba Mountain View Clinical Research

Greenville, South Carolina, 29607, United States

Location

New Phase Research and Development

Knoxville, Tennessee, 37909, United States

Location

Accellacare US Inc., d/b/a Accellacare of Knoxville

Knoxville, Tennessee, 37938, United States

Location

Elligo Clinical Research Center

Austin, Texas, 78704, United States

Location

Cedar Health Research, LLC

Dallas, Texas, 75251, United States

Location

Epic Medical Research - Texas

DeSoto, Texas, 75115, United States

Location

Great Lakes Research Institute El Paso Research

El Paso, Texas, 79936, United States

Location

Cedar Health Research, LLC

Euless, Texas, 76040, United States

Location

Juno Research LLC

Houston, Texas, 77040, United States

Location

Biopharma Informatic, LLC

Houston, Texas, 77043, United States

Location

Juno Research LLC

Houston, Texas, 77054, United States

Location

Southern Endocrinology Associates PA

Mesquite, Texas, 75149, United States

Location

Great Lakes Research Institute - McAllen Research

Pharr, Texas, 78557, United States

Location

Clinical Trials of Texas

San Antonio, Texas, 78229, United States

Location

Sugar Lakes Family Practice

Sugar Land, Texas, 77479, United States

Location

Pantheon Clinical Research

Bountiful, Utah, 84010, United States

Location

Alliance for Multispecialty Research Layton Research Center

Layton, Utah, 84041, United States

Location

Chrysalis Clinical Research, LLC

St. George, Utah, 84770, United States

Location

Washington Center for Weight Management and Research, Inc

Arlington, Virginia, 22206, United States

Location

Health Research of Hampton Roads

Newport News, Virginia, 23606, United States

Location

Selma Medical Associates

Winchester, Virginia, 22601, United States

Location

Allegiance Research Specialists

Milwaukee, Wisconsin, 53226, United States

Location

Cedic - Centro de Investigacion Clinica

CABA, Buenos Aires, 1060, Argentina

Location

Centro Medico Viamonte

CABA, Buenos Aires, 1120, Argentina

Location

Cemedic Centro de Especialidades Medicas

CABA, Buenos Aires, C1407GTN, Argentina

Location

Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada

CABA, Buenos Aires, C1425AGC, Argentina

Location

Consultorios Medicos Dr Besada

CABA, Buenos Aires, C1426ABP, Argentina

Location

Fundacion Respirar

CABA, Buenos Aires, C1426ABP, Argentina

Location

Cinme - Centro de Investigaciones Metabolicas

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1056ABI, Argentina

Location

Ciprec - Centro de Investigacion y Prevencion Cardiovascular

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1061AAT, Argentina

Location

Emeritus Research Sydney

Botany, New South Wales, 2019, Australia

Location

Novatrials

Charlestown, New South Wales, 2290, Australia

Location

Canopy Clinical Sutherland

Miranda, New South Wales, 2228, Australia

Location

Royal North Shore Hospital

St Leonards, New South Wales, 2065, Australia

Location

Canopy Clinical Wollongong

Wollongong, New South Wales, 2500, Australia

Location

Logan Hospital

Meadowbrook, Queensland, 4131, Australia

Location

Fusion Clinical Research

Norwood, South Australia, 5067, Australia

Location

Southern Adelaide Diabetes and Endocrine Services

Oaklands Park, South Australia, 5046, Australia

Location

Emeritus Research Camberwell

Camberwell, Victoria, 3124, Australia

Location

Austin Health, Heidelberg Repatriation Hospital

Heidelberg West, Victoria, 3081, Australia

Location

Canopy Clinical Altona North

North Altona, Victoria, 3025, Australia

Location

Universitair Ziekenhuis Antwerpen

Edegem, 2650, Belgium

Location

Universitair Ziekenhuis Gent

Ghent, 9000, Belgium

Location

Algemeen Ziekenhuis Groeninge - Campus Kennedylaan

Kortrijk, 8500, Belgium

Location

Universitair Ziekenhuis Leuven - Campus Gasthuisberg

Leuven, 3000, Belgium

Location

Centre Hospitalier Universitaire de Liege - Sart Tilman

Liège, 4000, Belgium

Location

Algemeen Ziekenhuis Sint-Maarten

Mechelen, 2800, Belgium

Location

Centres Hospitaliers Universitaires HELORA - Hôpital de Mons - Site Constantinople

