Effects of Bidomain Cognitive and Aerobic Training on Cognitive Functioning in Mild Cognitive Impairment.

NCT06867016 | Completed

• 1 other identifier: REC/MS-PT/O2029 Saliha Ashfaq
• Study Type: interventional
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims to assess the effects of Bidomain cognitive and aerobic training on both cognitive functioning and quality of life in individuals with mild cognitive impairment.

Conditions

Mild Cognitive Impairment

Keywords

Cognition; Old age; mild cognitive impairment; aerobic; cognitive training

Outcome Measures

Primary Outcomes (2)

• Mini-mental state examination (MMSE)

  The Mini-Mental State Examination (MMSE) is a widely used screening test for cognitive deficits, with scores ranging from 0 to 30. A score of 24 or below indicates potential cognitive impairment, particularly for patients aged 65 and older. The MMSE evaluates verbal abilities, where scores of 30-27 are considered normal, while lower scores indicate mild (26-21 points), moderate (20-10 points), or severe (9-0 points) dementia.

  8 weeks

• Short Cognitive Test (SKT)

  The SKT (Syndrom-Kurz-Test) is a recognized short cognitive performance test used to detect attention and memory deficits. It features subtest norm values ranging from 0 to 3, with a total score ranging from 0 to 27, where higher scores indicate more severe cognitive impairment. The SKT assesses memory performance and attention based on processing speed. The SKT (Syndrom-Kurz-Test) is a recognized short cognitive performance test used to detect attention and memory deficits. It features subtest norm values ranging from 0 to 3, with a total score ranging from 0 to 27, where higher scores indicate more severe cognitive impairment. The SKT assesses memory performance and attention based on processing speed.

  8 weeks

Secondary Outcomes (1)

• World health observational quality of life-BREF-100

  8 weeks

Study Arms (2)

Combined Cognitive & Aerobic Training Group

EXPERIMENTAL

The ACT combined training will consist of simultaneous aerobic exercise and cognitive training in a dual-task format.

Other: Combined Cognitive & Aerobics Training

Cognitive Training Group

ACTIVE COMPARATOR

Cognitive training group include cognitive training involving speed processing, memory recall, problem-solving, and visual attention exercises.

Other: Cognitive Training

Interventions

Combined Cognitive & Aerobics Training OTHER

The ACT combined training will consist of simultaneous aerobic exercise and cognitive training in a dual-task format, conducted twice a week for 8 weeks. The aerobic training (AT) will consist of twice-weekly sessions that include yoga, brisk walking, pedaling exercises, and step aerobics, alongside cognitive training involving speed processing, memory recall, problem-solving, and visual attention exercises. Each session will last approximately 20 minutes, and assessments will be performed at baseline, 4th week, and 8th week.

Combined Cognitive & Aerobic Training Group

Cognitive Training OTHER

Cognitive training involving speed processing, memory recall, problem-solving, and visual attention exercises. Each session will last approximately 20 minutes, and assessments will be performed at baseline, the 4th week, and the 8th week.

Cognitive Training Group

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Older adults 60 years \& above
• With normal vision and color perception
• Independent Individual capable of carrying out daily tasks
• Individuals scoring 21-25 on the Mini-Mental State Examination (MMSE)

You may not qualify if:

• Medication affecting the exercise capacity of individual
• Regular participation in aerobic training for the last six months
• Cardiovascular or other diseases that do not allow physical activity
• A diagnosed severe psychiatric disease (e.g., depression)
• Patients with cognitive impairment or other neurological impairments due to AD or dementia.

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

DHQ Chakwal

Chakwal, Punjab Province, 48800, Pakistan

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Cognitive Training

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Neurological Rehabilitation; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Officials

• Saliha Ashfaq, MS-NMPT*

  Riphah International University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 4, 2025
• First Posted: March 10, 2025
• Study Start: February 28, 2025
• Primary Completion: August 28, 2025
• Study Completion: August 28, 2025
• Last Updated: April 8, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)