Making Memory Better for Seniors With Mild Cognitive Impairment

NCT01532739 | Active Not Recruiting

• 1 other identifier: CDHA-RS/2012-227
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the feasibility and effectiveness of a cognitive training group in individuals with Mild Cognitive Impairment, using a new paradigm that will optimize ecological validity by (1) focusing on everyday memory problems, (2) supplementing traditional memory training with the teaching of an empirically-supported problem-solving approach, and (3) employing a clinically representative sample of individuals with MCI (e.g., not excluding those with mild affective symptoms).

Conditions

Mild Cognitive Impairment

Keywords

Mild Cognitive Impairment; Aging; Memory; Executive Function; Cognitive Intervention; Memory Training; Mental Health

Outcome Measures

Primary Outcomes (1)

• Change in everyday memory functioning

  Rivermead Behavioural Memory Test (3rd Edition)

  Measured at baseline and months 3, 5, 8

Secondary Outcomes (8)

• Change on traditional memory testing

  Measured at baseline and months 3, 5, 8

• Change in memory perception

  Measured at baseline and months 3, 5, 8

• Change in mood (i.e., self-report symptoms of depression)

  Measured at baseline and months 3, 5, 8

• Change in mood (i.e., self-report symptoms of anxiety)

  Measured at baseline and months 3, 5, 8

• Change in other psychiatric symptoms (informant-report)

  Measured at baseline and months 3, 5, 8

Study Arms (2)

Cognitive training

EXPERIMENTAL

Behavioral: Cognitive training

No cognitive training

NO INTERVENTION

Interventions

Cognitive training BEHAVIORAL

The cognitive training consists of 10 weekly 2-hour sessions. It is run with groups of MCI participants and their study partners (who help with reinforcing the strategies in everyday activities). The program provides information about memory and lifestyle factors in the first two weeks, followed by training and practice over the next eight weeks on empirically-supported cognitive strategies known to be effective at supporting day-to-day remembering in MCI. Participants learn to apply a core set of strategies (spaced retrieval, memory book logging) across a variety of common memory problems (e.g., remembering names, appointments, etc). To enhance the likelihood that these strategies will transfer to other settings beyond training, participants are also taught a memory problem solving approach that will cue them to recognize situations in which they need to: (1) stop and remember something, (2) select and apply an appropriate memory strategy, and (3) monitor that it is working.

Cognitive training

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinical diagnosis of Mild Cognitive Impairment

You may not qualify if:

• Clinical diagnosis of dementia
• History of neurological conditions known to impair cognition
• History of alcohol or drug abuse
• History of chronic psychiatric illness
• Current symptoms of moderate to severe depression (Geriatric Depression Scale \>19) or anxiety (Beck Anxiety Inventory \>15)

Sponsors & Collaborators

• Nova Scotia Health Authority: lead
• Nova Scotia Health Research Foundation: collaborator

Study Sites (1)

Neuropsychology Service, Nova Scotia Hospital

Dartmouth, Nova Scotia, B2Y 3Z9, Canada

Location

MeSH Terms

Conditions

Cognitive Dysfunction; Psychological Well-Being

Interventions

Cognitive Training

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Personal Satisfaction; Behavior

Intervention Hierarchy (Ancestors)

Neurological Rehabilitation; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Officials

• Karen A Chipman, PhD

  Nova Scotia Health Authority

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2012
• First Posted: February 14, 2012
• Study Start: December 5, 2011
• Primary Completion: December 5, 2025
• Study Completion: December 5, 2025
• Last Updated: August 21, 2024

Record last verified: 2024-08

Locations

CA (1)