Mons, 7000, Belgium

Location

tlc Diabetes and Endocrinology

Surrey, British Columbia, V3T 2V6, Canada

Location

Wharton Medical Clinic

Hamilton, Ontario, L8L 5G8, Canada

Location

North York Diagnostic and Cardiac Centre

North York, Ontario, M6B 3H7, Canada

Location

Centricity Research Oshawa Multispecialty

Oshawa, Ontario, L1J 2K9, Canada

Location

Heart Health Institute Research Incorporated

Scarborough Village, Ontario, M1B 4Z8, Canada

Location

Curans Heart Center

Thunder Bay, Ontario, P7B 5N3, Canada

Location

Centricity Research Toronto

Toronto, Ontario, M4G 3E8, Canada

Location

Diabetes Heart Research Centre

Toronto, Ontario, M6G 1M2, Canada

Location

Ecogene-21

Chicoutimi, Quebec, G7H 7K9, Canada

Location

Institut Universitaire de cardiologie et de pneumologie de Quebec

Québec, Quebec, G1V 4G5, Canada

Location

CardioVasc HR Incorporated

Saint-Jean-sur-Richelieu, Quebec, J3A 1J2, Canada

Location

Centre de Medecine Metabolique de Lanaudiere

Terrebonne, Quebec, J6X 4P7, Canada

Location

Medicus Services sro

Brandýs nad Labem, 250 01, Czechia

Location

Fakultni nemocnice Brno

Brno, 625 00, Czechia

Location

Endohope Havirov sro

Havířov, 736 01, Czechia

Location

PreventaMed sro

Olomouc, 779 00, Czechia

Location

CCR Ostrava sro

Ostrava, 702 00, Czechia

Location

Fakultni nemocnice Kralovske Vinohrady

Prague, 100 34, Czechia

Location

Vseobecna fakultni nemocnice v Praze

Prague, 128 08, Czechia

Location

Ob klinika as

Prague, 130 00, Czechia

Location

Institut klinicke a experimentalni mediciny

Prague, 140 21, Czechia

Location

Endohope klinika sro

Prague, 150 00, Czechia

Location

Endokrinologie Cerny Most sro

Prague, 198 00, Czechia

Location

Sanos Gandrup

Gandrup, 9362, Denmark

Location

Gentofte Hospital

Hellerup, 2900, Denmark

Location

Sanos Clinic

Herlev, 2730, Denmark

Location

Steno Diabetes Center Copenhagen

Herlev, 2730, Denmark

Location

Regionshospitalet Godstrup

Herning, 7400, Denmark

Location

Hvidovre Hospital

Hvidovre, 2650, Denmark

Location

Obesity Research Unit

Helsinki, 02290, Finland

Location

Health Step Finland

Kuopio, 70211, Finland

Location

Oulu University Hospital

Oulu, 90220, Finland

Location

Universitaetsklinikum Aachen

Aachen, 52074, Germany

Location

Kardiologische Praxis Dr med Wolfgang Jungmair

Bad Homburg, 61348, Germany

Location

Universitaets-Herzzentrum Freiburg - Bad Krozingen

Bad Krozingen, 79189, Germany

Location

Diabetespraxis Bad Mergentheim

Bad Mergentheim, 97980, Germany

Location

Universitaetsklinikum der Ruhr-Universitaet Bochum

Bad Oeynhausen, 32545, Germany

Location

Charite - Universitaetsmedizin Berlin, Campus Mitte

Berlin, 10117, Germany

Location

Velocity Clinical Research GmbH

Berlin, 10787, Germany

Location

Diabetespraxis Dr. Hermann Braun

Berlin, 13187, Germany

Location

Mvz am Bahnhof Spandau

Berlin, 13597, Germany

Location

Universitaetsklinikum Dresden

Dresden, 01307, Germany

Location

Zentrum fuer Klinische Studien Suedbrandenburg GmbH

Elsterwerda, 04190, Germany

Location

InnoDiab Forschung

Essen, 45136, Germany

Location

Praxis am Markt Dr. Bernd Becker

Essen, 45355, Germany

Location

Schwerpunktpraxis fuer Diabetes, Gefaess- & Ernaehrungsmedizin

Falkensee, 14612, Germany

Location

ClinPhenomics CVC GmbH

Frankfurt am Main, 60596, Germany

Location

Diabeteszentrum Hamburg West

Hamburg, 22607, Germany

Location

Endokrinologikum Hamburg

Hamburg, 22767, Germany

