Neurobic Exercise Program on Cognitive Abilities

NCT06601751 | Completed DMC

• 1 other identifier: Memoona Awan
• Study Type: interventional
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

This research aims to investigate the significance of a neurobic exercise program on cognitive abilities, memory retention, activities of daily living (ADL), and quality of life (QOL) among older adults with mild cognitive impairment in Pakistan. It aims to find the long-term effects of a neurobic exercise program by comparing subjective and objective memory and its effects on quality of life.

Conditions

Mild Cognitive Impairment

Keywords

Cognitive impairment; Neurobic exercise; Memory; ADL

Outcome Measures

Primary Outcomes (3)

• MOCA (Montreal Cognitive Assessment)

  The MOCA is a popular screening tool used to determine if cognitive impairment is present. It takes approximately ten minutes to complete. It evaluates visuospatial skills, attention, language, abstract reasoning, delayed recall, executive function, and orientation. MoCA is scored out of 30. A cut-off score of 26 signifies mild cognitive impairment.

  9 weeks

• Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)

  It is used to measure subjective memory. This test measures the informant's perception of the older person's cognitive decline. Older adults are required to compare their performance today with their performance ten years ago. Informants were asked to indicate the change on a 16-item scale from 1 (much improved) to 5 (much worse). The cut-off scores were based on the total score divided by the number of questions (average item score range 1- 5). Lower scores indicated better subjective memory performance.

  9 weeks

• Common Object Memory Test (COMT)

  It is used to measure objective memory. The COMT was designed to assess age related memory impairments in individuals with various educational, language, and cultural backgrounds. It included repeated presentations of colour photographs containing 10 common objects (button, chair, clock, comb, cup, key, knife, leaf, scissors and umbrella) and multiple opportunities for participants to recall and recognise the original list. The total COMT scores were summed across these three steps, and the possible range was 0-90. Higher scores indicated better objective memory performance.

  9 weeks

Secondary Outcomes (1)

• Modified Barthel ADL Index (BAI)

  9 weeks

Study Arms (2)

Neurobic exercise program

EXPERIMENTAL

Neurobic exercise program + Traditional Brain Exercises

Other: Neurobic Exercise Program

Traditional brain exercises

ACTIVE COMPARATOR

Traditional brain exercises calculation or memory games.

Other: Traditional Brain Exercise

Interventions

Neurobic Exercise Program OTHER

6 weeks to improve cognitive function, memory and overall brain health by introducing non-routine activities that require participants to utilise their multiple senses and remember sequences and patterns. Each activity would be performed 2-3 times/ session, for recalling the observation period set at 1 minute and at the end of the 9th week, the memory retention effect will be measured.

Neurobic exercise program

Traditional Brain Exercise OTHER

activities like calculation or memory games. These exercises will be conducted in 2 days/week for 60-minute sessions in 6 weeks. The memory retention effect will be measured at the end of the 9th week. It is intended to be the baseline for comparing the effectiveness of a neurobic exercise program.

Traditional brain exercises

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Older adults above 60
• Both male and female.
• Scored \<24 on the Montreal Cognitive Assessment (MoCA).
• Scored \>12 on the Modified Barthel ADL index (BAI).
• Ability to write and read as well as communicate well, willingness to participate in the study throughout the program

You may not qualify if:

• Neurological, musculoskeletal, psychiatric conditions, hearing loss and visual impairment.
• Older adults with a history of allergies to the food or flowers used in the activities.

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

ZUK old home and health care center, Ghulam Haider Road, House# I-546-547, 342, 343, Faiz Building St#5, Committee Chowk, Rawalpindi.

Rawalpindi, Punjab Province, Pakistan

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Dr.Aroosa Tariq, MS-NMPT

  RIPHAH INTERNATIONAL UNIVERSITY ISLAMABAD

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 16, 2024
• First Posted: September 19, 2024
• Study Start: September 22, 2024
• Primary Completion: May 25, 2025
• Study Completion: June 25, 2025
• Last Updated: July 8, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)