Location

Diabetologische Schwerpunktpraxis Hohenmoelsen

Hohenmölsen, 06679, Germany

Location

Braun Ambulantes Herzzentrum Kassel

Kassel, 34121, Germany

Location

Universitaetsklinikum Leipzig

Leipzig, 04103, Germany

Location

AmBeNet GmbH

Leipzig, 04107, Germany

Location

Universitaetsklinikum Schleswig-Holstein - Luebeck

Lübeck, 23538, Germany

Location

Marienhaus Klinikum Mainz

Mainz, 55131, Germany

Location

Kardiologische Praxis Doktor Jens Taggeselle

Markkleeberg, 04416, Germany

Location

Centrum für Diagnostik und Gesundheit

München, 80809, Germany

Location

Zentrum fuer Diabtes und Gefaesskrankheiten im Franziskus Carré Muenster

Münster, 48145, Germany

Location

Praxis Segner - Dr. Braun - Kirsch

Oberwürzbach, 66386, Germany

Location

Red-Institut GmbH

Oldenburg, 23758, Germany

Location

Gemeinschaftspraxis Prof Jacob/ Dr Jacob

Villingen-Schwenningen, 78048, Germany

Location

Zentrum fuer klinische Forschung Allgaeu Oberschwaben

Wangen, 88239, Germany

Location

IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant Orsola

Bologna, 40138, Italy

Location

Universita degli Studi Gabriele D Annunzio di Chieti e Pescara

Chieti, 66100, Italy

Location

Azienda Ospedaliero Universitaria Careggi

Florence, 50134, Italy

Location

IRCCS Centro Cardiologico Monzino

Milan, 20138, Italy

Location

Azienda Socio Sanitaria Territoriale Fatebenefratelli Sacco

Milan, 20157, Italy

Location

Ospedale Civico, Di Cristina e Benfratelli

Palermo, 90127, Italy

Location

Azienda Ospedaliero Universitaria Pisana

Pisa, 56126, Italy

Location

Fondazione Policlinico Tor Vergata

Roma, 00133, Italy

Location

Medical Corporation Hitomikai Motomachi Takatsuka Naika Clinic

Yokohama, Kanagawa, 231-0023, Japan

Location

Doujin Memorial Foundation, Meiwa Hospital

Chiyoda-ku, Tokyo, 101-0041, Japan

Location

Tokyo Asbo Clinic

Chuo-ku, Tokyo, 104-0031, Japan

Location

Medical Corp Seikoukai New Medical Research System Clinic

Hachioji-shi, Tokyo, 192-0046, Japan

Location

Medical Corporation AOT Shinagawa Strings Clinic

Minato-ku, Tokyo, 108-0075, Japan

Location

Clinical Research Hospital Tokyo

Shinjuku-ku, Tokyo, 160-0004, Japan

Location

Medical Corporation Hanabusakai Shinei Medical Healthcare Clinic

Suginami-ku, Tokyo, 166-0003, Japan

Location

Gabinet Leczenia Otylosci i Chorob Dietozaleznych dr hab n med Lucyna Ostrowska

Bialystok, 15-281, Poland

Location

Kresmed Spolka z Ograniczona Odpowiedzialnoscia

Bialystok, 15-481, Poland

Location

Etg Lublin Spzoo

Dębica, 39-200, Poland

Location

Futuremeds Spolka z ograniczona odpowiedzialnoscia

Gdynia, 81-384, Poland

Location

Uniwersyteckie Centrum Kliniczne im Prof K Gibinskiego Slaskiego UM w Katowicach

Katowice, 40-752, Poland

Location

Salvia-Lekston i Madej Spolka Jawna

Katowice, 40-772, Poland

Location

Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna

Lodz, 90-338, Poland

Location

Ekamed Spolka z Ograniczona Odpowiedzialnoscia

Lublin, 20-718, Poland

Location

Centrum Zdrowia Metabolicznego Pawel Bogdanski

Poznan, 60-589, Poland

Location

Clinical Research Center Spzoo Medic-R Spolka Komandytowa

Poznan, 61-731, Poland

Location

Futuremeds Spolka z ograniczona odpowiedzialnoscia

Warsaw, 00-215, Poland

Location

Clinical Best Solutions Sp zoo Spolka komandytowa

Warsaw, 00-710, Poland

Location

Ponce Medical School Foundation Inc

Ponce, 00716, Puerto Rico

Location

Puerto Rico Medical Research Inc.

Ponce, 00717, Puerto Rico

Location

Latin Clinical Trial Center

San Juan, 00909, Puerto Rico

Location

Wellness Clinical Research Vega Baja

Vega Baja, 00694, Puerto Rico

Location

Korea University Ansan Hospital

Ansan-si, Gyeonggi-do, 15355, South Korea

Location

Hallym University Sacred Heart Hospital

Anyang-si, Gyeonggi-do, 14068, South Korea

Location

The Catholic University of Korea Bucheon St Marys Hospital

Bucheon, Gyeonggi-do, 14647, South Korea

Location

Dong-A University Hospital

Busan, 49201, South Korea

Location

Kyungpook National University Hospital

Daegu, 41944, South Korea

Location

Yeungnam University Medical Center

Daegu, 42415, South Korea

Location

Daejeon Eulji Medical Center, Eulji University

Daejeon, 35233, South Korea

Location

Konyang University Hospital

Daejeon, 35365, South Korea

Location

Dongguk University Ilsan Hospital

Goyang-si, Gyeonggi-do, 10326, South Korea

Location

Gachon University Gil Medical Center

Incheon, 21565, South Korea

Location

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea

Location

Seoul National University Hospital

Seoul, 03080, South Korea

Location

Kangbuk Samsung Hospital

Seoul, 03181, South Korea

Location

Severance Hospital Yonsei University Health System

Seoul, 03722, South Korea

Location

KyungHee University Gangdong Hospital

Seoul, 05278, South Korea

Location

Seoul Metropolitan Government Seoul National University Boramae Medical Center

Seoul, 07061, South Korea

Location

The Catholic University of Korea Yeouido St Marys Hospital

Seoul, 07345, South Korea

Location

Ajou University Hospital

Suwon-si Gyeonggi-do, 16499, South Korea

Location

Pusan National University Yangsan Hospital

Yangsan-si, Gyeongsangnam-do, 50612, South Korea

Location

Centro Periferico de Especialidades Bola Azul

Almería, Andalusia, 04009, Spain

Location

Hospital Vithas Sevilla

Castilleja de la Cuesta, Andalusia, 41950, Spain

Location

Hospital Infanta Elena

Huelva, Andalusia, 21007, Spain

Location

Hospital Virgen del Camino

Sanlúcar de Barrameda, Andalusia, 11540, Spain

Location

Nuevas Tecnologias en Diabetes y Endocrinologia

Seville, Andalusia, 41003, Spain

Location

Hospital Quironsalud Infanta Luisa

Seville, Andalusia, 41010, Spain

Location

Hospital Medico Quirurgico San Rafael

A Coruña, Galicia, 15006, Spain

Location

Clinica Ruber SA

Pozuelo de Alarcón, Madrid, 28223, Spain

Location

Clinica Universidad de Navarra

Pamplona, Navarre, 31008, Spain

Location

Clinica Juaneda

Palma, 07014, Spain

Location

Hospital Universitario Doctor Peset

Valencia, 46017, Spain

Location

Universitaetsspital Basel

Basel, 4031, Switzerland

Location

Hopitaux Universitaires de Geneve

Geneva, 1211, Switzerland

Location

Kantonsspital Sankt Gallen

Sankt Gallen, 9007, Switzerland

Location

Stoffwechselzentrum Sankt Gallen

Sankt Gallen, 9016, Switzerland

Location

Universitaetsspital Zuerich

Zurich, 8091, Switzerland

Location

Ormeau Clinical Trials Ltd

Belfast, BT28BG, United Kingdom

Location

FutureMeds Birmingham

Birmingham, B21 9RY, United Kingdom

Location

Layton Medical Centre

Blackpool, FY3 7EN, United Kingdom

Location

Waterloo Medical Centre

Blackpool, FY4 3AD, United Kingdom

Location

Southmead Hospital

Bristol, BS10 5NB, United Kingdom

Location

The Rame Group Practice

Cornwall, PL11 2TB, United Kingdom

Location

Staploe Medical Centre

Ely, CB7 5JD, United Kingdom

Location

FutureMeds Glasgow

Glasgow, G20 7BE, United Kingdom

Location

Hull Royal Infirmary

Hull, HU3 2JZ, United Kingdom

Location

NIHR Leicestershire & Northamptonshire Commercial Research Delivery Centre

Leicester, LE5 4PW, United Kingdom

Location

Aintree University Hospital

Liverpool, L9 7AL, United Kingdom

Location

FutureMeds Newcastle

Newcastle upon Tyne, NE6 1SG, United Kingdom

Location

Atlantic Medical Group

Penzance, TR183DX, United Kingdom

Location

Clifton Medical Centre

Rotherham, S65 1DA, United Kingdom

Location

Ashfields Primary Care Centre

Sandbach, CW11 1EQ, United Kingdom

Location

Related Links

MeSH Terms

Conditions

ObesityOverweightBody Weight

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • MD

    Amgen

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 28, 2025

First Posted

March 5, 2025

Study Start

March 12, 2025

Primary Completion (Estimated)

January 21, 2027

Study Completion (Estimated)

April 16, 2027

Last Updated

October 20, 2025

Record last verified: 2025-10

Data Sharing

IPD Sharing
Will share

De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request.

Shared Documents
STUDY PROTOCOL, SAP, ICF, CSR
Time Frame
Data sharing requests relating to this study will be considered beginning 18 months after the study has ended and either 1) the product and indication have been granted marketing authorization in both the US and Europe or 2) clinical development for the product and/or indication discontinues and the data will not be submitted to regulatory authorities. There is no end date for eligibility to submit a data sharing request for this study.
Access Criteria
Qualified researchers may submit a request containing the research objectives, the Amgen product(s) and Amgen study/studies in scope, endpoints/outcomes of interest, statistical analysis plan, data requirements, publication plan, and qualifications of the researcher(s). In general, Amgen does not grant external requests for individual patient data for the purpose of re-evaluating safety and efficacy issues already addressed in the product labelling. Requests are reviewed by a committee of internal advisors. If not approved, a Data Sharing Independent Review Panel will arbitrate and make the final decision. Upon approval, information necessary to address the research question will be provided under the terms of a data sharing agreement. This may include anonymized individual patient data and/or available supporting documents, containing fragments of analysis code where provided in analysis specifications. Further details are available at the URL below.
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